Zusammenfassung
Die Probleme, die bei invasiver, massiver oder unkontrollierter Infektion entstehen, können für den chirurgischen Patienten deletär sein. Trotz Asepsis, Antisepsis, sorgfältiger chirurgischer Technik und Antibiotika stellt die Infektion immer noch eine Plage für uns und unsere Patienten dar. Wenn der Prozeß nicht durch Abwehrmechanismen, Drainagen oder Antibiotika unter Kontrolle gebracht werden kann, stellt sich bei einem Individuum mit Sepsis eine charakteristische Folge von Störungen der Zirkulation, der Organfunktion und des Metabolismus ein. Es existiert ein einheitlicher metabolischer Einfluß der Infektion, der in Qualität und Quantität allein von der Verletzung abhängig ist. Die Ausdrücke „Sepsis“ und „septisch“ werden i. allg. bei Patienten mit einem septischen Hauptherd wie generalisierter Peritonitis, einem intraperitonealen Abszeß, einem Leberabszeß, einem Lungenempyem, Lungenentzündung, schwerer Zellulitis, Gewebeischämie mit Infektion oder anderen Prozessen, die mit Nekrose und Invasion pathogener Organismen einhergehen, benutzt.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
Literatur
Baker CC, DeSantis J, Degutis LD, Baue AE (1985) The impact of a trauma service on trauma care in a university hospital. Am J Surg 149: 453–458
Baue AE (1981) Multiple organ or systems failure. In: Haimovici FD (ed) Vascular emergenices, chap 7. Appleton-Century-Crofts, New York, p 125
Baue AE (1983) Multiple systems failure and circulatory supports. Jpn J Surg 13: 69–85
Baue AE (1985) Recovery from multiple organ failure. Am J Surgery 149: 120–121
Baue AE, Guenther B, Hartl W, Pickafd P, Heberer G (1984) Altered hormonal activity in severely ill patients after injury or sepsis. Arch Surg 119: 1125–1132
Baue AE (1975) Multiple, progressive or sequential systems failure: a syndrome of the 1970s. Arch Surg 110: 779–781
Baue AE (1979) Multiple systems failure. In: Dudrick S (ed) The American college of surgeons manual on pre-and postoperative care. Saunders, Philadelphia
Baue AE, Guthrie D (1986) Modern aspects of multiple organ failure. In: Eigler FW, Peiper HJ, Schildberg FW, Witte J, Zumtobel V (eds) Stand and Gegenstand chirurgischer Forschung. Springer, Berlin Heidelberg New York Tokyo
Baue AE (1977) Sequential or multiple systems failure. In: Najarian J, Delaney J (eds) Critical surgical care. Stratton Intercon, New York, pp 293–300
Baue AE, Chaudry IH (1980) Prevention of multiple systems failure. Surg Clin North Am 60: 1167–1178
Border JR, Chenier R, McMenamy RH et al. (1976) Multiple systems organ failure: muscle fuel deficit with visceral protein malnutrition. Surg Clin North Am 565: 1147–1167
Border JR, Hassett J, LaDuca J, Seibel R, Steinberg S, Mills B, Losi P, Border D (1987) The gut origin septic states in blunt multiple trauma (ISS=40) in the ICU. Ann Surg 206 4: 427–448
Carrico CJ, Meakins JL, Marshall JC, Fry D, Maier RV (1986) Multiple-organ-failure syndrome. Arch Surg 121: 196–208
Cerra FB, Siegel JH, Border JR et al. (1979) The hepatic failure of sepsis: cellular vs. substrate. Surgery 86: 409–422
Cerra FB, Siegel JH, Coleman B et al. (1980) Septic autocannibalism: failure of exogenous nutritional support. Ann Surg 192: 570–580
Chaudry IH, Clemens MG, Baue AE (1986) Cellular and subcellular function of the liver and other vital organs in sepsis and septic shock. In: Sibbald WJ, Sprung CL (ed) New horizons: Perspectives on sepsis and septic shock, chap 4. Society of Critical Care Medicine Fullerton, pp 61–76
Chaudry IH, Sayeed MM, Baue AE (1976) Insulin resistance in experimental shock. Arch Surg 109: 412–415
Chaudry IH, Sayeed MM, Baue AE (1974) Effect of hemorrhagic shock on tissue adenine nucleotides in conscious rats. Can J Physiol Pharmacol 52: 131–137
Chaudry IH, Schleck S, Clemens MG, et al. (1982) Altered hepatocellular active transport: an early change in peritonitis. Arch Surg 117: 151–157
Chaudry IH, Wichterman KA, Baue AE (1979) Effect of sepsis on tissue adenine nucleotide levels. Surgery 85: 205–211
Clemens MG, Chaudry IH, McDermott PD, et al. (1983) Regulation of glucose production from lactate in experimental sepsis. Am J Physiol 244: R794 - R800
Clemens MG, Chaudry IH, Daigneau N, et al. (1984) Insulin resistance and depressed gluconeogenic capability during early hyperglycemic sepsis. J Trauma 24: 701–708
Deutschman CS, Konstantinides FN, Tsai M, Simmons RL, Cerra FB (1987) Physiology and metabolism in isolated viral septicemia. Arch Surg 122: 21–25
Eiseman B, Beart R, Norton L (1977) Multiple organ failure. Surg Gynecol Obstet 144: 323–326
Faist E, Baue AE, Dittmar H, Heberer G (1983) Das mehrfache Organversagen beim polytraumatisierten Patienten. Krankenhausarzt 56: 1–14
Faist E, Baue AE, Dittmer H, Heberer G (1983) Multiple organ failure in polytrauma patients. J Trauma 23: 775–787
Fath JJ, Cyr St JA, Konstantinides FN, Alden P, Ascher NL, Bianco RW, Foker JE, Cerra FB (1985) Alterations in amino acid clearance during ischemia predict hepatocellular ATP changes. Surgery 98: 396–404
Fry DE, Pearlstein L, Fulton RL, Polk HC Jr (1980) Multiple system organ failure. Arch Surg 115: 1316–140
Ghosh S, Liu M (1983) Changes in a-adrenergic receptors in dog livers during endotoxic shock. J Surg Res 34: 239–245
Goris RJA, Boekhorst TPA, Nuytinck JKS, Gimbrere JSF (1985) Multiple organ failure. Arch Surg 120: 1109–1115
Goris RJA, Boekholtz WKF, van Bebber IPT, Nuytinck JKS, Schillings PHM (1986) Multiple organ failure and sepsis without bacteria. Arch Surg 121: 897–901
Guillem JG, Clemens MG, Chaudry IH, et al. (1983) Hepatic gluconeogenic capability in sepsis is depressed before changes in oxidative capability. J Trauma 22: 723–729
Hassett J, Cerra FB, Siegel J, Moyer E, Yu L, Border JR, McMenamy R (1982) Multiple systems organ failure — very brief summary. Injury 14 (1): 93–97
Heideman M, Hugli TE (1984) Anaphylatoxin generation in multisystem organ failure. J Trauma 24: 1038–1043
Keller GA, West MA, Cerra FB, Simmons RL (1985) Multiple systems organ failure — modulation of hepatocyte protein synthesis by endotoxin activated Kupffer cells. Ann Surg 201: 87–95
Knaus WA, Draper EA, Wagner DP, Zimmerman JE (1985) Prognosis in acute organ-system failure. Ann Surg 202: 685–693
Liu M, Onji T (1981) Effects of endotoxin on the myocardial (Nat +K)-ATPase enzyme system: involvement of lipids in endotoxin-induced changes in enzyme activities. Biochem Med 25: 315–326
Liu M, Takeda H (1982) Endotoxin-induced stimulation on phospholipase A activities in dog hearts. Biochem Med 28: 62–69
Lucas CE (1976) The renal response to acute injury and sepsis. Surg Clin North Am 56: 953–975
Maetani S, Nishikawa T, Hirakawa A, Tobe Takayoshi T (1986) Role of blood transfusion in organ system failure following major abdominal surgery. Ann Surg 203: 275–281
Nunes G, Blaisdell FW, Margarette S (1970) Mechanism of hepatic dysfunction following shock and trauma. Arch Surg 100: 546–556
Ohkawa M, Chaudry IH, Clemens MG, et al. (1983) Hepatic mitochondrial responses to sepsis and septic shock. Cire Shock 10: 273–274
Pasque MK, Murphy CE, Tright PV, et al. (1983) Myocardial adenosine triphosphate levels during early sepsis. Arch Surg 118: 1437–1440
Perry MO, Fantini G (1987) Ischemia: profile of an enemy. J Vasc Surg 3: 231–234
Polk HC, Baue AE, Trunkey DD, Frye DE (1981) Multiple system organ failure. Contemp Surg 19: 107–139
Polk HC, Shield CL (1977) Remote organ failure: a valid sign of occult intra-abdominal infection. Surgery 81: 310–313
Raymond RM, Harkema JM, Emerson TE (1981) In vivo skeletal muscle insulin resistance during E. coli endotoxin shock in the dog. Circ Shock 8: 425–433
Schieppati E, Doglio G, Grosso RM, Bumaschny E (1986) Cirugia abdominal en 138 pacientes de alto riesgo. Rev Argent Cir 50: 220–226
Schumer W (1968) Localization of energy pathway block in shock. Surgery 64: 55–59
Shaw JHF, Wolfe RR (1984) A conscious septic dog model with hemodynamic and metabolic responses similar to responsiveness of human. Surgery 95: 553–561
Shen, Peng-Fei, Zhang, Shi-chun (1987) Acute renal failure and multiple organ system failure. Arch Surg 122: 1131–1133
Tilney NL, Bailey GL, Morgan AP (1973) Sequential system failure after rupture of abdominal aortic aneurysms: an unsolved problem in postoperative care. Ann Surg 178: 117–122
Vito L, Dennis RC, Weisel RD, Hechtman HB (1974) Sepsis presenting as acute respiratory insufficience. Surg Gynecol Obstet 138: 896–900
Wichterman KA, Baue AE, Chaudry IH (1980) Sepsis and septic shock. A review of laboratory models and a proposal. J Surg Res 29: 189–201
Wichterman KA, Chaudry IH, Baue AE (1979) Studies of peripheral glucose uptake during sepsis. Arch Surg 114: 740–745
Wiles JB, Cerra FB, Siegel JH, Border JR (1980) The systemic septic response: Does the organism matter? Crit Care Med 8: 55–60
Wolfe RR, Burke JF (1978) Glucose and lactate metabolism in experimental septic shock. Am J Physiol 235: R219 - R227
Zapol WM, Snider MT (1977) Pulmonary hypertension in severe acute respiratory failure. N Engl J Med 296: 476–480
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1989 Springer-Verlag Berlin Heidelberg
About this chapter
Cite this chapter
Baue, A.E. (1989). Zelluläre und subzelluläre Funktionen der vitalen Organe bei Sepsis und Multiorganversagen. In: Reinhart, K., Eyrich, K. (eds) Sepsis. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-09869-1_16
Download citation
DOI: https://doi.org/10.1007/978-3-662-09869-1_16
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-662-09870-7
Online ISBN: 978-3-662-09869-1
eBook Packages: Springer Book Archive