Skip to main content

Biologische Mechanismen der Chronifizierung — Konsequenzen für die Prävention

  • Chapter
Psychologische Schmerztherapie

Zusammenfassung

In den vergangenen Jahren erbrachten vielfältige elektrophysiologische und molekularbiologische Untersuchungen Hinweise auf die Beteiligung zentralnervöser Strukturen an der Entwicklung und Aufrechterhaltung von Sensitivierungsvorgängen, die in der Folge zu chronischem Schmerz führen können. Darüber hinaus wurde zunehmend deutlich, dass neben somatischen Faktoren insbesondere psychosoziale Faktoren am Prozess der Chronifizierung wesentlich beteiligt sind. Es steht daher zu vermuten, dass auf der Basis eines durch somatische Faktoren bedingten chronischen Schmerzes im Verlauf einer jahrelangen Schmerzerkrankung ein die gesamte Person einnehmender chronifizierter Schmerz entstehen kann.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 54.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Literatur

  • Baron R, Saguer M (1993) Postherpetic neuralgia. Are C-nociceptors involved in signalling and maintenance of tactile allodynia? Brain 116:1477–1496

    Article  PubMed  Google Scholar 

  • Becera L, Breiter HC, Wise R, Gonzalez G, Borsook D (2001) Reward circuitry activation by noxious thermal stimuli. Neuron 32:927–946

    Article  Google Scholar 

  • Besson JM (1999) The neurobiology of pain. Lancet 353: 1610–1615

    Article  PubMed  CAS  Google Scholar 

  • Bromm B, Lorenz J (1998) Neurophysiological evaluation of pain.Electroenceph Clin Neurophysiol 107:227–253

    Article  PubMed  CAS  Google Scholar 

  • Büchel C, Coull JT, Friston KJ (1999) The Predictive Value of Changes in Effective Connectivity for Human Leanrning. Science 283:1538–1541

    Article  PubMed  Google Scholar 

  • Flor H, Elbert T, Knecht S et al. (1995) Phantom-limb pain as a perceptual correlate of cortical reorganisation following arm amputation. Nature 375:482–484

    Article  PubMed  CAS  Google Scholar 

  • Hunt SP, Pini A, Evan G (1987) Induction of c-fos-like proteins in spinal cord neurons following sensory stimulation. Nature 328:632–634

    Article  PubMed  CAS  Google Scholar 

  • Jones AKP, Cunningham VJ, Ha-Kawa S et al. (1994) Original Scientific Papers — Changes in Central opioid Receptor Binding in Relation to Inflammation and Pain in Patients with Rheumatoid Arthritis. Br J Rheumatol 33:909–916

    Article  PubMed  CAS  Google Scholar 

  • Kandel ER (2001) The molecular biology of memory storage: a dialogue between genes and synapses. Science 294: 1030

    Article  PubMed  CAS  Google Scholar 

  • McQuay HJ (1994) Do Preemptive treatments provide better pain control? In: Gebhart FG, Hammond DL, Jensen TS (eds) Proceedings of the 7th World Congress on Pain, Progress in Pain Research and Management, vol 2. IASP Press, Seattle

    Google Scholar 

  • Melzack R, Casey KL (1968) Sensorymotivational and central control determinants of pain. In: Kenshalo DR (ed) The skin senses. CC Thomas, Springfield, pp 423–439

    Google Scholar 

  • Melzack R, Coderre TJ, Katz J, Caccarino AL (2001) Central neuroplasticity and pathological pain. Ann N Y Acad Sci 933:157–174

    Article  PubMed  CAS  Google Scholar 

  • Miltner WHR, Braun C, Arnold M, Witte H, Taub E (1999) Coherence of gamma-band EEG activity as a basis for associative learning. Nature 397:434–436

    Article  PubMed  CAS  Google Scholar 

  • Mogil JS (1999) The genetic mediation of individual differences in sensitivity to pain and its inhibition (nociception/gene mapping/strain difference). Proc Natl Acad Sci USA 96:7744–7751

    Article  PubMed  CAS  Google Scholar 

  • Petrovic P, Kalso E, Petersson KM, Ingvar M (2002) Placebo and Opioid Analgesia — Imaging a Shared Neuronal Network. Science 295:1737–1740

    Article  PubMed  CAS  Google Scholar 

  • Peyron R, Laurent B, Garcia-Larrea L (2000) Functional imaging of brain responses to pain. A reviw and meta-analysis. Neurophysiol Clin 2000/30:63–88

    Google Scholar 

  • Ploghaus A,Tracey I, Gati JS, Clare S, Menon RS, Matthews PM, Rawlins JNP (1999) Dissociation pain from its anticipation in the human brain. Science 284:1979–1981

    Article  PubMed  CAS  Google Scholar 

  • Rainville P, Duncan GH, Prive DD, Carrier B, Bushneil MC (1997) Pain affect encoded in human anterior cingulate but not somatosensory cortex. Science 277:968–971

    Article  PubMed  CAS  Google Scholar 

  • Sandkühler J (1996) Neurobiology of spinal nociception: new concepts. Prog Brain Res 110:207–224

    Article  PubMed  Google Scholar 

  • Tölle TR, Bethele A, Schadrack J, Zieglänsberger W (1996) Involvement of flutamatergic neurotransmission and protein kinase C in spinal plasticity and the development of chronic pain. Prog Brain Res 110:193–206

    Article  PubMed  Google Scholar 

  • Tölle TR, Kaufmann T, Siessmeier T et al. (1999) Region-specific encoding of sensory and affective components of pain in the human brain: A positron emission tomography correlation analysis. Ann Neurol 45/1:40–47

    Article  PubMed  Google Scholar 

  • Tölle TR, Schadrack J, Castro-Lopes JM, Zieglgänsberger W (1995) Immediate-early genes in noiception.In:Tölle TR, Schradack J, Zieglgänsberger W (Hrsg) Immediate-early genes in the central nervous system. Springer, Berlin Heidelberg New York Tokio, pp 51–77

    Chapter  Google Scholar 

  • Tölle TR, Schadrack J, Castro-Lopes JM, Evan G, Roques BP und Zieglgänsberger W (1994) Effects of Kelatorphan and Morphine before and after noxious nxious stimulation on immediate-early gene expression in rat spinal cord neurons. Pain 56, 103–112

    Article  PubMed  Google Scholar 

  • Tölle TR, Wester HJ, Schwaiger M,Contrad B, Bartenstein P,Willoch F (2000) The cingulate cortex in acute and chronic pain: H2 150, 18FDG, and 11C-Diprenorphine PET Studies. In: Devor M, Rowbotham MC, Wiesenfeld-Hallin Z (eds) Proceedings of the 9th World Congress on Pain, Progress in Pain Research and Management, vol 16. IASP Press, Seattle

    Google Scholar 

  • Treede RD, Kenshalo DR, Gracely RH, Jones AK (1999/2000) The cortical representation of pain. Pain 79/2–3:105–11, Pain 84/2–3:442–444

    Google Scholar 

  • Urban MO, Gebhart GF (1999) Supraspinal contributions to hyperlagesia. Proc Natl Acad Sci USA 96:7687–7692

    Article  PubMed  CAS  Google Scholar 

  • Wagner KJ, Willoch F, Kochs EF et al. (2001) Dose dependent regional cerebral blood flow changes during remifentanil infusion in human: a positron emisson tomography study. Anaesthesiology 94/5:732–739

    Article  CAS  Google Scholar 

  • Wall PD (1988) The prevention of postoperative pain. Pain 33:289–290

    Article  PubMed  CAS  Google Scholar 

  • Wiech K, Preißl H, Birbaumer N (2001) Neuronale Netzwerke und Schmerzverarbeitung — Ergebnisse bildgebender Verfahren. Anesthesist 2001 50:2–12

    Article  Google Scholar 

  • Willoch F, Rosen G,Tölle TR et al. (2000) Phantom limb pain in the human brain: unraveling neural circuities of phantom limb sensations using positron emission tomography. Ann Neurol 48:842–849

    Article  PubMed  CAS  Google Scholar 

  • Willoch F, Tölle TR, Wester HJ et al. (1999) Central pain after pontine infarction is associated with changes in opioid receptor binding: a PET study with 11C-Diprenorphine. Am J Neuroradiol 20:686–690

    PubMed  CAS  Google Scholar 

  • Woolf CJ (1983) Evidence of a central component of post-injury pain. Nature 306:686–688

    Article  PubMed  CAS  Google Scholar 

  • Woolf CJ, Mannion RJ (1999) Neuropathic pain: aetiology, symptoms, mechanisms, and managment. Lancet 353:1959–1964

    Article  PubMed  CAS  Google Scholar 

  • Zubieta J-K, Smith YR, Bueller JA et al. (2001) Reginal Mu opioid receptor regulation of sensory and affective dimensions of pain. Science 293:311–315

    Article  PubMed  CAS  Google Scholar 

Download references

Authors

Rights and permissions

Reprints and permissions

Copyright information

© 2004 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Tölle, T.R., Berthele, A. (2004). Biologische Mechanismen der Chronifizierung — Konsequenzen für die Prävention. In: Psychologische Schmerztherapie. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-09587-4_4

Download citation

  • DOI: https://doi.org/10.1007/978-3-662-09587-4_4

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-662-09588-1

  • Online ISBN: 978-3-662-09587-4

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics