Abstract
As with other organs in communication with the external environment, the uterus is subjected to and is capable of responding to a wide variety of antigenic challenge. However, what is unique to the uterus is its encounter with allogeneic placental trophoblast cells during pregnancy. It is this local immunological relationship between the early trophoblast and the uterine mucosa at the time of implantation which is the focus of the present review.
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References
Bulmer J, Morrison L, Longfellow M, Ritson A, Pace D (1991) Granulated lymphocytes in human endometrium: histochemical and immunohisto-chemical studies. Hum Reprod 6: 791–798
Charnock-Jones DS, Sharkey AM, Rajput-Williams J, Burch D, Schofield PJ, Fountain SA, Boocock CA, Smith SK (1993) Identification and localization of alternatively spliced mRNAs for vascular endothelial growth factor in human uterus and steroid regulation in endometrial carcinoma cell lines. Biol Reprod 48: 1120–1128
Chumbley G, King A, Robertson K, Holmes N, Loke YW (1994) Resistance of HLA-G and HLA-A2 transfectants to lysis by decidual NK cells. Cell Immunol 155: 312–322
King A, Loke YW (1991) On the nature and function of human uterine granular lymphocytes. Immunol Today 12: 432–435
King A, Loke YW (1993) Effect of IFN-γ and IFN-α on killing of human trophoblast by decidual LAK cells. J Reprod Immunol 23: 51–62
King A, Wellings V, Gardner L, Loke YW (1989) Immunocytochemical characterisation of the unusual large granular lymphocytes in human endometrium throughout the menstrual cycle. Hum Immunol 24: 195–205
King A, Balendran N, Wooding P, Carter NP Loke YW (1991) CD3- leukocytes present in the human uterus during early placentation: phenotypic and morphologic characterisation of the CD56++ population. Dev Immunol 1: 169–190
King A, Wooding P, Gardner L, Loke YW (1993) Expression of perforin, gran-zyme A and TIA-1 by human uterine CD56+ cells implies they are activated and capable of effector functions. Hum Reprod 8: 2061–2067
King A, Boocock C, Sharkey AM, Gardner L, Beretta A, Siccardi AG, Loke YW (1996) Evidence for the expression of HLA-C class I mRNA and protein by human first trimester trophoblast. J Immunol 156: 2068–2076
Ljunggren H-G, Kärre K (1990) In search of the ‘missing self’: MHC molecules and NK cell recognition. Immunol Today 11: 237–244
Loke YW, King A (1995) Human implantation: cell biology and immunology. Cambridge University Press, Cambridge
Loke YW, King A (1996) Immunology of human implantation: an evolutionary perspective. Human Reprod 11: 283–286
More IAR (1987) The normal human endometrium. In: Fox H (ed) Haines and Taylor’s obstetrical and gynaecological pathology, vol 1, 3rd edn. Churchill Livingstone, Edinburgh, pp 302–319
Parham P (1995) Antigen presentation by class I major histocompatibility complex molecules: a context for thinking about HLA-G. Am J Reprod Immunol 34: 10–19
Sharkey AM, Jokhi PP, King A, Loke YW, Brown KD, Smith SK (1994) Expression of c-kit ligand at the human materno-fetal interface. Cytokine 6: 195–205
Starkey PM, Sargent IL, Redman CWG (1988) Cell populations in human early pregnancy decidua: characterisation and isolation of large granular lymphocytes by flow cytometry. Immunology 65: 129–134
Yokoyama WM (1995) Natural killer cell receptors. Curr Opin Immunol 7: 110–120
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© 1997 Springer-Verlag Berlin Heidelberg
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Loke, Y.W., King, A. (1997). The Immune System Acting in the Human Endometrium. In: Beier, H.M., Harper, M.J.K., Chwalisz, K. (eds) The Endometrium as a Target for Contraception. Ernst Schering Research Foundation Workshop, vol 18. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-10323-4_4
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DOI: https://doi.org/10.1007/978-3-662-10323-4_4
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