Skip to main content
SpringerLink
Log in

Mediastinal-, Lungen- und Pleuratumoren

  • Chapter
Therapie innerer Krankheiten

  • 18 Accesses

Zusammenfassung

Im Bereich des mediastinums lassen sich verschiedenste Raumforderungen nachweisen, die in etwa 60% durch eine Neoplasie bedingt sind. In etwa 30% handelt es sich um eines malignen Mediastinaltumor. Der Anteil der malignen Tumoren Liegt bei Patienten, bei denen ein Tumor zufälling entdeckt wurde, nur bei 10%, bei den symptomatischen Patienten jedoch bei etwa 50% [39]. Die häufigsten Raumforderungen sind in Tabelle 1 zusammengestellt [39].

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 54.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Literatur

  1. Antman K, Shemin R, Ryan L, Klegar K, Osteen R, Herman T, Lederman G, Corson J (1988) Malignant mesothelioma: 19. prognostic variables in a registry of 180 patients, the Dana Farber Cancer Institute and Brigham and Women‘s Hospital experience over two decades, 1965–1985. J Clin Oncol 6:147 –153

    Google Scholar 

  2. Ardizzoni A, Hansen H, Dombernowsky P, et al. (1997) 20. Topotecan, a new active drug in the second-line treatment of small-cell lung cancer: a phase II study in patients with refractory and sensitive disease. J Clin Oncol 15:2090 –2096

    Google Scholar 

  3. Bakowski MT, Crouch IC (1983) Chemotherapy for non-small cell lung cancer: a reappraisal and look to the future. Cancer Treat Rep 10: 159–172

    Article  CAS  Google Scholar 

  4. Becker N, Wahrendorf J (1997) Krebsatlas der Bundesrepublik Deutschland. 3. Aufl., Springer Verlag, Berlin Heidel berg New York

    Google Scholar 

  5. Blossom GB, Steiger Z, Stephenson LW (1997) Neoplasms 23. of the mediastinum. In: De Vita V Jr, Hellman S, Rosenberg SA (eds) Cancer - principles and practice of oncology, 5th edn, pp 951– 969, Lippincott-Raven, Philadelphia

    Google Scholar 

  6. Calvert AH, Newell DR, Gumbrell LA, O’Reilly S, Burnell M, Boxall FE, Siddik ZH, Judson IR, Gore ME, Wiltshaw E (1989) Carboplatin dosage: a prospective evaluation of a simple formula based on renal function. J Clin Oncol 7: 1748–1756

    PubMed  CAS  Google Scholar 

  7. Carbone DP (1997) The biology of lung cancer. Sem Oncol 24: 38–401

    Google Scholar 

  8. Choi NC, Carey RW, Kaufman D, Grillo HC, Younger J, Wilkins EW (1987) Small cell carcinoma of the lung. A progress report of 15 years‘ experience. Cancer 59: 6–14

    Article  PubMed  CAS  Google Scholar 

  9. Cox JD, Byhard RW, Komaki R (1983) The role of radiotherapy in squamous, large cell, and adenocarcinoma of the lung. Sem Oncol to: 81–94

    Google Scholar 

  10. Cullen MH, Joshi R, Chetiyawardana AD, Woodroffe CM (1988) Mitomycin, ifosfamide, and cis-platin in non-small cell lung cancer: treatment good enough to compare. Br J Cancer 58: 359–361

    Article  PubMed  CAS  Google Scholar 

  11. Drings P, Becker H, Bülzebruck H, Djawid N, Ruchalla F, Stiefel O, Tessen HW (1988) Die Chemotherapie des nicht-kleinzelligen Bronchialkarzinoms mit Ifosfamid in Kornbination mit Cisplatin, Etoposid oder Vindesin. Onkologie u [Suppl2]: 47–56

    Google Scholar 

  12. Drings P, Bülzebruck H, Hruska D, Manke RG, Schuler G (1986) EPICO in der Chemotherapie des kleinzelligen Bronchialkarzinoms. Aktuelle Onkologie 29: Fortschritte in der Chemotherapie: 104–114

