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Genetics of Neurospora

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Genetics and Biotechnology

Part of the book series: The Mycota ((MYCOTA,volume 2))

Abstract

Many advances, particularly in molecular techniques, have transformed work on Neurospora crassa. All areas of biological research have felt their impact. These include the areas of basic genetics begun by Dodge, Lindegren, and the Beadle and Tatum group prior to 1955 (Horowitz 1991); biochemical genetics, enzymology, and morphogenesis between 1945 and the present; and regulation and compartmentation of biochemical activities since 1965 (see Perkins 1992a). Most of the work in these areas might have been abandoned without molecular approaches, particularly in view of the spectacular development of yeast as an experimental system for genetic, cellular, and biochemical problems. The most recent edition (the fourth) of the classic treatise, Fungal Genetics, by Fincham et al. (1979) should be consulted for the status of work in N. crassa, especially genetics, up to that time.

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References

  • Akins RA, Lambowitz AM (1985) General method for cloning Neurospora crassa nuclear genes by complementation of mutants. Mol Cell Biol 5: 2272–2278

    PubMed  CAS  Google Scholar 

  • Arnaise S, Zickler D, Glass NL (1993) Heterologous expression of mating-type genes in filamentous fungi. Proc Natl Acad Sci USA 90: 6676–6620

    Google Scholar 

  • Asch DK, Frederick G, Kinsey JA, Perkins DD (1992) Analysis of junction sequences resulting from integration at nonhomologous loci in Neurospora crassa. Genetics 130: 737–748

    PubMed  CAS  Google Scholar 

  • Baker TI, Cords CE, Howard CA, Radloff RJ (1990) The nucleotide excision repair epistasis group in Neurospora crassa. Curr Genet 18: 207–209

    PubMed  CAS  Google Scholar 

  • Beadle GW, Tatum EL (1945) Neurospora. II. Methods of producing and detecting mutations concerned with nutritional requirements. Am J Bot 32: 678–686

    Google Scholar 

  • Bell-Pedersen D, Dunlap JC, Loros JJ (1992) The Neuro-spora circadian clock-controlled gene, ccg-2, is allelic to eas and encodes a fungal hydrophobin required for formation of the conidial rodlet layer. Genes Dev 6: 2382–2394

    PubMed  CAS  Google Scholar 

  • Berlin V, Yanofsky C (1985a) Protein changes during the asexual cycle of Neurospora crassa. Mol Cell Biol 5: 839–848

    PubMed  CAS  Google Scholar 

  • Berlin V, Yanofsky C (1985b) Isolation and characterization of genes differentially expressed during conidiation of Neurospora crassa. Mol Cell Biol 5: 849–855

    PubMed  CAS  Google Scholar 

  • Bojko M (1989) Two kinds of “recombination nodules” in Neurospora crassa. Genome 32: 309–317

    PubMed  CAS  Google Scholar 

  • Borgeson CE, Bowman BJ (1990) Mutations that affect circadian rhythms in Neurospora crassa can alter the reduction of cytochromes by blue light. J Biol Rhythms 5: 291–301

    PubMed  CAS  Google Scholar 

  • Bowman BJ, Vazquez-Laslop N, Bowman EJ (1992) The vacuolar ATPase of Neurospora crassa. J Bioenerg Biomembr 24: 361–370

    PubMed  CAS  Google Scholar 

  • Brody S, Martins SA (1979) Circadian rhythms in Neuro-spora crassa: effects of unsaturated fatty acids. J Bacteriol 137: 912–915

    PubMed  CAS  Google Scholar 

  • Butler DK, Metzenberg RL (1989) Premeiotic change of nucleolus organizer size in Neurospora crassa. Genetics 122: 783–791

    PubMed  CAS  Google Scholar 

  • Cambareri EB, Jensen BC, Schabtach E, Selker EU (1989) Repeat-induced G-C to A-T mutations in Neuro-spora. Science 244: 1571–1575

    PubMed  CAS  Google Scholar 

  • Cambareri EB, Singer MJ, Selker EU (1991) Recurrence of repeat-induced point mutation (RIP) in Neurospora crassa. Genetics 127: 699–710

    PubMed  CAS  Google Scholar 

  • Case ME, Schweizer M, Kushner SR, Giles NH (1979) Efficient transformation of Neurospora crassa by utilizing hybrid plasmid DNA. Proc Natl Acad Sci USA 76: 5259–5263

    PubMed  CAS  Google Scholar 

  • Catcheside DEA (1986) A restriction and modification model for the initiation and control of recombination in Neurospora. Genet Res 47: 157–165

    PubMed  CAS  Google Scholar 

  • Catcheside DG, Corcoran D (1973) Control of non-allelic recombination in Neurospora crassa. Aust J Biol Sci 26: 93–124

    Google Scholar 

  • Cheng R, Baker TI, Cords CE, Radloff RJ (1993) MEI-3, a recombination and repair gene of Neurospora crassa, encodes a recA-like protein. Mutat Res 294: 223–234

    Google Scholar 

  • Cramer CL, Davis RH (1984) Polyphosphate-cation interaction in the amino acid-containing vacuole of Neuro-spora crassa. J Biol Chem 259: 5152–5157

    PubMed  CAS  Google Scholar 

  • Davis RH (1962) Consequences of a suppressor gene effective with pyrimidine and proline mutants of Neurospora. Genetics 47: 351–360

    PubMed  CAS  Google Scholar 

  • Davis RH (1972) Metabolite distribution in cells. Science 178: 835–840

    PubMed  CAS  Google Scholar 

  • Davis RH (1985) Compartmental and regulatory mechanisms in the arginine pathways of Neurospora crassa and Saccharomyces cerevisiae. Microbiol Revs 50: 280–313

    Google Scholar 

  • Davis RH, de Serres FJ (1970) Genetic and microbiological methods for Neurospora crassa. Methods Enzymol 17A: 79–143

    Google Scholar 

  • Debuchy R, Coppin E (1992) The mating types of Podospora anserina: functional analysis and sequence of the fertilization domains. Mol Gen Genet 233: 113–121

    PubMed  CAS  Google Scholar 

  • De Serres FJ (1992) Characteristics of spontaneous and induced specific-locus mutation in the ad-3 region of Neurospora crassa: utilization in genetic risk assessment. Environ Mol Mutagen 20: 246–259

    PubMed  Google Scholar 

  • De Serres FJ, Mailing HV (1971) Measurement of recessive lethal damage over the entire genome and at two specific loci in the ad-3 region of a two-component heterokaryon of Neurospora crassa. In: Hollaender A (ed) Chemical Mutagens, vol 2. Plenum Press, NY, pp 311–342

    Google Scholar 

  • De Serres FJ, Brockman HE, Barnett WE, K0lmark HG (1971) Mutagen specificity in Neurospora crassa. Mutat Res 12: 129–142

    PubMed  Google Scholar 

  • Drake JW (1970) The molecular basis of mutation. Holden-Day, San Francisco

    Google Scholar 

  • Dunlap JC (1993) Genetic analysis of circadian clocks. Annu Rev Physiol 55: 683–728

    PubMed  CAS  Google Scholar 

  • Duran R, Gray PM (1989) Nuclear DNA, an adjunct to morphology in fungal taxonomy. Mycotaxon 36: 205–219

    Google Scholar 

  • Ebbole D (1990) Vectors for construction of translational fusions to ß-galactosidase. Fungal Genet Newsl 37: 15–16

    Google Scholar 

  • Faugeron G, Rhounim L, Rossignol JL (1990) How does the cell count the number of ectopic copies of a gene in the premeiotic inactivation process acting in Ascobolus immersus? Genetics 124: 585–591

    PubMed  CAS  Google Scholar 

  • Fincham JRS (1989) Fungal transformation. Microbiol Revs 53: 148–170

    CAS  Google Scholar 

  • Fincham JRS, Day PR, Radford A (1979) Fungal genetics. Univ California Press, Berkeley

    Google Scholar 

  • Foss E, Lande R, Stahl FW, Steinberg CM (1993) Chiasma interference as a function of genetic distance. Genetics 133: 681–691

    PubMed  CAS  Google Scholar 

  • Foss HM, Selker EU (1991) Efficient pairing in a Neuro-spora mutant defective in chromosome pairing. Mol Gen Genet 231: 49–52

    PubMed  CAS  Google Scholar 

  • Free SJ, Rice PW, Metzenberg RL (1979) Arrangement of the genes coding for ribosomal ribonucleic acids in Neurospora crassa. J Bacteriol 137: 1219–1226

    PubMed  CAS  Google Scholar 

  • Fu YH, Lee HJ, Young JL, Jarai G, Marzluf GA (1990) Nitrogen and sulfur regulatory circuits of Neurospora. In: Davidson EH, Ruderman JV, Posakony JW (eds) Developmental biology. Wiley-Liss, New York, pp 319–335

    Google Scholar 

  • Garnjobst L (1953) Genetic control of heterocaryosis in Neurospora crassa. Am J Bot 40: 607–614

    Google Scholar 

  • Geever RF, Huiet L, Baum JA, Tyler BM, Patel VB, Rutledge BJ, Case ME, Giles NH (1989) DNA sequence, organization and regulation of the qa gene cluster of Neurospora crassa. J Mol Biol 207: 15–34

    PubMed  CAS  Google Scholar 

  • Giles NH, Case ME, Baum J, Geever R, Huiet L, Patel V, Tyler B (1985) Gene organization and regulation of the qa (quinic acid) gene cluster of Neurospora crassa. Microbiol Revs 49: 338–358

    CAS  Google Scholar 

  • Glass NL, Kuldau GA (1992) Mating type and vegetative incompatibility in filamentous ascomycetes. Annu Rev Phytopathol 30: 201–224

    PubMed  CAS  Google Scholar 

  • Glass NL, Lee L (1992) Isolation of Neurospora crassa A mating-type mutants by repeated induced point ( RIP) mutation. Genetics 132: 125–133

    Google Scholar 

  • Glass NL, Vollmer SJ, Staben C, Grotelueschen J, Metzenberg RL, Yanofsky C (1988) DNAs of the two mating-type alleles of Neurospora crassa are highly dissimilar. Science 241: 570–573

    PubMed  CAS  Google Scholar 

  • Glass NL, Grotelueschen J, Metzenberg RL (1990a) Neurospora crassa A mating-type region. Proc Natl Acad Sci USA 87: 4912–4916

    Google Scholar 

  • Glass NL, Metzenberg RL, Raju NB (1990b) Homothallic Sordariaceae from nature: the absence of strains containing only the a mating-type sequence. Exp Mycol 14: 274–289

    Google Scholar 

  • Goyon C, Faugeron G (1989) Targeted transformation of Ascobolus immersus and de novo methylation of the resulting DNA sequences. Mol Cell Biol 9: 2818–2827

    CAS  Google Scholar 

  • Griffiths AJF (1982) Null mutants of the A and a mating-type alleles of Neurospora crassa. Can J Genet Cytol 24: 167–176

    Google Scholar 

  • Griffiths AJF, DeLange AM (1978) Mutations of the a mating-type gene in Neurospora crassa. Genetics 88: 239–254

    PubMed  CAS  Google Scholar 

  • Hager KM, Yanofsky C (1990) Genes expressed during conidiation of Neurospora crassa: molecular characterization of con-13. Gene 96: 153–159

    PubMed  CAS  Google Scholar 

  • Harding RW, Shropshire W Jr (1980) Photocontrol of carotenoid biosynthesis. Annu Rev Plant Physiol 31: 217–238

    CAS  Google Scholar 

  • Hinnebusch AG (1988) Mechanisms of gene regulation in the general control of amino acid biosynthesis in Saccharomyces cerevisiae. Microbiol Revs 52: 248–273

    CAS  Google Scholar 

  • Horowitz NH (1991) Fifty years ago: the Neurospora revolution. Genetics 127: 631–635

    PubMed  CAS  Google Scholar 

  • Houlahan MB, Mitchell HK (1948) Evidence for an interrelation in the metabolism of lysine, arginine, and pyrimidines in Neurospora. Proc Natl Acad Sci USA 34: 465–470

    PubMed  CAS  Google Scholar 

  • Ishii C, Nakamura K, Inoue H (1991) A novel phenotype of an excision-repair mutant in Neurospora crassa mutagen sensitivity of the mus-18 mutant is specific to UV. Mol Gen Genet 228: 33–39

    PubMed  CAS  Google Scholar 

  • Johnston M (1987) A model fungal gene regulatory mechanism: the GAL genes of Saccharomyces cerevisiae. Microbiol Revs 51: 458–476

    CAS  Google Scholar 

  • Kang S, Metzenberg RL (1990) Molecular analysis of nuc-1 +, a gene controlling phosphorus acquisition in Neurospora crassa. Mol Cell Biol 10: 5839–5848

    PubMed  CAS  Google Scholar 

  • Kang S, Metzenberg RL (1993) Insertional mutagenesis in Neurospora crassa: cloning and molecular analysis of the preg + gene controlling the activity of the transcriptional activator NUC-1. Genetics 133: 193–202

    PubMed  CAS  Google Scholar 

  • King JS, Mortimer RK (1990) A polymerization model of chiasma interference and corresponding computer simulation. Genetics 126: 1127–1138

    PubMed  CAS  Google Scholar 

  • Kinsey JA (1989) Restricted distribution of the Tad transposon in strains of Neurospora crassa. Curr Genet 15: 271–275

    PubMed  CAS  Google Scholar 

  • Kinsey JA (1990) Tad, a LINE-like transposable element of Neurospora, can transpose between nuclei in heterokaryons. Genetics 126: 317–323

    PubMed  CAS  Google Scholar 

  • Kinsey JA, Helber J (1989) Isolation of a transposable element from Neurospora crassa. Proc Natl Acad Sci USA 86: 1929–1933

    PubMed  CAS  Google Scholar 

  • Klionsky DJ, Herman PK, Emr SD (1990) The fungal vacuole: composition, function and biogenesis. Microbiol Revs 54: 266–292

    CAS  Google Scholar 

  • Krumlauf R, Marzluf GA (1980) Genome organization and characterization of the repetitive and inverted repeat DNA sequencecs of Neurospora crassa. J Biol Chem 255: 1138–1145

    PubMed  CAS  Google Scholar 

  • Lauter FR, Russo VE (1991) Blue light induction of conidiation-specific genes in Neurospora crassa. Nucl Acids Res 19: 6883–6886

    PubMed  CAS  Google Scholar 

  • Lauter FR, Russo VE, Yanofsky C (1992) Developmental and light regulation of eas, the structural gene for the rodlet protein of Neurospora. Genes Dev 6: 2373–2381

    PubMed  CAS  Google Scholar 

  • Leslie JF (1993) Fungal vegetative compatibility. Annu Rev Phytophathol 31: 127–151

    CAS  Google Scholar 

  • Loros JJ, Denome SA, Dunlap JC (1989) Molecular cloning of genes under control of the circadian clock in Neuro-spora. Science 243: 385–388

    PubMed  CAS  Google Scholar 

  • Lu BC (1993) Spreading the synaptonemal complex of Neurospora crassa. Chromosoma 102: 464–472

    PubMed  CAS  Google Scholar 

  • Marzluf GA (1981) Regulation of nitrogen metabolism and gene expression in fungi. Microbiol Revs 45: 437–461

    CAS  Google Scholar 

  • Marzluf GA, Metzenberg RL (1968) Positive control by the cys-3 locus in regulation of sulfur metabolism in Neurospora. J Mol Biol 33: 423–437

    PubMed  CAS  Google Scholar 

  • Matsuyama SS, Nelson RE, Siegel RW (1974) Mutations specifically blocking differentiation of macroconidia in Neurospora crassa. Dev Biol 41: 278–287

    PubMed  CAS  Google Scholar 

  • Mattem D, Brody S (1979) Circadian rhythms in Neurospora crassa: effects of saturated fatty acids. J Bacteriol 139: 977–988

    Google Scholar 

  • McClintock B (1945) Neurospora. I. Preliminary observations of the chromosomes of Neurospora crassa. Am J Bot 32:671–678

    Google Scholar 

  • McClung CR, Fox BA, Dunlap JC (1989) The Neurospora clock gene frequency shares a sequence element with the Drosophila clock gene per. Nature 339: 558–562

    PubMed  CAS  Google Scholar 

  • McNally M, Free S (1988) Isolation and characterization of a Neurospora glucose-repressible gene. Curr Genet 14: 545–551

    PubMed  CAS  Google Scholar 

  • Metzenberg RL, Chia W (1979) Genetic control of phosphorus assimilation in Neurospora crassa: dose-dependent dominance and recessiveness in constitutive mutants. Genetics 93: 625–643

    PubMed  CAS  Google Scholar 

  • Metzenberg RL, Glass NL (1990) Mating type and mating strategies in Neurospora. BioEssays 12: 53–59

    PubMed  CAS  Google Scholar 

  • Metzenberg RL, Grotelueschen J (1990) Neurospora crassa restriction polymorphism map. Genet Maps 5: 3. 22–3. 29

    Google Scholar 

  • Metzenberg RL, Gleason MK, Littlewood BS (1974) Genetic control of alkaline phosphatase synthesis in Neurospora: the use of partial diploids in dominance studies. Genetics 77: 25–43

    PubMed  CAS  Google Scholar 

  • Metzenberg RL, Stevens JN, Selker EU, MorzyckaWroblewska E (1985) Identification and chromosomal distribution of 5S rRNA genes in Neurospora crassa. Proc Natl Acad Sci USA 82: 2067–2071

    PubMed  CAS  Google Scholar 

  • Morzycka-Wroblewska E, Stevens JN, Selker EU, Metzenberg RL (1985) Concerted evolution of dispersed Neurospora crassa SS RNA genes: pattern of sequence conservation between allelic and non-allelic genes. Mol Cell Biol 5: 46–51

    PubMed  CAS  Google Scholar 

  • Mylyk OM (1975) Heterokaryon incompatibility genes in Neurospora crassa detected using duplication-producing chromosome rearrangements. Genetics 80: 107–124

    PubMed  CAS  Google Scholar 

  • Nawrath C, Russo VE (1990) Fast induction of translatable mRNA by blue light in Neurospora crassa wt: the we-1 and we-2 mutants are blind. J Photochem Photobiol B 4: 261–271

    PubMed  CAS  Google Scholar 

  • Nelson MA, Metzenberg RL (1992) Sexual development genes of Neurospora crassa. Genetics 132: 149–162

    PubMed  CAS  Google Scholar 

  • Nelson MA, Morelli G, Caratolli A, Romano N, Macino G (1989) Molecular cloning of a Neurospora crassa carotenoid biosynthetic gene (albino-3) regulated by blue light and the products of the white collar genes. Mol Cell Biol 9: 1271–1276

    PubMed  CAS  Google Scholar 

  • Orbach MJ (1992) Untitled note in Fungal Genet Newsl 39: 92

    Google Scholar 

  • Orbach MJ, Porro EB, Yanofsky C (1986) Cloning and characterization of the gene for ß-tubulin from a benomyl-resistant mutant of Neurospora crassa and its use as a dominant selectable marker. Mol Cell Biol 6: 2452–2461

    PubMed  CAS  Google Scholar 

  • Orbach MJ, Vollrath D, Davis RW, Yanofsky C (1988) An electrophoretic karyotype of Neurospora crassa. Mol Cell Biol 8: 1469–1473

    PubMed  CAS  Google Scholar 

  • Orbach MJ, Sachs MS, Yanofsky C (1990) The Neurospora crassa arg-2 locus. Structure and expression of the gene encoding the small subunit of arginine-specific carbamoyl phosphate synthetase. J Biol Chem 265: 10981–10987

    Google Scholar 

  • Orr-Weaver TL, Szostak JW (1985) Fungal recombination. Microbiol Revs 49: 33–58

    CAS  Google Scholar 

  • Pandit NN, Russo VEA (1992) Reversible inactivation of a foreign gene, hph, during the asexual cycle in Neurospora crassa transformants. Mol Gen Genet 234: 412–422

    PubMed  CAS  Google Scholar 

  • Perkins DD (1986a) Hints and precautions for the care, feeding and breeding of Neurospora. Fungal Genet Newsl 33: 35–41

    Google Scholar 

  • Perkins DD (1986b) Determining the order of genes, centromeres, and rearrangement breakpoints in Neurospora by tests of duplication coverage. J Genetics 65: 121–144

    CAS  Google Scholar 

  • Perkins DD (1992a) Neurospora: the organism behind the molecular revolution. Genetics 130: 687–701

    PubMed  CAS  Google Scholar 

  • Perkins DD (1992b) Neurospora chromosomes. In: Federoff N, Botstein D (eds) Barbara McClintock’s ideas in the century of genetics. Cold Spring Harbor Lab Press, Cold Spring Harbor, NY, pp 33–44

    Google Scholar 

  • Perkins DD, Barry EG (1977) The cytogenetics of Neurospora. Adv Genetics 19: 133–285

    CAS  Google Scholar 

  • Perkins DD, Newmeyer D, Taylor CW, Bennett DC (1969) New markers and map sequences in Neurospora crassa, with a description of mapping by duplication coverage, and of multiple translocation stocks for testing linkage. Genetica 40: 247–278

    PubMed  CAS  Google Scholar 

  • Perkins DD, Radford A, Newmeyer D, Björkman M (1982) Chromosomal loci of Neurospora crassa. Microbiol Revs 46: 426–570

    CAS  Google Scholar 

  • Perkins DD, Kinsey JA, Asch DK, Frederick G (1993) Chromosome rearrangements recovered following transformation of Neurospora crassa. Genetics 134: 729–736

    PubMed  CAS  Google Scholar 

  • Picard M, Debuchy R, Coppin E (1991) Cloning the mating types of the heterothallic fungus Podospora anserina: developmental features of haploid transformants carrying both mating types. Genetics 128: 539–547

    PubMed  CAS  Google Scholar 

  • Raju NB (1992) Genetic control of the sexual cycle in Neurospora. Mycol Res 96: 241–262

    Google Scholar 

  • Rhounim L, Rossignol JL, Faugeron G (1992) Epimutation of repeated genes in Ascobolus immersus. EMBO J 11: 4451–4457

    PubMed  CAS  Google Scholar 

  • Rodland KD, Russell PJ (1982) Regulation of ribosomal RNA cistron nubmer in a strain of Neurospora crassa with a duplication of the nucleolus organizer region. Biochim Biophys Acta 697: 162–169

    PubMed  CAS  Google Scholar 

  • Rodland KD, Russell PJ (1983) Segregation of heterogeneous rDNA segments during demagnification of a Neurospora crassa strain possessing a double nucleolar organizer. Curr Genet 7: 379–384

    CAS  Google Scholar 

  • Romano N, Macino G (1992) Quelling: transient inactivation of gene expression in Neurospora crassa by transformation with homologous sequences. Mol Microbiol 6: 3343–3353

    PubMed  CAS  Google Scholar 

  • Russell PJ, Rodland KD (1986) Magnification of rRNA gene number in a Neurospora crassa strain with a partial deletion of the nucleolus organizer. Chromosoma 93: 337–340

    PubMed  CAS  Google Scholar 

  • Sachs M, Ebbole D (1990) The use of lacZ gene fusions in Neurospora crassa. Fungal Genet Newsl 37: 35–36

    Google Scholar 

  • Sachs M, David M, Werner S, RajBhandary UL (1986) Nuclear genes for cytochrome oxidase subunits of Neurospora crassa. Isolation and characterization of cDNA clones for subunits IV, V, VI, and possibly VII. J Biol Chem 261: 869–873

    Google Scholar 

  • Sargent ML, Briggs WR (1967) The effect of light on a circadian rhythm of conidiation in Neurospora. Plant Physiol 42: 1504–1510

    PubMed  CAS  Google Scholar 

  • Sargent ML, Briggs WR, Woodward DO (1966) The circadian nature of a rhythm expressed by an invertase-less strain of Neurospora crassa. Plant Physiol 41: 1343–1349

    PubMed  CAS  Google Scholar 

  • Schechtman M (1987) Isolation of telomere DNA from Neurospora crassa. Mol Cell Biol 7: 3168–3177

    PubMed  CAS  Google Scholar 

  • Schmidhauser TJ, Lauter FR, Russo VEA, Yanofsky C (1990) Cloning, sequence, and photoregulation of al-1, a carotenoid biosynthetic gene of Neurospora crassa. Mol Cell Biol 10: 5064–5070

    PubMed  CAS  Google Scholar 

  • Selitrennikoff CP, Nelson RE, Siegel RW (1974) Phase-specific genes for macroconidiation in Neurospora crassa. Genetics 78: 679–690

    PubMed  CAS  Google Scholar 

  • Selker EU (1988) DNA sequence duplications trigger gene inactivation in Neurospora crassa. Proc Natl Acad Sci USA 85: 6870–6874

    PubMed  CAS  Google Scholar 

  • Selker EU (1990a) DNA methylation and chromatin structure: a view from below. Trends Biochem Sci 15: 103–107

    PubMed  CAS  Google Scholar 

  • Selker EU (1990b) Premeiotic instability of repeated sequences in Neurospora crassa. Annu Rev Genet 24: 579–613

    PubMed  CAS  Google Scholar 

  • Selker EU (1993) Control of DNA methylation in fungi. In: Jost JP, Saluz HP (eds) DNA methylation: molecular biology and biological significance. Birkhauser, Basel, pp 212–217

    Google Scholar 

  • Selker EV, Garrett PW (1988) DNA sequence duplications trigger gene inactivation in Neurospora crassa. Proc Natl Acad Sci USA 85: 6870–6874

    PubMed  CAS  Google Scholar 

  • Selker EU, Stevens JN (1985) DNA methylation at asymmetric sites is associated with numerous transition mutations. Proc Natl Acad Sci USA 82: 8114–8118

    PubMed  CAS  Google Scholar 

  • Selker EU, Yanofsky C, Driftmier K, Metzenberg RL, Alzner-DeWeerd B, RajBhandary U (1981) Dispersed 5S RNA genes in N. crassa: structure, expression and evolution. Cell 24: 819–828

    PubMed  CAS  Google Scholar 

  • Selker EU, Jensen BC, Richardson GA (1987a) A portable signal causing faithful DNA methylation de novo in Neurospora crassa. Science 238: 48–53

    PubMed  CAS  Google Scholar 

  • Selker EU, Cambareri EB, Jensen BC, Haack KR (1987b) Rearrangement of duplicated DNA in specialized cells of Neurospora. Cell 51: 741–752

    PubMed  CAS  Google Scholar 

  • Selker EU, Cambareri E, Garrett P, Jensen B, Haack K, Foss E, Turpen C, Singer M, Kinsey J (1989) Use of RIP to inactivate genes in Neurospora crassa. Fungal Genet Newsl 36: 76–77

    Google Scholar 

  • Shear CL, Dodge BO (1927) Life histories and heterothallism of the red breadmolds of the Monilia sitophila group. J Agric Res 34: 1019–1042

    Google Scholar 

  • Sommer T, Chambers JAA, Eberle J, Lauter FR, Russo VEA (1989) Fast light-regulated genes of Neurospora crassa. Nucl Acids Res 17: 5713–5723

    PubMed  CAS  Google Scholar 

  • Springer ML, Yanofsky C (1989) A morphological and genetic analysis of conidiophore development in Neurospora crassa. Genes Dev 3: 559–571

    PubMed  CAS  Google Scholar 

  • Springer ML, Yanofsky C (1992) Expression of con genes along the three sporulation pathways of Neurospora crassa. Genes Dev 6: 1052–1057

    PubMed  CAS  Google Scholar 

  • Springer ML, Hager KM, Garrett-Engele C, Yanofsky C (1992) Timing of synthesis and cellular location of two conidiation-specific proteins of Neurospora crassa. Dev Biol 152: 255–262

    PubMed  CAS  Google Scholar 

  • Staben C, Yanofsky C (1990) Neurospora crassa a mating-type region. Proc Natl Acad Sci USA 87: 4917–4921

    Google Scholar 

  • Staben C, Jensen BC, Singer M, Pollock J, Schectman M, Kinsey J, Selker EU (1989) Use of a bacterial hygromycin B resistance gene as a dominant selectable marker in Neurospora crassa transformation. Fungal Genet Newsl 36: 79–81

    Google Scholar 

  • Stadler DR (1983) Repair and nutation following UV damage in heterokaryons of Neurospora. Mol Gen Genet 190: 227–232

    CAS  Google Scholar 

  • Stadler DR, Macleod H (1984) A dose-rate effect in UV mutagenesis in Neurospora. Mutat Res 127: 3947

    Google Scholar 

  • Stadler D, Macleod H, Dillon D (1991) Spontaneous mutation at the mtr locus of Neurospora: the spectrum of mutant types. Genetics 129: 39–45

    PubMed  CAS  Google Scholar 

  • Timberlake WE (1990) Molecular genetics of Aspergillus development. Annu Rev Genet 24: 5–36

    PubMed  CAS  Google Scholar 

  • Tomita H, Soshi T, Inoue H (1993) The Neurospora uvs-2 gene encodes a protein which has homology to yeast RAD18, with unique zinc finger motifs. Mol Gen Genet 238: 225–233

    PubMed  CAS  Google Scholar 

  • Turgeon BG, Bohlmann H, Ciuffetti LM, Chrisitansen SK, Yang G, Schäfer, Yoder OC (1993) Cloning and analysis of the mating type genes from Cochliobolus heterostrophus. Mol Gen Genet 238: 270–284

    PubMed  CAS  Google Scholar 

  • Vaughn LE, Davis RH (1981) Purification of vacuoles from Neurospora crassa. Mol Cell Biol 1: 797–806

    PubMed  CAS  Google Scholar 

  • Vollmer SJ, Yanofsky C (1986) Efficient cloning of genes of Neurospora crassa. Proc Natl Acad Sci USA 83: 4869–4873

    PubMed  CAS  Google Scholar 

  • Weiss RL (1973) Intracellular localization of ornithine and arginine pools in Neurospora crassa. J Biol Chem 248: 5409–5413

    PubMed  CAS  Google Scholar 

  • Yajima H, Inoue H, Oikawa A, Yasui A (1991) Cloning and functional characterization of a eucaryotic DNA photolyase gene from Neurospora crassa. Nucl Acids Res 19: 5359–5362

    PubMed  CAS  Google Scholar 

  • Yarden O, Yanofsky C (1991) Chitin synthase 1 plays a major role in cell wall biogenesis in Neurospora crassa. Genes Dev 5: 2420–2430

    PubMed  CAS  Google Scholar 

  • Yarden O, Plamann M, Ebbole DJ, Yanofsky C (1992) cot-1, a gene required for hyphal elongation in Neuro-spora crassa, encodes a protein kinase. EMBO J 11: 2159–2166

    Google Scholar 

  • Zickler D, Moreau PJF, Huynh AD, Slezec AM (1992) Correlation between pairing initiation sites, recombination nodules and meiotic recombination in Sordaria macrospora. Genetics 132: 135–148

    PubMed  CAS  Google Scholar 

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© 1995 Springer-Verlag Berlin Heidelberg

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Davis, R.H. (1995). Genetics of Neurospora . In: Kück, U. (eds) Genetics and Biotechnology. The Mycota, vol 2. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-10364-7_1

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  • DOI: https://doi.org/10.1007/978-3-662-10364-7_1

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