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Abstract

Cells, especially single cell organisms like yeast, must contend with frequent fluctuations in the availability of nutrients, variations in pH, temperature and external osmolarity, exposure to UV irradiation, dehydration and a large range of potentially toxic environmental compounds. In response to abrupt and adverse changes in the quality of their environment unicellular organisms invoke a variety of programmed stress responses. Characterization of these responses — the mechanisms involved in sensing stress, the signaling pathways that transmit that information to various parts of the cell and the resulting compensatory changes in gene expression and metabolism — permits us to understand how cells adapt and survive under non-ideal growth conditions.

Keywords

Heat Stress Osmotic Stress Unfold Protein Response Fission Yeast Heat Shock Factor 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin Heidelberg 2004

Authors and Affiliations

  • W. Mark Toone
  • Nic Jones

There are no affiliations available

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