Hypersplenismus und Splenektomie bei inneren Krankheiten

  • V. Diehl
  • M. Pfreundschuh

Zusammenfassung

Als Hypersplenismus oder Hyperspleniesyndrom bezeichnet man folgenden Symptomenkomplex:
  • periphere Zytopenie (Verminderung der Zellen des peripheren Blutes, wobei die einzelnen Zellreihen unterschiedlich stark betroffen sein können);

  • zellreiches (hyperregeneratorisches) Knochenmark;

  • Splenomegalie;

  • Besserung der Zytopenie nach Splenektomie.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Literatur

  1. 1.
    Brigden ML (1992) Overwhelming postsplenectomy infection still a problem. West J Med 157: 440–443PubMedGoogle Scholar
  2. 2.
    Crosby WH (1972) Splenectomy in hematological disorders. N Engl J Med 286: 1252PubMedCrossRefGoogle Scholar
  3. 3.
    Cusack JC Jr, Seymour JF, Lerner S, Keating MJ, Pollock RE (1997) Role of splenectomy in chronic lymphocytic leukemia. J Am Coll Surg 185: 237–243PubMedGoogle Scholar
  4. 4.
    Diehl V, Schaadt M, Kalden JR, Hagedorn CH, Schmidt N, Deinhardt J (1978) Der Einfluß der Splenektomie auf den Immunstatus des Hodgkin-Patienten. Klin Wochenschr 56: 809PubMedCrossRefGoogle Scholar
  5. 5.
    Ebaugh FG, McIntyre OR (1979) Palpable Spleens: ten-year follow-up. Ann Intern Med 9o: 13oGoogle Scholar
  6. 6.
    Hess CE, Ayers CR, Sanduusky WR et al. (1976) Mechanisms of dilutional anemia in massive splenomegaly. Blood 47: 629PubMedGoogle Scholar
  7. 7.
    Hosea SW, Brown EJ, Hamburger Mi (1981) Opsonic requirements for intravascular clearance after splenectomy. N Engl J Med 304: 245–250PubMedCrossRefGoogle Scholar
  8. 8.
    Jaiyesimi IA, Kantarjian HM, Estey EH (1993) Advances in 20. therapy for hairy cell leukemia. A review. Cancer 72: 5–16 21.Google Scholar
  9. 9.
    Livingson CD, Levine BA, Sirinek KR (1983) Site of splenic autotransplantation affects protection from sepsis. Am J Surg 146: 734CrossRefGoogle Scholar
  10. 10.
    Marble KR, Deckers OJ, Kern KA (1993) Changing role of splenectomy for hematologic disease. J Surg Oncol 52:169-171PubMedCrossRefGoogle Scholar
  11. 11.
    Meer JWM van de (1994) Defects in host-defense mechanisms. In: Rubin RH, Young LS (eds) Clinical approach 23. to infection in the comprised host. 3rd ed. Plenum Press New York 24.Google Scholar
  12. 12.
    Moore GE, Stevens RE, Moore EE, Aragon GE (1983) Failure of splenic implants of protect against fatal postsplenectomy infection. Am J Surg 146: 413PubMedCrossRefGoogle Scholar
  13. 13.
    Musser G, Lazar G, Hocking W, Busuttil RW (1984) 25. Splenectomy for hematologic disease. The UCLA experience with 306 patients. Ann Surg 200: 40Google Scholar
  14. 14.
    O’Reilly RA (1996) Splenomegaly at a United States County 26. Hospital; Diagnostic evaluation of 170 patients. Am J Med Sci 312: 160–165PubMedCrossRefGoogle Scholar
  15. 15.
    Di Padova F, Dürig M, Harder F et al. (1985) Impaired anti- 27. pneumococcal antibody production in patients without spleens. Br Med J 290: 14CrossRefGoogle Scholar
  16. 16.
    Parker AC, Mac Pherson ACS, Richmond J (1977) Value of radiochromium investigation in autimmune hemolytic anema. Br Med J 1: 208 28.Google Scholar
