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The Vertebrate Organizer pp 279–298Cite as

A Critical Role for Retinoid Receptors in Axial Patterning and Neuronal Differentiation

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Abstract

Vitamin A is required for growth, vision, reproduction, morphogenesis, hematopoiesis, immune function, and differentiation of normal and malignant tissues (Sporn 1994). Vitamin A deficiency during development leads to a spectrum of well-characterized defects collectively called the fetal vitamin A deficiency (VAD) syndrome. Retinoic acid (RA) excess produces a spectrum of developmental defects affecting many of the same tissues as VAD, e.g. the heart, CNS, eyes, ears and reproductive tissues. Sensitivity of the same embryonic tissues to RA deficiency or excess suggested that endogenous RA levels required precise regulation for development to proceed correctly.

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Authors and Affiliations

  1. Laboratory of Molecular Embryology, Institute of Cell Biology and Neurosciences, School of Medicine, University of Buenos Aires, Paraguay 3rd Floor, 1121, Buenos Aires, Argentina

    Andrés E. Carrasco

  2. Department of Developmental and Cell Biology, University of California, 5205 McGaugh Hall, Irvine, California, 92697-2300, USA

    Bruce Blumberg

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  1. Andrés E. Carrasco
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  2. Bruce Blumberg
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Editors and Affiliations

  1. FB9 Department of Zoophysiology, University Duisburg-Essen, Universitätsstraße 5, 45117, Essen, Germany

    Horst Grunz

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© 2004 Springer-Verlag Berlin Heidelberg

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Carrasco, A.E., Blumberg, B. (2004). A Critical Role for Retinoid Receptors in Axial Patterning and Neuronal Differentiation. In: Grunz, H. (eds) The Vertebrate Organizer. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-10416-3_17

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  • DOI: https://doi.org/10.1007/978-3-662-10416-3_17

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-05732-8

  • Online ISBN: 978-3-662-10416-3

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