Innate Immune Responses in Viral Encephalitis

  • C. S. Reiss
  • D. A. Chesler
  • J. Hodges
  • D. D. C. Ireland
  • N. Chen
Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 265)

Abstract

Innate immunity in the central nervous system (CNS) is essential in host responses to pathogens. The brain does not have the continuous monitoring by T cells engaged in immune surveillance nor the lymphatic drainage that are characteristic of the periphery. Similarly, the brain has specialized non-renewing neurons, and thus the effector mechanisms of the peripheral immune system which permit swelling (incompatible with a bony skull) and eliminate infected cells by apoptosis are modified.

Keywords

Migraine Superoxide Aspirin Prostaglandin Glucocorticoid 

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Copyright information

© Springer-Verlag Berlin Heidelberg 2002

Authors and Affiliations

  • C. S. Reiss
    • 1
  • D. A. Chesler
    • 1
  • J. Hodges
    • 1
  • D. D. C. Ireland
    • 1
  • N. Chen
    • 1
  1. 1.Biology DepartmentNew York UniversityNew YorkUSA

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