Skip to main content
SpringerLink
Log in

Manipulation of Th Responses by Oral Tolerance

  • Chapter
Redirection of Th1 and Th2 Responses

Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 238))

Abstract

The gastrointestinal tract is the major site of antigenic contact in the body. A complex and precise gastrointestinal immune system allows the accomplishment of two distinct features: absorption of nutrients avoiding hypersensitivity to food antigens and exclusion of microbiologic pathogens (Kagnoee 1996; Newby 1984; Strobel 1990).

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 39.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Abreu-Martin MT, Targan SR (1996) Lamina propria lymphocytes: A unique population of mucosal lymphocytes. In: Kagnoll’ M F, H Kiyono (eds) Essentials of mucosal immunology Academic, San Diego, pp 227-245

    Google Scholar 

  • Al-Sabbagh A, Garcia G, Slavin A, Weiner HL, Nelson P (1997) Combination therapy with oral myelin basic protein and oral methotrexate enhances suppression of experimental autoimmune encephalomyelitis. Neurology 45: A421

    Google Scholar 

  • Al-Sabbagh A, Miller A, Santos LMB, Weiner HL (1994) Antigen-driven tissue-specific suppression following oral tolerance: orally administered myelin basic protein suppresses proteolipid induced experimental autoimmune encephalomyelitis in the SJL mouse. Eur J Immunol 24: 2104–2109

    PubMed  CAS  Google Scholar 

  • Al-Sabbagh A, Nelson P, Sobel RA, Weiner HL (1996) Antigen-driven peripheral immune tolerance: suppression of experimental autoimmune encephalomyelitis and collagen induced arthritis by aerosol administration of myelin basic protein or type II collagen. Cell Immunol 171: 111 119

    Google Scholar 

  • Allen JB, Wong HL, Costa GL, Bienkowski MJ, Wahl SM (1993) Suppression of monocyte function and differential regulation of IL-1 and IL-lra by IL-4 contribute to resolution of experimental arthritis. J Immunol 151: 4344–4351

    PubMed  CAS  Google Scholar 

  • Andre C, Heremans JF, Vaerman JP, Cambiaso CL (1975) A mechanism for the induction of immu- nological tolerance by antigen feeding: antigen-antibody complexes. J Exp Med 142: 1509 1519

    Google Scholar 

  • Bagot M, Charue D, Flechet ML, Terki N, Toma A, Revuz J (1995) Oral desensitization in nickel allergy induces a decrease in nickel-specific T-cells. Eur J Dermatol 5: 614 617

    Google Scholar 

  • Barnett ML, Kremer JM, St. Claair EW, Clegg DO, Furst D, Weisman M, Fletcher M.IF, Lavin PT, Finger E, Morales A, Le CH, Trentham DE (1998) Treatment of rheumatoid arthritis with oral type Il collagen: results of a multicenter double-blind placebo controlled trial. Arthritis Rheum 41: 290 297s

    Google Scholar 

  • Burnett ML, Combitchi D, Trentham DE (1996) A pilot trial of oral type II collagen in the treatment of juvenile rheumatoid arthritis. Arthritis Rheum 39: 623–628

    Google Scholar 

  • Becker KJ, McCarron RM, Hallenbeck JM (1997) Oral tolerance to myelin basic protein decreases stroke size. Stroke 28: 246

    Google Scholar 

  • Bergerot I, Fioix C, Peterson J, Moulin V, Bask C, Fabien N, Lindblad M, Mayer A, Czerkinsky C, Holmgren J, Thivolet C (1997) A cholera toxoid-insulin conjugate as an oral vaccine against spontaneous autoimmune diabetes. Proc Natl Acad Sci USA 94: 4610–4614

    PubMed  CAS  Google Scholar 

  • Bieganowska KD, Ausubel LJ, Modabber Y, Slovik E, Messersmith W, Haller DA (1997) Direct ex vico analysis of activated Fas-sensitive autoreactive T cells in human autoimmune disease. J Exp Med 185: 1581 1594

    Google Scholar 

  • Bitar D, Whitacre CC (1988) Suppression of experimental autoimmune encephalomyelitis by the oral administration of myelin basic protein. Cell Immunol I I2: 364–370

    Google Scholar 

  • Blanas E, Carbone FR, Allison J, Miller JFAP, Heath WR (1996) Induction of autoimmune diabetes by oral administration of autoantigen. Science 274: 1707–1709

    PubMed  CAS  Google Scholar 

  • Bridoux F, Badou A, Saoudi A, Bernard I, Druet E, Pasquier R, Druet P, Pelletier L (1997) Transforming growth factor b (TGF-b)-dependent inhibition of T helper cell 2 (Th2)-induced autoimmunity by self-major histocompatibility complex (MHC) class II-specific regulatory CD4+ T cell line. J Exp Med 185: 1769 1775

    Google Scholar 

  • Bruce MG, Ferguson A (1986a) The influence of intestinal processing on the immunogenicity and molecular size of absorbed circulating ovalbumin in mice. Immunology 59: 295 300

    Google Scholar 

  • Bruce MG, Ferguson A (19866) Oral tolerance to ovalbumin in mice: studies of chemically modified and of “biologically filtered” antigen. Immunology 57: 627–30

    Google Scholar 

  • C’ebra JJ, George A, Schrader CE (1991) A microculture containing TI-12 and dendritic cells supports the production of IgA by clones from both primary and IgA memory B cells and by single germinal center B cells from Peyer’s patches. Immunol Res 10: 389–392

    Google Scholar 

  • Challacombe SJ, Tomasi TB (1980) Systemic tolerance and secretory immunity after oral immunization. J Exp Med 152: 1459 1472

    Google Scholar 

  • Chase M (1946) Inhibition of experimental drug allergy by prior feeding of the sensitizing agent. Proc Soc Exp Biol Med 61: 257–259

    PubMed  CAS  Google Scholar 

  • Chen Y, Hancock W, Marks R, Gonnella PA, Weiner HL (1997) Mechanisms of recovery from cell-mediated autoimmune disease: T cell deletion and immune deviation following encephalomyelitis in myelin basic protein T cell receptor transgenic mice. Cell Immunol (in press)

    Google Scholar 

  • Chen Y, Inobe J-I, Kuchroo VK, Baron JL, Janeway CA, Weiner HL (1996) Oral tolerance in myelin basic protein T-cell receptor transgenic mice: suppression of autoimmune encephalomyelitis and dose-dependent induction of regulatory cells. Proc Natl Acad Sci USA 93: 388 391

    Google Scholar 

  • Chen Y, Inobe J-I, Marks R, Gonnella P, Kuchroo VK, Weiner HL (1995a) Peripheral deletion of antigen-reactive T cells in oral tolerance. Nature 376: 177–180

    PubMed  CAS  Google Scholar 

  • Chen Y, Inobe.I-I, Weiner HL (1995b) Induction of oral tolerance to myelin basic protein in CD-8 depleted mice: both CD4+ and CD8 + T cells mediate active suppression. J Immunol 156: 910 916

    Google Scholar 

  • Chen Y, Kuchroo VK, Inobe J-I, Haller DA, Weiner H L (1994) Regulatory T cell clones induced by oral tolerance: suppression of autoimmune encephalomyelitis. Science 265: 1237 1240

    Google Scholar 

  • Chomarat P, Vannier E, Dechanet J, Dinnarelo CA, Miossec P (1995) Balance of Ill receptor antagonism/III beta in rheumatoid synovium and its regulation by IL-4 and IL-I0. J Immunol 154: 1432–39

    PubMed  CAS  Google Scholar 

  • Coffman R, Lehman D, Shrader B (1989) Transforming growth factor beta (TGFb) specifically enhances IgA production by lipopolysaccharide-stimulated marine B lymphocytes. J Exp Med 144: 3411 16

    Google Scholar 

  • Coutant R, Zeidler A, Rappaport R, Schatz D, Schwartz S, Raskin P, Rogers D, Bode B, Crockett S, Marks J, Deeb L, Chalew S, MacLauren N (1998) Oral insulin therapy in newly diagnosed immune mediated (type I) diabetes. Preliminary analysis of a randomized, double-blind, placebo controlled study. Diabetes 47: A97

    Google Scholar 

  • Cross AH, Tuohy VK, Raine CS (1993) Development of reactivity to new myelin antigens during chronic relapsing autoimmune demyelination. Cell Immunol 146: 261 270

    Google Scholar 

  • Daynes R, Araneo B, Dowell T, Huang K, Dudley D (1990) Regulation of murine lymphokine production in vivo Ill The lymphoid tissue microenvironment exerts regulatory influences over T helper cell function. J Exp Med 171: 979–996

    PubMed  CAS  Google Scholar 

  • Deeni RL, Targan SR (1995) The role of TOEh in molding the activation state of lamina propria T cells. Gastroenterology 108 (abstract)

    Google Scholar 

  • Desvinges C, Bour H, Nicolas JF, Kaiserlian D (1996) Lack of oral tolerance but oral priming for contact sensitivity to dinitrolluorobenzene in major histocompatihility complex class II-deficient mice and in CD4+ T cell-depleted mice. Eur J Immunol 26: 1756–1761

    Google Scholar 

  • Elson CO, Ealding W (1984) Cholera toxin feeding did not induce oral tolerance in mice and abrogated oral tolerance to an unrelated protein antigen..I Immunol 133: 2892 2897

    Google Scholar 

  • Elson CO, Tomasi M, Dertzbaugh MT, Thaggard G, Hunter R, Weaver C (1996) Oral antigen delivery by way of a multiple emulsion system enhances oral tolerance. In: Weiner HL, Mayer LF (eds) Oral tolerance: mechanisms and applications. Ann New York Acad Sci, New York, pp I56–162

    Google Scholar 

  • Fava RA, Olsen NJ, Postlethwaite AE, Broadley KN, Davidson JM, Nancy LB, Lucas C, Townes AS (1991) TGFb induced neutrophil recruitment to synovial tissues. J Exp Med 173: 1121–32

    PubMed  CAS  Google Scholar 

  • Feldman M, Brennan FM, Maini RN (1996) Role of cytokines in rheumatoid arthritis. Ann Rev Immunol 14: 397–440

    Google Scholar 

  • Ferber IA, Brocke S, Taylor-Edwards C, Ridgway W, Dinisco C’, Steinman L, Dalton D, Fathman CG (1996) Mice with disrupted IFN-g gene are susceptible to the induction of experimental autoimmune encephalomyelitis ( EAE ). J Immunol I56: 5–7

    Google Scholar 

  • Frei K, Engster FI-P, Bopst M, Constantinescu CS, Lavi E, Fontana A (1997) Tumour necrosis factor a and lymphotoxin a are not required for induction of acute experimental autoimmune encephalomyelitis. J Exp Med 1852177–2182

    Google Scholar 

  • Friedman A, Weiner HL (1994) Induction of eanergy or active suppression following oral tolerance is determined by antigen dosage. Proc Natl Acad Sci USA 91: 6688–6692

    PubMed  CAS  Google Scholar 

  • Fujihashi K, McGhee JR, Kweon MN, Cooper MD, Tonegawa S, Takahashi I, Hiroi T, Mestecky I, Kiyono H (1996) gad T Cell-deficient mice have impaired mucosal immunoglobulin A responses. J Exp Med 183: 1929–1935

    Google Scholar 

  • Fukaura H, Kent SC, Pietrusewicz MJ, Khoury SJ, Weiner HL, Haller DA (1996) Induction of circulating myelin basic protein and proteolipid protein specific TGE-b1 secreting Th3 T cells by oral administration of myelin in multiple sclerosis patients. J Clin Invest 98: 70 77

    Google Scholar 

  • Garside P, Steel M, Liew FY, Mowat AM (1995a) CD4+ but not CD8+ T cells are required for the induction of oral tolerance. Int Immunol 7: 501 504

    Google Scholar 

  • Garside P, Steel M, Worthey EA, Satoskar A, Alexander J, Bluethmann H, Liew FY, Mowat M (1995h) T helper 2 cells are subject to high dose oral tolerance and are not essential for its induction. J Immunol 154: 5649–5655

    PubMed  CAS  Google Scholar 

  • Gonnella PA, Chen Y, Inobe i-I, Quartulli M, Weiner HL (1998) In situ immune response in gut associated lymphoid tissue (GA LT) following oral antigen in TeR transgenic mice. J Immunol 160: 4708 4718

    Google Scholar 

  • Groux H, O’Garra A, Bigler M, Rouleau M, Antonenko S, de Vries.1E, Roncarolo MG (1997) A CD4+ T cell subset inhibits antigen-specific T cell responses and prevents colitis. Nature 389: 737 742

    Google Scholar 

  • Haller DA, Duby AD, Lee SJ, Benjamin D, Seidman JG, Weiner HL (1988) Oligoclonal T-lymphocyte in the cerebrospinal fluid of patients with inflammatory central nervous system diseases..) Exp Med 167: 1313

