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Epidemiology of Mycotoxin-Related Disease

  • C. P. Wild
  • A. J. Hall
Part of the The Mycota book series (MYCOTA, volume 6)

Abstract

Many human diseases have been suggested to result from exposure to mycotoxins. For the majority of such diseases, however, the epidemiological data establishing a causal link between exposure and disease are lacking. The purpose of this chapter is to review data associating specific mycotoxin exposures with human mycotoxicoses and to suggest avenues of research which could improve the understanding of mycotoxin-related disease. In particular, we discuss the possibility of improving measurements of mycotoxin exposure and discuss strategies for future epidemiological research on this topic. The epidemiological data are considered in relation to the causal criteria of Hill (1965).

Keywords

Ergot Alkaloid Cyclopiazonic Acid Indian Childhood Cirrhosis Tenuazonic Acid Aflatoxin Exposure 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Adhikari M, Ramjee G, Berjak P (1994) Aflatoxin, Kwashiorkor, and morbidity. Nat Toxins 2:1–3PubMedCrossRefGoogle Scholar
  2. Bhat RV, Beedu SR, Ramaskrishna Y, Munshi KL (1989) Outbreak of trichothecene mycotoxicosis associated with consumption of mould-damaged wheat products in Kashmir valley, India. Lancet, Jan 7:35–37CrossRefGoogle Scholar
  3. Blunden G, Roch OG, Rogers DJ, Coker RD, Bradburn N, John AE (1991) Mycotoxins in food. Med Lab Sci 48:271–282PubMedGoogle Scholar
  4. Bosch X, Munoz N (1989) Epidemiology of hepatocellular carcinoma. In: Bannasch P, Keppler D, Weber G (eds) Liver cell carcinoma. Kluwer Dordrecht, pp 3–14Google Scholar
  5. Bourgeois CH, Shank RC, Grossman EA, Johnson DO, Wooding WL, Chandavimol P (1971) Acute aflatoxin B1 toxicity in the Macaque and its similarities to Reye’s syndrome. Lab Invest 24:206–216PubMedGoogle Scholar
  6. Brinton WT, Vastbinder EE, Greene JW, Marx JJ, Hutcheson RH, Schaffner W (1987) An outbreak of organic dust toxic syndrome in a college fraternity. JAMA 258:1210–1212PubMedCrossRefGoogle Scholar
  7. Campbell TC, Chen J, Liu C, Li J, Parpia B (1990) Nonassociation of aflatoxin with primary liver cancer in a cross-sectional survey in the People’s Republic of China. Cancer Res 50:6882–6893PubMedGoogle Scholar
  8. Castegnaro M, Plestina R, Dirheimer G, Chemozemsky IN, Bartsch H (1994) Mycotoxins, endemic nephropathy and urinary tract tumours. IARC Sci Publ No 115, IARC, LyonGoogle Scholar
  9. Chu FS (1991) Current immunochemical methods for mycotoxin analysis. In: Vanderlaan M, Stanker LH, Watkins BE, Roberts DW (eds) Immunoassays for trace chemical analysis, ACS Symposium Series 451, Washington DC, pp 140–157Google Scholar
  10. Croft WA, Jarvis BB, Yatawara CS (1986) Airborne outbreak of trichothecene toxicosis. Atmos Environ 20:549–552CrossRefGoogle Scholar
  11. Demeke T, Kidane Y, Wuhib E (1979) Ergotism—a report on an epidemic, 1977–78. Ethiop Med J 17: 107–113PubMedGoogle Scholar
  12. Denning DW (1987) Aflatoxin and human disease. Adv Drug React Ac Pois Rev 4:175–209Google Scholar
  13. De Vries HR, Lamplugh SM, Hendrickse RG (1987) Aflatoxins and kwashiorkor in Kenya: a hospital based study in rural Kenya. Ann Trop Paediatr 7:249–57PubMedGoogle Scholar
  14. Edmondson HA Craig JR (1987) Neoplasms of the liver. In: Schiff L, Schiff ER (eds) Disease of the liver. Lippincott, Philadelphia, pp 1109–1158Google Scholar
  15. Eppley RM, Bailey WJ (1973) 12,13-Epoxy-Δ9-tricothecenes as the probable mycotoxins responsible for stachyborytoxicosis. Science 181:758–760PubMedCrossRefGoogle Scholar
  16. Ermakov VV (1992) Biogeochemical regioning problems and the biogeochemical selenium provinces in the former USSR (1992) Biol Trace Element Res 33: 171–185CrossRefGoogle Scholar
  17. Goodman LS, Gilman AC (eds) (1991) The pharmacological basis of therapeutics. MacMillan, New YorkGoogle Scholar
  18. Gordon KE, Masotti RE, Waddell WR (1993) Tremorgenic encephalopathy: a role of mycotoxins in the production of CNS disease in humans? Can J Neurol Sci 20: 237–239PubMedGoogle Scholar
  19. Gröger D (1972) Ergot. In: Kadis S, Ciegler A, Ajl SJ (eds) Microbial toxins, vol 8. Academic Press, New York, pp 321–373Google Scholar
  20. Groopman JD, Wild CP, Hasler J, Chen J, Wogan GN, Kensler TW (1993) Molecular epidemiology of aflatoxin exposures: validation of aflatoxin-N-7-guanine levels in urine as a biomarker in experimental rat models and humans. Environ Health Perspect 99:107–113PubMedCrossRefGoogle Scholar
  21. GÜnther R, Abbas HK, Mirocha CJ (1989) Acute pathological effects on rats of orally administered wortmannin-containing preparations and purified wortmannin from Fusarium oxysporum. Food Chem Toxicol 3:173–179Google Scholar
  22. Hall AJ, Wild CP (1994) Epidemiology of aflatoxin-related disease. In: Eaton DA, Groopman JD (eds) The toxicology of aflatoxins: human health, veterinary and agriculture significance. Academic Press, New York, pp 233–258Google Scholar
  23. Hendrickse RC (1991) Clinical implications of food contamination by aflatoxins. Ann Acad Med 20:84–90Google Scholar
  24. Hendrickse RG, Coulter J, Lamplugh S, MacFarlane S, Williams T, Orner M, Suliman G (1982) Aflatoxins and kwashiorkor: a study in Sudanese children. Br Med J 285:843–6CrossRefGoogle Scholar
  25. Hendry KM, Cole EC (1993) A review of mycotoxins in indoor air. Toxicol Environ Health 38:183–198CrossRefGoogle Scholar
  26. Hesseling PB (1990) Onyalai at Rundu, Namibia 1981–1988: age, sex morbidity, mortality and seasonal variation of 612 hospitalized patients. Trans R Soc Trop Med Hyg 84:605–607PubMedCrossRefGoogle Scholar
  27. Hesseling PB (1992) Onyalai. Bailliére’s Clin Haematol 5:457–473CrossRefGoogle Scholar
  28. Hill AB (1965) The environment and disease: association or causation. J R Soc Med 58:295–300Google Scholar
  29. Hollstein M, Sidranksy D, Vogelstein B, Harris CC (1991) p53 mutations in human cancers. Science 253:49–53PubMedCrossRefGoogle Scholar
  30. Hsia CC, Wu JL, Lu XQ, Li YS (1988) Natural occurrence and clastogenic effects of nivalenol, 3-acetodeoxynivalenol, 15-acetyl-deoxynivalenol and zearalenone in corn from a high risk area of esophageal cancer. Cancer Detect Prev 13:79–88PubMedGoogle Scholar
  31. Hudson GJ, Wild CP, Zarba A, Groopman JD (1992) Aflatoxins isolated by immunoaffinity chromatography from foods consumed in Gambia, West Africa. Nat Toxins 1:100–115PubMedCrossRefGoogle Scholar
  32. Hurwitz ES (1989) Reye’s syndrome. Epidemiol Rev 11: 249–253PubMedGoogle Scholar
  33. IARC (1993) Some naturally occurring substances: food items and constituents, heterocyclic aromatic amines and mycotoxins. IARC Monographs on the Evaluation of Carcinogenic Risks to Humans, vol 56. IARC, LyonGoogle Scholar
  34. Joffe AZ (1971) Alimentary toxic aleukia. Chap 5. In: Kadis S, Ciegler A, Ajl SJ (eds) Microbial toxins, vol 7. Academic Press, New YorkGoogle Scholar
  35. Joffe AZ (1974) Toxicity of Fusarium paoe and F. sporotrichioides and its relation to alimentary toxic aleukia. In: Purchase IFH (ed) Mycotoxins, Chap 11. Elsevier, Amsterdam, pp 229–262Google Scholar
  36. King B (1979) Outbreak of ergotism in Wollo, Ethiopia. Lancet, June 30:1411Google Scholar
  37. Krishnamachari KA, Bhat RV (1976) Poisoning by ergoty bajra (pearl millet) in man. Indian J Med Res 64: 1624–1628PubMedGoogle Scholar
  38. Krishnamachari KA, Bhat RV, Nagarajan V, Tilak TBG (1975a) Hepatitis due to aflatoxicosis. Lancet, May 10:1061–1063CrossRefGoogle Scholar
  39. Krishnamachari KA, Bhat RV, Nagarajan V, Tilak TBG (1975b) Investigations into an outbreak of hepatitis in parts of western India. Indian J Med Res 63:1036–1049PubMedGoogle Scholar
  40. Lee YW, Mirocha CJ, Shroeder DJ, Walser MM (1985) TDP-1, a toxic component causing tibial dyschondroplasia in broiler chickens, and trichothecenes from Fusarium roseum graminearum. Appl Environ Microbiol 50:102–107PubMedGoogle Scholar
  41. Li F-S, Duan Y-J, Yan S-J, Guan J-Y, Zou L-M, Wei F-C, Mong L-Y, Li L, Li S-Y (1990) Presenile (early ageing) changes in tissues of Kaschin-Beck disease and its pathogenetic significance. Mech Ageing Dev 54:102–107CrossRefGoogle Scholar
  42. Liu X, Luo X, Hu W (1992) Studies on the epidemiology and etiology of moldy sugarcane poisoning in China. Biomed Environ Sci 5:161–177PubMedGoogle Scholar
  43. Ludolph AC, He F, Spencer PS, Hammerstad J, Sabri M (1991) 3-Nitropropionic acid-exogenous animal neurotoxin and possible human striatal toxin. Can J Neurol Sci 18:492–498PubMedGoogle Scholar
  44. Lutsky I, Mor N, Yagen B, Joffe AZ (1978) The role of T-2 toxin in experimental aleukia: a toxicity study in cats. Toxicol Appl Pharmacol 43:111–124PubMedCrossRefGoogle Scholar
  45. Magee R (1991) St Anthony’s fire revisited. Med J Aust 154:145–149PubMedGoogle Scholar
  46. Marasas WFO, van Rensburg SJ, Mirocha CJ (1979) Incidence of Fusarium species and the mycotoxins deoxynivalenol and zearalenone in corn produced in esophageal cancer areas in Transkei. J Agric Food Chem 27:1108–11PubMedCrossRefGoogle Scholar
  47. Marasas WFO, Wehner FC, van Rensburg SJ, van Schalkwyk DJ (1981) Mycoflora of corn produced in human esophageal cancer areas in Transkei, southern Africa. Phytopathology 71:792–6CrossRefGoogle Scholar
  48. Marasas WFO, Jaskiewicz K, Venter FS, van Schalkwyk DJ (1988) Fusarium moniliforme contamination of maize in oesophageal cancer areas in Transkei. S Afr Med J 74:110–4PubMedGoogle Scholar
  49. Michelot D, Toth B (1991) Poisoning by Gyromitra esculenta — a review. J Appl Toxicol 11:235–243PubMedCrossRefGoogle Scholar
  50. Mirocha CJ, Pathre S (1973) Identification of the toxic principle in a sample of poaefusarin. Appl Microbiol 26:719–724PubMedGoogle Scholar
  51. Ngindu A, Johnson BK, Kenya PR, Ngira JA, Ocheng DM, Nandwa H, Omondi TN, Jansen AJ, Ngare W, Kaviti JN, Gatei D, Siongok TA (1982) Outbreak of acute hepatitis caused by aflatoxin poisoning in Kenya. Lancet, June 12:1346–1348CrossRefGoogle Scholar
  52. Park DL, Pohland AE (1989) Sampling and sample preparation for detection and quantitation of natural toxicants in food and feed. J Assoc Off Anal Chem 72:399–404PubMedGoogle Scholar
  53. Petkova-Bocharova T, Castegnaro M, Michelon J, Maru V (1991) Ochratoxin and other mycotoxins in cereals from an area of Balkan endemic nephropathy and urinary tract tumours in Bulgaria. In: Castegnaro M, Plestina R, Dirheimer G, Chernozemsky IN, Bartsch H (eds) Mycotoxins, endemic nephropathy and urinary tract tumours. IARC Sci Publ, Lyon, France No 115, pp 83–87Google Scholar
  54. Qian GS, Ross RK, Yu MC, Yuan JM, Gao YT, Henderson BE, Wogan GN, Groopman JD (1994) A follow-up study of urinary markers of aflatoxin exposure and liver cancer risk in Shanghai, People’s Republic of China. Cancer Epid Biomarkers Prev 3:3–10Google Scholar
  55. Rabie CJ, Van Rensburg SJ, Van der Watt JJ, LÜbben A (1975) Onyalai — the possible involvement of a mycotoxin produced by Phomasorghina in the aetiology. S Afr Med J 49:1647–1650PubMedGoogle Scholar
  56. Ramjee G, Berjak P, Adhikari M, Dutton MF (1992) Aflatoxins and kwashiorkor in Durban, South Africa. Ann Trop Paediatr 12:241–247PubMedGoogle Scholar
  57. Rao BL, Husain A (1985) Presence of cyclopiazonic acid in kodo millet (Paspalum scrobiculatum) causing ‘kodua poisoning’ in man and its production by associated fungi. Mycopathologia 89:177–180CrossRefGoogle Scholar
  58. Rheeder JP, Marasas WFO, Thiel PG, Sydenham EW, Shephard GS, van Schalkwyk DJ (1992) Fusarium moniliforme and fumonisins in corn in relation to human esophageal cancer in Transkei. Phytopathology 82: 353–11CrossRefGoogle Scholar
  59. Riley RT, An NH, Showker JL, Yoo HS, Norred WP, Chamberlain WJ, Wang E, Merrill AM, Motelin G, Beasley VR Haschek WM (1993) Alteration of tissue and serum sphinganine to sphingosine ratio: an early biomarker in pigs of exposure to fumonisin-containing foods. Toxicol Appl Pharmacol 118:105–112PubMedCrossRefGoogle Scholar
  60. Robinson P (1967) Infantile cirrhosis of the liver in India with special reference to probable aflatoxin aetiology. Clin Pediatr 6:57–62CrossRefGoogle Scholar
  61. Rodricks JV, Eppley RM (1974) Stachbotrys and stachybotryotoxicosis. In: Purchase IFH (ed) Mycotoxins, Chap 9. Elsevier, Amsterdam, pp 181–197Google Scholar
  62. Ross RK, Yuan J-M, Yu MC, Wogan GN, Qian G-S, Tu J-T, Groopman JD, Gao Y-T, Henderson BE (1992) Urinary aflatoxin markers and risk of hepatocellular carcinoma. Lancet 339:943–946PubMedCrossRefGoogle Scholar
  63. Saito M, Ohtsubo K (1974) Trichothecene toxins of Fusarium species. In: Purchase IFH (ed) Mycotoxins, Chap 12. Elsevier Amsterdam, pp 263–281Google Scholar
  64. Shank RC (1981) Environmental toxicoses in humans. In: Shank RC (ed) Mycotoxins and N-nitroso compounds: environmental risks, vol I. CRC Press, Boca Raton, pp 107–140Google Scholar
  65. Sorenson WG, Frazer DG, Jarvis BB, Simpson J, Robinson VA (1987) Trichothecene mycotoxins in aerosolized conidia of Stachybotrys atra. Appl Environ Microbiol 53:1370–1375PubMedGoogle Scholar
  66. Steyn PS, Rabie CJ (1976) Characterisation of magnesium and calcium tenuazonate from Phoma sorghina. Phytochemistry 15:1977–1979CrossRefGoogle Scholar
  67. Stoloff L (1983) Aflatoxin as a cause of primary liver-cell cancer in the United States. A probability study. Nutr Cancer 5:165–186PubMedCrossRefGoogle Scholar
  68. Sydenham EW, Thiel PG, Marasas WFO, Shephard GS, van Schalkwyk DJ, Koch KR (1990) Natural occurrence of some Fusarium mycotoxins in corn from low and high esophageal cancer prevalence areas of the Transkei, southern Africa. J Agric Food Chem 38: 1900–1903CrossRefGoogle Scholar
  69. Tandon HD (1993) Handling toxicoses of unknown origin. Food Additives Contaminants 10:105–113CrossRefGoogle Scholar
  70. Tandon BN, Krischnamurthy L, Koshy A, Tandon HD, Ramalingaswami V, Bhandari JR, Mathur MM, Mathur PD (1977) Study of an epidemic of jaundice presumably due to toxic hepatitis in northwest India. Gastroenterology 72:488–9PubMedGoogle Scholar
  71. Tandon HD, Tandon BN, Ramalingaswami V (1978) Epidemic of toxic hepatitis in India of possible mycotoxic origin. Arch Pathol Lab Med 102:372–376PubMedGoogle Scholar
  72. Thiel PG, Marasas WFO, Sydenham EW, Shephard GS, Gelderblom WCA (1992) The implications of naturally occurring levels of fumonisins in corn for human and animal health. Mycopathologia 117:3–9PubMedCrossRefGoogle Scholar
  73. Ueno Y (1974) Citreoviridin from Penicillium citreo-viride Biourge. In: Purchase IFH (ed) Mycotoxins. Chap 3. Elsevier, Amsterdam, pp 283–302Google Scholar
  74. van Rensburg SJ, Altenkirk B (1974) Claviceps purpurea ergotism. In: Purchase IFH (ed) Mycotoxins. Elsevier, Amsterdam, pp 69–96Google Scholar
  75. Whitaker TB, Park DL (1994) Problems associated with accurately measuring aflatoxin in food and feeds: errors associated with sampling, sample preparation, and analysis. In: Eaton DL, Groopman JD (eds) The toxicology of aflatoxins: human health, veterinary, and agricultural significance. Academic Press, New York, pp 433–450Google Scholar
  76. WHO (1979) World Health Organization Environmental Health Criteria 11, Mycotoxins WHO, GenevaGoogle Scholar
  77. WHO (1990) International Programme on Chemical Safety. Environmental Health Criteria 105, Selected mycotoxins: ochratoxins, trichothecenes, ergot. World Health Organization, GenevaGoogle Scholar
  78. Wild CP, Montesano R (1991) Letter to the editor. Cancer Res 51:3825–3827PubMedGoogle Scholar
  79. Wild CP, Jiang YZ, Sabbioni G, Chapot B, Montesano R (1990) Evaluation of methods for quantitation of aflatoxin-albumin adducts and their application to human exposure assessment. Cancer Res 50:245–251PubMedGoogle Scholar
  80. Wild CP, Fortuin M, Donato F, Whittle HC, Hall AJ, Wolf CR, Montesano R (1993) Aflatoxin, liver enzymes and hepatitis B virus infection in Gambian children. Cancer Epid Biomarkers Prev 2:555–561Google Scholar
  81. Yadgiri B, Reddy V, Tulpule PG, Srikantia SG, Gopalan C (1970) Aflatoxin and Indian childhood cirrhosis. Am J Clin Nutr 23:94–98PubMedGoogle Scholar
  82. Zhen Y, Yang S, Ding L, Han F, Yang W, Liu Q (1984) The culture and isolation of fungi from the cereals in five high risk and three low incidence counties of oesophageal cancer in Henan province (China). Chin J Oncol 6:27–29Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1996

Authors and Affiliations

  • C. P. Wild
    • 1
  • A. J. Hall
    • 2
  1. 1.Unit of Environmental CarcinogenesisInternational Agency for Research on CancerLyon Cedex 08France
  2. 2.Communicable Disease Epidemiology UnitLondon School of Hygeine and Tropical MedicineLondonUK

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