The Regulation of eIF4F During Cell Growth and Cell Death

  • Simon J. Morley
Part of the Progress in Molecular and Subcellular Biology book series (PMSB, volume 27)


Much effort has been focused on questions concerning the highly regulated processes of cell growth, proliferation and programmed cell death (apoptosis). Hormones, growth factors and ligands exert pleiotypic effects through activation of specific cell-surface receptors, and via transmembrane signalling and activation of common protein kinase/phosphatase cascades inside the cell. These, in turn, trigger an array of cellular responses, culminating in either cell growth and division, differentiation or cell death. One of the obligatory, early responses in all of these processes is a modulation of the rate of protein synthesis, mediated by regulating the phosphorylation of translation initiation factor polypeptides and their association into functional complexes. This chapter will review current knowledge about the regulation of these initiation factor proteins in response to cell growth and cell death.


Initiation Factor Translation Initiation Factor Eukaryotic Initiation Factor Internal Ribosome Entry Site Activity eIF4F Complex 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer-Verlag Berlin Heidelberg 2001

Authors and Affiliations

  • Simon J. Morley
    • 1
  1. 1.Biochemistry Laboratory, School of Biological SciencesUniversity of SussexBrightonUK

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