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Splicing Regulation in Drosophila Sex Determination

  • Chapter
Regulation of Alternative Splicing

Part of the book series: Progress in Molecular and Subcellular Biology ((PMSB,volume 31))

Abstract

Posttranscriptional regulation is of fundamental importance for establishing the gene expression programs that determine sexual identity in the fruitfly Drosophila melanogaster. The protein Sex-lethal acts as a master regulatory switch, being expressed exclusively in female flies and inducing female-specific patterns of alternative splicing on target genes. As a consequence, other regulatory factors are expressed in a sex-specific manner, and these factors control somatic and germline sexual differentiation, sexual behavior and X chromosome dosage compensation. Here, we review the molecular mechanisms responsible for splicing regulation in Drosophila sexual determination.

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  1. Gene Expression Programme, European Molecular Biology Laboratory, Meyerhofstrasse 1, 69117, Heidelberg, Germany

    J. Valcárcel

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  1. P. Förch
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  1. Institute of Molecular Genetics of Montpellier, CNRS, 1919 Route de Mende, BP 5051, 34293, Montpellier Cedex 05, France

    Philippe Jeanteur

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Förch, P., Valcárcel, J. (2003). Splicing Regulation in Drosophila Sex Determination. In: Jeanteur, P. (eds) Regulation of Alternative Splicing. Progress in Molecular and Subcellular Biology, vol 31. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-09728-1_5

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  • DOI: https://doi.org/10.1007/978-3-662-09728-1_5

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