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Schmerztherapie in der Kinderhämatoonkologie

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Book cover Schmerztherapie bei Kindern

Zusammenfassung

Noch vor 20 Jahren vertraten viele Ärzte die Meinung, junge Kinder empfänden keine Schmerzen, und ältere Kinder würden Schmerzen besser verarbeiten als Erwachsene. Aus diesem Mythos folgte logischerweise, dass Kindern bei extrem schmerzhaften Ereignissen wie Unfällen, Verbrennungen oder Operationen Analgetika vorenthalten oder in zu niedrigen Dosen verabreicht wurden [57]. In den 1980er Jahren war die nozizeptive Kompetenz von Kindern eine wissenschaftlich anerkannte Tatsache, und dennoch gehörte eine suffiziente Schmerztherapie an US-amerikanischen Kinderkliniken nicht zum Behandlungsstandard [42].

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Literatur

  1. Anderson BJ, Holford NHG (1997) Rectal paracetamol dosing regimens: determination by computer simulation. Pediatr Anaesth 7: 451–455

    Article  CAS  Google Scholar 

  2. Anderson PM, Schroeder G, Skubitz KM (1998) Oral glutamine reduces the duration and severity of stomatitis after cytotoxic cancer chemotherapy. Cancer 83:1433–1439

    Article  CAS  PubMed  Google Scholar 

  3. Anundi I, Lahteenmaki T, Rundgren M, Moldeus P, Lindros KO (1993) Zonation of acetaminophen metabolism and cytochom P 450 2Ei-mediated toxicity studied in isolated periportal and perivenous hepatocytes. Biochem Pharmacol 45:1251–1259

    Article  CAS  PubMed  Google Scholar 

  4. Brauer HG, Fisch UW, Krause M, Lang F, Vergin H (1997) Prävention NSAR-bedingter Magenschleimhautschäden mit Misoprostol. Z Allg Med 73:1265–1270

    Google Scholar 

  5. Bjorkman R (1995) Central antinociceptive effects of non-steroidal anti-inflammatory drugs and paracetamol: experimental studies in the rat. Acta Anaesthesiol Scand 103 (Suppl): 1–44

    CAS  Google Scholar 

  6. Bösenberg AT, Ratcliffe S (1998) The respiratory effects of tramadol in children under halothane anaesthesia. Anaesthesia 53: 960–964

    Article  PubMed  Google Scholar 

  7. Collins JJ, Grier HE, Kinney HC, Berde CB (1995) Control of severe pain in children with terminal malignancy. J Pediat 126: 653–657

    Article  CAS  PubMed  Google Scholar 

  8. Collins JJ, Berde CB (1995) Intravenous amitryptiline in pediatrics. J Pain Symptom Manag 10: 471–475

    Article  CAS  Google Scholar 

  9. Collins JJ (1996) Intractable pain in children with terminal cancer. J Palliativ Care 12: 29–34

    CAS  Google Scholar 

  10. Collins JJ, Grier HE, Sethna NF, Wilder RT, Berde CB (1996) Regional anesthesia for pain associated with terminal malignancy. Pain 65: 63–69

    Article  CAS  PubMed  Google Scholar 

  11. Collins J (1998) Commentary: Symptom management in children at the end of life. J Pain Symptom Manag 15: 259–260

    Article  CAS  Google Scholar 

  12. Dangel T (1998) Chronic pain management in children. Part I: cancer and phantom pain. Pediatr Anaesth 8: 5–10

    Article  CAS  Google Scholar 

  13. Darsey EH, Outlaw AC (1994) Age-related considerations for the use of opiods in pediatric pain management. Pain Digest 4:12–20

    Google Scholar 

  14. Dellemijn PLI, Vanneste JAL (1997) Randomised double-blind active-placebo-controlled crossover trial of intravenous fentanyl in neuropathic pain. Lancet 349: 753–758

    Article  CAS  PubMed  Google Scholar 

  15. Denecke H, Glier B, Klinger R, Kröner-Herwig B, Nilges P, Redegeld M, Weiß L (1997) Qualitätssicherung in der Therapie chronischer Schmerzen. X. Instrumente zur Erfassung von Schmerz bei Kindern. Schmerz 11:120–125

    Article  CAS  PubMed  Google Scholar 

  16. Dowd JE, Cimaz R, Fink CW (1995) Nonsteroidal antiinflammatory drug-induced gastroduodenal injury in children. Arthritis Rheum 38:1225–1231

    Article  CAS  PubMed  Google Scholar 

  17. Elliott S, Miser A, Dose A, Betcher D, O’Fallon J, Ducos R, Shah N, Goh T, Monzon C, Tschetter L (1991) Epidemiologic features of pain in pediatric cancer patients: a cooperative community based study. Clin J Pain 7: 263–268

    Article  CAS  PubMed  Google Scholar 

  18. Gan TJ, Ginsberg B, Glass PSA, Fortney J, Jhaveri R, Perno R (1997) Opioid-sparing effects of low-dose infusion of naloxone in patient-administered morphine-sulfate. Anesthesiology 87:1075–1081

    Article  CAS  PubMed  Google Scholar 

  19. Gazarian M, Berkovitsch M, Koren G, Silverman ED, Laxer RM (1995) Experience with misoprostol therapy for NSAID gastropathy in children. Ann Rheum Dis 54: 277–280

    Article  CAS  PubMed  Google Scholar 

  20. Gourlay GK, Boas RA (1992) Fatal outcome with use of rectal morphine for postoperative pain control in an infant. BMJ 304: 766–767

    Article  CAS  PubMed  Google Scholar 

  21. Greenberg HS, Kim J, Posner JB (1980) Epidural spinal cord compression from metastatic tumor: results with a new treatment protocol. Ann Neurol 8:361–366

    Article  CAS  PubMed  Google Scholar 

  22. Hagen NA, Babul N (1997) Comparative clinical efficacy and safety of a novel controlled-released Oxycodone formulation and controlled released hydromorphone in the treatment of cancer pain. Cancer 79:1428–1437

    Article  CAS  PubMed  Google Scholar 

  23. Henry D, Lim LL, Rodriguez LAG, Gutthann SP, Carson JL, Griffin M (1996) Variability in risk of gastrointestinal complications with individuel non-steroidal antiinflammatory drugs: results of a collaborative meta-analysis. BMJ 66: 229–237

    Google Scholar 

  24. Heubi JE, Barbacci MB, Zimmerman HJ (1998) Therapeutic misadventure with acetaminophen: hepatotoxicity after multiple doses in children. J Pediatr 132: 22–27

    Article  CAS  PubMed  Google Scholar 

  25. Hurwitz ES (1989) Reye’s syndrome. Epidemiol Rev 11: 249–253

    CAS  PubMed  Google Scholar 

  26. Jacobson SJ, Kopecky EA, Joshi P, Babul N (1997) Randomised trial of oral morphine for painful episodes of sickle-cell disease in children. Lancet 350:1358–1361

    Article  CAS  PubMed  Google Scholar 

  27. Jakobs H, Rister M (1997) Die Fremdeinschätzung von Schmerzen bei Kindern. Klin Pädiatr 209:384–388

    Article  CAS  PubMed  Google Scholar 

  28. Kalso E, Vainio A (1988) Hallucinations during morphine but not during oxycodone treatment. Lancet II: 912

    Article  Google Scholar 

  29. Kant T, Christrup LL, Rasmussen M (1997) Recommended use of morphine in neonates, infants and children based on a literature review: Part I — pharmacokinetics. Pediatr Anaesth 7: 5–11

    Article  Google Scholar 

  30. Kant T, Christrup LL, Rasmussen M (1997) Recommended use of morphine in neonates, infants and children based on a literature review: Part II — clinical use. Pediatrics Anaesth 7: 93–101

