Zusammenfassung
In den vergangenen Jahren erbrachten vielfältige elektrophysiologische und molekularbiologische Untersuchungen Hinweise auf die Beteiligung zentralnervöser Strukturen an der Entwicklung und Aufrechterhaltung von Sensitivierungsvorgängen, die in der Folge zu chronischem Schmerz führen können. Darüber hinaus wurde zunehmend deutlich, dass neben somatischen Faktoren insbesondere psychosoziale Faktoren am Prozess der Chronifizierung wesentlich beteiligt sind. Es steht daher zu vermuten, dass auf der Basis eines durch somatische Faktoren bedingten chronischen Schmerzes im Verlauf einer jahrelangen Schmerzerkrankung ein die gesamte Person einnehmender chronifizierter Schmerz entstehen kann.
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Tölle, T.R., Berthele, A. (2004). Biologische Mechanismen der Chronifizierung — Konsequenzen für die Prävention. In: Psychologische Schmerztherapie. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-09587-4_4
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DOI: https://doi.org/10.1007/978-3-662-09587-4_4
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