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Weichteilsarkome

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Therapiekonzepte Onkologie

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Zusammenfassung

Es werden mindestens 15 histologische Subtypen unterschieden, wobei die histopathologische Typisierung von geringerer prognostischer Relevanz ist als der histopathologische Differenzierungsgrad und die Tumorgröße; diese beiden Prognosefaktoren sind daher in der Stadieneinteilung der UICC berücksichtigt [1, 4, 5, 6].

In diesem Kapitel werden ausschießlich Weichteilsarkome des Erwachsenen berücksichtigt. Hinsichtlich der Therapie von Ewing- und Kaposi-Sarkomen wird auf die entsprechenden Kapitel dieses Buches, hinsichtlich der Therapie von Weichteilsarkomen des Kindes- und Jugendalters auf entsprechende pädiatrische Behandlungsprotokolle verwiesen.

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Literatur

  1. Enzinger FM, Weiss SW (eds) (1988) Soft Tissue Tumors. C. V. Mosby Compay, St. Louis Washington, D.C., Toronto

    Google Scholar 

  2. McClay EF (1989) Epidemiology of Bone and Soft Tissue Sarcomas. Sem Oncol 16: 264–272

    CAS  Google Scholar 

  3. Silverberg E, Boring CC, Squires TS (1990) Cancer Statistics, 1990. In: Ca-A Cancer Journal for Clinicians, Vol. 40:9–26, American Cancer Society, Inc

    Google Scholar 

  4. Lack E, Steinberg S, White D (1989) Extremity soft tissue sarcomas: Analysis of prognostic variables in 300 cases and evaluation of tumor necrosis as a factor in stratifying higher-grade sarcomas. J Surg Oncol 41: 263–273

    Article  PubMed  CAS  Google Scholar 

  5. UICC (1990) TNM-Atlas. Illustrierter Leitfaden zur TNM/pTNM-Klassifikation maligner Tumoren. Spiessl B et al. (eds) Springer-Verlag, Berlin Heidelberg New York, S 85–87

    Google Scholar 

  6. Suit HD, Mankin HJ, Wood WC, Gebhardt MC, Harmon DC, Rosenberg A, Tepper JE, Rosenthal D (1988) Treatment of the patient with stage Mo soft tissue sarcoma. J Clin Oncol 6: 854–862

    PubMed  CAS  Google Scholar 

  7. Heise HW, Myers MH, Russel WO (1986) Recurrence-free survival time for surgically treated soft tissue sarcoma patients. Cancer 57: 172–177

    Article  PubMed  CAS  Google Scholar 

  8. Lawrence W, Donegan W, Natarajan N (1987) Adult soft tissue sarcomas: A pattern of care survey of the American College of Surgeons. Ann Surg 205: 349–359

    Article  PubMed  Google Scholar 

  9. Suit HD, Spiro IJ (1992) Role of radiation therapy in management of patient with sarcoma of soft tissue. 34th Annual Meeting of the American Society for Therapeutic Radiology and Oncology. Refresher Course 105, New Orleans

    Google Scholar 

  10. Yang JC, Rosenberg SA (1989) Surgery for Adult Patients with Soft Tissue Sarcomas. Sem Oncol 16: 289–296

    CAS  Google Scholar 

  11. Enneking WF, Spanier SS, Goodman MA (1980) A system for the surgical staging of musculoskeletal sarcoma. Clin Orthopaed 15: 106–120

    Google Scholar 

  12. Rydholm A, Gustafson P, Roser B, Willén H, Akerman M, Herrlin K, Alvegärd T (1991) Limb-sparing surgery without radiotherapy based on anatomic location of soft tissue sarcoma. J Clin Oncol 9: 1757–1765

    PubMed  CAS  Google Scholar 

  13. Brant TA, Parsons JT, Marcus RB, Spanier SS, Heare TC, van der Griend RA, Enneking WF, Million RR (1990) Preoperative irradiation for soft tissue sarcomas of the trunk and extremities in adults. Int J Radiat Oncol Biol Phys 19: 899–906

    Article  PubMed  CAS  Google Scholar 

  14. Brennan MF (1989) Management of extremity soft-tissue sarcoma. Am J Surg 158: 71–78

    Article  PubMed  CAS  Google Scholar 

  15. Brennan MF, Casper ES, Harrison LB, Shui MH, Gaynor J, Hajdu SI (1991) The role of multimodality therapy in soft-tissue sarcoma. Ann Surg 214: 328–338

    Article  PubMed  CAS  Google Scholar 

  16. Lawrence TS, Lichter AS (1992) Soft tissue sarcomas. In: Perez CA, Brady LW (eds) Principles and practice of radiation oncology. Lippincott Company, Philadelphia, 1403

    Google Scholar 

  17. Tepper JE (1989) Role of radiation therapy in the management of patients with bone and soft tissue sarcomas. Sem Oncol 16: 281–288

    CAS  Google Scholar 

  18. Robinson M, Barr L, Fisher C, Fryatt I, Stotter A, Harmer C, Wiltshaw E, Westbury G (1990) Treatment of extremity soft tissue sarcomas with surgery and radiotherapy. Radiother Oncol 18: 221–233

    Article  PubMed  CAS  Google Scholar 

  19. Yang JC, Glatstein EJ, Rosenberg SA, Antman KH (1993) Sarcomas of soft tissues. In: DeVita VT, Hellman S, Rosenberg SA (eds) Cancer, principles and practice of oncology. Lippincott Company, Philadelphia, 1465–1466

    Google Scholar 

  20. Brennan MF, Hilaris B, Shuk MH, Lane J, Magill G, Friedriech C, Hajdu SI (1987) Local recurrence in adult soft-tissue sarcoma. Arch Surg 122: 1289–1293

    Article  PubMed  CAS  Google Scholar 

  21. Shui MH, Hilaris BS, Harrison LB, Brennan MF (1991) Brachytherapy and function-saving resection of soft tissue sarcoma arising in the limb. Int J Radiat Oncol Biol Phys 21: 1485–1492

    Article  Google Scholar 

  22. Shui MH, Collin C, Hilaris B et al. (1986) Limb preservation and tumor control in the treatment of popliteal and anticubital soft tissue sarcomas. Cancer 57: 1632–1639

    Article  Google Scholar 

  23. Talbert ML, Zagars GK, Sherman NE, Romsdahl MM (1990) Conservative surgery and radiation therapy for soft tissue sarcoma of the wrirst, hand ankle and foot. Cancer 66: 2482–2491

    Article  PubMed  CAS  Google Scholar 

  24. Tran LM, Mark R, Meier R, Calcaterra TC, Parker RG (1992) Sarcomas of the head and neck. Cancer 70: 169–177

    Article  PubMed  CAS  Google Scholar 

  25. Jaques DP, Coit DG, Hajdu SI, Brennan MF (1990) Management of primary and recurrent soft-tissue sarcoma of the retroperitoneum. Ann Surg 212: 51–59

    Article  PubMed  CAS  Google Scholar 

  26. Sindelar WF, Kinsella TJ, Chen PW, DeLaney TF, Tepper JE, Rosenberg SA, Glatstein E (1993) Intraoperative radiotherapy in retroperitoneal sarcomas. Arch Surg 128: 402–410

    Article  PubMed  CAS  Google Scholar 

  27. Mazeron J, Suit H (1987) Lymph nodes as sites of metastases from sarcoma of soft tissue. Cancer 60: 1800–1808

    Article  PubMed  CAS  Google Scholar 

  28. Jablons D, Steinberg S, Roth J (1989) Metastasectomy for soft tissue sarcoma: Further evidence for efficacy and prognostic factors. J Thorac Cardiovasc Surg 97: 695–705

    PubMed  CAS  Google Scholar 

  29. van Geel A, Pastorino U, Pietraszek A, Schmitz P (1993) Surgery of lung metastases from soft tissue sarcoma. Eur J Cancer 27A (Suppl 6): S 183