  17. 17.
    Pinca A, Di Palma A, Soriani S, Sprocati M, Manella P, Georgacopulo P, Bagni B, Vullo C (1992) Effectiveness of partial splenic embolizations as treatment for hypersplenism in thalassamia major: a 7-year follow up. Eur J 29. Haematol 49: 49–52CrossRefGoogle Scholar
  18. 18.
    Pfreundschuh M, Löffler M, Rühl U et al. (1988) Therapie der Hodgkin-Lymphome - Ergebnisse der Deutschen Hodgkin- 30. Studiengruppe. Onkologie 11: 48–52PubMedCrossRefGoogle Scholar
  19. 19.
    Randi ML, Fabris F, Dona S, Girolami A (1987) Evaluation 31. of platelet function in postsplenectomy thrombocytosis. Folia Haematol 114: 252–256Google Scholar
  20. 20.
    Rosse WF (1987) The spleen as a filter. N Engl J Med 317: 704PubMedCrossRefGoogle Scholar
  21. 21.
    Scholz KH, Herrmann C, Tebbe U, Chemnitius JM, Helmchen U, Kreuzer H (1993) Myocardial infarction in young patients with Hodgkin’s disease–potential pathogenic role of radiotherapy, chemotherapy and splenectomy. Clin Invest 71: 57–64CrossRefGoogle Scholar
  22. 22.
    Shimm DS, Linggood RM, Weitzman SA (1983) Overwhelming postsplenectomy infection in Hodgkin’s disease: Pathogenesis and prevention. Clin Radiol 34: 95Google Scholar
  23. 23.
    Silverstein MN, ReMine WH (1979) Splenectomy in myeloid metaplasia. Blood 53: 515PubMedGoogle Scholar
  24. 24.
    Simberkoff MS, Corss AP, Al-Ibrahim M et al. (1986) Efficacy of pneumococcal vaccine in high-risk-patients: results of a Veterans Administrations coopertaive study. N Engl J Med 315: 1318PubMedCrossRefGoogle Scholar
  25. 25.
    Stephens BJ, Justice JL, Sloan DA, Yoder JA (1997) Elective Laparoscopic splenectomy for hematological disorder. Am Surg 63: 700–103PubMedGoogle Scholar
  26. 26.
    Turner J, Turner AR, Evan-Wong A (1992) Successful splenectomy for lymphoproliferative disease on octogenarians. Br. J Surg 79: 775Google Scholar
  27. 27.
    Velden JW van der, Putten WL van, Guinee VF, Pfeiffer R, Leeuwen FE van, Linden EA van der, Vardomskaye I, Lane W, Durand M, Lagarde C (1988) Subsequent development of acute non-lymphocytic leukemia in patients treatment for Hodgkin’s disease. Int J Cancer 42: 252–255PubMedCrossRefGoogle Scholar
  28. 28.
    Wanebo HJ, Kennedy BJ, Winchester DP, Stewart AK, Fremgen AM (1997) Role of spenectomy in gastric cancer surgery: adverse affect of elective splenectomy of longterm survival. J Am Coll Surg 185: 177–184PubMedGoogle Scholar
  29. 29.
    Watson DI, Coventry BJ, Chin T, Gill PG, Malyche P (1997) Laproscopic versus open splenectomy for immune thrombocytopenia. Surgery 121: 18–22PubMedCrossRefGoogle Scholar
  30. 30.
    Wobbes T, Sluis RF van der, Lubbers E-JC (1984) Removal of the massive spleen:a surgical risk? Am J Surg 147: 800PubMedCrossRefGoogle Scholar
  31. 31.
    Zarrabi MH, Rosner F (1986) Rarity of failure or penicillin prophylaxis to prevent postsplenectomy sepsis. Arch Intern Med 146: 1207PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1999

Authors and Affiliations

  • V. Diehl
  • M. Pfreundschuh

There are no affiliations available

Personalised recommendations