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Immune Responses in Glioblastoma: an Avenue to Effective Cancer Therapy or a Mere Epiphenomenon?

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Protective and Pathological Immune Responses in the CNS

Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 265))

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Abstract

Glioblastoma multiforme is the most aggressive and unfortunately the most common brain tumor. Malignant gliomas account for one third of all brain tumors. The future of patients diagnosed with glioblastoma is grim: most of them die within a year and even the most intricate attempts at therapy generally fail (Hill et al. 1999; Holland 2000; Kleihues and Cavenee 2000). Glioblastomas are genetically and morphologically extremely heterogenous, with regions of necrosis and hemorrhage, palisading tumor cells, and infiltration zones surrounded by locally activated microglial cells, a resident monocytic cell population of the brain. Typical for glioblastomas are microvascular infiltrations, a sign of massive neovascularization (Fig. 1) that is so consistent that it is used in tumor classification. Infiltration by immune cells is regionally heterogenous, but occasionally massive leukocytic infiltrations are observed.

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Authors and Affiliations

  1. Institute of Brain Research, University of Tuebingen, Calwer Strasse 3, 72076, Tuebingen, Germany

    H. J. Schluesener, R. Meyermann & M. Deininger

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  1. H. J. Schluesener
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  2. R. Meyermann
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  3. M. Deininger
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Editors and Affiliations

  1. Department of Microbiology and Immunology, Thomas Jefferson University Philadelphia, 1020 Locust St., 19107-6799, Philadelphia, PA, USA

    Bernhard Dietzschold

  2. USDA-ARS-National Animal Disease Center, 2300 Dayton Ave, P.O. Box 70, 50010, Ames, IA, USA

    Jürgen A. Richt D.V.M., Ph.D.

  3. Institute of Virology, Justus-Liebig-Universität Giessen, Frankfurter Str. 107, 35392, Giessen, Germany

    Jürgen A. Richt D.V.M., Ph.D.

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Schluesener, H.J., Meyermann, R., Deininger, M. (2002). Immune Responses in Glioblastoma: an Avenue to Effective Cancer Therapy or a Mere Epiphenomenon?. In: Dietzschold, B., Richt, J.A. (eds) Protective and Pathological Immune Responses in the CNS. Current Topics in Microbiology and Immunology, vol 265. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-09525-6_13

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