    Google Scholar 

  • Haller DA, Weiner HL (1995) Immunologic mechanisms and therapy in multiple sclerosis. Immunol Rev 144: 75–107

    Google Scholar 

  • Hancock WW, Polanski M, Zhang ZJ, Blogg N, Weiner HL (1995) Suppression of insulitis in NOD mice by oral insulin administration is associated with selective expression of IL-4 IL-10 TGF-h and prostaglandin-E. Amer J Pathol 147: 1193–1199

    CAS  Google Scholar 

  • Harrison LC (1992) Islet cell antigens in insulin-dependent diabetes: Pandora’s box revisited. Immunol Today 13: 348–352

    PubMed  CAS  Google Scholar 

  • Higgins P, Weiner HL (1988) Suppression of experimental autoimmune encephalomyelitis by oral administration of myelin basic protein and its fragments. J Immunol 140: 440–445

    PubMed  CAS  Google Scholar 

  • Hines KL, Christ M, Wahl M (1993) Cytokine regulation of the immune response: an in vivo model. Immunomethods 3: 13 22

    Google Scholar 

  • Hörnquist E, Lycke N (1993) Cholera toxin adjuvant greatly promotes antigen priming of T cells. Eur J Immunol 23: 2136–2143

    PubMed  Google Scholar 

  • Husky S, Jensenius.IC, Svehag S-E (1986) Passage of undegraded dietary antigen into the blood of healthy adults. Further characterization of the kinetics of uptake and the size distribution of the antigen. Scand J Immunol 24: 447 452

    Google Scholar 

  • Husby S, Mestecky J, Moldoveanu Z, Holland S, Elson CO (1994) Oral tolerance in humans: T cell but not B cell tolerance after antigen feeding. J Immunol 152: 4663 4670

    Google Scholar 

  • Inobe J-I, Stavin AJ, Komagata Y, Chen Y, Liu L, Weiner HL (1998) II-4 is a differentiation factor for TGF-(3 secreting Th3 cells and oral administration of II-4 enhances oral tolerance in experimental allergic encephalomyelitis. Eur J Immunol 28: 2780 2790

    Google Scholar 

  • Janes SP, Kwan WC, Sneller MC ’ (1990) T cells in inductive and ellector compartments of intestinal mucosal immune system of non-human primates differ in lymphokine mRNA expression lymphokine utilization and regulatory function. Immunol 144: 1251 1256

    Google Scholar 

  • Kagnofl MF (1996) Essential of mucosal immunology. Kagnoll MF, Kagnofl KH (eds) Academic, San Diego

    Google Scholar 

  • Karpus WJ, Lukacs NW (1996) The role of chemokines in oral tolerance: abrogation of nonresponsiveness by treatment with antimonocyte chemolactic protein-I. In: Weiner HL, Mayer LF (eds) Oral tolerance: mechanisms and applications. Ann New York Acad Sci, New York, pp 133–144

    Google Scholar 

  • Kasama T, Stricter RM, Lukacs NW, Lincoln PM, Burdick MD, Kunkel SL (1995) 0–10 expression and chemokine regulation during the evolution of murine type II CIA. Clin Invest 95: 2868 2876

    Google Scholar 

  • Ke Y, Kapp JA (1996) Oral antigen inhibits priming of CD8+ CTL CD4+ T cells and antibody responses while activating CD8+ suppressor. T cells.I Immunol 156: 916 921

    Google Scholar 

  • Ke Y, Pearce K, Lake JP, Ziegler HK, Kapp JA (1997) gd T lymphocytes regulate the induction and maintenance of oral tolerance. Immunol I58:36I0–3618

    Google Scholar 

  • Khalil N, Bereznay O, Sporn M, Greenberg AH (1989) Macrophage production of TGFb and fibroblast collagen synthesis in the chronic pulmonary inflammation. J Exp Med 170: 727 37

    Google Scholar 

  • Khoury SJ, Hancock WW, Weiner HL (1992) Oral tolerance to myelin basic protein and natural recovery from experimental autoimmune encephalomyelitis as associated with downregulation of inflammatory cytokines and differential upregulation of transforming growth factor b interleukin 4 and prostaglandin E expression in the brain. J Exp Med 176: 1355 1364

