Morphological Changes in Merkel Cells of Mucosa Underlying Dentures

Summary

In this study, we investigated Merkel cells which are found in large numbers in the palatal rugae area functioning as mechanoreceptors. The morphological changes occurring as a consequence of the abnormal mechanical stimulation exerted by the denture base over the palatal mucosa were observed. Degeneration of Merkel cells and sensory nerve fibers was recognized on the first day after the denture plate was placed. Thus, continuous mechanical stimulation, even for a very short term can influence the nature and property of the sensory nerve fibers. Further, necrosis or apoptosis of Merkel cells was induced by strong continuous mechanical stimulation exerted by the denture base on the underlying mucosa.