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Mesotheliom

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Therapiekonzepte Onkologie

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Zusammenfassung

Das maligne Mesotheliom entwickelt sich meist als ein diffuser Tumor der Pleura, des Peritoneums oder seltener des Perikards oder der Tunica vaginalis. Meist besteht ein seröser Erguß, der abgeschilferte maligne Mesotheliomzellen enthält. Das diffuse maligne Mesotheliom kann sowohl pathologisch als auch klinisch mit einer Vielzahl von entzündlichen Prozessen und malignen Tumoren verwechselt werden, bes. mit Adenokarzinomen und/oder Sarkomen. Für die Differentialdiagnose besonders gegenüber Adenokarzinomen sind oft (immun-)histochemische Methoden (PAS-D, Keratin) hilfreich. Es gibt im wesentlichen drei histologische Typen: epithelial (50%–60%), sarkomatös (10%–20%), und Mischtyp [6, 7]. Epitheliale Subtypen sollen eine bessere Prognose aufweisen als sarkomatöse Varianten [8–11]. Maligne Mesotheliome metastasieren meist zunächst lokoregional; eine extrathorakale lymphatische und/oder hämatogene Metastasierung ist bei Diagnosestellung relativ selten, wird aber bei Autopsien häufig beobachtet [12].

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Authors
  1. J. Klastersky
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  1. Innere Klinik und Poliklinik (Tumorforschung), Westdeutsches Tumorzentrum Essen, Universitätsklinikum Essen, Hufelandstraße 55, 45122, Essen, Deutschland

    Siegfried Seeber  & Jochen Schütte  & 

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© 1993 Springer-Verlag Berlin Heidelberg

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Klastersky, J. (1993). Mesotheliom. In: Seeber, S., Schütte, J. (eds) Therapiekonzepte Onkologie. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-10495-8_11

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  • DOI: https://doi.org/10.1007/978-3-662-10495-8_11

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-56872-8

  • Online ISBN: 978-3-662-10495-8

  • eBook Packages: Springer Book Archive

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