    Google Scholar 

  13. Fornasiero A, Daniele O, Sperandio P, Morandi P, Fosser VP, Cartei G, Fiorentio MV (1985) Chemotherapy of invasive or metastatic thymoma: report of 11 cases. Cancer Treat Rep 68: 1205–1210

    Google Scholar 

  14. Ganz P, Figlin RA, Haskell CM, La Soto N, Siau J, for the UCLA Solid Tumor Study Group (1989) Supportive care versus supportive care and combination chemotherapy in metastastic non-small cell lung cancer. Cancer 63: 1271–1278

    Article  Google Scholar 

  15. Gatzemeier U (1989) Chemotherapie des nicht-kleinzelligen Bronchialkarzinoms. In: Nagel GA, Bach F (Hrsg) Aktuelle Onkologie 51, 10 Jahre Mitomycin in der Bundesrepublik. Zuckschwerdt, München, pp 69–90

    Google Scholar 

  16. Gerl A, Clemm C, Kohl P, Niedermaier J, Schalhorn A (1994) Primär extragonadale Keimzelltumoren. Med Klinik 89: 240–244

    CAS  Google Scholar 

  17. Göldel N, Böning L, Fredrik A, Hölzel D, Hartenstein R, Wilmanns W (1989) Chemotherapy of invasive thymoma. A retrospective study of 22 cases. Cancer 63: 1493–1500

    Article  PubMed  Google Scholar 

  18. Gralla RJ, Casper ES, Kelsen DP, Braun DW, Dukeman ME, Martini N, Young CW, Golbey RB (1981) Cisplatin and vindesine combination chemotherapy for advanced carcinoma of the lung. Annals Int Med 95: 414–420

    Article  CAS  Google Scholar 

  19. Hartenstein R, Abenhardt W (1995) Behandlung maligner Körperhöhlenergüsse und intraperitoneale Chemotherapie. In: Huhn D, Herrmann R (Hrsg) Medikamentöse Therapie maligner Erkrankungen, 3. Aufl., Gustav Fischer, Stuttgart, S 477–491

    Google Scholar 

  20. Hartlapp JH, Klieche L, Kessler H, Lorenz J, Planker M, Zöllner A (1989) Etoposide (VP 16) and vincristine as treatment in extensive stage small cell lung cancer. ASCO Proc 8: 970, p 249

    Google Scholar 

  21. Häußinger KE, Kohlhäufel E (1997) Ätiologie und Epidemiologie des Bronchialkarzinoms. In: Schalhorn A (Hrsg) Tumorzentrum München - Empfehlungen zur Diagnostik, Therapie und Nachsorge: Tumoren der Lunge und des Mediastinums, pp 137–143, München

    Google Scholar 

  22. Ihde DC (1984) Current status of therapy for small cell carcinoma of the lung. Cancer 54: 2722–2728

    Article  PubMed  CAS  Google Scholar 

  23. Johnson, DH, Greco JA, Strupp J, Hande KR, Hainsworth JD (1990) Prolonged administration of oral etoposide in patients with relapsed or refractory small-cell lung cancer: a phase II trial. J Clin Oncol 8: 1613–1617

    PubMed  CAS  Google Scholar 

  24. Kies MS, Mira JG, Growley JI, Chen TT, Pazdur R, Grozea PN, Rivkin SE, Coltman CA Jr, Ward JH, Livingston RB (1987) Multimodal therapy for limited small-cell lung cancer; a randomized study of induction combination chemotherapy with or without thoracic radiation in complete responders; and with wide-field versus reduced field radiation in partial responders; a Southwest Oncology Group study. J Clin Oncol 5: 592–600

    PubMed  CAS  Google Scholar 

  25. Klastersky J, Sculier JP, Dumont IP, Becquart D, Vandermoten G, Rocmans F, Michael J, Longeval F, Dalesio 0 (1985) Combination chemotherapy with adriamycin, etoposide, and cyclophosphamide for small cell carcinoma of the lung. Cancer 56: 71–75

    CAS  Google Scholar 

  26. Kristjansen PEG, Hansen HH (1990) Management of small cell lung cancer: a summary of the third International Association for the Study of Lung Cancer workshop on small cell lung cancer. J Natl Cancer Inst 82: 263–266

    Article  PubMed  CAS  Google Scholar 

  27. Livingston RB (1980) Small cell carcinoma of the lung. Blood 56: 575–584

    PubMed  CAS  Google Scholar 

  28. Livingston RB (1988) Treatment of advanced non-small cell lung cancer; the Southwest Oncology Group experience. Sem Oncol 15 (Suppl 7): 37–41

    CAS  Google Scholar 

  29. Longeval E, De Jager R, Tatgnon H, Klastersky J, EORTC Lung Cancer Working Group (1980) Cisplatin-Vp 16–213 combination chemotherapy in non small cell bronchogenic carcinoma; phase I-II clinical trial. Proc AACR & ASCO 21: 368 (C–195)

    Google Scholar 

  30. Maassen W, Greschuchna D, Martinez I (1985) The role of surgery in the treatment of small cell carcinoma of the lung. Rec Results Cancer Res 97: 107–115

    Article  CAS  Google Scholar 

  31. Masaoka A, Monden Y, Nakahara K, Tanioka T (1981) Follow-up study of thymomas with special reference to their clinical stages. Cancer 48: 2485–2492

    Article  PubMed  CAS  Google Scholar 

  32. Meyer G, Vogt-Moykopf I (1987) Operatives Management der Bronchialkarzinome. Onkolog Forum 1: 8–16

    Google Scholar 

  33. Morstyn G, Ihde DC, Lichter SA, Bunn PA, Carney DN, Glatstein E, Minna JD (1984) Small cell lung cancer 1973–1983; early progress and recent obstacles. Int J Rad Oncol Biol Phys 10: 515–539

    Article  CAS  Google Scholar 

  34. Natale R, Hilaris B, Goldbey R, Wittes R (1979) Induction chemotherapy in small cell carcinoma of the lung (SCCL). Proc AACR & ASCO 20: 343 (C–214)

    Google Scholar 

  35. Nathrath W, Müller A, Müller-Höcker J (1997) Tumoren des Mediastinums - Pathologie. In: Schalhorn A (Hrsg) Tumorzentrum München - Empfehlungen zur Diagnostik, Therapie and Nachsorge: Tumoren der Lunge and des Mediastinums, pp 137–143, München

    Google Scholar 

  36. Niederle N, Schütte J (1985) Chemotherapeutic results in small cell lung cancer. Rec Results Cancer Res 97: 127–145

    Article  CAS  Google Scholar 

  37. Perez CA, Einhorn L, Oldham RK, Cohen H et al. reporting for the Southeastern Cancer Study Group (1983) Preliminary report on a randomized trial of radiotherapy to the thorax in limited small cell carcinoma of the lung treated with multiagent chemotherapy. ASCO Proc 2:C–742,190

    Google Scholar 

  38. Perry MC, Eaton WL, Propert KJ, Ware JH, Zimmer B, Chahinian F, Skarin A, Carey RW, Kreisma H, Faulkner C, Comis R, Green MR (1987) Chemotherapy with or without radiation therapy in limited small cell carcinoma of the lung. New Engl J Med 316: 912–918

    Article  PubMed  CAS  Google Scholar 

  39. Ramanathan KR, Belani CP (1997) Chemotherapy for advanced non-small cell lung cancer: pat, present future. Sem Oncol 24: 440–454

    CAS  Google Scholar 

  40. Ruckdeschel J (1997) Combined modality therapy of non smll cell lung cancer. Sem Oncol 24: 429–439

    CAS  Google Scholar 

  41. Ruffle P, Feld R, Minkin S, Cormier Y et al. (1989) Diffuse malignant mesothelioma of the pleura in Ontario and Quebec: a retrospective study off 332 patients. J Clin Oncol 7: 1157–1168

    Google Scholar 

  42. Sauer H, Wilmanns W (1991) Internistische Therapie maligner Erkrankungen. 3. Aufl., Urban & Schwarzenberg, München

    Google Scholar 

  43. Schalhorn A (1985) Bronchialkarzinom: Möglichkeiten und Grenzen der Chemotherapie. Teil I: Kleinzelliges Bronchialkarzinom. Fortschr Med 103:309–311. Teil II: Nicht-kleinzelliges Bronchialkarzinom. Fortschr Med 103: 453–456

    PubMed  CAS  Google Scholar 

  44. Schalhorn A, Sunder-Plassmann L (1994) Bronchialkarzinom. In: Wilmanns W, Huhn D, Wilms K (Hrsg) Internistische Onkologie. Thieme, Stuttgart, pp 490–507

    Google Scholar 

  45. Seeber S, Niederle N (1983) Chemotherapie des kleinzelligen Bronchialkarzinoms. In: Hellriegel KP, Sack H (Hrsg) Bronchialkarzinom, Mammakarzinom. Springer, Berlin Heidelberg New York, pp 11–18

    Google Scholar 

  46. Sobin LH, Wittekind C (eds) (1997) TNM: Classification of malignant tumours, 5th edition, Wiley-Liss, New York

    Google Scholar 

  47. Souhami RL, Geddes DM, Spiro SG, Harper PG, Tobias JS, Mantell BS, Fearon F, Bradbury I (1984) Radiotherapy in small cell cancer of the lung treated with combination chemotherapy: a controlled trial. Br Med J 288: 1643–1646

    Article  CAS  Google Scholar 

  48. Strauss MJ, Moran RE, Shakney SE (1983) Growth characteristics of lung cancer. In: Srauss MJ (ed) Lung cancer. Clinical diagnosis and treatment. Grune & Stratton, New York, pp 63–84

    Google Scholar 

  49. Woitowitz HI (1987) Epidemiologie und Prävention des malignen Pleuramesothelioms. Med Klin 82: 578–581

    CAS  Google Scholar 

  50. v Zandwijk N, Giaccone G (1996) Treatment of metastatic non-small cell lung cancer. Current Op Oncol 8: 120–125

    Article  Google Scholar 

Download references

Authors
  1. A. Schalhorn
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Medizinische Klinik und Poliklinik II Klinikum Großhadern, Ludwig-Maximilians-Universität München, Marchioninistraße 15, D-81377, München, Deutschland

    Gustav Paumgartner

  2. Neurologische Klinik und Poliklinik, Universität München Klinikum Großhadern, Marchioninistraße 15, D-81377, München, Deutschland

    Th. Brandt

  3. Medizinische Kernklinik und Poliklinik, Universitäts-Krankenhaus Eppendorf, Martinistraße 52, D-20246, Hamburg, Deutschland

    H. Greten

  4. Abteilung für Nephrologie Zentrum Innere Medizin und Dermatologie, Medizinische Hochschule Hannover, Carl-Neuberg-Straße 1, D-30625, Hannover, Deutschland

    K. M. Koch

  5. Krankenhaus Zehlendorf Pneumologie I, Am Heckeshorn 33, D-14109, Berlin, Deutschland

    H. Lode

  6. Medizinische Universitätsklinik, Innere Medizin A, Albert-Schweitzer-Straße 33, D-48149, Münster, Deutschland

    J. van de Loo

  7. Medizinische Poliklinik, Universität München, Pettenkoferstraße 8a, D-80336, München, Deutschland

    M. Schattenkirchner

  8. Medizinische Klinik II, Universität Gießen, Klinikstraße 36, D-35392, Gießen, Deutschland

    W. Seeger

  9. Medizinische Klinik und Poliklinik I Klinikum Großhadern, Ludwig-Maximilians-Universität München, Marchioninistraße 15, D-81377, München, Deutschland

    G. Steinbeck

  10. Medizinische Klinik und Poliklinik, Universität Heidelberg, Bergheimer Straße 58, D-69115, Heidelberg, Deutschland

    R. Ziegler

Rights and permissions

Reprints and permissions

Copyright information

© 1999 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Schalhorn, A. (1999). Mediastinal-, Lungen- und Pleuratumoren. In: Paumgartner, G., et al. Therapie innerer Krankheiten. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-10477-4_26

Download citation

  • DOI: https://doi.org/10.1007/978-3-662-10477-4_26

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-662-10478-1

  • Online ISBN: 978-3-662-10477-4

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation