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Regulation of Purine Release

  • Chapter
Purinergic and Pyrimidinergic Signalling I

Part of the book series: Purinergic and Pyrimidinergic Signalling ((HEP,volume 151 / 1))

Abstract

With the unequivocal demonstration that purine and pyrimidine nucleosides and nucleotides function as key extracellular messengers in all mammalian tissue systems (Ralevic and Burnstock 1998), a major challenge has been to understand the factors that govern purine availability in the extracellular space and the dynamics of the process. The focus of the present chapter is to summarize recent knowledge on purine release under various physiological and pathophysiological conditions.

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Abbreviations

BRL44408:

(±)2-((4,5-dihydro-1H-imidazol-2-yl)methyl)-2,3-dihydro-1methyl-1H-isoindole

6-OHDA:

6-hydroxydopamine

ACh:

acetylcholine

ADP:

adenosine diphosphate

ANOVA:

analysis of variance

ATP:

adenosine 5′-triphosphate

CH-38083:

7,8-(methylenedioxi)-14? -alloberbanol

LPS:

bacterial lipopolysaccharide

LTD:

long-term depression

LTP:

long term potentiation

NA:

noradrenaline

PHAL:

Phaseolus vulgaris leucoagglutinin

SFi:

nucleus septofimbrialis

TS:

nucleus triangularis septi

vVNAB:

ventral part of the ventral noradrenergic bundle

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Authors
  1. B. Sperlágh
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  2. E. S. Vizi
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Editors and Affiliations

  1. Institute of Pharmacological Sciences, University of Milan, Via Balzaretti, 9, 20133, Milan, Italy

    Maria Pia Abbracchio

  2. Department of Molecular Pharmacology and Biological Chemistry, Northwestern University Medical School, Searle 8-477 (S-215), 303 East Chicago Avenue, 60611, Chicago, IL, USA

    Michael Williams

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Sperlágh, B., Vizi, E.S. (2001). Regulation of Purine Release. In: Abbracchio, M.P., Williams, M. (eds) Purinergic and Pyrimidinergic Signalling I. Purinergic and Pyrimidinergic Signalling, vol 151 / 1. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-09604-8_7

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  • DOI: https://doi.org/10.1007/978-3-662-09604-8_7

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