HTLV-1-Mediated Immunopathological CNS Disease

  • B. Kitze
  • K. Usuku
Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 265)


Human T-lymphotropic virus 1 (HTLY-1) was the first known human retrovirus. It was discovered in a patient with cutaneous T cell lymphoma (Poiesz et al. 1980; Reitz et al. 1981). A little later, Japanese and American researchers established that this retrovirus was the cause of adult T cell lymphoma/leukemia (ATL), a characteristic lymphoma recognized in Japan years before (Uchiyama et al. 1977). Nervous system involvement had been shown in murine leukemia virus (MLV; Pal et al. 1983) and human immunodeficiency virus (HIV) infections (Snider et al. 1983). Therefore several research groups investigated in short succession patients with chronic progressing myelopathies, called tropical spastic paraparesis (TSP) in tropical countries, for antiretroviral antibodies (Gessain et al. 1985; Rodgers-Johnson et al. 1985; Osame et al. 1986). They clearly established that a majority of the patients had serum antibodies to HTLV-1. Subsequently, a new disease entity was defined and called HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP; Osame 1990).


Spastic Paraparesis Tropical Spastic Paraparesis High Proviral Load Specific Humoral Immune Response Photropic Virus Type 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer-Verlag Berlin Heidelberg 2002

Authors and Affiliations

  • B. Kitze
    • 1
  • K. Usuku
    • 2
  1. 1.Department of Neurology, Faculty of MedicineUniversity of GöttingenGöttingenGermany
  2. 2.Department of Medical Informatics, Faculty of MedicineUniversity of KagoshimaKagoshima 890Japan

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