Zusammenfassung
Die Aufklärung der molekulargenetischen Grundlagen der Krebsentsstehung hat in den letzten Jahren wesentliche neue Erkenntnisse erbracht, durch die es möglich geworden ist, Patienten mit einem familiär bedingten erhöhten Krebsrisiko aufgrund genetischer Untersuchungsmethoden zu identifizieren. Insbesondere bei den erblichen gastrointestinalen Karzinomen, allen voran der familiären polypösen Adenomatose (FAP) und dem nichtpolypösen kolorektalen Karzinom (HNPCC) konnten so neue interdisziplinäre klinische Konzepte entwickelt werden, die zu einer wesentlichen Verbesserung der Krebsvorsorge und -früherkennung beitragen.
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von Knebel Doeberitz, M., von Knebel Doeberitz, C., Gebert, J. (2001). Hereditäre Tumoren des Gastrointestinaltrakts. In: Siewert, J.R., Harder, F., Rothmund, M. (eds) Praxis der Viszeralchirurgie. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-09420-4_6
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