    Google Scholar 

  31. Kramer C, Tawney M (1998) A fatal overdose of transdermal administered fentanyl. J Am Osteopath Assoc 98: 385–386

    CAS  PubMed  Google Scholar 

  32. Lemann M, Chaussade S, Halphen M, Floune B, Morcau J, Bommelaer G, Attar A (1996) Low-dose polyethylene glycol (PEG) in chronic obstipation: double-blind, placebo-controlled, crossover trial. Gastroenterology 110: A704

    Google Scholar 

  33. Levy M (1986) The international agranulocytosis and aplastic anemia study. Risks of agranulozytosis and aplastic anemia. A first report of their relation to drug use with special references to analgesics. JAMA 256:1749–1757

    Article  Google Scholar 

  34. Levy ME (1996) Pharmacologic treatment of cancer pain. N Engl J Med 335:1124–1132

    Article  CAS  PubMed  Google Scholar 

  35. Ljungman G, Kreuger A, Gordh T, Berg T, Sörensen S, Rawal N (1996) Treatment of pain in pediatric oncology: a Swedish nationwide survey. Pain 68: 385–394

    Article  CAS  PubMed  Google Scholar 

  36. Ljungman G, Kreuger A, Gordh T, Berg T, Sörensen S (1997) Pain in children with cancer — a Swedish interview investigation. Fourth international symposium on pediatric pain, June 29 — July 4, Helsinki, Finland, p 32

    Google Scholar 

  37. Lteif AN, Zimmerman D (1998) Bisphoshonates for treatment of childhood hypercalcemia. Pediatrics 102: 990–993

    Article  CAS  PubMed  Google Scholar 

  38. Lynn A, Nespeca MK, Bratton SL, Strauss S, Shen DD (1998) Clearance of morphine in postoperative infants during intravenous infusion: the influence of age and surgery. Anesth Analg 86: 958–963

    CAS  PubMed  Google Scholar 

  39. Mackie AM, Coda BC, Hill HF (1991) Adolescents use patient-controlled analgesia effectively for relief from prolonged oropharyngeal mukositis pain. Pain 46: 265–269

    Article  CAS  PubMed  Google Scholar 

  40. McGrath P, Hsu E, Cappelli M, Luke B, Goodman J, Dunn-Geier J (1990) Pain from pediatric cancer: a survey of an outpatient oncology clinic. J Psychosoc Oncol 8:109–124

    Article  Google Scholar 

  41. McGrath PJ, Beyer J, Cleeland C, Eland J, McGrath PA, Portenoy R (1990) Report of the consensus conference on the management of pain in childhood cancer. Report of the subcommittee on assessment and methodological issues in the management of pain in childhood cancer. Pediatrics 5 (2 Suppl): 814–817

    Google Scholar 

  42. McGrath PJ (1990) Pain in children: Nature, assessment and treatment. Controlling children’s pain: a practical approach to assessment and management. Guilford, New York

    Google Scholar 

  43. McQuay HJ, Tramer M, Nye BA, Carroll D, Wiffen PJ, Moore RA (1996) A systematic review of antidepressants in neuropathic pain. Pain 68: 217–227

    Article  CAS  PubMed  Google Scholar 

  44. Mercadante S (1997) Malignant bone pain: pathophysiology and treatment. Pain 69:1–18

    Article  CAS  PubMed  Google Scholar 

  45. Mulberg AE, Linz C, Bern E, Tucker L, Verhave M, Grand RJ (1993) Identification of nonsteroidal antiinflammatory drug-induced gastroduodenal injury in children with juvenile rheumatoid arthritis. J Pediatr 122: 647–649

    Article  CAS  PubMed  Google Scholar 

  46. Mullan S (1973) Surgical management of pain in cancer of the head and neck. Surg Clin North Am 53: 203–210

    CAS  PubMed  Google Scholar 

  47. Olkkola KT, Hmunen K, Maunuksela EL (1995) Clinical pharmakokinetics and pharmacodynamics of opioid analgesia in infants and children. Clin Pharmacokinet 28: 385–404

