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Purinergic and Pyrimidinergic Signalling I pp 1–16Cite as

Purinergic Neurotransmission: An Historical Background

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Part of the book series: Purinergic and Pyrimidinergic Signalling ((HEP,volume 151 / 1))

Abstract

It was not until the second decade of the last century that basic research findings on purines and their effects on tissue function began to appear sporadically in the literature. BASS (1914) reported on the presence of adenine (most probably as AMP) in the blood, while Thannhauser and Bommes (1914) administered the purine nucleoside adenosine subcutaneously to humans, and found it, unlike adenine, to be reasonably non-toxic. Administration of AMP had depressor activity (Fruend 1920) which led to the now seminal study of Drery and Szent-Gyorgi (1929) on the cardiovascular actions of adenosine and AMP. These included the demonstration of sinus bradycardia, heart block, reduction in atrial conduction, and at higher doses, “apprehension” and somnolence. In that same year, the purine nucleotide, ATP was discovered (Lohmann 1929; Fiske and Subbarow 1929).

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Authors
  1. M. P. Abbracchio
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  2. M. Williams
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  1. Institute of Pharmacological Sciences, University of Milan, Via Balzaretti, 9, 20133, Milan, Italy

    Maria Pia Abbracchio

  2. Department of Molecular Pharmacology and Biological Chemistry, Northwestern University Medical School, Searle 8-477 (S-215), 303 East Chicago Avenue, 60611, Chicago, IL, USA

    Michael Williams

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Abbracchio, M.P., Williams, M. (2001). Purinergic Neurotransmission: An Historical Background. In: Abbracchio, M.P., Williams, M. (eds) Purinergic and Pyrimidinergic Signalling I. Purinergic and Pyrimidinergic Signalling, vol 151 / 1. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-09604-8_1

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