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Humoral Immunity

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Human and Animal Relationships

Part of the book series: The Mycota ((MYCOTA,volume 6))

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Abstract

The humoral immune response to fungal infection is of interest for three primary reasons. First, the antibody response to systemic infection has been used for diagnosis of infections by fungi that often require several weeks before the laboratory can report results from routine fungal cultures. As a consequence, complement fixation, immunopre-cipitation, and enzyme-linked immunoassays (EIA) for antifungal antibodies have found use in diagnosis of infections by fungi such as Blastomyces dermatitidis, Coccidioides immitis, and Histoplasma capsulatum. The second basis for interest in humoral immunity is the role of antibody in resistance to some fungal infections. Cellular immunity is responsible for resistance to most infections, but the availability of powerful new monoclonal antibodies (m Abs) has made possible studies which demonstrated the ability of antibodies to alter the course of infections by yeasts such as Candida albicans and Cryptococcus neoformans. Finally, the humoral response may contribute to the pathogenesis of some fungal infections.

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Authors and Affiliations

  1. Department of Microbiology and the Cell and Molecular Biology Program, University of Nevada, Reno, NV, 89557, USA

    T. R. Kozel & D. M. Lupan

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  1. T. R. Kozel
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  2. D. M. Lupan
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  1. Department of Microbiology and Immunology - 43-239 CHS, UCLA School of Medicine, Los Angeles, CA, 90024, USA

    Dexter H. Howard

  2. Plant Research Center, Mycotoxin Programme, Agriculture Canada, Ottawa, Ontario, K1A 0C6, Canada

    J. David Miller

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Kozel, T.R., Lupan, D.M. (1996). Humoral Immunity. In: Howard, D.H., Miller, J.D. (eds) Human and Animal Relationships. The Mycota, vol 6. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-10373-9_4

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  • DOI: https://doi.org/10.1007/978-3-662-10373-9_4

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