    Article  CAS  PubMed  Google Scholar 

  48. Oliveri MB, Mautalen CA, Rodriguez Fuchs CA, Romanelli MC (1991) Vertebral compression fractures at the onset of acute lymphoblastic leukemia in a child. Henry Ford Hosp Med J 39: 45–48

    CAS  PubMed  Google Scholar 

  49. Patel RI, Davis PJ, Orr RJ (1996) Single-dose ondansetron prevents postoperative vomiting in pediatric outpatients. Anesth Analg 85: 538–545

    Google Scholar 

  50. Pegelow CH (1992) Survey of pain management therapy provided for children with sickle cell disease. Clin Pediat Philadelphia 31: 211–4

    Article  CAS  Google Scholar 

  51. Portenoy RK, Foley KM, Inturrisi CE (1990) The nature of opioid responsiveness and its implications for neuropathic pain: new hypotheses derived from studies of opioid infusions. Pain 43: 273–286

    Article  CAS  PubMed  Google Scholar 

  52. Pothmann R, Goepel R (1985) Comparison of the Visual Analog Scale (VAS) and a Smiley Analog Scale for the evaluation of pain in children. In: Fields HL, Dubner R, Cervero F (eds) Proc 4th World Congress on Pain. Advances in pain research and therapy, vol 9. Raven, New York

    Google Scholar 

  53. Pryle BJ, Grech H, Stoddart PA, Carson R, O’Mahoney TO, Reynolds F (1992) Toxicity of norpethidine in sickle cell crisis. BMJ 304:1478–1479

    Article  CAS  PubMed  Google Scholar 

  54. Ragg P (1997) Opioids in children. In: McKenzie IM, Gaukroger PB, Ragg PC, Brown TCK (eds) Manual of acute pain management in children. Churchill Livingston, New York, pp 25–38

    Google Scholar 

  55. Reimann J (1983) Kauend gegen Kinetosen. Dtsch Apotheker Z 123: 898–899

    Google Scholar 

  56. Reuben SS, Connelly NR, Lurie S, Klarr M, Gibson CS (1998) Dose-response of ketorolac as an adjunct to patient-controlled analgesia morphine in patients after spinal fusion surgery. Anesth Analg 87: 98–102

    CAS  PubMed  Google Scholar 

  57. Schechter NL (1989) The undertreatment of pain in children: an overview. Paediatr Clin North Am 36: 781–794

    CAS  Google Scholar 

  58. Schechter NL (1990) Report of the consensus conference on the management of pain in childhood cancer. Pediatrics 5 (Suppl 2): 813–834

    Google Scholar 

  59. Shannon M, Berde CB (1989) Pharmacologic Management of pain in children and adolescents. Pediatr Clin North Am 36: 855–871

    CAS  PubMed  Google Scholar 

  60. Sirkiä K, Saarinen UM, Ahlgren B, Hovi L (1997) Terminal care of the child with cancer at home. Acta Paediatr 86:1125–1130

    Article  PubMed  Google Scholar 

  61. Sirkiä K, Hovi L, Pouttu J, Saarinen-Pihkala UM (1998) Pain medication during terminal care of children with cancer . J Pain Symptom Manage 15: 220–226

    Article  PubMed  Google Scholar 

  62. Sittl R, Huber H, Griessinger N, Richter R, Sorge J (1993) Grundlagen der Tumorschmerztherapie bei Kindern und Jugendlichen. In: Meier U, Kaiser R, Moir CR (Hrsg) Schmerz beim Kind. Springer, Berlin Heidelberg New York Tokio, S 41–49

    Chapter  Google Scholar 

  63. Southall D (1997) Prevention and control of pain in children. A manual for health care professionals. Royal College of Paediatrics and Child Health, BMJ Publishing Group, London

    Google Scholar 

  64. Tobias JD, Martin LD, Wetzel RC (1990) Ketamine by continuous infusion for sedation in the pediatric intensive care unit. Crit Care Med 18: 819–821

