Polyposis Syndromes

  • J.-C. Givel
  • E. D. Reis


First described as a mendelian dominant trait by Cuthbert Dukes in 1930 [20], the syndromes of multiple polyps of the gastrointestinal (GI) tract, particularly the colon and rectum, have later been found to be much more complex. It is now recognized that a number of different syndromes exists in which pedunculated or sessile polyps may arise and involve the mucosa of various parts of the digestive tract. These growths may be single or multiple and may or may not show a familial pattern. Histological features may be those of an inflammatory mass, hamartoma, lymphoid polyp, lipoma, lymphosarcoma, neurofibroma, or the mucosal cell growth known as adenoma. The literature is replete with different denominations for these conditions, and it is clear that syndromes overlap. The original, concise definitions are now interacting within a larger picture of mucosal cell transformation.


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© Springer-Verlag Berlin Heidelberg 1998

Authors and Affiliations

  • J.-C. Givel
  • E. D. Reis

There are no affiliations available

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