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Checkpoint Controls Halting the Cell Cycle

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The Molecular Biology of Schizosaccharomyces pombe

Abstract

The concept of checkpoint controls was first applied to biological systems by Weinert and Hartwell (Weinert and Hartwell 1988), when they observed that a rad9 mutant of S. cerevisiae was sensitive to DNA damage because it could not arrest the cell cycle before entering mitosis to allow time for the damage to be repaired. Subsequently, the checkpoint concept has been applied to many other biological processes, for example the monitoring of chromosome segregation during mitosis (Chap. 11). Checkpoints that respond directly to changes in DNA structure have become known as DNA-integrity checkpoints and encompass a number of related biological phenomena. In this chapter, we will run through the different DNA-integrity checkpoint sub-pathways, concentrating mainly on the DNA damage checkpoint about which the most is known. We will discuss the different checkpoint-protein complexes and how they might function in signal generation as well as in DNA repair and DNA replication. While checkpoint pathways were defined in terms of the induced delay they cause in cell cycle progression (Chap. 3), it has subsequently become clear that checkpoint pathways and proteins also participate in the coordination of repair with DNA replication and may regulate the choice of repair pathways for certain types of DNA damage (Chap. 7).

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Authors
  1. Antony M. Carr
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  2. Thomas Caspari
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Editors and Affiliations

  1. Department of Genetics, Institute of Molecular Biology, University of Copenhagen, Øster Farimagsgade 2A, 1353, Copenhagen K, Denmark

    Richard Egel

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© 2004 Springer-Verlag Berlin Heidelberg

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Carr, A.M., Caspari, T. (2004). Checkpoint Controls Halting the Cell Cycle. In: Egel, R. (eds) The Molecular Biology of Schizosaccharomyces pombe . Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-10360-9_4

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  • DOI: https://doi.org/10.1007/978-3-662-10360-9_4

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-05631-4

  • Online ISBN: 978-3-662-10360-9

  • eBook Packages: Springer Book Archive

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