Akute Leukämien

  • W. Hiddemann

Zusammenfassung

Akute Leukämien sind maligne Erkrankungen hämatopoetischer Stammzellen, die bei erhaltener Teilungsfähigkeit mit einem teilweisen oder völligem Verlust der Fähigkeit zur Ausdifferenzierung zu reifen Funktionszellen verbunden sind. Je nach betroffener hämatopoetischer Zellreihe wird zwischen den beiden Hauptformen der akuten lymphatischen und der akuten myeloischen Leukämie unterschieden.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Literatur

  1. 1.
    Bennett JM, Catovsky D, Daniel MT et al. (1985) Proposed revised criteria of the classification of acute myeloid leukemia. Ann Intern Med 103: 626–629CrossRefGoogle Scholar
  2. 2.
    Bishop JF, Matthews JP, Graham AY et al. (1996) A randomized study of high-dose cytarabine in induction in acute myeloid leukemia. Blood 87: 1710–1717PubMedGoogle Scholar
  3. 3.
    Büchner T (1996) Akute myeloische Leukämie. Internist 37: 1008–1012PubMedGoogle Scholar
  4. 4.
    Büchner T, Hiddemann W, Wörmann B et al. (1998) Intensified therapy of AML–the role of the HAM combination. In: Hiddemann W, Büchner T, Wörmann B, Ritter J, Creutzig U, Keating M, Plunkett W (eds) Acute Leukemias VII: Experimental Approaches and Novel Therapies: Springer-Verlag 821–824CrossRefGoogle Scholar
  5. 5.
    Büchner T, Hiddemann W, Koenigsmann M et al. (1991) Recombinant human granulocyte-macrophage colony-stimulating factor after chemotherapy in patients with acute myeloid leukemia at higher age or after relapse. Blood 78: 1190–1197PubMedGoogle Scholar
  6. 6.
    Büchner T, Urbanitz D, Hiddemann W et al. (1985) Intensified induction and consolidation with or without maintenance chemotherapy for acute myeloid leukemia (AML): Two multicenter studies of the German AML Cooperative Group. J Clin Oncol 3: 1583–1589PubMedGoogle Scholar
  7. 7.
    Camitta B. Mahoney D, Leventhal B et al. (1994) Intensive intravenous methotrexate and mercaptopurine treatment of higher risk non-T, non-B acute lymphocytic leukemia. A Pedriatric Oncology Group Study. J Clin Oncol 12: 1383–1389PubMedGoogle Scholar
  8. 8.
    Cassileth PA, Lynch E, Hines JD et al. (1992) Varying intensity of postremission therapy in acute myeloid leukemia. Blood 79: 1924–1930PubMedGoogle Scholar
  9. 9.
    Cheson BD, Cassileth PA, Head DR et al. (1990) Report of the National Cancer Institute-sponsored workshop on definitions of diagnosis and responses on acute myeloid leukemia. J Clin Oncol 8: 813–819PubMedGoogle Scholar
  10. 10.
    Clarkson B, Gaynor J, Little C et al. (1990) Importance of long-term follow-up in evaluating treatment regimens for adults with acute lymphoblastic leukemia. Hematol Blood Transfus 33: 397–408Google Scholar
  11. 11.
    Cline MJ (1994) The molecular basis of leukemia. N Engl J Med 330: 328–336CrossRefPubMedGoogle Scholar
  12. 12.
    Degos L (1994) Is acute promyelocytic leukemia a curable disease? Treatment strategy for a long-term survival. Leukemia 8: 9111–9113Google Scholar
  13. 13.
    Dekker AW, van’t Veer MB, Haak HL et al. (1994) Conventional remisson induction followed by intensive consolidation without maintenance therapy in adult acute lymphoblastic leukemia. Results from a phase II clinical trial in 130 patients. Blood 84, Suppl 1: 144aGoogle Scholar
  14. 14.
    Dicke KA, Hoelzer D, Gorin NC et al. (1993) The role of bone marrow transplantation in adult acute lymphocytic leukemia. Ann Oncol 4: 581–590CrossRefGoogle Scholar
  15. 15.
