Abstract
Many human diseases have been suggested to result from exposure to mycotoxins. For the majority of such diseases, however, the epidemiological data establishing a causal link between exposure and disease are lacking. The purpose of this chapter is to review data associating specific mycotoxin exposures with human mycotoxicoses and to suggest avenues of research which could improve the understanding of mycotoxin-related disease. In particular, we discuss the possibility of improving measurements of mycotoxin exposure and discuss strategies for future epidemiological research on this topic. The epidemiological data are considered in relation to the causal criteria of Hill (1965).
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References
Adhikari M, Ramjee G, Berjak P (1994) Aflatoxin, Kwashiorkor, and morbidity. Nat Toxins 2:1–3
Bhat RV, Beedu SR, Ramaskrishna Y, Munshi KL (1989) Outbreak of trichothecene mycotoxicosis associated with consumption of mould-damaged wheat products in Kashmir valley, India. Lancet, Jan 7:35–37
Blunden G, Roch OG, Rogers DJ, Coker RD, Bradburn N, John AE (1991) Mycotoxins in food. Med Lab Sci 48:271–282
Bosch X, Munoz N (1989) Epidemiology of hepatocellular carcinoma. In: Bannasch P, Keppler D, Weber G (eds) Liver cell carcinoma. Kluwer Dordrecht, pp 3–14
Bourgeois CH, Shank RC, Grossman EA, Johnson DO, Wooding WL, Chandavimol P (1971) Acute aflatoxin B1 toxicity in the Macaque and its similarities to Reye’s syndrome. Lab Invest 24:206–216
Brinton WT, Vastbinder EE, Greene JW, Marx JJ, Hutcheson RH, Schaffner W (1987) An outbreak of organic dust toxic syndrome in a college fraternity. JAMA 258:1210–1212
Campbell TC, Chen J, Liu C, Li J, Parpia B (1990) Nonassociation of aflatoxin with primary liver cancer in a cross-sectional survey in the People’s Republic of China. Cancer Res 50:6882–6893
Castegnaro M, Plestina R, Dirheimer G, Chemozemsky IN, Bartsch H (1994) Mycotoxins, endemic nephropathy and urinary tract tumours. IARC Sci Publ No 115, IARC, Lyon
Chu FS (1991) Current immunochemical methods for mycotoxin analysis. In: Vanderlaan M, Stanker LH, Watkins BE, Roberts DW (eds) Immunoassays for trace chemical analysis, ACS Symposium Series 451, Washington DC, pp 140–157
Croft WA, Jarvis BB, Yatawara CS (1986) Airborne outbreak of trichothecene toxicosis. Atmos Environ 20:549–552
Demeke T, Kidane Y, Wuhib E (1979) Ergotism—a report on an epidemic, 1977–78. Ethiop Med J 17: 107–113
Denning DW (1987) Aflatoxin and human disease. Adv Drug React Ac Pois Rev 4:175–209
De Vries HR, Lamplugh SM, Hendrickse RG (1987) Aflatoxins and kwashiorkor in Kenya: a hospital based study in rural Kenya. Ann Trop Paediatr 7:249–57
Edmondson HA Craig JR (1987) Neoplasms of the liver. In: Schiff L, Schiff ER (eds) Disease of the liver. Lippincott, Philadelphia, pp 1109–1158
Eppley RM, Bailey WJ (1973) 12,13-Epoxy-Δ9-tricothecenes as the probable mycotoxins responsible for stachyborytoxicosis. Science 181:758–760
Ermakov VV (1992) Biogeochemical regioning problems and the biogeochemical selenium provinces in the former USSR (1992) Biol Trace Element Res 33: 171–185
Goodman LS, Gilman AC (eds) (1991) The pharmacological basis of therapeutics. MacMillan, New York
Gordon KE, Masotti RE, Waddell WR (1993) Tremorgenic encephalopathy: a role of mycotoxins in the production of CNS disease in humans? Can J Neurol Sci 20: 237–239
Gröger D (1972) Ergot. In: Kadis S, Ciegler A, Ajl SJ (eds) Microbial toxins, vol 8. Academic Press, New York, pp 321–373
Groopman JD, Wild CP, Hasler J, Chen J, Wogan GN, Kensler TW (1993) Molecular epidemiology of aflatoxin exposures: validation of aflatoxin-N-7-guanine levels in urine as a biomarker in experimental rat models and humans. Environ Health Perspect 99:107–113
GÜnther R, Abbas HK, Mirocha CJ (1989) Acute pathological effects on rats of orally administered wortmannin-containing preparations and purified wortmannin from Fusarium oxysporum. Food Chem Toxicol 3:173–179
Hall AJ, Wild CP (1994) Epidemiology of aflatoxin-related disease. In: Eaton DA, Groopman JD (eds) The toxicology of aflatoxins: human health, veterinary and agriculture significance. Academic Press, New York, pp 233–258
Hendrickse RC (1991) Clinical implications of food contamination by aflatoxins. Ann Acad Med 20:84–90
Hendrickse RG, Coulter J, Lamplugh S, MacFarlane S, Williams T, Orner M, Suliman G (1982) Aflatoxins and kwashiorkor: a study in Sudanese children. Br Med J 285:843–6
Hendry KM, Cole EC (1993) A review of mycotoxins in indoor air. Toxicol Environ Health 38:183–198
Hesseling PB (1990) Onyalai at Rundu, Namibia 1981–1988: age, sex morbidity, mortality and seasonal variation of 612 hospitalized patients. Trans R Soc Trop Med Hyg 84:605–607
Hesseling PB (1992) Onyalai. Bailliére’s Clin Haematol 5:457–473
Hill AB (1965) The environment and disease: association or causation. J R Soc Med 58:295–300
Hollstein M, Sidranksy D, Vogelstein B, Harris CC (1991) p53 mutations in human cancers. Science 253:49–53
Hsia CC, Wu JL, Lu XQ, Li YS (1988) Natural occurrence and clastogenic effects of nivalenol, 3-acetodeoxynivalenol, 15-acetyl-deoxynivalenol and zearalenone in corn from a high risk area of esophageal cancer. Cancer Detect Prev 13:79–88
Hudson GJ, Wild CP, Zarba A, Groopman JD (1992) Aflatoxins isolated by immunoaffinity chromatography from foods consumed in Gambia, West Africa. Nat Toxins 1:100–115
Hurwitz ES (1989) Reye’s syndrome. Epidemiol Rev 11: 249–253
IARC (1993) Some naturally occurring substances: food items and constituents, heterocyclic aromatic amines and mycotoxins. IARC Monographs on the Evaluation of Carcinogenic Risks to Humans, vol 56. IARC, Lyon
Joffe AZ (1971) Alimentary toxic aleukia. Chap 5. In: Kadis S, Ciegler A, Ajl SJ (eds) Microbial toxins, vol 7. Academic Press, New York
Joffe AZ (1974) Toxicity of Fusarium paoe and F. sporotrichioides and its relation to alimentary toxic aleukia. In: Purchase IFH (ed) Mycotoxins, Chap 11. Elsevier, Amsterdam, pp 229–262
King B (1979) Outbreak of ergotism in Wollo, Ethiopia. Lancet, June 30:1411
Krishnamachari KA, Bhat RV (1976) Poisoning by ergoty bajra (pearl millet) in man. Indian J Med Res 64: 1624–1628
Krishnamachari KA, Bhat RV, Nagarajan V, Tilak TBG (1975a) Hepatitis due to aflatoxicosis. Lancet, May 10:1061–1063
Krishnamachari KA, Bhat RV, Nagarajan V, Tilak TBG (1975b) Investigations into an outbreak of hepatitis in parts of western India. Indian J Med Res 63:1036–1049
Lee YW, Mirocha CJ, Shroeder DJ, Walser MM (1985) TDP-1, a toxic component causing tibial dyschondroplasia in broiler chickens, and trichothecenes from Fusarium roseum graminearum. Appl Environ Microbiol 50:102–107
Li F-S, Duan Y-J, Yan S-J, Guan J-Y, Zou L-M, Wei F-C, Mong L-Y, Li L, Li S-Y (1990) Presenile (early ageing) changes in tissues of Kaschin-Beck disease and its pathogenetic significance. Mech Ageing Dev 54:102–107
Liu X, Luo X, Hu W (1992) Studies on the epidemiology and etiology of moldy sugarcane poisoning in China. Biomed Environ Sci 5:161–177
Ludolph AC, He F, Spencer PS, Hammerstad J, Sabri M (1991) 3-Nitropropionic acid-exogenous animal neurotoxin and possible human striatal toxin. Can J Neurol Sci 18:492–498
Lutsky I, Mor N, Yagen B, Joffe AZ (1978) The role of T-2 toxin in experimental aleukia: a toxicity study in cats. Toxicol Appl Pharmacol 43:111–124
Magee R (1991) St Anthony’s fire revisited. Med J Aust 154:145–149
Marasas WFO, van Rensburg SJ, Mirocha CJ (1979) Incidence of Fusarium species and the mycotoxins deoxynivalenol and zearalenone in corn produced in esophageal cancer areas in Transkei. J Agric Food Chem 27:1108–11
Marasas WFO, Wehner FC, van Rensburg SJ, van Schalkwyk DJ (1981) Mycoflora of corn produced in human esophageal cancer areas in Transkei, southern Africa. Phytopathology 71:792–6
Marasas WFO, Jaskiewicz K, Venter FS, van Schalkwyk DJ (1988) Fusarium moniliforme contamination of maize in oesophageal cancer areas in Transkei. S Afr Med J 74:110–4
Michelot D, Toth B (1991) Poisoning by Gyromitra esculenta — a review. J Appl Toxicol 11:235–243
Mirocha CJ, Pathre S (1973) Identification of the toxic principle in a sample of poaefusarin. Appl Microbiol 26:719–724
Ngindu A, Johnson BK, Kenya PR, Ngira JA, Ocheng DM, Nandwa H, Omondi TN, Jansen AJ, Ngare W, Kaviti JN, Gatei D, Siongok TA (1982) Outbreak of acute hepatitis caused by aflatoxin poisoning in Kenya. Lancet, June 12:1346–1348
Park DL, Pohland AE (1989) Sampling and sample preparation for detection and quantitation of natural toxicants in food and feed. J Assoc Off Anal Chem 72:399–404
Petkova-Bocharova T, Castegnaro M, Michelon J, Maru V (1991) Ochratoxin and other mycotoxins in cereals from an area of Balkan endemic nephropathy and urinary tract tumours in Bulgaria. In: Castegnaro M, Plestina R, Dirheimer G, Chernozemsky IN, Bartsch H (eds) Mycotoxins, endemic nephropathy and urinary tract tumours. IARC Sci Publ, Lyon, France No 115, pp 83–87
Qian GS, Ross RK, Yu MC, Yuan JM, Gao YT, Henderson BE, Wogan GN, Groopman JD (1994) A follow-up study of urinary markers of aflatoxin exposure and liver cancer risk in Shanghai, People’s Republic of China. Cancer Epid Biomarkers Prev 3:3–10
Rabie CJ, Van Rensburg SJ, Van der Watt JJ, LÜbben A (1975) Onyalai — the possible involvement of a mycotoxin produced by Phomasorghina in the aetiology. S Afr Med J 49:1647–1650
Ramjee G, Berjak P, Adhikari M, Dutton MF (1992) Aflatoxins and kwashiorkor in Durban, South Africa. Ann Trop Paediatr 12:241–247
Rao BL, Husain A (1985) Presence of cyclopiazonic acid in kodo millet (Paspalum scrobiculatum) causing ‘kodua poisoning’ in man and its production by associated fungi. Mycopathologia 89:177–180
Rheeder JP, Marasas WFO, Thiel PG, Sydenham EW, Shephard GS, van Schalkwyk DJ (1992) Fusarium moniliforme and fumonisins in corn in relation to human esophageal cancer in Transkei. Phytopathology 82: 353–11
Riley RT, An NH, Showker JL, Yoo HS, Norred WP, Chamberlain WJ, Wang E, Merrill AM, Motelin G, Beasley VR Haschek WM (1993) Alteration of tissue and serum sphinganine to sphingosine ratio: an early biomarker in pigs of exposure to fumonisin-containing foods. Toxicol Appl Pharmacol 118:105–112
Robinson P (1967) Infantile cirrhosis of the liver in India with special reference to probable aflatoxin aetiology. Clin Pediatr 6:57–62
Rodricks JV, Eppley RM (1974) Stachbotrys and stachybotryotoxicosis. In: Purchase IFH (ed) Mycotoxins, Chap 9. Elsevier, Amsterdam, pp 181–197
Ross RK, Yuan J-M, Yu MC, Wogan GN, Qian G-S, Tu J-T, Groopman JD, Gao Y-T, Henderson BE (1992) Urinary aflatoxin markers and risk of hepatocellular carcinoma. Lancet 339:943–946
Saito M, Ohtsubo K (1974) Trichothecene toxins of Fusarium species. In: Purchase IFH (ed) Mycotoxins, Chap 12. Elsevier Amsterdam, pp 263–281
Shank RC (1981) Environmental toxicoses in humans. In: Shank RC (ed) Mycotoxins and N-nitroso compounds: environmental risks, vol I. CRC Press, Boca Raton, pp 107–140
Sorenson WG, Frazer DG, Jarvis BB, Simpson J, Robinson VA (1987) Trichothecene mycotoxins in aerosolized conidia of Stachybotrys atra. Appl Environ Microbiol 53:1370–1375
Steyn PS, Rabie CJ (1976) Characterisation of magnesium and calcium tenuazonate from Phoma sorghina. Phytochemistry 15:1977–1979
Stoloff L (1983) Aflatoxin as a cause of primary liver-cell cancer in the United States. A probability study. Nutr Cancer 5:165–186
Sydenham EW, Thiel PG, Marasas WFO, Shephard GS, van Schalkwyk DJ, Koch KR (1990) Natural occurrence of some Fusarium mycotoxins in corn from low and high esophageal cancer prevalence areas of the Transkei, southern Africa. J Agric Food Chem 38: 1900–1903
Tandon HD (1993) Handling toxicoses of unknown origin. Food Additives Contaminants 10:105–113
Tandon BN, Krischnamurthy L, Koshy A, Tandon HD, Ramalingaswami V, Bhandari JR, Mathur MM, Mathur PD (1977) Study of an epidemic of jaundice presumably due to toxic hepatitis in northwest India. Gastroenterology 72:488–9
Tandon HD, Tandon BN, Ramalingaswami V (1978) Epidemic of toxic hepatitis in India of possible mycotoxic origin. Arch Pathol Lab Med 102:372–376
Thiel PG, Marasas WFO, Sydenham EW, Shephard GS, Gelderblom WCA (1992) The implications of naturally occurring levels of fumonisins in corn for human and animal health. Mycopathologia 117:3–9
Ueno Y (1974) Citreoviridin from Penicillium citreo-viride Biourge. In: Purchase IFH (ed) Mycotoxins. Chap 3. Elsevier, Amsterdam, pp 283–302
van Rensburg SJ, Altenkirk B (1974) Claviceps purpurea ergotism. In: Purchase IFH (ed) Mycotoxins. Elsevier, Amsterdam, pp 69–96
Whitaker TB, Park DL (1994) Problems associated with accurately measuring aflatoxin in food and feeds: errors associated with sampling, sample preparation, and analysis. In: Eaton DL, Groopman JD (eds) The toxicology of aflatoxins: human health, veterinary, and agricultural significance. Academic Press, New York, pp 433–450
WHO (1979) World Health Organization Environmental Health Criteria 11, Mycotoxins WHO, Geneva
WHO (1990) International Programme on Chemical Safety. Environmental Health Criteria 105, Selected mycotoxins: ochratoxins, trichothecenes, ergot. World Health Organization, Geneva
Wild CP, Montesano R (1991) Letter to the editor. Cancer Res 51:3825–3827
Wild CP, Jiang YZ, Sabbioni G, Chapot B, Montesano R (1990) Evaluation of methods for quantitation of aflatoxin-albumin adducts and their application to human exposure assessment. Cancer Res 50:245–251
Wild CP, Fortuin M, Donato F, Whittle HC, Hall AJ, Wolf CR, Montesano R (1993) Aflatoxin, liver enzymes and hepatitis B virus infection in Gambian children. Cancer Epid Biomarkers Prev 2:555–561
Yadgiri B, Reddy V, Tulpule PG, Srikantia SG, Gopalan C (1970) Aflatoxin and Indian childhood cirrhosis. Am J Clin Nutr 23:94–98
Zhen Y, Yang S, Ding L, Han F, Yang W, Liu Q (1984) The culture and isolation of fungi from the cereals in five high risk and three low incidence counties of oesophageal cancer in Henan province (China). Chin J Oncol 6:27–29
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Wild, C.P., Hall, A.J. (1996). Epidemiology of Mycotoxin-Related Disease. In: Howard, D.H., Miller, J.D. (eds) Human and Animal Relationships. The Mycota, vol 6. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-10373-9_11
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DOI: https://doi.org/10.1007/978-3-662-10373-9_11
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