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Centromere and Kinetochore Structure and Function

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The Molecular Biology of Schizosaccharomyces pombe

Abstract

The centromere is the site on the chromosome where the kinetochore, a reactive protein machine, is assembled. Fission yeast centromeres, like those of metazoans, are large complex structures where the kinetochore is embedded in silent heterochromatin. These features make fission yeast an excellent model system for centromere research. The actions of the kinetochores, in concert with the spindle, ensure the strict segregation of chromosomes during mitosis and meiosis.

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Authors
  1. Robin Allshire
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Editors and Affiliations

  1. Department of Genetics, Institute of Molecular Biology, University of Copenhagen, Øster Farimagsgade 2A, 1353, Copenhagen K, Denmark

    Richard Egel

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Allshire, R. (2004). Centromere and Kinetochore Structure and Function. In: Egel, R. (eds) The Molecular Biology of Schizosaccharomyces pombe . Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-10360-9_10

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  • DOI: https://doi.org/10.1007/978-3-662-10360-9_10

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-05631-4

  • Online ISBN: 978-3-662-10360-9

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