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Die Rolle der Antikörper bei bakterieller Sepsis

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Sepsis

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Zusammenfassung

Dieses Symposium beschäftigte sich mit verschiedenen biologischen Manifestationen und Spätfolgen der Sepsis. Einige Teilnehmer haben versucht, Sepsis als ein rein chemisches Phänomen zu definieren, andere sind auf der Suche nach den sepsisgetriggerten Mediatoren, die die Gewebeschädigungen hervorrufen. Ein Mikrobiologe hingegen definiert Sepsis kurz als das Eindringen von Mikroorganismen und deren zelluläre Produkte (eingeschlossen sind Exo- und Endotoxine) in die Blutbahn und ihr dortiges Überleben. Hiernach resultiert die Sepsis aus dem Versagen eines oder mehrerer homöostatisch wirksamer Mechanismen, die Mikroben auf ihre symbiotischen Nischen wie Intestinum, obere Luftwege und Haut begrenzen oder eine Entfernung aus dem Blutkreislauf sichern. Bis die Mediatoren der Entzündung durch mikrobielle Produkte erfolgreich aktiviert worden sind und ihre Wirkung klinisch erkennbar ist, gestaltet sich eine Intervention schwierig, wenn nicht sogar unmöglich. Sepsis ist somit eine Frage der Interaktion zwischen dem Menschen und seiner mikrobiellen Flora, der immunologischen Effektormechanismen, die diese Interaktion steuern, und der früh und oft inapparent auftretenden pathologischen Ereignisse, die sie unterbrechen.

Diese Arbeit wurde durch die Stipendien AI 21620 und AI 21171 des United States Public Health Service und der Veterans Administration der USA unterstützt. Sie wurde von Frau May Fong maschinengeschrieben. Dies ist der Bericht Nr. 19 des Centre for Immunochemistry der University of California, San Francisco.

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Literatur

  1. Baumgartner JD, Glauser MP, McCutchan TA, Ziegler EJ, van Melle G, Klauber MP, Vogt M, Muehlen E, Luethy R, Chiolero R et al. (1985) Prevention of gram-negative shock and death in surgical patients by antibody to endotoxin core glycolipid. Lancet 11: 59–63

    Article  Google Scholar 

  2. Brown EJ, Hosea W, Frank MM (1983) The role of antibody and complement in the reticuloendothelial clearance of pneumococci from the bloodstream. Rev Infect Dis 5: 5797–5805

    Article  Google Scholar 

  3. Capel PJA, Groeneboer O, Grosveld G, Pondman KW (1978) The binding of activated C3 to polysaccharides and immunoglobulins. J Immunol 121: 2566–2572

    PubMed  CAS  Google Scholar 

  4. Clas F, Loos M (1981) Antibody-independent binding of the first component of complement (C1) and its subcomponent Clq to the S and R forms of Salmonella minnesota. Infect Immun 31: 1138–1144

    CAS  Google Scholar 

  5. Cross AS, Gemski P, Sadoff JC, f rskov F, Orskov I (1984) The importance of the K1 capsule in invasive infections caused by Escherichia coli. J Infect Dis 149: 184–193

    Article  CAS  Google Scholar 

  6. Delacroix DL, Vaerman JP (1983) Function of the human liver in IgA homeostasis in plasma. Ann NY Acad Sci 409: 383–401

    Article  PubMed  CAS  Google Scholar 

  7. Edwards MS, Kasper DL, Jennings HJ, Baker CJ, Nicholson-Weller A (1982) Capsular sialic acid prevents activation of the alternative complement pathway by type III, group B streptococci. J Immunol 128: 1278–1283

    PubMed  CAS  Google Scholar 

  8. Epps DE van, Williams RC Jr (1976) Suppression of leukocyte chemotaxis by human IgA myeloma components. J Exp Med 144: 1227–1242

    Article  Google Scholar 

  9. Feaison DT (1984) Cellular receptors for fragments of the third component of complement. Immunology Today 5: 105

    Article  Google Scholar 

  10. Fearon DT, Augsten KF (1980) The alternative pathway of complement — a system for host resistance to microbial infection. N Engl J Med 303: 259–263

    Article  PubMed  CAS  Google Scholar 

  11. Fierer J, Finley F (1979) Deficient serum bactericidal activity against Escherichia coli in patients with cirrhosis of the liver. J Clin Invest 63: 912–921

    Article  PubMed  CAS  Google Scholar 

  12. Frank MM (1979) Complement system in host defense and inflammation. Rev Infect Dis 1: 483–501

    Article  PubMed  CAS  Google Scholar 

  13. Gmeiner J, Luderitz O, Westphal O (1969) Biochemical studies on lipopolysaccharides of Salmonella R mutants 6. Investigations on the structure of the lipid A component. Eur J Biochem 7: 370–379

    Article  PubMed  CAS  Google Scholar 

  14. Griffiss JM (1975) Bactericidal activity of meningococcal antisera: blocking by IgA of lytic antibody in human convalescent sera. J Immunol 114: 1779–1784

    PubMed  CAS  Google Scholar 

  15. Griffiss J (1982) Serum IgA: modulation of complement activation and induction of susceptibility to bacterial dissemination. Infection 10: 246–251

    Article  PubMed  CAS  Google Scholar 

  16. Griffiss JM (1982) Epidemic meningococcal disease. Synthesis of a hypothetical immunoepidemiologic model. Rev Infect Dis 4: 159–172

    Article  PubMed  CAS  Google Scholar 

  17. Griffiss JM (1983) Biologic function of the serum IgA system: Modulation of complement-mediated effector mechanisms and conservation of antigenic mass. Ann NY Acad Sci 409: 697–707

    Google Scholar 

  18. Griffiss JM, Bertram MA (1977) Immunoepidemiology of meningococcal disease in military recruits. II. Blocking of serum bactericidal activity by circulating IgA early in the course of invasive disease. J Infect Dis 136: 733–739

    Article  PubMed  CAS  Google Scholar 

  19. Griffiss JM, Goroff DK (1983) IgA blocks IgM and IgG-initiated immune lysis by separate molecular mechanisms. J Immunol 130: 2882–2885

    PubMed  CAS  Google Scholar 

  20. Griffiss JM, Jarvis GA (1987) Interaction of serum IgA with complement components: the molecular basis of IgA blockade. In: McGhee JR, Mestecky J, Ogra PL, Bienenstock J (eds) Recent advances in mucosal immunology. vol 216B. Plenum, New York

    Google Scholar 

  21. Griffiss JM, Schneider H, O’Brien JP (1985) Lysis of Neisseria gonorrhoeae initiated by binding of normal human IgM to an hexosamine-containing LOS epitope is augmented by strain permissive feedback through the alternative pathway of complement activation. In: Schoolnik GK, Brooks GF, Falkow S, Frasch CE, Knapp JS, McCutchan JA, Morse SA (eds) The pathogenic Neisseriae: proceedings of the Fourth International Symposium. American Society for Microbiology, Washington DC

    Google Scholar 

  22. Griffiss JM, Schecter S, Eads MM, Yamasaki R, Jarvis G (1988) Regulation of complement activation on bacterial surfaces. In: Kohler H, Lo Verde PT (eds) Vaccines: new concepts and developments. Longman, London

    Google Scholar 

  23. Hitchcock PJ, Leive L, Mäkelä PH, Rietschel ET, Strittmatter W, Morrison DCA (1986) Review of lipopolysaccharide nomenclature past, present and future. J Bacteriol 166: 699–705

    PubMed  CAS  Google Scholar 

  24. Homma J, Matsuura M, Kanegasaki S, Kawakubo Y, Kojima Y, Shibukawa N, Kumazawa Y, Yamamoto A, Tanamotot K, Yasuda T et al. (1985) Structural requirements of lipid A responsible for the functions: a study with chemically synthesized lipid A and its analogues. J Biochem 98: 395–406

    PubMed  CAS  Google Scholar 

  25. Hostetter MK, King RS (1987) Role of the C3d receptor in the proliferative response of the B lymphocyte (Abs). Clin Res 35:477 A

    Google Scholar 

  26. Jarvis GA, Vedros NA (1987) Sialic acid of group B Neisseria meningitis regulates alternative complement pathway activation. Infect Immun 55: 174–180

    PubMed  CAS  Google Scholar 

  27. Joiner KA, Hammer CH, Brown EJ, Cole RJ, Frank MM (1982) Studies on the mechanism of bacterial resistance to complement-mediated killing. I. Terminal complement components are deposited and released from Salmonella minnesota 5218 without causing bacterial death. J Exp Med 55: 797–808

    Article  Google Scholar 

  28. Kuhn HM, Basu S, Mayer H (1987) Comparison of enterobacterial common antigen from different species by serological techniques. Eur J Biochem 162: 69–74

    Article  PubMed  CAS  Google Scholar 

  29. Levy NJ, Nicholson-Weller A, Baker CJ, Kasper DL (1984) Potentiation of virulence by group B streptococcal polysaccharides. J Infect Dis 149: 851–860

    Article  PubMed  CAS  Google Scholar 

  30. Lowell GH, Smith LF, Griffiss JM, Brandt BL, MacDermott RP (1980) Antibody-dependent mononuclear cell-mediated antimeningococcal activity. Comparison of the effects of convalescent and postimmunization immunoglobulins G, M and A. J Clin Invest 66: 260–267

    Article  PubMed  CAS  Google Scholar 

  31. Nikaido H (1973) Biosynthesis and assembly of lipopolysaccharide and the outer membrane layer of gram negative cell wall. In: Leive L (ed) Microbiology series. vol. I Dekker, New York

    Google Scholar 

  32. Owen RL, Jones AL (1974) Epithelial cell specialization within human Peyer’s patches: an ultrastructural study of intestinal lymphoid follicles. Gastroenterology 66: 189–203

    PubMed  CAS  Google Scholar 

  33. Palva L, Mäkelä PH (1980) Lipopolysaccharide heterogeneity in Salmonella typhimurium analyzed by sodium dodecyl sulfate/polyacrylamide gel electrophoresis. Eur J Biochem 107: 137–143

    Article  PubMed  CAS  Google Scholar 

  34. Podack EB, Tschoop J, Müller-Eberhard HJ (1982) The molecular organization of C9 within the membran attack complex of complement. Induction of circular C9 polymerization by the C5b-C8 assembly. J Exp Med 156: 268

    Article  PubMed  CAS  Google Scholar 

  35. Rietschel ET, Brade H, Brade L, Kaca W, Kawahara K, Lindner B, Luderitz T, Tornita T, Schade U, Seydel U et al. (1985) Newer aspects of the chemical structure and biological activity of bacterial endotoxins. In: Ten Cate JW, Bühler HR, Stark A, Levin J (eds) Bacterial endotoxins: structure, biomedical significance and detection with the Lirnulus amoebocyte lysate test. Liss, New York

    Google Scholar 

  36. Russell MW, Mestecky J (1988) Induction of the mucosal immune response. Rev Infect Dis (in press)

    Google Scholar 

  37. Russell-Jones GJ, Ey PL, Reynolds BL (1980) The ability of IgA to inhibit the complement-mediated lysis of target red blood cells sensitized with IgG antibody. Mol Immunol 17: 1173–1180

    Article  PubMed  CAS  Google Scholar 

  38. Shenep JL, Barton RP, Mogan KA (1985) Role of antibiotic class in the rate of liberation of endotoxin during therapy for experimental gram-negative bacterial sepsis. J Infect Dis 151: 1012–1018

    Article  PubMed  CAS  Google Scholar 

  39. Suzuki I, Kitamura K, Kiyono H, Kurita T, Green OR, McGhee JR (1986) Isotype-specific immunoregulation. Evidence for a distinct subset of T contrasuppressor cells for IgA responses in murine Peyer’s patches. J Exp Med 164: 501–516

    Article  PubMed  CAS  Google Scholar 

  40. Taylor PW (1976) Immunochemical investigations of lipopolysaccharides and acidic polysaccharides from serum-sensitive and serum-resistant strains of Escherichia coli isolated from urinary tract infections. J Med Microbiol 9: 405

    Article  PubMed  CAS  Google Scholar 

  41. Varki A, Kornfeld S (1980) An autosomal dominant gene regulates the extent of 9-O acetylation of murine erythrocyte sialic acid. A probable explanation for the variation in capacity to activate the human alternative complement pathway. J Exp Med 152: 532–544

    Article  PubMed  CAS  Google Scholar 

  42. Warner L, Ermak T, Griffiss JM (1987) Mucosal and serum immunity following commensal enteric colonization. In: McGhee JR, Mestecky J, Ogra PL, Bienenstock J (eds) Recent advances in mucosal immunology. vol 216B. Plenum, New York

    Google Scholar 

  43. Wilton JMA (1978) Suppression by IgA of IgG mediated phagocytosis by human polymorphonuclear leukocytes. Clin Exp Immunol 34: 423–428

    PubMed  CAS  Google Scholar 

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Authors
  1. J. M. L. Griffiss
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Editors and Affiliations

  1. Universitätsklinikum Steglitz Klinik für Anästhesiologie und operative Intensivmedizin, Freie Universität Berlin, Hindenburgdamm 30, D-1000, Berlin 45, Deutschland

    K. Reinhart  & K. Eyrich  & 

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© 1989 Springer-Verlag Berlin Heidelberg

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Griffiss, J.M.L. (1989). Die Rolle der Antikörper bei bakterieller Sepsis. In: Reinhart, K., Eyrich, K. (eds) Sepsis. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-09869-1_25

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  • DOI: https://doi.org/10.1007/978-3-662-09869-1_25

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-662-09870-7

  • Online ISBN: 978-3-662-09869-1

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