The gp43 from Paracoccidioides brasiliensis: A Major Diagnostic Antigen and Vaccine Candidate

  • Luiz R. Travassos
  • Carlos P. Taborda
  • Leo K. Iwai
  • Ed Cio Cunha-Neto
  • Rosana Puccia
Part of the The Mycota book series (MYCOTA, volume 12)


The gp43, a 43,000 dalton glycoprotein from Paracoccidioides brasiliensis, is one of those rare examples of a major diagnostic antigen in serological assays (e.g., Mendes-Giannini et al. 1990) that also contains epitopes eliciting an immunoprotective cellular immune response. Its role in fungal virulence is not clearly defined which raises the ques-tion as to the selective pressure that keeps its expression constant in both yeast and mycelium phase of this dimorphic pathogenic species.


Gp43 Gene Capture Enzyme Immunoassay Gp43 Isoforms Peripheral Blood Mononudear Cell Major Diagnostic Antigen 
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Copyright information

© Springer-Verlag Berlin Heidelberg 2004

Authors and Affiliations

  • Luiz R. Travassos
    • 1
  • Carlos P. Taborda
    • 2
  • Leo K. Iwai
    • 3
  • Ed Cio Cunha-Neto
    • 1
  • Rosana Puccia
    • 1
  1. 1.Departamento de Microbiologia, Imunologia e ParasitologiaUniversidade Federal de São Paulo (UNIFESP)Brazil
  2. 2.Departamento de MicrobiologiaUniversidade de São Paulo (USP)Brazil
  3. 3.Laboratório de ImunologiaINCOR, USPSão PauloBrazil

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