Abstract

The quantitative determinations of the effects of different wavelengths or spectral regions in sunlight on skin and on molecules in skin are important not only to devise appropriate protective measures against the deleterious actions of light exposure, but also to assess the molecular bases of the effects mediated by molecular absorbers. Such absorbers include the macromolecular structures of nucleic acids, proteins, and lipids, as well as smaller, possibly key, molecules such as urocanic acid and numerous photodynamic sensitizers as well as psoralens.

Keywords

Ozone Sarcoma Photosynthesis Pyrimidine Sorb 

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References

  1. 1.
    Setlow R. Action spectroscopy. Adv Biol Med Phys 1957; 5:37–74.PubMedGoogle Scholar
  2. 2.
    Coohill TP. Action spectra again? Photochem Photobiol 1991; 54:859–870.PubMedCrossRefGoogle Scholar
  3. 3.
    Morowitz HJ. Absorption effects in volume irradiation of microorganisms. Science 1950; 111:229–230.PubMedCrossRefGoogle Scholar
  4. 4.
    Anderson RR. Tissue optics and photoimmunology. In: Parrish JA, Kripke ML, Morison WL, eds. Photoimmunology. New York:Plenum Med Bk Co., 1983:61–76.CrossRefGoogle Scholar
  5. 5.
    Kelfkens G, DeGruijl FR, Van der Leun JC. Tumorigenesis by shortwave ultraviolet-A: Papillomas versus squamous cell carcinomas. Carcinogen 1991; 12:1377–1382.CrossRefGoogle Scholar
  6. 6.
    DeFabo EC, Noonan FP. Mechanism of immune suppression by ultraviolet irradiation in vivo I. Evidence for the existence of a unique photoreceptor in skin and its role in photoimmunology. J Exp Med 1983; 158:84–98.CrossRefGoogle Scholar
  7. 7.
    Gibbs NK, Norval M, Traynor NJ et al. Action spectra for the trans to cis isomerization of urocanic acid in vitro and in vivo. Photochem Photobiol 1993; 57:584–590.PubMedCrossRefGoogle Scholar
  8. 8.
    Gibbs NK. Correction: Action spectra for the trans to cis isomerization of urocanic acid in vitro and in vivo. Photochem Photobiol 1993; 58:769.CrossRefGoogle Scholar
  9. 9.
    Morrison H, Avnir D, Bernasconi C et al. Z/E photoisomerization of urocanic acid. Photochem Photobiol 1980; 32:711–714.CrossRefGoogle Scholar
  10. 10.
    Morrison H, Bernasconi C, Pandey G. A wavelength effect on urocanic acid E/Z photoisomerization. Photochem Photobiol 1984; 40:549–550.PubMedCrossRefGoogle Scholar
  11. 11.
    Kraemer KH, Lee ML, Scotto J. DNA repair protects against cutaneous and internal neoplasia: Evidence from xeroderma pigmentosum. Carcinogen 1984; 5:511–514.CrossRefGoogle Scholar
  12. 12.
    Kraemer KH. Sunlight and skin cancer: Another link revealed. Proc Natl Acad Sci USA 1997; 94:11–14.PubMedCrossRefGoogle Scholar
  13. 13.
    Setlow RB. The wavelengths in sunlight effective in producing skin cancer: A theoretical analysis. Proc Natl Acad Sci USA 1974; 71:3363–3366.PubMedCrossRefGoogle Scholar
  14. 14.
    Freeman SE, Hacham H, Gange RW et al. Wavelength dependence of pyrimidine dimer formation in DNA of human skin irradiated in situ with ultraviolet light. Proc Natl Acad Sci USA 1989; 86:5605–5609.PubMedCrossRefGoogle Scholar
  15. 15.
    Parrish JA, Jaenicke KF, Anderson RR. Erythema and melanogen-esis action spectra of normal human skin. Photochem Photobiol 1982; 36:187–191.PubMedCrossRefGoogle Scholar
  16. 16.
    Ley RD. Photoreactivation of UV-induced pyrimidine dimers and erythema in the marsupial Monodelphis domestica. Proc Natl Acad Sci USA 1985; 82:2409–2411.PubMedCrossRefGoogle Scholar
  17. 17.
    DeGruijl FR, Sterenborg HJCM, Forbes PD et al. Wavelength dependence of skin cancer induction by ultraviolet irradiation of albino hairless mice. Cancer Res 1993; 53:53–60.Google Scholar
  18. 18.
    Setlow RB, Grist E, Thompson K et al. Wavelengths effective in the induction of malignant melanoma. Proc Natl Acad Sci USA 1993; 90:6666–6670.PubMedCrossRefGoogle Scholar
  19. 19.
    DeGruijl FR, Van der Leun JC. Estimate of the wavelength dependency of ultraviolet carcinogenesis in humans and its relevance to risk assessment of stratospheric ozone depletion. Health Phys 1994; 67:319–325.CrossRefGoogle Scholar
  20. 20.
    Clayton RK. Light and Living Matter, Volume 1: The Physical Part. New York:McGraw Hill, 1970:147.Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1997

Authors and Affiliations

  • Richard B. Setlow

There are no affiliations available

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