Signal Transduction Pathways and Heterotrimeric G Proteins

  • K. A. Borkovich
Part of the The Mycota book series (MYCOTA, volume 3)


In eukaryotic cells, many environmental stimuli are sensed by a class of receptors known as the seven-helix family. Based on amino acid sequence analysis and other criteria (for review see Ross 1989; Birnbaumer et al. 1990; Dohlman et al. 1991; Khorana 1992), these proteins are predicted to contain seven transmembrane helical domains that anchor them to the plasma membrane. Examples of seven-helix receptors are opsins, ß and α-adrenergic receptors, ml and m2 acetylcholine receptors, and somatostatin, bradykinin, and odorant receptors. Ligands that bind such receptors include light, odorants, hormones, growth factors, and neurotransmitters.


Fission Yeast Pertussis Toxin Neurospora Crassa Schizosaccharomyces Pombe Disruption Mutant 
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Copyright information

© Springer-Verlag Berlin Heidelberg 1996

Authors and Affiliations

  • K. A. Borkovich
    • 1
  1. 1.Department of Microbiology and Molecular GeneticsUniversity of Texas at Houston-Medical SchoolHoustonUSA

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