    Google Scholar 

  • Khoury SJ, Lider O, Al-Sabbagh A, Weiner HL (1990) Suppression of experimental autoimmune encephalomyelitis by oral administration of myelin basic protein Ill. Synergistic effect of lipopolysaccharide. Cell Immunol 131: 302–310

    Google Scholar 

  • Kjerrulf M, Grdic D, Lycke N (1996) Impaired mucosal IgA responses but intact oral tolerance in IFN-g receptor deficient mice. FASEB J 10: A1418

    Google Scholar 

  • Kweon M, Fujihashi K, Yamamoto M, Van Colt JL, McGhee JR, Kiyono H (1996) Mucosally induced tolerance in IL-4-/-hut not IEN-g -/-mice. FASEB J 10: A1028

    Google Scholar 

  • Lehmann P, Forsthuber T, Miller A, Sercarz E (1992) Spreading of T-cell autoimmunity to cryptic determinants of an autoantigen. Nature 358: 155 157

    Google Scholar 

  • Liblau RS, Singer SM, McDevitt HO (1995) Thl and Th2 CD4 T cells in the pathogenesis of organ-specific autoimmune diseases. Immunol Today 16: 34 38

    Google Scholar 

  • Lider O, Santos LMB, Lee CSY, Higgins PJ, Weiner HL (1989) Suppression of experimental allergic encephalomyelitis by oral administration of myelin basic protein II. Suppression of disease and in vitro immune responses is mediated by antigen-specific CD8+T lymphocytes. J Immunol 142: 748–752

    PubMed  CAS  Google Scholar 

  • Lowney ED (1968) Immunologic unresponsiveness to a contact sensitizer in man.J Invest Dermatol 51: 411 417

    Google Scholar 

  • MacDonald TT (1983) lmmunosuppression caused by antigen feeding II Suppressor T cells mask Peyer’s patches B cell priming to orally administered antigen. Eur J Immunol 13:138 142

    Google Scholar 

  • Marinaro M, Boyaka PN, Finkelman ED, Kiyono H, Jackson R.I, Jirillo E, McGhee JR (1997) Oral but not parental interleukin (IL)-12 redirects T helper 2 (Th2)-type responses to an oral vaccine without altering mucosal IgA responses. J Exp Med 185: 415 427

    Google Scholar 

  • Maron R, Blogg NS, Polanski M, Hancock W, Weiner HL (1996) Oral tolerance to insulin and the insulin B-chain. Ann N Y Acad Sci 778: 346 357

    Google Scholar 

  • Marth T, Strober W, Kelsall BL (1996) High close oral tolerance in ovalbumin TCR-transgenic mice: systemic neutralization of IL-12 augments TGF-beta secretion and T cell apoptosis..I Immunol 157: 2348–2357

    CAS  Google Scholar 

  • Mattingly JA, Waksman BF! (1978) Immunologic suppression after oral administration of antigen I. Specific suppressor cells formed in rat Peyer’s patches after oral administration of sheep erythrocytes and their systemic migration.J Immunol 121: 1878 1882

    Google Scholar 

  • Meyer AL, Benson JM, Gienapp IE, Cox KL, Whitacre CC (1996) Suppression of murine chronic relapsing experimental autoimmune encephalomyelitis by the oral administration of myelin basic protein. J Immunol 157: 4230 4238

    Google Scholar 

  • Miller A, Al-Sabbagh A, Santos L, Das MP, Weiner HL (1993) Epitopes of myelin basic protein that trigger TGF-h release following oral tolerization are distinct from encephalitogenic epitopes and mediate epitope driven bystander suppression. J Immunol 151: 7307 7315

    Google Scholar 

  • Miller A, Lider O, Abramsky O, Weiner ElL (1994) Orally administered myelin basic protein in neonates princes for immune responses and enhances experimental autoimmune encephalomyelitis in adult animals. Eur J Immunol 24: 1026–1032

    PubMed  CAS  Google Scholar 

  • Miller A, Lider O, Al-Sabbagh A, Weiner H (1992a) Suppression of experimental autoimmune encephalomyelitis by oral administration of myelin basic protein V. Hierarchy of suppression by myelin basic protein from different species. J Neuroimmunol 39: 243 250

    Google Scholar 

  • Miller A, Lider O, Roberts AB, Sporn MB, Weiner HL (1992b) Suppressor T cells generated by oral tolerization to myelin basic protein suppress both in vitro and in vivo immune responses by the release of TGFb following antigen specific triggering. Proc Natl Acad Sci USA 89: 421 425

    Google Scholar 

  • Miller A, Lider O, Weiner H L (1991) Antigen-driven bystander suppression following oral administration of antigens. J Exp Med 174: 791 798

    Google Scholar 

  • Miller S, Hanson D (1979) Inhibition of specific immune responses by feeding protein antigens IV. Evidence for tolerance and specific active suppression of cell-mediated immune responses to ovalbumin. J Immunol 123: 2344

    Google Scholar 

  • Miossee P, Briolay J, Dechanet.I, Wijdenes J, Martinez- Valdez H, Banchereau.I (1992) Inhibition of the production of proinllammatory cytokines and Ig by IL-4 in an ex vivo model of rheumatoid synovitis. Arthritis Rheum 35: 874–883

    Google Scholar 

  • Moore KW, O’Garra A, de Waal Malefyt R, Vies P, Mosman TR (1993) Interleukin 10. Ann Rev Immunol 11: 165 190

    Google Scholar 

  • Mosmann TR, Sad S (1996) The expanding universe of T-cell subsets: Tht Th2 and more. Immunol Today 17: 138 146

    Google Scholar 

  • Mowat AM (1987) The regulation of immune responses to dietary protein antigens. Immunol Today 8: 93 98

    Google Scholar 

  • Nagler-Anderson C’, Bober LA, Robinson ME, Siskind OW, Thorbeke FJ (1986) Suppression of type II collagen-induced arthritis by intragastric administration of soluble type II collagen. Proc Natl Acad Sci USA 83: 7443 7446

    Google Scholar 

  • Nelson PA, Akselhand Y, Dearborn S, Al-Sabbagh A, Tian Z.1, Gonnella P, Zamvil S, Chen Y, Weiner H L (1996) Effect of oral beta interferon on subsequent immune responsiveness. In: Weiner HL, Mayer LE (eds) Oral tolerance: mechanisms and applications. New York Acad Sci, New York, pp 145 155

    Google Scholar 

  • Neutra RM, Kraehenbuhl i-P (1996) M cells as a pathway for antigen uptake and processing. In: Kagnolf MF, Kiyono H teds) Essentials of mucosal immunology Academic, San Diego, pp 29–33

    Google Scholar 

  • Newby TJ (1984) Protective immune responses in the intestinal tract In: Newby TJ, Stokes CR (eds) Local immune responses of the gut. CRC, Boca Raton, Florida, pp 143–198

    Google Scholar 

  • Ngan J, Kind LS (1978) Suppressor T cells for IgE and 1gG in Peyer’s patches of mice made tolerant by the oral administration of ovalbumin..l Immunol 120: 861 865

    Google Scholar 

  • Nussenblatt RB, fiery I, Weiner HL, Ferris F, Shiloach J, Ramaley N, Perry C, Caspi R, Haller DA, Foster S, Whitcup SM (1997) Treatment of uveitis by oral administration of retinal antigens: Results of a Phase I/II randomized masked trial. Am J Opthalmol 123: 583–592

    Google Scholar 

  • Peng Hi, Turner MW, Strobel S (1990) The generation of a “tolerogen” after the ingestion of ovalbumin is time-dependent and unrelated to serum levels of immunoreactive antigen. Clin Exp Immunol 81: 510–515

    Google Scholar 

  • Powrie F, Carlino J, Leach MW, Mauze S, Coffman RL (1996) A critical role for transforming growth factor-beta but not interleukin 4 in the suppression of T helper type I-mediated colitis by CD45RB (low) CD4 + T cells. J Exp Med 183: 2669–2674

    PubMed  CAS  Google Scholar 

  • Richman LK, Chiller JM, Brown WR, Hanson DO, Vaz NM (1978) Enterically induced immunological tolerance I Induction of suppressor T lymphocytes by intragastric administration of soluble proteins. J Immunol 121: 2429 2433

    Google Scholar 

  • Rizzo LV, Miller-Rivero NE, Chan C-C’, Wiggert B, Nussenblatt RB, Caspi RR (1994) Interleukin-2 treatment potentiates induction of oral tolerance in a marine model of autoimmunity. Clin Invest 94: 1668 1672

    Google Scholar 

  • Rollwagon FM and Baqar S (1996) Oral cytokine administration. Immunol Today 17: 548 550

