Zusammenfassung
Häufigkeit und Inzidenz: Der Anteil hochmaligner Non-HodgkinLymphome (NHL) an der Gesamtzahl maligner Erkrankungen liegt bei ca. 2–3%, wobei die Häufigkeit der NHL stetig zunimmt. So stieg die jährliche Inzidenzrate in den USA von 1950–1989 von 5,9 auf 13,7 pro 100000 Einwohner. Die Ursachen dieser Entwicklung, die auch in Westeuropa zu beobachten ist, sind noch nicht geklärt [9, 83].
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
Literatur
Brittinger G, Bartels H, Common H et al. (1984) Clinical and prognostic relevance of the Kiel dassification of non-Hodgkin lymphomas: results of a prospective multicenter study by the Kiel lymphoma study group. Hematol Oncol 2: 269–306
Cabanillas F, Hagemeister FB, Bodey GP et al. (1982) IMVP 16: An effective regimen for patients with lymphoma who have relapsed after initial combination chemotherapy. Blood 60: 693–697
Coiffier B, Gisselbrecht C, Herbrecht R et al. (1989) LNH-84 regimen: a multicenter study of intensive chemotherapy in 737 patients with aggressive malignant lymphoma. J Clin Oncol 7: 1018–1026
Coleman CN, Picozzi VJ, Cox RS et al. (1989) Treatment of lymphoblastic lymphoma in adults. J Clin Oncol 4: 399–404
Coltman CA, Dahlberg S, Jones SE et al. (1988) Southwest Oncology Group Studies in diffuse large cell lymphoma: A subset analysis. In: Kimura K (ed) Cancer Chemotherapy: Challenges for the future, Tokyo: Excerpta Medica, 1988: 194–202
Connors JM, Klimo P, Fairy RN, Voss N (1987) Brief chemotherapy and involved field radiation therapy for limited-stage, histologically aggressive lymphoma. Ann Int Med 107: 25–30
Connors JM, Klimo P (1988) MACOP-B chemotherapy for malignant lymphomas and related conditions: 1987 update and additional observations. Semin Hematol 25: 41–46
De Bruin PC, Noorduyn AL, van der Valk P et al. (1993) Noncutaneous T-cell lymphomas. Recognition of a lymphoma type with a relatively favorable prognosis. Cancer 71: 2604–2612
Devesa SS, Fears T (1992) Non-Hodgkin-lymphoma time trends: United States and International Data. Cancer Res 52: 5432–5440
DeVita VT Jr, Jaffe ES, Hellman S (1985) Hodgkin’s disease and the non-Hodgkin’s lymphomas. In: Cancer-principles and practice of oncology (eds: DeVita VT, Hellman S, Rosenberg SA). JB Lippincott Company: 1623–1709
Dhaliwal HS, Rohatiner AZS, Gregory W et al. (1993) Combination chemotherapy for intermediate and high grade non-Hodgkin’s lymphoma. Br J Cancer 68: 767–774
Dixon DO, Neilan B, Jones SE et al. (1986) Effect of age on therapeutic outcome in advanced diffuse histiocytic lymphoma: the Southwest Oncology Group experience. J Clin Oncol 4: 295–305
Doglioni C, Wotherspoon AC, Moschini A et al. (1992) High incidence of primary gastric lymphoma in northeastern Italy. Lancet 339: 834–835
Engelhard M, Meusers P, Brittinger G et al. (1991) Prospective multicenter trial for the response-adapted treatment of high-grade malignant non-Hodgkin’s lymphomas: Updated results of the COP-BLAM/IMVP-16 protocol with randomized adjuvant radiotherapy. Ann Oncol 2 (Suppl 2): 177–180
Engert A, Engelhard M, Scheulen M, Baltes-Engler S et al. (1993) Phase-II study of idarubicin, ifosfamide, and VP-16 (IIVP-16) in patients with relapsed aggressive non-Hodgkin’s lymphoma. Ann Hematol 67 (Suppl): A 30 [Ann Oncol 1994 submitted]