    European Group for the Immunological Characterization of Leukemias (EGIL); Bene MC, Castoldi G, Knapp W et al. (1995) Proposals for the immunological classification of acute leukemias. Leukemia 9:1783–1786Google Scholar
  16. 16.
    Fiere D, Lepage E, Sebban C et al. (1993) Adult acute lymphoblastic leukemia: a multicentric randomized trial testing bone marrow transplantation as postremission therapy. J Clin Oncol 11: 1990–2001PubMedGoogle Scholar
  17. 17.
    Gale RP, Büchner T Horowitz MM, Zhang MJ (1993) Chemotherapy versus bone marrow transplantation for adults with acute myelogenous leukemia (AML) in first remission. Blood 82; Suppl:168 aGoogle Scholar
  18. 18.
    Hoelzer D (1993) Acute lymphoblastic leukemia–progress in children, less in adults. N Engl J Med 329: 1343–1345CrossRefPubMedGoogle Scholar
  19. 19.
    Hoelzer D (1994) Treatment of acute lymphoblastic leukemia. Sem Hemtol 31: 1–15Google Scholar
  20. 20.
    Hoelzer D, Ludwig WD, Thiel E et al. (1996) Improved outcome in adult-B-cell acute lymphoblastic leukemia. Blood 87: 495–452PubMedGoogle Scholar
  21. 21.
    Larson RA, Dodge RK, Burns CP et al. (1995) A five-drug remission induction regimen with intensive consolidation for adults with acute lymphoblastic leukemia: Cancer and Leukemia Group B study 8811. Blood 5: 2025–2037Google Scholar
  22. 22.
    Mandelli F, Annino L, Vegna ML et al. (1996) Adult acute lymphoblastic leukemia (ALL): Results of the Gimema ALL 0288 trial. Br J Hematol 93: 144–152Google Scholar
  23. 23.
    Mayer RJ, Davis RB, Schiffer CA et al. (1994) Intensive post-remission chemotherapy in adults with acute myeloid leukemia. N Engl J Med 331: 896–942CrossRefPubMedGoogle Scholar
  24. 24.
    Ohno R, Tomonaga M, Kobayashi T et al. (1990) Effect of granulocyte colony-stimulating factor after intensive induction therapy in relapsed or refractory acute leukemia. N Engl J Med 323: 871–877CrossRefPubMedGoogle Scholar
  25. 25.
    Ottmann OG, Hoelzer D, Gracien E et al. (1995) Concomittant granulocyte colony-stimulating factor and induction chemoradiotherapy in adult acute lymphoblastic leukemia: a randomised phase II trial. Blood 86: 444–454PubMedGoogle Scholar
  26. 26.
    Rowe JM, Andersen J, Mazza JJ et al. (1993) Phase III randomized placebo-controlled study of granulocyte-macrophage-colony stimulating factor (GM-CSF) in adult patients (55–7o years) with acute myelogenous leukemia (AML). A study of the Eastern Cooperative Oncology Group (ECOG). Blood 82; Suppl 1:329 aGoogle Scholar
  27. 27.
    Swansbury GJ, Lawler SD, Alimena G et al. (1994) Longterm survival in acute myelogenous leukemia: A second follow-up of the Fourth International Workshop on chromosomes in leukemia. Cancer Genet Cytogenet 73: 1–7CrossRefPubMedGoogle Scholar
  28. 28.
    von Schilling C, Duyster J, Herrmann F (1996) Fortschritte im Verständnis der Leukämieentstehung. Internist 37: 971–981Google Scholar
  29. 29.
    Warrell RP, Frankel SR, Miller WH et al. (1991) Differentiation therapy of acute promyelocytic leukemia with tretinoin (all-trans-retinoic acid). N Engl J Med 324: 1385–1393CrossRefPubMedGoogle Scholar
  30. 30.
    Zittoun RA, Mandelli F,Willemze R et al. (1995) Autologous or allogeneic bone marrow transplantation compared with intensive chemotherapy in acute myelogenous leukemia. N Engl J Med 332: 217–223CrossRefPubMedGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1999

Authors and Affiliations

  • W. Hiddemann

There are no affiliations available

Personalised recommendations