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Neuroendokrine Darm- und Pankreastumoren (Apudome)

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Therapiekonzepte Onkologie

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Zusammenfassung

Die Diagnose basiert auf dem Nachweis neuroendokriner Eigenschaften der Tumorzellen (APUD) mit positiver argyrophiler Färbung und Chromogranin AImmunreaktivität. Die klassischen „Midgut“-Karzinoide enthalten Serotonin und weisen eine positive Silberfärbung (Masson) auf. Andere neuroendokrine immunhistochemische Marker sind die neuronenspezifische Enolase (NSE) und das Synaptophysin. Das biologische Tumorverhalten zeigt eine Abhängigkeit von der Lokalisation des Primärtumors. Appendix-Karzinoide, die die häufigsten Tumoren darstellen (30%) und oft zufällig bei der Appendektomie mit einem Durchmesser von < 1 cm gefunden werden, sind selten maligne. Andere Dünndarmkarzinoide weisen eine potentielle Malignität auf und metastasieren vorzugsweise in regionale Lymphknoten und in die Leber. Multiple, synchrone Primärtumoren werden bei 20%–30% der Patienten beobachtet. Es werden üblicherweise fünf histologische Varianten des Karzinoids beschrieben: glandulär, trabeculär, nestförmig, undifferenziert und gemischtförmig. Tumoren mit nestförmigem Wachstumsverhalten sollen einen gutartigeren Verlauf aufweisen als Tumoren mit glandulärem oder undifferenziertem Wachstumsmuster.

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Authors
  1. B. Eriksson
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  2. K. Öberg
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Editors and Affiliations

  1. Innere Klinik und Poliklinik (Tumorforschung), Westdeutsches Tumorzentrum Essen, Universitätsklinikum Essen, Hufelandstraße 55, 45122, Essen, Deutschland

    Siegfried Seeber  & Jochen Schütte  & 

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© 1993 Springer-Verlag Berlin Heidelberg

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Eriksson, B., Öberg, K. (1993). Neuroendokrine Darm- und Pankreastumoren (Apudome). In: Seeber, S., Schütte, J. (eds) Therapiekonzepte Onkologie. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-10495-8_27

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  • DOI: https://doi.org/10.1007/978-3-662-10495-8_27

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-56872-8

  • Online ISBN: 978-3-662-10495-8

  • eBook Packages: Springer Book Archive

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