Splicing Regulation in Drosophila Sex Determination

  • P. Förch
  • J. Valcárcel
Part of the Progress in Molecular and Subcellular Biology book series (PMSB, volume 31)

Abstract

Posttranscriptional regulation is of fundamental importance for establishing the gene expression programs that determine sexual identity in the fruitfly Drosophila melanogaster. The protein Sex-lethal acts as a master regulatory switch, being expressed exclusively in female flies and inducing female-specific patterns of alternative splicing on target genes. As a consequence, other regulatory factors are expressed in a sex-specific manner, and these factors control somatic and germline sexual differentiation, sexual behavior and X chromosome dosage compensation. Here, we review the molecular mechanisms responsible for splicing regulation in Drosophila sexual determination.

Keywords

Codon Glycine Adenosine Polypeptide Arginine 

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Copyright information

© Springer-Verlag Berlin Heidelberg 2003

Authors and Affiliations

  • P. Förch
  • J. Valcárcel
    • 1
  1. 1.Gene Expression ProgrammeEuropean Molecular Biology LaboratoryHeidelbergGermany

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