Zusammenfassung
Wichtigste Unterscheidung in Seminom (spermatozytär, klassisch) und Nichtseminom (embryonales Karzinom, Dottersacktumor, Chorionkarzinom, reifes und unreifes Teratom, selten: Polyembryom, Teratom mit malignen Veränderungen) — Einteilung nach WHO [8]. Histopathologische Malignitätsgrade werdrn nicht unterschieden. Frühform: Carcinoma in situ (Cis) bzw. Testikuläre intraepitheliale Neoplasie (TIN); in 5% der Fälle bei Diagnose im kontralateralen Hoden vorhanden [9,10].
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Literatur
Pottern LM, Goedert JJ (1986) Epidemiology of Testicular Cancer. In: Javadpour N (ed) Principles and Management of Testicular Cancer. Thieme, New York, pp 108–119
Senturia YD (1987) The Epidemiology of Testicular Cancer. Br J Urol 60: 285–291
Osterlind A (1986) Diverging trends in incidence and mortality of testicular cancer in Denmark, 1943–1982. Br J Cancer 53: 501
Heimdal K, Fossa SD, Johansen A (1990) Increasing incidence and changing stage distribution of testicular carcinoma in Norway 1970–1987. Br J Cancer 62: 277–278
Levi F, Te VC, La Vecchia C (1990) Testicular cancer trends in the Canton of Vaud, Switzerland, 1974–1987. Br J Cancer 62: 871–873
Sommerhoff CH (1982) Altersverteilung. In: Weißbach L, Hildenbrand G (Hrsg) (1991) Register und Verbund-Studie für Hodentumoren — Bonn. Ergebnisse einer prospektiven Untersuchung. Zuckschwert, München, S 209–214
Forman D, Gallagher R, Moller H et al. (1990) Aetiology and epidemiology of testicular cancer: report of consensus group. In: Newling DWW and Jones WG (Hrsg) Prostate cancer and testicular cancer. Wiley-Liss Inc, New York, S 245–253
Mostofi FK, Sobin LH (1977) Histological typing of testis tumours. International Histologial Classification of Tumours, No 16. WHO Genf
Von der Maase H (1991) Diagnosis and management of carcinoma in situ of the testis. In: Horwich A (ed) Testicular cancer. Investigation and management. Chapman & Hall Medical, London-New York, pp 319–330
Dieckmann KP, Loy V, Huland H (1989) Das Carcinoma in situ des Hodens: Klinische Bedeutung, Diagnostik und Therapie. Urologe A 28: 271–280
Einhorn LH (1987) Treatment strategies of testicular cancer in the Unites States. In: Rorth M, Daugaard G, Skakkebaek NE et al. (eds) Carcinoma in situ and Cancer of the Testis. Blackwell Scientific Publ, Oxford, pp 399–405
UICC (1992) TNM Klassifikation maligner Tumoren. Hermanek P, Scheibe O, Spiessl B, Wagner G (Hrsg) Springer-Verlag Berlin, 4. Auflage, 2. Revision
Hartlapp HJ, Weißbach L (1982) Zur Notwendigkeit der Unterteilung des Stadium II bei Hodentumoren. In: Illiger HJ, Sack H, Seeber S, Weißbach L (Hrsg) Nichtseminomatöse Hodentumoren. Beiträge zur Onkologie 8, Karger, Basel, S72–75
Bosl GJ, Geller NL, Cirrincione C et al. (1983) Multivariate analysis of prognostic variables in patients with metastatic testicular cancer. Cancer Res 43: 3403–3407
Cavalli F, Monfardini S, Pizzocaro G (1980) Report on the international workshop on staging and treatment of testicular cancer. Eur J Cancer 16: 1367–1372
Droz JP, Kramar A, Ghosn M et al. (1988) Prognostic factors in advanced nonseminomatous testicular cancer. Cancer 62: 564–568
Medical Research Council Working Party on Testicular Tumours (1985) Prognostic factors in advanced non-seminomatous germ-cell testicular tumours. Lancet ii: 8–11
Ozols RF, Ihde DC, Linehan WM et al. (1988) A randomized trial of standard chemotherapy vs a high-dose chemotherapy regimen in the treatment of poor prognosis nonseminomatous germ cell tumors. J Clin Oncol 6: 1031–1040
Scheulen ME, Niederle N, Pfeiffer R, Schmidt CG (1988) Prognostische Faktoren bei Patienten mit fortgeschrittenen nichtseminomatösen Hoden-Karzinomen. In: Schmoll HJ, Weißbach L (Hrsg) Diagnostik und Therapie von Hodentumoren. Springer, Berlin, S 96–110
Stoter G, Sylvester R, Sleijfer DT et al. (1987) Multivariate analysis of prognostic factors in patients with disseminated nonseminomatous testicular cancer: results from a European Organization for Research on Treatment of Cancer Multiinstitutional Phase III Study. Cancer Res 47: 2714–2718
Stoter G, Bosl GJ, Droz JP et al. (1990) Prognostic factors in metastatic germ cell tumours. In: Newling DW, Jones WG (eds) Prostate cancer and testicular cancer. Wiley-Liss Inc, New York, pp 313–319
Birch R, Williams S, Cone A et al. (1986) Prognostic factors for favorable outcome in disseminated germ cell tumors. J Clin Oncol 4: 400–407
Weißbach L, Hildenbrand G (1984) Register und Verbundstudie für Hodentumoren. Ein Ergebnisbericht nach sieben Jahren. Z allg Med 60: 156–163
Droz JP, van Oosterom AT (1993) Treatment Options in Clinical Stage I Nonseminomatous Germ Cell Tumours of the Testis: A Wager on the Future? Eur J Cancer 26A: 1038–1044
Stoter G, Sylvester R (1994) Prognostic Factors in Disseminated Non-Seminomatous Testicular Cancer. Proc ASCO 13:230 Abstract-No 705
Mead GM, Stenning SP (1994) Prognostic Factors for Metastatic Germ Cell Cancer Treated with Platinum-Based Chemotherapy: The International Germ Cell Cancer Collaborative Group project to Standardize Risk Criteria. Proc ASCO 13:251 Abstract-No 790
Bajorin DF, Mazumdar M, Motzer RJ, Vlamis V, Bosl GJ (1994) Model Comparisons Prediction Germ Cell Tumor Response to Chemotherapy. Proc ASCO 13, 232 Abstract-No 715
Heidenreich A, Stark L, Derschum W, Vietsch H von (1993) Die organerhaltende Therapie des bilateralen Hodentumors. Urologe A 32: 43
Weißbach L (1993) Ist eine organerhaltende Operation des Hodentumors gerechtfertigt? Urologe A 32: 49
Donohue JP (1990) Nerve-sparing retroperitoneal lymphadenectomy. In: Jaeger, Hartlapp JH (Hrsg) Aktueller Stand der Diagnostik und Therapie von Hodentumoren, Karger, Basel, S 195–204
Huland H, Dieckmann KP, Sauerwein D (1992) Nerverhaltende retroperitoneale Lymphadenektomie mit intraoperativer Elektrostimulation bei Patienten mit nichtseminomatösen Hodentumoren. Urologe A 31: 1–7
Weißbach L, Boedefeld EA for the Testicular Tumor Study Group (1987) Localization of Solitary and Multiple Metastases in Stage II Nonseminomatous Testis Tumor as Basis for a Modified Staging Lymph Node Dissection in Stage I. J Urol 138: 77–82
Jaeger N, Weißbach L (1990) Indikation und Ausmaß der Salvage-Lymphadenektomie beim germinalen Hodentumor. Akt Urol 21: 57–63
Fox EP, Einhorn LH, Weathers T et al. (1992) Outcome analysis for patients with persistent germ cell carcinoma in postchemotherapy retroperitoneal lymph node dissections. Proc Am Soc Clin Oncol 11: Abstract No 608
Bajorin DF, Herr H, Motzer RJ, Bosl GJ (1992) Current perspectives on the role of adjunctive surgery in combined modality treatment for patients with germ cell tumors. Sem Oncol 19: 148–158
Jäger N, van Ahlen H (1992) Die klinische Bedeutung der Marker AFP, HCG und LDH beim fortgeschrittenen Keimzelltumor. Urologe B 32: 21–23
Herr HW, Toner GC, Geller NL, Bosl GJ (1991) Patient Selection for Retroperitoneal Lymph Node Dissection after Chemotherapy for Nonseminomatous Germ Cell Tumors. Eur Urol 19: 1–5
Fossa SD, Aass N, Ous S, Hole J, Stenwig AE, Lien HH, Paus E, Kaalhus O (1989) Histology of Tumor Residuals Following Chemotherapy in Patients with Advanced Nonseminomatous Testicular Cancer. J Urol 142: 1239–1242
Levitt MD, Reynolds PM, Sheiner HJ, Byrne MJ (1985) Non-seminomatous germ cell testicular toumours: residual masses after chemotherapy. Br J Surg 72: 19–22
Fossa SD, Ous S, Lien HH, Stenwig AE: Post-Chemotherapy Lymph Node Histology in Radiologically Normal Patients With Metastatic Nonseminomatous Testicular Cancer. J Urol 141: 557–559
Donohue JP, Rowland RG, Kopecky K, Steidle ChP, Geier G, Ney KG, Einhorn L, Williams S, Loehrer P (1987) Correlation of Computerized Tomographic Changes and Histological Findings in 80 Patients Having Radical Retroperitoneal Lymph Node Dissection after Chemotherapy for Testis Cancer. J Urol 137: 1176–1179
Toner GC, Herr HW, Panicek DM, Heelan RT, Geller NL, Lin SY, Whitmore WF, Fair WR, Morse MJ, Sogani PC, Bosl GJ (1990) Patients Selection For Retroperitoneal Lymph Node Dissection After Chemotherapy For Nonseminomatous Germ Cell Tumors. J Urol AUA, Abstract No 828
Murphy BR, Roth BJ, Foster RS, Bihrle R, Rowland RG, Messemer J, Sc B, Wahle G, Einhorn LH, Donohue JP (1993) Surgical salvage of chemorefractory germ cell tumors. J Urol 149: 454A — AUA Abstract No 967
Kührer I, Kratzik C, Wiltschke C (1991) Single Agent Carboplatin for Stage I Seminoma. Onkologie 14, Suppl 4: 23
Oliver RTD (1991) A comparison of the biology and prognosis of seminoma and non-seminoma. In: Horwich A (ed) Testicular cancer. Investigation and management. Chapman & Hall Medical, London-New York, pp 51–67
Horwich B, Dearnaley DP, Duchesne GM et al. (1989) Simple Nontoxic Treatment of Advanced Metastatic Seminoma With Carboplatin. J Clin Oncol 7: 11501156
Horwich A, Dearnaley D, Mason M, A Hearn R (1991) Single agent carboplatin for advanced seminoma. Proc Am Soc Clin Oncol 10: Abstract No 550
Schmoll HJ, Harstrick A, Bokemeyer C et al. (1993) Single agent Carboplatin for advanced seminoma. Cancer 72: 237–243
Clemm C, Hartenstein R, Willich N, Heim M, Wagner M, Williams W (1988) VIP-Chemotherapie beim Seminom mit großer Tumormasse. In: Schmoll HJ, Weißbach L (Hrsg) Diagnostik und Therapie von Hodentumoren. Springer, Berlin, S 461–467
Fossa SD, Borge L, Aass N et al. (1987) The treatment of advanced metastatic seminoma: Experience in 55 cases. J Clin Oncol 5: 1071–1077
Sandeman TF, Yang C (1988) Results of Adjuvant Chemotherapy for Low-Stage Nonseminomatous Germ Cell Tumors of the Testis With Vascular Invasion. Cancer 62: 1417–1475
Madej G, Pawinski A (1991) Risk-related adjuvant chemotherapy for stage I nonseminoma of the testis. Clin Oncol 3: 270–272
Gonnermann D (1991) Primäre Chemotherapie beim Nichtseminom im Stadium I, Onkologie 14, Suppl 4: 14
Chevreau C, de Forni M, Soulie M Mihura J, Plante P (1991) Is adjuvant chemotherapy a beneficial treatment in stage I high non seminomatous testicular germ cell tumour? Eur J Cancer Suppl 2: Abstract No 651
Studer UE, Fey MF, Calderoni A, Kraft R, Mazzucchelli L, Sonntag RW (1993) Adjuvant Chemotherapy after Orchiectomy in High-Risk Patients with Clinical Stage I Non-Seminomatous Testicular Cancer. Eur Urol 23: 444–449
Cullen MH (1994) Short course adjuvant chemotherapy in high risk stage I nonseminomatous germ cell tumours of the testis: An MRC Study Report. In: Germ Cell Tumours III (ed by Jones WG, Harden P, Appleyard I ), Elsevier Science Ltd Oxford New York Tokyo, p 201–202
Pont J, Albrecht W, Höltl W (1994) NSGCT Stage 1— Adjuvant chemotherapy for patients with vascular invasion and surveillance for patients without vascular invasion: Update of a prospective Trial after 8 years. In: Germ Cell Tumours III (ed by Jones WG, Harden P, Appleyard I ), Elsevier Science Ltd Oxford New York Tokyo, pp 207–208
Oliver RTD, Raja MA, Ong J, Gallagher CJ (1992) Pilot Study to Evaluate Impact of a Policy of Adjuvant Chemotherapy for High Risk Stage 1 Malignant Teratoma on Overall Relapse Rate of Stage 1 Cancer Patients. J Urol 148: 1453–1456
Weißbach L, Hartlapp HJ (1991) Adjuvant chemotherapy of metastatic stage II non-seminomatous testis tumor. J Urol 146: 1295–1298
Williams SD, Stablein DM, Einhorn LH et al. (1987) Immediate adjuvant chemotherapy versus observation with treatment at relapse in pathological stage II testicular cancer. N Engl J Med 317: 1433–1488
Williams SD, Birch R, Einhorn LH et al. (1987) Treatment of disseminated germ cell tumors with cisplatin, bleomycin, and either vinblastine or etoposide. N Engl J Med 316: 1435–1440
Stoter G, Kaye S, Jones W et al. (1987) Cisplatin and Vp 16 ± Bleomycin (BEP vs EP) in good risk patients with disseminated non-seminomatous testicular cancer; results of a randomized EORTC-GU group study. Proc ECCO P 179: Abstract No 681
Einhorn LH, Williams SD, Loehrer PJ et al. (1989) Evaluation of optimal duration of chemotherapy in favorable-prognosis disseminated germ cell tumors: a southeastern cancer study group protocol. J Clin Oncol 7: 387–391
Bajorin DF, Sarosdy MF, Pfister DG et al. (1993) Randomized trial of etoposide and carboplatin in patients with good risk germ cell tumours. A multiinstitutional study. J Clin Oncol 11: 598–606
Loehrer PJ, Elson P, Johnson DH et al. (1991) A randomized trial of cisplatin plus etoposide with or without bleomycin in favorable prognosis disseminated germ cell tumors: an ECOG study. Proc Am Soc Clin Oncol 10: Abstract No 540
Ozols RF, Ihde DC, Linehan WM et al. (1988) A randomized trial of standard chemotherapy vs a high-dose chemotherapy regimen in the treatment of poor prognosis non-seminomatous germ-cell tumors. J Clin Oncol 6: 1031–1040
Nichols CR, Williams SD, Loehrer PJ et al. (1991) Randomized study of cisplatin dose intensity in advanced germ cell tumors. A Southeastern and Southwest Oncology Group Protocol. J Clin Oncol 9: 1163–1172
Loehrer PJ, Einhorn LH, Elson P, Williams SD, Havlin K, Vogelzang NJ, Crawford ED, Trump DL (1993) Phase III study of cisplatin plus etoposide with either bleomycin of ifosfamide in advanced stage germ cell tumors: an intergroup trial. Proc Am Soc Clin Oncol 12:261 — Abstract No 831
Chevreau C, Droz JP, Pico JL, Biron P, Kerbrat P, Cure H, Heron JF, Chevallier B, Fargeot P, Kramar A, Bouzy J (1993) Early Intensified chemotherapy with autologous bone marrow transplantation in first line treatment of poor risk nonseminomatous germ cell tumours. Preliminary results of a french randomized trial-Eur Urol 23: 213–218
Loehrer PJ, Einhorn LH, Williams SD et al. (1986) VP-16 plus ifosfamide plus cisplatin as salvage therapy in refractory germ cell cancer. J Clin Oncol 4: 528–536
Harstrick A, Schmoll HJ, Wilke H et al. (1991) Cisplatin, etoposide and ifosfamide salvage therapy for refractory or relapsing germ cell carcinoma. J Clin Oncol 9: 1549–1555
Ghosn M, Droz JP, Theodore C et al. (1988) Salvage chemotherapy in refractory germ cell tumors with etoposide plus ifosfamide plus high-dose cisplatin. Cancer 62: 24–27
Munshi NC, Loehrer PJ, Roth BJ et al. (1990) Vinblastine, ifosfamide and cisplatin as second line chemotherapy in metastatic germ cell tumors. Proc Am Soc Clin Oncol 9: Abstract No 520
Nichols CR, Tricot G, Williams SD et al. (1989) Dose intensive chemotherapy in refractory germ cell cancer — A phase I/II trial of high dose carboplatin and etoposide with autologous bone marrow transplantation. J Clin Oncol 7: 932939
Nichols CR, Andersen J, Lazarus HM et al. (1992) High-dose carboplatin and etoposide with autologus bone marrow transplantation in refractory germ cell cancer. An Eastern Cooperative Oncology Group protocol. J Clin Oncol 72: 237–243
Linkesch W, Krainer M, Wagner A (1992) Phase I/II trial of ultrahigh carboplatin, etoposide, cyclophosphamide with ABMT in refractory or relapsed non-seminomatous germ cell tumors. Proc Am Soc Clin Oncol 11: Abstract No 600
Broun ER, Nichols CR, Turns M, Einhorn LH (1993) First line salvage therapy with conventional dose induction therapy and high dose chemotherapy with autologous bone marrow rescue for germ cell cancer. Proc Am Soc Clin Oncol 12: Abstract No 702
Siegert W, Beyer J, Strohscheer I et al. (1994) High dose treatment with carboplatin, etoposide and ifosfamide followed by autologous stem cell transplantation in relapsed or refractory germ cell cancers. A phase I/II study. J Clin Oncol 12: 1223–1231
Dieckmann KP, Besserer A, Loy V (1993) Low-dose radiotherapy for testicular intraepithelial neoplasia (Carcinoma in situ testis) — J Urol 149:454A — AUA Abstract No 964
Giwercman A, von der Maase H, Berthelsen JG, Rorth M, Bertelsen A, Skakkebaek NE (1991) Localized irradiation of testes with carcinoma in situ: Effects on leydig cell function and eradication of malignant germ cells in 20 patients. J Clin Endocrinol Metab 73: 596
Bussar-Maatz R, Weißbach L (1994) Prognosis of the HCG positive Seminoma. J Cancer Res Clin Oncol, Suppl 120: 65
Schmidberger H, Bamberg M, Schorcht J, Souchon R, Walter F, Born H, Flink MA (1994) Radiotherapy in Stage I, IIA and IIB Seminoma Testis. J Cancer Res Clin Oncol, Suppl 120: 66
Clemm Ch, Gerl A, Wendt TG, Pollinger B, Winkler PA, Wilmanns W (1993) Derzeitiger Stand der Therapie von ZNS-Metastasen bei Keimzelltumoren. Urologe A 32: 217–224
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Weißbach, L..., Harstrick, A., Bussar-Maatz, R. (1995). Hodentumoren. In: Seeber, S., Schütte, J. (eds) Therapiekonzepte Onkologie. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-10494-1_42
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