    Google Scholar 

  • Santos LMB, Al-Sabbagh A, Londono A, Weiner HL (1994) Oral tolerance to myelin basic protein induces regulatory TGF-(3-secreting T cells in Peyer’s patches of SJL mice. Cell Immunol 157: 439 447

    Google Scholar 

  • Seder RA, Marth T, Sieve MC, Strober W, Letterio II, Roberts AB, Kelsall B (1998) Factors involved in the differentiation of TGF-15 producing cells from naive CD4+ T cells: IL-4 and IFN-y have opposing effects, while TGF-(3 positively regulates its own production.. Immunol 160: 5719 5728

    Google Scholar 

  • Sieper J, Kary S, Sörensen H, Alten R, Eggens U, Huge W, Hiepe F, Kühne A, Listing J, Ulbrich N, Braun J, Zink A, Mitchison NA (1996) Oral type II collagen treatment in early rheumatoid arthritis. Arthritis Rheum 39: 41–51

    PubMed  CAS  Google Scholar 

  • Strobel S (1990) Mechanisms of gastrointestinal immunoregulation and food induced injury to the gut. Eur.1 Clin Nutr 45: 1–9

    Google Scholar 

  • Sun J-B, Holmgren C, Czerkinsky C (1994) Cholera toxin B subunit: an efficient transmucosal carrier-delivery system for induction of peripheral immunological tolerance. Proc Nall Acad Sci USA 91: 10795–10799

    CAS  Google Scholar 

  • Sun.IB, Rask C, Olsson T, Holmgren J, Czerkinsky C (1996) Treatment of experimental autoimmune encephalomyelitis by feeding myelin basic protein conjugated to cholera toxin B subunit. Proc Natl Acad Sci USA 93: 7196 7201

    Google Scholar 

  • Tada Y, Ho A, Koh DR, Mak TW (1996) Collagen-induced arthritis in CD4- or CD8- deficient mice. J Immunol I56: 4520 4526

    Google Scholar 

  • Terato K, Xiu JY, Miyahara H, Cremer MA, Griffiths MM (1996) Induction of chronic autoimmune arthritis in DBA/I mice by oral administration of type II collagen and Escherichia coli lipopolysacclaride. Brit J Rheumatol 35: 1 11

    Google Scholar 

  • Thompson HS, Staines NA (1986) Suppression of collagen-induced arthritis with pregastrically or intravenously administered type II collagen. Agents Actions I9: 318–319

    Google Scholar 

  • Thorbecke GJ, Shah R, Leu CH, Kuruvilla AP, Hardison AM, Palladino MA (1992) Involvement of endogenous TNFa and TGFb during induction of collagen type 11 arthritis in nice. Proc Natl Acad Sci USA 89: 7375–7379

    PubMed  CAS  Google Scholar 

  • Trentham DE, Dynesius-Trentham RA, Gray EJ, Combitchi D, Lorenzo C, Sewell KL, Haller DA, Weiner HL (1993) Effects of oral administration of type 11 collagen on rheumatoid arthritis. Science 261: 1727–1730

    PubMed  CAS  Google Scholar 

  • Vajdy M, Kosco-Vilbois MH, Kopf M, Köhler G, Lycke N (1995) Impaired mucosal immune responses in interleukin 4-targeted mice. J Exp Med 181: 41–53

    PubMed  CAS  Google Scholar 

  • Vaz NM, Maia LCS, Hanson DG, Lynch JM (1977) Inhibition of homocytotropic antibody responses in adult inbred mice by previous feeding of the specific antigen. J Allergy Clin Immunol 60: 110 115

    Google Scholar 

  • von Herrath MG, Dyrberg T, Oldstone MBA (1996) Oral insulin treatment suppresses virus-induced antigen-specific destruction of beta cells and prevents autoimmune diabetes in transgenic mice. J Clin Invest 98: 1324 1331

    Google Scholar 

  • Wahl S (1992) Transforming growth factor beta (TGFb) in inflammation: a cause and a cure Clin Immunol 12: 61 74

    Google Scholar 

  • Wahl SM (1994) TGFb: the good the had and the ugly. J Exp Med 180: 1587 90

    Google Scholar 

  • Wahl SM, Allen JB, Costa GL, Wong HL, Dasch JR (1993) Reversal of acute and chronic synovial inflammation by anti-TGFb. J Exp Med 177: 225 230