Filipovich AH, Mathur A, Kamat D, Shapiro RS (1992) Primary immunodeficiencies: Genetic risk factors for lymphoma. Cancer Res 52 (Suppl): 5465–5467
Fisher RI, Gaynor ER, Dahlberg S et al. (1993) Comparison of a standard regimen (CHOP) with three intensive chemotherapy regimens for advanced non-Hodgkin’s lymphoma. N Engl J Med 328: 1002–1006
Gerhartz HH, Engelhard M, Brittinger G et al. (1993) Randomized, double-blind, placebo-controled phase III study of recombinant human granulocyte-macrophage colony-stimulating factor as adjunct to induction treatment of high-grade malignant non-Hodgkin’s lymphomas. Blood 82: 2329–2339
Gisselbrecht C, Bosly A, Lepage E et al. (1993) Autologous hematopoietic stem cell transplantation in intermediate and high grade non-Hodgkin’s lymphoma: a review. Ann Oncol 4 (Suppl 1): 7–13
Gobbi PG, Diongi P, Barbieri F et al. (1990) The role of surgery in the multimodal treatment of primary gastric non-Hodgkin’s lymphomas. A report of 76 cases and review of the literature. Cancer 65: 2528–2536
Gordon LI, Harrington D, Andersen J et al. (1992) Comparison of a second generation combination chemotherapeutic regimen (m-BACOD) with a standard regimen (CHOP) for advanced diffuse non-Hodgkin’s lymphoma. N Engl J Med 327: 1342–1349
Grogan L, Corbally N, Dervan PA et al. (1994) Comparable prognostic factors and survival in elderly patients with aggressive non-Hodgkin’s lymphoma treated with standard-dose adriamycin-based regimens. Ann Oncol 5 (Suppl l): 47–51
Grossbard ML, Lambert JM, Goldmacher VS et al. (1993) Anti-B4-blocked ricin: a phase I trial of 7-day continuous infusion in patients with B-cell neoplasms. J Clin Oncol 11: 726–737
Haioun C, Lepage E, Gisselbrecht C et al. (1992) Autologous bone marrow transplantation versus sequential chemotherapy in first complete remission aggressive non-Hodgkin’s lymphoma: 1st interim analysis on 370 patients (LNH-87 protocol). Proc Am Soc Clin Oncol 11: 316 (abstr)
Harris NL, Jaffe ES, Stein H et al. (1994) A revised European-American classification of lymphoid neoplasms: A proposal from the International Lymphoma Study Group. Blood 84:1361–1392
Hoelzer D, Thiel E, Löffler H et al. (1984) Intensified therapy in acute lymphoblastic and acute undifferentiated leukemia in adults. Blood 64: 38–47
Jones SE, Müller TP, Connors JM (1989) Long-term follow-up and analysis for prognostic factors for patients with limited-stage diffuse large-cell lymphoma treated with initial chemotherapy with or without adjuvant radiotherapy. J Clin Oncol 7: 1186–1191
Kadin ME (1994) Primary Ki-1-positive anaplastic large-cell lymphoma: A distinct clinicopathologic entity. Ann Oncol 5 (Suppl 1): 25–30
Kath R, Höffken K, Günzel K et al. (1990) Chemotherapie des nicht-endemischen Burkitt-Lymphoms. Dtsch med Wschr 115: 1219–1226
Köppler H, Pflüger KH, Eschenbach I et al. (1994) Randomised comparison of CHOEP versus alternating hCHOP/IVEP for high-grade non-Hodgkin’s lymphomas: Treatment results and prognostic risk factors analysis in a multi-centre trial. Ann Oncol 5: 49–55
Kwak L, Olshen R, Halpern J et al. (1988) Dose intensity: relationship to prognostic factors for diffuse large cell lymphoma. Proc Am Soc Clin Oncol 7: 226 (abstr)
Lee KA, Finnegan MC, Sheridan E et al. (1994) Analysis of the p53 gene, its expression and protein stabilization in non-Hodgkin’s lymphomas. Annals of Oncology 5: 85–88
Lepage E, Gisselbrecht C, Haioun C et al. (1992) Relative received dose intensity (DI) in poor risk lymphoma patients: Higher DI correlates with longer survival. A study from GELA. Blood 80 (Suppl 1 ): 158 (abstr 621)
Lennert K, Feller AC (1990) Histopathologie der Non-Hodgkin-Lymphome. Springer Verlag
Liang R, Todd D, Chan TK et al. (1993) COPP chemotherapy for elderly patients with intermediate and high grade non-Hodgkin’s lymphoma. Hematol Oncol 11:43 —50
Longo DL, DeVita VT, Duffey PL et al. (1991) Superiority of ProMACE-CytaBOM over ProMACE-MOPP in the treatment of advanced diffuse aggressive lymphoma: results of a prospective randomized trial. J Clin Oncol 9: 25–38
Maksymiuk AW, Bratvold JS, Ezzat W et al. (1993) Non-Hodgkin’s-Lymphoma in Saskatchewan — a review of 10 years’ experience. Cancer 73: 711–719
Magrath I (1992) Molecular basis of lymphomagenesis. Cancer Research 52 (Suppl): 5529–5540
Maor MH, Velasquez WS, Fuller LM, Silvermintz KB (1990) Stomach conservation in stages IE and IIE gastric non-Hodgkin’s lymphoma. J Clin Oncol 8: 266–271
McKelvey EM, Gottlieb JA, Wilson HE et al. (1976) Hydroxyldaunomycin (adriamycin) combination chemotherapy in malignant lymphoma. Cancer 38: 1484–1493
McMaster ML, Johnson DH, Greer JP et al. (1991) A brief-duration combination chemotherapy for elderly patients with poor-prognosis non-Hodgkin’s lymphoma. Cancer 67: 1487–1492
Meyer RM, Hryniuk WM, Goodyear MGE (1991) The role of dose intensity in determining outcome in intermediate-grade non-Hodgkin’s lymphoma. J Clin Oncol 9: 339–347
Meyer RM, Quirt IC, Skillings JR et al. (1993) Escalated as compared with standard doses of doxorubicin in BACOP therapy for patients with non-Hodgkin’s lymphoma. N Engl J Med, 329: 1770–1776
Miller TP, Grogan TM, Dalton WS et al. (1991) P-glycoprotein expression in malignant lymphoma and reversal of dinical drug resistance with chemotherapy plus high-dose verapamil. J Clin Oncol 9: 17–24
Milpied N, Ifrah N, Kuentz M et al. (1989) Bone marrow transplantation for adult poor prognosis lymphoblastic lymphoma in first complete remisson. Br J Haematol 73: 82–87
Montserrat E, Garcia-Conde, Vinolas N, Estapé J (1991) ProMACE-CytaBOM vs. CHOP in the treatment of unfavorable lymphomas: a randomized trial. Blood 78 (Suppl 1): 127a
Morel P, Lepage E, Brice P et al. (1992) Prognosis and treatment of lymphoblastic lymphoma in adults: a report of 80 patients. J Clin Oncol 10 (7): 1078–1085
Niehans GA, Jaszcz W, Brunetto V et al. (1992) Immunohistochemical identification of P-glycoprotein in previously untreated, diffuse large cell and immunoblastic lymphomas. Cancer Res 52: 3768–3775
Nissen NI, Ersboll J, Hansen HS et al. (1983) A randomized study of radiotherapy versus radiotherapy plus chemotherapy in stage I—II non-Hodgkin’s lymphomas. Cancer 52: 1–7
Nouwrousian MR, Mengelkoch B, Kleine-Herzbruch R et al. (1993) Intensified sequential combination chemotherapy (CEBOPP/VIML), G-CSF and radiation in patients with high grade malignant non-Hodgkin’s lymphoma (NHL). Ann Hematol 67 (Suppl): A88
O’Connel MJ, Anderson J, Earle JD et al. (1984) Combined modality therapy of advanced unfavorable non-Hodgkin’s lymphoma (NHL). An ECOG randomized clinical trial. Proc Amer Soc Onc 241
Offit K, Lo Coco F, Louie DC et al. (1994) Rearrangement of the bd-6 gene as a prognostic marker in diffuse large-cell lymphoma. N Engl J Med 331: 74–80
O’Reilly S, Klimo P, Connors JM et al. (1991) Low-dose ACOP-B and VABE: weekly chemotherapy for elderly patients with advanced-stage diffuse large-cell lymphoma. J Clin Oncol 9: 741–747
Ostermann B, Jonsson H, Tavelin B, Lenner P (1993) Non-Hodgkin’s lymphoma in northern Sweden. Acta Oncologica 32: 507–516
Parker BA, Santarelli M, Green MR et al. (1993) AMOPLACE treatment of intermediate and high-grade malignant lymphoma: a cancer and leukemia group B study. J Clin Oncol 11: 248–254
Pettengel R, Gurney H, Radford JA et al. (1992) Granulocyte colony-stimulating factor to prevent dose-limiting neutropenia in non-Hodgkin’s lymphoma: a randomized controlled trial. Blood 80: 1430–1436
Philip T, Guglielmi C, Hagenbeek A et al. (1992) The PARMA international randomized prospective study in relapsed non Hodgkin lymphoma: Second interim analysis of 172 patients. Blood 80 (Suppl 1): 67 (abstr)
Sack H, Budach V, Stuschke M, Hoederat A (1992) Non-Hodgkin lymphomas (NHL) — Early stages: Interim results of a multi-centre trial. Cancer Res Clin Oncol 118 (Suppl): R115
Salles G, Shipp MA, Coiffier B (1994) Chemotherapy of non-Hodgkin’s aggressive lymphomas. Semin Hematol 31: 46–69
Santini G, Congui AM, Coser P et al. (1991) Autologous bone marrow transplantation for advanced stage adult lymphoblastic lymphoma in first CR: A study of the NHLGSG. Leukemia 5 (Suppl 1): 42–45
Scherr PA, Hutchinson GB, Neiman RS (1992) Non-Hodgkin’s lymphoma and occupational exposure. Cancer Res 52 (Suppl): 5503–5509
Shapiro RS, McClain K, Frizzera G et al. (1988) Epstein-Barr virus associated B cell lymphoproliferative disorders following bone marrow transplantation. Blood 71: 1234–1243
Shipp MA, Klatt MM, Yeap B et al. (1989) Patterns of relapse in large-cell lymphoma patients with bulk disease: implications for the use of the adjuvant radiation therapy. J Clin Oncol 7: 613–618
Shipp MA, Yeap BY, Harrington DP et al. (1990) The m-BACOD combination chemotherapy regimen in large-cell lymphoma: analysis of the completed trial and comparison with the M-BACOD regimen. J Clin Oncol 8: 84–93
Slater DE, Mertelsmann R, Kaziner B et al. (1986) Lymphoblastic lymphoma in adults. J Clin Oncol 4: 57–67
Solal-Celigny P, Chastang C, Herrera A et al. (1987) The importance of age in survival of patients treated with chemotherapy for aggressive non-Hodgkin’s lymphoma. J Clin Oncol 6: 1838–1844
Somers R, Carde P, Thomas J et al. (1994) EORTC study of non-Hodgkin’s lymphoma: Phase III study comparing CHVmP-VB and ProMACE-MOPP in patients with stage II, III, and IV intermediate and high grade lymphoma. Ann Oncol 5 (Suppl 2): 85–89
Sonneveld P, Michiels JJ (1990) Full dose chemotherapy in elderly patients with non-Hodgkin’s lymphoma: a feasibility study using a mitoxantrone containing regimen. Br J Cancer 62: 105–108
Stansfield AG, Diebold J, Kapanci Y et al. (1988) Updated Kiel classification for lymphomas. The Lancet: 292–293
Steinke B, Buss K, Reinold H-M (1992) Cyclic alternating chemotherapy of high-grade malignant non-Hodgkin’s lymphomas with VIM-Bleo and CHOP. Eur J Cancer 28: 100–104
