Skip to main content
SpringerLink
Log in

Mechanisms of Phototoxic and Photoallergic Reactions

  • Chapter
Textbook of Contact Dermatitis

Abstract

Solar radiation represents the most important environmental stress human beings are exposed to. Within the spectrum of solar radiation that is reaching the Earth’s surface, the ultraviolet and visible portion of the electromagnetic radiation are of particular importance to human cutaneous biology because this is the radiation that enters the skin and blood, much of this radiation being absorbed by molecules within the skin, and photon energy being sufficient to cause electronic excitation that may lead to unimolecular and bimolecular chemical reactions. The ultraviolet (UV) portion of the electromagnetic spectrum is divided into three regions: UVC, 200–290 nm, UVB, 290–320 nm, and UVA, 320–400 nm.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 74.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Epstein JH, Wintroub BU (1985) Photosensitivity due to drugs. Drugs 30: 42 - 57

    Article  PubMed  CAS  Google Scholar 

  2. Elmets CA (1993) Cutaneous phototoxicity. In: Lim HW, Soter NA (eds) Clinical photomedicine. Dekker, New York, pp 207 - 226

    Google Scholar 

  3. Gould JW, Mercurio MG, Elmets CA (1995) Cutaneous photosensitivity diseases induced by exogenous agents. J Am Acad Dermatol 33:551-573; quiz 574 - 576

    Google Scholar 

  4. Gonzalez E, Gonzalez S (1996) Drug photosensitivity, idiopathic photodermatoses, and sunscreens (see comments) (published erratum appears in J Am Acad Dermatol 1997, 37:1019). J Am Acad Dermatol 35(6):871-885; quiz 886 - 887

    Google Scholar 

  5. Epstein JH (1983) Phototoxicity and photoallergy in man. J Am Acad Dermatol 8: 141 - 147

    Article  PubMed  CAS  Google Scholar 

  6. Epstein JH (1999) Phototoxicity and photoallergy. Semin Cutan Med Surg 18: 274 - 284

    Article  PubMed  CAS  Google Scholar 

  7. Kochevar IE (1987) Mechanisms of drug photosensitization. Photochem Photobiol 45: 891 - 895

    Article  PubMed  CAS  Google Scholar 

  8. Ljunggren B, Bjellerup M (1986) Systemic drug photosensitivity. Photodermatol 3: 26 - 35

    PubMed  CAS  Google Scholar 

  9. Dall Acqua F, Vedaldi D, Bordin F, Rodighiero G (1979) New studies on the interaction between 8-methoxypsoralen and DNA in vitro. J Invest Dermatol 73: 191 - 197

    Article  Google Scholar 

  10. Laskin JD, Lee E, Laskin DL, Gallo MA (1986) Psoralens potentiate ultraviolet light-induced inhibition of epidermal growth factor binding. Proc Nail Acad Sci USA 83: 8211 - 8215

    Article  CAS  Google Scholar 

  11. Laskin JD, Lee E (1991) Psoralen binding and inhibition of epidermal growth factor binding by psoralen/ultraviolet light ( PUVA) in human epithelial cells. Biochem Pharmacol 41: 125-132

    Google Scholar 

  12. Zarebska Z (1994) Cell membrane, a target for PUVA therapy. J Photochem Photobiol B 23: 101 - 109

    Article  PubMed  CAS  Google Scholar 

  13. Anthony FA, Laboda HM, Costlow ME (1997) Psoralen-fatty acid adducts activate melanocyte protein kinase C: a proposed mechanism for melanogenesis induced by 8methoxypsoralen and ultraviolet A light Photodermatol Photoimmunol Photomed 13: 9 - 16

    CAS  Google Scholar 

  14. Coven TR, Walters IB, Cardinale I, Krueger JG (1999) PUVA-induced lymphocyte apoptosis: mechanism of action in psoriasis. Photodermatol Photoimmunol Photomed 15: 22 - 27

    Article  PubMed  CAS  Google Scholar 

  15. Enomoto DN, Schellekens PT, Yong SL, ten Berge IJ, Mekkes JR, Bos JD (1997) Extracorporeal photochemotherapy (photopheresis) induces apoptosis in lymphocytes: a possible mechanism of action of PUVA therapy. Photochem Photobiol 65: 177 - 180

    Article  PubMed  CAS  Google Scholar 

  16. Bergner TH and Przybilla B (1993) Phototoxicity. In: Macher E, Kolde G, Bröcker EB (eds) Licht and Haut. Jahrbuch der Dermatologie. Biermann, Ziilpich, pp 101 - 133

    Google Scholar 

  17. Lim HW (1989) Mechanisms of phototoxicity in porphyria cutanea tarda and erythropoietic protoporphyria. Immunol Ser 46: 671 - 685

    PubMed  CAS  Google Scholar 

  18. Hasan T, Kochevar IE, McAuliffe DJ, Cooperman BS, Abdulah D (1984) Mechanism of tetracycline phototoxicity. J Invest Dermatol 83: 179 - 183

    Article  PubMed  CAS  Google Scholar 

  19. Kaidbey KH, Mitchell FN (1989) Photosensitizing potential of certain nonsteroidal anti-inflammatory agents. Arch Dermatol 125: 783 - 786

    Article  PubMed  CAS  Google Scholar 

  20. Kochevar IE, Morison WL, Lamm JL, McAuliffe DJ, Western A, Hood AF (1986) Possible mechanism of piroxicam-induced photosensitivity. Arch Dermatol 122: 1283 - 1287

    Article  PubMed  CAS  Google Scholar 

  21. Elmets CA (1986) Drug-induced photoallergy. Dermatol Clin 4: 231 - 241

    PubMed  CAS  Google Scholar 

  22. Ferguson J, Addo HA, Jones S, Johnson BE, Frain-Bell W (1985) A study of cutaneous photosensitivity induced by amiodarone. Br J Dermatol 113: 537 - 549

    Article  PubMed  CAS  Google Scholar 

  23. Horio T (1984) Photoallergic reaction. Classification and pathogenesis. Int J Dermatol 23: 376 - 382

    Article  PubMed  CAS  Google Scholar 

  24. Schurer NY, Holzle E, Plewig G, Lehmann P (1992) Photosensitivity induced by quinidine sulfate: experimental reproduction of skin lesions. Photodermatol Photoimmunol Photomed 9: 78 - 82

    PubMed  CAS  Google Scholar 

  25. Emmett EA (1978) Drug photoallergy. Int J Dermatol 17: 370 - 379

    PubMed  CAS  Google Scholar 

Download references

Authors
  1. Renz Mang
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Jean Krutmann
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. St. John’s Institute of Dermatology, St. Thomas’s Hospital, SE1 7EH, London, UK

    Richard J. G. Rycroft

  2. Department of Dermatology, Gentofte Hospital, University of Copenhagen, Niels Andersens Vej 65, 2900, Hellerup, Denmark

    Torkil Menné

  3. Hautklinik der Städtischen Kliniken Dortmund, Abteilung Dermatologie, Universität Witten/Herdecke, Beurhausstraße 40, 44137, Dortmund, Germany

    Peter J. Frosch

  4. Clinique Dermatologique Laboratoire de Dermatochimie, Univ. Louis Pasteur, 1 Place de L’Hôpital, 67091, Strasbourg, France

    Jean-Pierre Lepoittevin

Rights and permissions

Reprints and permissions

Copyright information

© 2001 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Mang, R., Krutmann, J. (2001). Mechanisms of Phototoxic and Photoallergic Reactions. In: Rycroft, R.J.G., Menné, T., Frosch, P.J., Lepoittevin, JP. (eds) Textbook of Contact Dermatitis. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-10302-9_6

Download citation

  • DOI: https://doi.org/10.1007/978-3-662-10302-9_6

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-662-10304-3

  • Online ISBN: 978-3-662-10302-9

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation