Chromosome Cohesion and Segregation
Eukaryotic cells have multiple chromosomes as carts for the genetic information. In order to ensure faithful reproduction for proliferation in mitosis, or providing an opportunity for genetic reassortment in meiosis, cells must have the ability to deliver their chromosomes properly and in good order to the daughter cells. Chromosome missegregation leads to aneuploidy, the most common genetic aberrations causing birth defects or cancer. During the cell cycle, therefore, the order and timing of dynamic changes in chromosomal morphology and behavior must be tightly controlled to coincide with the cytoskeletal changes that coordinately participate in the processes of genome redistribution.
KeywordsRecombination Catalysis Cysteine Serine Assure
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