    Google Scholar 

  • Waldo FB, Van Den Wall Bake AWL, Mestecky J, Husby S (1994) Suppression of the immune response by nasal immunization. Clin Immunol Immunopathol 72: 30 34

    Google Scholar 

  • Weiner H L (1997) Oral tolerance: immune mechanisms and treatment of autoimmune diseases. Immunol Today 18: 335 343

    Google Scholar 

  • Weiner HL, Friedman A, Miller A, Khoury Si, Al-Sabbagh A, Santos LMB, Sayegh M, Nussenblatt RB, Trentham DE, Haller DA (1994) Oral tolerance: Immunologic mechanisms and treatment of animal and human organ-specific autoimmune diseases by oral administration of autoantigens. Ann Rev Immunol 12: 809–837

    Google Scholar 

  • Weiner HL, Inobe.I-I, Kuchroo V, Chen Y (1996) Induction and Characterization of TGF-beta secreting Th3 cells. FASEB J 10: A1444

    Google Scholar 

  • Weiner HL, Mayer LF (1996) Oral tolerance: mechanisms and applications. Ann N Y Acad Sci, New York, pp 1 453

    Google Scholar 

  • Wilson AD, Bailey M, Williams NA, Stokes CR (1991) The in vitro production of cytokines by mucosal lymphocytes immunized by oral administration of keyhole limpet hemocyanin using cholera toxin as an adjuvant. Eur J Immunol 21: 2333 2339

    Google Scholar 

  • Wright JK, Cawston TE, Hazelman BL (1991) TGFb stimulates the production of tissue inhibitor of metalloproteinases (TIM P) by human synovial and skin fibroblasts. Biochem Biophys Acta 1094: 207 210

    Google Scholar 

  • Xu-Amano J, Kiyono H, Jackson RI, Staats HF, Fujihashi K, Burrows PD, Elson CO, Pillai S, McGhee JR (1990) Helper T cell subsets for immunoglobulin A responses: oral immunization with tetanus toxoid and cholera toxin as adjuvant selectively induces Th2 cells in mucosa associated tissues. J Exp Med 178: 1309–1320

    Google Scholar 

  • Yoshino S, Quattrocchi E, Weiner HL (1995) Oral administration of type II collagen suppresses antigen-induced arthritis in Lewis rats. Arthritis Rheum 38: 1092 1096

    Google Scholar 

  • Zhang J, Markovic S, Raus J, Lacet B, Weiner HL, Haller DA (1993) Increased frequency of IL-2 responsive T cells specific for myelin basic protein and proteolipid protein in peripheral blood and cerebrospinal fluid of patients with multiple sclerosis. J Exp Med 179: 973–984

    Google Scholar 

  • Zhang JZ, Lee CSY, Lider O. Weiner HL (1990) Suppression of adjuvant arthritis in Lewis rats by oral administration of type I1 collagen. J Immunol 145: 2489–2493

    CAS  Google Scholar 

  • Zhang Z, Michael J (1990) Orally inducible immune unresponsiveness is abrogated by IFN-g treatment. J Immunol 144: 4163–4165

    PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Center for Neurologic Diseases, Brigham and Women’s Hospital, Harvard Medical School, 77 Avenue Louis Pasteur, HIM 730, Boston, MA, 02215, USA

    G. Garcia & H. L. Weiner

Authors
  1. G. Garcia
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. H. L. Weiner
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. DNAX Research Institute of Molecular and Cellular Biology, Inc., 901 California Avenue, 94304-1104, Palo Alto, CA, USA

    Robert L. Coffman Ph.D.

  2. Cattedra di Immunologia Clinica e Allergologia, Istituto di Clinica Medica III, Servizio di Immunoallergologia Viale Morgagni, 85, I-50134, Firenze, Italy

    Sergio Romagnani M.D. (Head) (Head)

Rights and permissions

Reprints and permissions

Copyright information

© 1999 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Garcia, G., Weiner, H.L. (1999). Manipulation of Th Responses by Oral Tolerance. In: Coffman, R.L., Romagnani, S. (eds) Redirection of Th1 and Th2 Responses. Current Topics in Microbiology and Immunology, vol 238. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-09709-0_6

Download citation

  • DOI: https://doi.org/10.1007/978-3-662-09709-0_6

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-662-09711-3

  • Online ISBN: 978-3-662-09709-0

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation