Neuronal Latency in Human and Animal Herpesvirus Infections

  • K. Borchers
  • H. J. Field
Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 253)


“Latency is a reversibly non-productive infection of a cell by a replication-competent virus” (Garcia-Blanco and Cullen 1991). Latently infected tissues contain virus that can be recovered by cocultivation, contain viral DNA and, possibly, latency-associated transcripts (LATs) but in general no viral antigen. Alternatively, latency may be defined as: “The continued presence of virus in a host in which no infectious virus can be detected but is, however, capable of reactivation to produce infectious virus” (Wildy et al. 1982).


Herpes Simplex Virus Herpes Simplex Virus Type Trigeminal Ganglion Infectious Virus Herpes Simplex Encephalitis 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer-Verlag Berlin Heidelberg 2001

Authors and Affiliations

  • K. Borchers
    • 1
  • H. J. Field
    • 2
  1. 1.Institut für VirologieFreie Universität BerlinBerlinGermany
  2. 2.Centre for Veterinary ScienceCambridge UniversityCambridgeUK

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