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Inhibition of fibrinolysis in blood: circadian fluctuation and possible relevance to coronary artery disease

  • F. Andreotti
  • G. J. Davies
  • A. Maseri
  • C. Kluft

Abstract

The end-product of coagulation is a clot with a fibrin meshwork. Fibrin, however, is not a permanent structure, but stimulates a biochemical pathway that leads to its lysis pathway and fragmentation of the clot. Essential components of this, as a consequence, are the plasminogen activators (PAs). PAs convert the zymogen plasminogen to the ultimate fibrinolytic enzyme plasmin (Fig. 1). At least two types of PAs have been identified in plasma: one produced and secreted by endothelial cells (first isolated in urine), called tissue-type PA (t-PA), and another called urinary-type PA or urokinase (UK). UK was later also identified in plasma, mainly as a proenzyme known as pro-urokinase (pro-UK). t-PA and pro-UK both activate plasminogen, preferentially in the presence of fibrin, but by different mechanisms (for review, see [5]).

Keywords

Plasminogen Activator Plasminogen Activator Inhibitor Fibrinolytic Activity Circadian Variation Fibrinolytic System 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin Heidelberg 1989

Authors and Affiliations

  • F. Andreotti
    • 1
  • G. J. Davies
    • 1
  • A. Maseri
    • 1
  • C. Kluft
    • 2
  1. 1.Cardiovascular Research Unit RPMSHammersmith HospitalLondonUK
  2. 2.TNO Gaubius InstituteLeidenThe Netherlands

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