Taal BG, den Hartog Jager FCA, Burgers JMV et al. (1989) Primary non-Hodgkin’s lymphoma of the stomach: changing aspects and therapeutic choices. Eur J Cancer Clin Oncol 25: 439–450
The International Non-Hodgkin’s lymphoma prognostic factors project (1993) A predictive model for aggressive Non-Hodgkin’s-lymphoma. N Engl J Med 329: 987–949
Tigaud J-D, Demolombe S, Bastion Y et al. (1991) Ifosfamide continuous infusion plus etoposide in the treatment of elderly patients with aggressive lymphoma: a phase II study. Hematol Oncol 9: 225–233
Tirelli U, Zagonel V, Errante D et al. (1992) A prospective study of a new combination chemotherapy regimen in patients older than 70 years with unfavorable non-Hodgkin’s lymphoma. J Clin Oncol 10: 228–236
Tondini C, Zanini M, Lombardi F et al. (1993) Combined modality treatment with primary CHOP chemotherapy followed by locoregional irradiation in stage I and II histologically aggressive non-Hodgkin’s lymphomas. J Clin Oncol 11: 720–725
Trümper L, Renner Ch, Nahler M et al. (1994) Intensification of the CHOEP regimen for high grade non-Hodgkin’s lymphoma by G-CSF: Feasibility of a 14-day regimen. Onkologie 17: 69–71
Tura S, Zinzani PL, Mazza P et al. (1992) ABMT vs. DHAP in residual disease following third generation regimens for aggressive non-Hodgkin’s lymphoma. Blood 80 (Supp 1 ): 157 (Abstr)
Velasquez WS, Cabanillas F, Salvadore P et al. (1988) Effective salvage therapy for lymphoma with cisplatin in combination with high dose AraC and dexamethasone (DHAP). Blood 71: 117–122
Velasquez WS, Hagemeister F, McLaughlin P et al. (1992) E-SHAP: An effective treatment for refractory and relapsing lymphoma. A long follow-up. Proc Am Soc Clin Oncol 11: 326 (Abstr 1111)
Vitetta ES, Stone M, Amlot P et al. (1991) Phase I immunotoxin trial in patients with B-cell lymphoma. Cancer Res 51: 4052–4058
Vose JM, Armitage JO, Weisenburger DD et al. (1988) The importance of age in survival of patients treated with chemotherapy for agressive non-Hodgkin’s lymphoma. J Clin Oncol 6: 1838–1844
Weick JK, Dahlberg S, Fisher RIO et al. (1991) Combination chemotherapy of intermediate-grade and high-grade non-Hodgkin’s lymphoma with MACOP-B: a southwest oncology group study. J Clin Oncol 9: 748–753
Weisenburger DD (1994) Epidemiology of non-Hodgkin’s lymphoma: Recent findings regarding an emerging epidemic. Ann Oncol 5 (Suppl 1): 19–24
Yano T, van Krieken JHJM, Magrath IT et al. (1992) Histogenetic correlations between subcategories of small noncleaved cell lymphomas. Blood 79: 1282–1290
Yunis JJ, Mayer MG, Arnesen MA et al. (1989) Bd-2 and other genomic alterations in the prognosis of large-cell lymphoma. N Engl J Med 320: 1047–1054
Zahm SH, Blair A (1992) Pesticides and Non-Hodgkin’s lymphoma. Cancer Res 52 (Suppl): 5485–5488
Ziegler JL (1981) Burkitt’s lymphoma. N Engl J Med 305: 735–745
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1995 Springer-Verlag Berlin Heidelberg
About this chapter
Cite this chapter
Trenn, G., Engelhard, M., Brittinger, G. (1995). Hochmaligne Non-Hodgkin-Lymphome. In: Seeber, S., Schütte, J. (eds) Therapiekonzepte Onkologie. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-10494-1_11
Download citation
DOI: https://doi.org/10.1007/978-3-662-10494-1_11
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-540-58586-2
Online ISBN: 978-3-662-10494-1
eBook Packages: Springer Book Archive