    Article  CAS  PubMed  Google Scholar 

  65. Tobias JD (1997) Propofol sedation for the terminal care in a pediatric patient. Clin Pediatr 5: 291–293

    Article  Google Scholar 

  66. Tramer MR, Reynolds JM, Moore RA, McQuay HJ (1997) Efficacy, dose-response, and safety of ondansetron in prevention of postoperative nausea and vomiting. Anesthesiology 87:1277–1289

    Article  CAS  PubMed  Google Scholar 

  67. Van Hoogdalem EJ, de Boer AG, Breimer DD (1991) Pharmacokinetics of rectal drug administration. Clin Pharmacokinet 21:11–26

    Article  PubMed  Google Scholar 

  68. Vargas-Schaffer G, Pichard-Leandri E (1997) Neuropathic pain in young children with cancer. Eur J Palliat Care 15:19–25

    Google Scholar 

  69. Wallace MS, Lee J, Sorkin L, Dunn JS, Yaksh T, Yu A (1997) Intravenous lidocaine: effects on controlling pain after anti-DG2 antibody therapy in children with neuroblastoma — a report of a series. Anesth Analg 85: 794–796

    CAS  PubMed  Google Scholar 

  70. Weisman SJ, Bernstein B, Schechter NL (1998) Consequences of inadequate analgesia during painful procedures in children. Arch Pediatr Adolesc Med 152:147–149

    Article  CAS  PubMed  Google Scholar 

  71. Westlin JE, Letocha H, Jakobson A, Strang P, Martinsson U, Nilsson S (1995) Rapid, reproducible pain relief with 131Jod-MIBG in a boy with disseminated neuroblastoma. Pain 60:111–114

    Article  CAS  PubMed  Google Scholar 

  72. World Health Organization (1998) Cancer pain relief and palliative care in children. WHO, Geneva

    Google Scholar 

  73. Wolfe J, Grier HE, Klar N, Levin SB, Ellbogen JM, Salem-Schatz S, Emanuel EJ, Weeks JC (2000) Symptoms and suffering at the end of life in children with cancer. N Engl J Med 342:326–333

    Article  CAS  PubMed  Google Scholar 

  74. Wright PM, O’Toole DP, Barron DW (1993) The influence of naloxone infusion on the action of intrathecal diamorphine: low-dose naloxone and neuroendocrine response. Acta Anaesthesiol Scand 36: 230–233

    Article  Google Scholar 

  75. Zeltzer LK, Altman A, Cohen D, LeBaron S, Maunuksela L, Schechter NL (1990) Report of the consensus conference on the management of pain in childhood cancer. Report of the subcommittee on the management of pain associated with procedures in children with cancer. Pediatrics 5 (Suppl 2): 826–831

    Google Scholar 

  76. Zernikow B, Bauer AG, Andler W (2000) Pain control in paediatric oncology, (submitted)

    Google Scholar 

  77. Zernikow B, Lindena G (2000) Long acting morphine for pain control in paediatric oncology, (submitted)

    Google Scholar 

  78. Zernikow B, Bauer A, Andler W (2000) STOP — A nationwide quality improvement program of pain control in pediatric oncology. 5th Int Symp Paediatric Pain, London, June 18–21

    Google Scholar 

  79. Zernikow B, Grießinger N, Fengler R (1999) Praktische Schmerztherapie in der Kinderonkologie. Empfehlungen der Qualitätssicherungsgruppe der Gesellschaft für Pädiatrische Onkologie und Hämatologie (GPOH). Monatsschr Kinderheilkd 147: 438–56

    Article  Google Scholar 

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  1. Vestische Kinderklinik, Universität Witten-Herdecke, Dr.-Friedrich-Steiner-Straße 5, 45711, Datteln, Deutschland

    Boris Zernikow

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Zernikow, B. (2001). Schmerztherapie in der Kinderhämatoonkologie. In: Zernikow, B. (eds) Schmerztherapie bei Kindern. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-09815-8_9

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  • DOI: https://doi.org/10.1007/978-3-662-09815-8_9

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