Carcinoma of the Lung: Changing Sex Distribution and Histopathologic Cell Types

  • Armando E. Fraire
  • Sharon P. Cooper
  • S. Donald Greenberg
  • Patricia A. Buffler

Abstract

This hospital based study of 1391 patients with histopathologically documented carcinoma of the lung sought to determine the frequencies of major cell types over two 8 year periods (1971–1978 and 1979–1986). The 1391 patients were accessioned in the Cancer Registry Files of the Ben Taub General Hospital, Houston, Texas. Nine hundred and sixty six were men and 425 were women. Seven hundred and four (535 men, 169 women) were seen in the first period of 1971–1978 (Group A), and 687 (431 men, 256 women) were seen in the second period of 1979–1986 (Group B). This study showed the following statistically significant findings: (1) An increase in the proportion of women with carcinoma of the lung (p > 0.001); (2) A difference in the overall distribution of major cell types between men and women (p = 0.001); (3) A decrease in the proportion of squamous cell carcinoma among white men (p = 0.040); (4) An increase in the proportion of small cell carcinoma among white men (p = 0.007); and (5) An increase in the proportion of small cell carcinoma among white women (p = 0.017). This study further showed an increase in the proportion of adenocarcinoma in black and white men and women together (from 25.5% in Group A to 26.6% in Group B); however, this increase did not reach statistical significance. Furthermore, in contrast to previously published studies, our data did not show an increase of adenocarcinoma in women. The cause(s) for these changes remain unknown. However, an understanding of these shifting patterns of major histopathologic cell types is clinically relevant, since tumor cell type is a major determinant in the prognosis and treatment of lung cancer.

Keywords

Combustion Adenocarcinoma Uranium Beach Peri 

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Copyright information

© Springer-Verlag Berlin Heidelberg 1992

Authors and Affiliations

  • Armando E. Fraire
  • Sharon P. Cooper
  • S. Donald Greenberg
  • Patricia A. Buffler

There are no affiliations available

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