Splicing Regulation in Drosophila Sex Determination

  • P. Förch
  • J. Valcárcel
Part of the Progress in Molecular and Subcellular Biology book series (PMSB, volume 31)


Posttranscriptional regulation is of fundamental importance for establishing the gene expression programs that determine sexual identity in the fruitfly Drosophila melanogaster. The protein Sex-lethal acts as a master regulatory switch, being expressed exclusively in female flies and inducing female-specific patterns of alternative splicing on target genes. As a consequence, other regulatory factors are expressed in a sex-specific manner, and these factors control somatic and germline sexual differentiation, sexual behavior and X chromosome dosage compensation. Here, we review the molecular mechanisms responsible for splicing regulation in Drosophila sexual determination.


Alternative Splice Splice Site Dosage Compensation Splice Regulation Splice Enhancer 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer-Verlag Berlin Heidelberg 2003

Authors and Affiliations

  • P. Förch
  • J. Valcárcel
    • 1
  1. 1.Gene Expression ProgrammeEuropean Molecular Biology LaboratoryHeidelbergGermany

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