    Article  Google Scholar 

  30. Willett CG, Suit HD, Tepper JE, Mankin HJ, Convery K, Rosenberg AL, Wood WC (1991) Intraoperative electron beam radiation therapy for retroperitoneal soft tissue sarcoma. Cancer 68: 278–283

    Article  PubMed  CAS  Google Scholar 

  31. ICRU Report 50 (1993) Landberg T et al. (Hrsg) Prescribing, recording, and reporting photon beam therapy. ICRU

    Google Scholar 

  32. Robinson M, Cassoni H, Harmer C, Fisher C, Thomas J, Westbury G (1991) High dose hyperfractionated radiotherapy in the treatment of extremity soft tissue sarcomas. Radiother Oncol 22: 118–126

    Article  PubMed  CAS  Google Scholar 

  33. Sadoski C, Suit HD, Rosenberg A, Mankin H, Efrid J (1993) Preoperative radiation, surgical margins, and local control of extremity sarcomas of soft tissue. J Surg Oncol 52: 223–230

    Article  PubMed  CAS  Google Scholar 

  34. Barwick WJ, Goldberg JA, Scully SP, Harrelson JM (1992) Vascularized tissue transfer for closure of irradiated wound after soft tissue sarcoma resection. Ann Surg 216: 591–595

    Article  PubMed  CAS  Google Scholar 

  35. Bujko K, Suit HD, Springfield DS, Convery K (1993) Wound healing after preoperative radiation for sarcoma of soft tissues. Surg Gyn Obstet 176: 124–134

    CAS  Google Scholar 

  36. Willett GC, Schiller AL, Suit HD, Mankin HJ, Rosenberg A (1987) The histologic response of soft tissue sarcoma to radiation therapy. Cancer 60: 1500–1504

    Article  PubMed  CAS  Google Scholar 

  37. Schmitt G, Mills EED, Levin V, Pape H, Smit BJ, Zamboglou N (1989) The role of neutrons in the treatment of soft tissue sarcomas. Cancer 64: 2064–2068

    Article  PubMed  CAS  Google Scholar 

  38. Wambersie A (1988) Fast neutron therapy at the end of 1988 — a survey of the clinical data. Strahlenther Oncol 166: 51–60

    Google Scholar 

  39. Slater JD, McNeese MD, Peters LJ (1986) Radiation therapy for unresectable soft tissue sarcomas. In J Radiat Oncol Biol Phys 12: 1729–1734

    Google Scholar 

  40. Tepper JE, Suit HD (1985) Radiaton therapy alone for sarcoma of soft tissue. Cancer 56: 475–479

    Article  PubMed  CAS  Google Scholar 

  41. Issels RD, Bosse D, Abdel-Rahmen S et al. (1993) Preoperative systemic etoposide/ifosfamide/doxorubicin chemotherapy combined with regional hyperthermia in high-risk sarcoma: a pilot study. Cancer Chemother Pharmacol 31 (Suppl 2): 233–237

    Google Scholar 

  42. Oleson JR, Samulski TM, Leopold KA, Clegg ST, Dewhirst MW, Dodge RK, George SL (1993) Sensitivity of hyperthermia trial outcomes to temperature and time: implications for thermal goals of treatment. Int J Radiat Oncol Biol Phys 25: 289–297

    Article  PubMed  CAS  Google Scholar 

  43. Brennan MF, Friedrich C, Almadrones L, Magill G (1987) Prospective randomized trial examining the cardiac toxcity of adjuvant doxorubicin in high grade extremity sarcomas. In. Adjuvant therapy of cancer V (Ed: Salmon S ), Grune and Stratton, 745–751

    Google Scholar 

  44. Benjamin R, Legha S, Patel S, Nicaise C (1993) Single-agent ifosfamide studies in sarcomas of soft tissue and bone: the M.D. Anderson Experience. Cancer Chemother Pharmacol 31 (Suppl 2): 174–179

