Investigational trials of the Hemopump at the Texas Heart Institute: practical issues

  • O. H. Frazier
Conference paper


When we were first introduced to the Hemopump, we were skeptical about it. We feared that the device would cause hemolysis, as well as other problems. In fact, we told Dr. Wampler that we did not think it would work, but we did the initial animal experiments anyway. To paraphrase the famous Frenchman Claude Bernard, however, “You have to decide on the experiment and hang your ideas outside the laboratory, do the experiment, and see what nature says, not what you think.” We did the animal experiments, and they went very well, as has been reported in the literature (5). We saw no abnormality in plasma-free hemoglobin levels or hematologic profiles (Figs. 1, 2). The animals tolerated the intraventricular device very well.


Cardiopulmonary Bypass Intra Aortic Balloon Pump Axial Flow Pump Distal Abdominal Aorta Emergency Coronary Artery Bypass 
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  1. 1.
    Duncan JM, Frazier OH, Radovancevic B, Velebit V (1989) Implantation techniques for the Hemopump. Ann Thorac Surg 48: 733–735PubMedCrossRefGoogle Scholar
  2. 2.
    Frazier OH, Macris MP, Wampler RK, Duncan JM, Sweeney MS, Fuqua JM (1990) Treatment of cardiac allograft failure by use on an intraaortic axial flow pump. J Heart Transplant 9: 408–414PubMedGoogle Scholar
  3. 3.
    Frazier OH, Radovancevic B (1990) Ventricular assist devices. Cardiac Surgery: State of the Art Reviews 4: 335–347Google Scholar
  4. 4.
    Frazier OH, Wampler RK, Duncan JM, et al (1990) First human use of the Hemopump, a catheter-mounted ventricular assist device. Ann Thorac Surg 49: 299–304PubMedCrossRefGoogle Scholar
  5. 5.
    Wampler RK, Moise JC, Frazier OH, Olsen DB (1988) In vivo evaluation of a peripheral vascular access axial flow blood pump. ASAIO Transactions 34: 450–454PubMedGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1991

Authors and Affiliations

  • O. H. Frazier
    • 1
  1. 1.Texas Heart InstituteHoustonUSA

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