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Pharmakologische Intervention bei einigen Enzymaktivitäten in verschiedenen Gehirnarealen während Hypoxie und posthypoxischer Erholung

  • G. Benzi
Conference paper

Zusammenfassung

In der Pathophysiologie des Gehirns treten Hypoxie und Altern häufig in unterschiedlicher Kombination gemeinsam auf. Das Verhalten des Gehirnmetabolismus unter diesen Bedingungen ist ein bedeutendes Problem für die experimentelle Forschung und Klinik. Die Komplexität dieses Problems hat zu spezifischen experimentellen Untersuchungen geführt, die verschiedene Modelle und Evaluationsparameter benutzen. Über lange Jahre wurde die Wirkung von Pharmaka auf das Altern des Gehirns und auf zerebrovaskuläre Erkrankungen ihrem Einfluß auf die zerebrale Durchblutung zugeschrieben und die metabolische Wirkung dabei als sekundär eingestuft. Vor kurzem ließ sich nun nachweisen, daß Pharmaka den Energiestoffwechsel des Gehirns, gemessen an Enzymaktivitäten, verändern. Diese pharmakologischen Wirkungen wurden von einer Vielzahl von Faktoren wie Alter, Dauer eines Insultes, Gehirnareal und subzellulare Fraktion beeinflußt [1, 3, 4, 5, 8, 10, 25, 26, 27].

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Copyright information

© Springer-Verlag Berlin Heidelberg 1985

Authors and Affiliations

  • G. Benzi
    • 1
  1. 1.Istituto di FarmacologiaFacoltà di Scienze MM.FF.NNPaviaItalien

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