    Google Scholar 

  45. Antman K, Elias A (1990) Dana-Farber Cancer Institute studies in advanced sarcomas. Sem Oncol 17 (Suppl 2): 7–15

    CAS  Google Scholar 

  46. van Glabbeke M, van Oosterom A, Ooterhuis J et al. (1994) Prognostic factors in advanced soft tissue sarcoma: An overview of 1742 patient treated with doxorubicin containing first line regimens by the EORTC Soft Tissue and Bone Sarcoma Group. Proc Am Soc Clin Oncol 13: 474

    Google Scholar 

  47. Elias A, Ryan L, Aisner J, Antman K (1990) Mesna, doxorubicin, ifosfamide, dacarbazine (MAID) regimen for adults with advanced sarcoma. Sem Oncol 17 (Suppl 4): 41–49

    CAS  Google Scholar 

  48. Borden EC, Amato DA, Rosenbaum C et al. (1987) Randomized comparison of three adriamycin regimens for metastatic soft tissue sarcomas. J Clin Oncol 5: 840–850

    PubMed  CAS  Google Scholar 

  49. Mouridsen HT, Bastholt L, Somers R et al. (1987) Adriamycin versus epirubicin in advanced soft tissue sarcomas. A randomized phase II/phase III study of the EORTC Soft Tissue and Bone Sarcoma Group. Eur J Cancer Clin Oncol 23: 1477–1483

    Article  PubMed  CAS  Google Scholar 

  50. Gottlieb JA, Baker LH, O’Bryan RM et al. (1975) Adriamycin (NSC-123127) used alone and in combination for soft tissue and bony sarcomas. Cancer Chemother Rep 6: 271–282

    Google Scholar 

  51. Schütte J, Mouridsen HT, Stewart W et al. (1990) Ifosfamide plus adriamycin in previously untreated patients with advanced soft tissue sarcoma. Eur J Cancer 26: 558–561

    Article  PubMed  Google Scholar 

  52. Casali P, Pastorino U, Azzarelli A, Bertulli R, Zucchinelli P, Devizzi L, Santoro A (1993) Perspectives on anthracyclines plus ifosfamide in advanced soft tissue sarcomas. Cancer Chemother Pharmacol 31 (Suppl 2): 228–232

    Google Scholar 

  53. Yap B-S, Baker LH, Sinkovics JG et al. (1980) Cyclophosphamide, vincristine, adriamycin, and DTIC (CYVADIC) combination chemotherapy for the treatment of advanced sarcomas. Cancer Treat Rep 64: 93–98

    PubMed  CAS  Google Scholar 

  54. Pinedo HM, Bramwel VHC, Mouridsen HT et al. (1984) Cyvadic in advanced soft tissue sarcoma: a randomized study comparing two schedules. Cancer 53: 1825–1832

    Article  PubMed  CAS  Google Scholar 

  55. Weh H, Agarwal K, Zornig C, Schwart R, Dietel M, Hossfeld D (1993) Treatment results obtained in metastatic soft-tissue sarcoma with a combination of doxorubicin and ifosfamide. Cancer Chemother Pharmacol 31 (Suppl 2 ): 189193

    Google Scholar 

  56. Omura GA, Major FJ, Blessing JA et al. (1983) A randomized study of adriamycin with and without dimethyl trazenoimidazole carboxamide in advanced uterine sarcomas. Cancer 52: 626–632

    Article  PubMed  CAS  Google Scholar 

  57. Schoenfeld D, Rosenbaum C, Horton J et al. (1982) A comparison of adriamycin versus vincristine and adriamycin, and cyclophosphamide for advanced sarcoma. Cancer 50: 2757–2762

    Article  PubMed  CAS  Google Scholar 

  58. Muss HB, Bundy D, DiSaia PJ et al. (1985) Tratment of recurrent advanced uterine sarcoma: A randomized trial of doxorubicin versus doxorubicin and cyclophosphamide. Cancer 55: 1648–1653

    Article  PubMed  CAS  Google Scholar 

  59. Lerner H, Amato D, Stevens C et al. (1983) Leiomyosarcoma: The Eastern Cooperative Oncology Group experience with 222 patients. Proc Am Assoc Cancer Res 24: 142

    Google Scholar 

  60. Edmonson J, Blum R, Ryan L et al. (1992) Phase III Eastern Cooperative Oncology Group study of doxorubicin alone versus ifosfamdie + doxorubicin or mitomycin + doxorubicin + cisplatin against soft tissue sarcomas. Proc Am Soc Clin Oncol 11: 413

    Google Scholar 

  61. Santoro A, Rouesse J, Steward W et al. (1990) A randomized EORTC study in advanced soft tissue sarcomas: ADM vs. ADM + IFS vs. CYVADIC. Proc Am Soc Clin Oncol 9: 309

    Google Scholar 

  62. Antman K, Baker L, Balcerak S et al. for CALGB & SWOG (1991) A randomized study of doxorubicin & dacarbazine & ifosfamide in advanced sarcoma. Eur J Cancer 27 (Suppl 2 ): 350

    Google Scholar 

  63. Baker LH, Frank J Fine G et al. (1987) Combination chemotherapy using adriamycin, DTIC, cyclophosphamide, and actinomycin d for advanced soft tissue sarcomas: A randomized comparative trial. A phase III, Southwest Oncology Group Study (7613). J Clin Oncol 5: 851–861

    PubMed  CAS  Google Scholar 

  64. Zalupski M, Ryan J, Hussein M, Baker L (1993) Defining the role of adjuvant chemotherapy for patients with soft tissue sarcoma of the extremities. In: Adjuvant Therapy of Cancer VII (Ed: Salmon S ), J.B. Lippincott, 385–392

    Google Scholar 

  65. Ravaud A, Binh Bui N, Coindre J, Kantor G, Stöckle E, LaGarde P, Becouarn Y, Chauvergne J, Bonichon F, Maree D (1990) Adjuvant chemotherapy with CyVADIC in high-risk soft tissue sarcoma: A randomized prospective trial. In. Adjuvant Therapy of Cancer VI (Ed: Salmon S ), W.B. Saunders, 556–566

    Google Scholar 

  66. Chang A, Kinsella T, Glatsein E (1988) Adjuvant chemotherapy for patients with high-grade soft-tissue sarcomas of the extremitis. J Clin Oncol 6: 1491–1500

    PubMed  CAS  Google Scholar 

  67. Gherlinzoni F, Picci P, Bacci G, DeCristofaro R, Cazzola A, Zmerly H, Campanacci D (1993) Late results of a randomized trial for the treatment of soft tissue sarcomas of the extremities in adult patients. Proc Am Soc Clin Oncol 12: 468

    Google Scholar 

  68. Azzarelli A, Quagliuolo V, Fissi S, Casali P, Garbuglia A, Bignami P, Santoro A, Andreola S, Gennari L (1992) Intra-arterial induction chemotherapy for soft tissue sarcomas. Ann Oncol 3 (Suppl 2): 67–70

    Article  Google Scholar 

  69. Konya A, Vigvary Z (1992) Neoadjuvant intraarterial chemotherapy for soft tissue sarcomas. Ann Oncol 3 (Suppl 2): 127–129

    Article  Google Scholar 

  70. Lackuran R, Weiss A (1994) Results of intra-arterial preoperative chemotherapy. Proc Am Soc Clin Oncol 13: 477

    Google Scholar 

  71. Priebat D, Malawer M, Markan Y, Barnhill M, Shmookler B, Perry D, Jelinek J, Edwards P, Schulof R (1994) Clinical outcome of neoadjuvant intraarterial cisplatin and continuous intravenous infusion adriamycin for large high grade unresectable/borderline soft tissue sarcomas of the extremities. Proc Am Soc Clin Oncol 13: 473

    Google Scholar 

  72. Rosen G, Eilber F, Eckardt J, Holmes C, Forscher CA, Lowenbraun S, Selch M, Fu YS (1993) Präoperative Chemotherapie in der Behandlung von Weichteilsarkomen. Chirurg 64: 443–448

    PubMed  CAS  Google Scholar 

  73. Eilber F, Eckardt J, Rosen G, Forscher C, Selch M, Fu Y (1994) Improved complete response rate with neoadjuvant chemotherapy and radiaton for high grade soft tissue sarcoma. Proc Am Soc Clin Oncol 13: 473

    Google Scholar 

  74. Inbar M, Abu Abid S, Lev D, Chaitchuk S, Klausner J (1994) r-tumor necrosis factor-alpha with melphalan administration via isolated limb perfusion for extensive soft tissue sarcoma. Proc Am Soc Clin Oncol 13: 481

    Google Scholar 

  75. Lienard D, Ewalenko D, Delmott JJ, Renard N, Lejeune FJ (1992) High-dose recombinant tumor necrosis factor-alpha in combination with interferon-gamma and melphalan in isolation perfusion of the limbs for melanoma and sarcoma. J Clin Oncol 10: 52–60

    PubMed  CAS  Google Scholar 

  76. Rossi C, Vecciato A, Da Pian P, Nitti D, Lise M, Melanotte P, Turra S, Vigliani F (1992) Adriamycin in hyperthermic perfusion for advanced limb sarcomas. Ann Oncol 3 (Supp12): 111–113

    Article  Google Scholar 

  77. Di Filippo F, Ciannarelli D, Botti C, Carlini S, Cavaliere F, Garinei R, Schiratti M, Casaldi V, Tedesco M, Cavaliere R (1992) Hyperthermic antiblastic perfusion for the treatment of soft tissue limb sarcoma. Ann Oncol 3 (Suppl 2): 71–74

    Article  Google Scholar 

  78. Schraffordt Koops H, Eggermont A, Lienard D, van Geel B, Lejeune F (1993) Isolated limb perfusion with high dose TNF-a, gamma-IFN and melphalan in patients with irresectable soft tissue sarcomas: A highly effective limb saving procedure. Eur J Cancer 29A (Suppl 6): 183

    Article  Google Scholar 

  79. Steward W, Verweij J, Somers R, Spooner D, Kerbrat P, Clavel M, Crowther D, Rouesse J, Tursz T, Tueni E, van Oosterom A, Warwick J, Greifenberg B, Thomas D, van Glabbeke M (1993) Granulocyte-macrophage colony-stimulating factor allows safe escalation of dose-intensity of chemotherapy in metastatic adult soft tissue sarcomas: A study of the European Organization for Research and Treatment of Cancer Soft Tissue and Bone Sarcoma Group. J Clin Oncol 11: 15–21

    PubMed  CAS  Google Scholar 

  80. Vadhan-Raj S, Broymeyer H, Burgess M, Papadoupoulos N, Linke K, Patel S, Plager C, Thompson P, Goodman B, Hague N, Caron D, Garrison L, Benjamin R (1994) Schedule-dependent reduction in CyAdic chemotherapy-induced multi-lineage hematopoietic toxicity by PIXY321 in patients with sarcoma. Proc Am Soc Clin Oncol 13: 475

    Google Scholar 

  81. Fredericks WJ, Chen YF, Baker RM (1991) Immunoblot detection of p-glycoprotein in human tumors and cell lines. In: Ozols (ed): Molecular and Clinical Advances in Anticancer Drug Resistance. Kluver Academic Publishers, Boston, S 121–149

    Chapter  Google Scholar 

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  1. J. Scütte
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  2. M. Stuschke
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  3. S. Seeber
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  1. Innere Klinik und Poliklinik (Tumorforschung) Westdeutsches Tumorzentrum Essen, Universitätsklinikum Essen, Hufelandstraße 55, 45122, Essen, Deutschland

    Siegfried Seeber  & Jochen Schütte  & 

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Scütte, J., Stuschke, M., Seeber, S. (1995). Weichteilsarkome. In: Seeber, S., Schütte, J. (eds) Therapiekonzepte Onkologie. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-10494-1_35

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