Skip to main content

Maligne viszerale Tumoren des Kindes

  • Chapter
Praxis der Viszeralchirurgie
  • 71 Accesses

Zusammenfassung

Das Neuroblastom und das Nephroblastom oder Wilms-Tumor zählen zu den häufigsten soliden malignen Tumoren des Bauchraums im Säuglings- und Kindesalter. Beide Tumorformen werden im Erwachsenenalter nur äußerst selten gesehen. Basierend auf der engen Zusammenarbeit mit der Deutschen Gesellschaft für Pädiatrische Onkologie und Hämatologie (GPOH) werden Therapieoptimierungsstudien wie die Neuro- und Nephroblastomstudie in Anlehnung an die Ergebnisse internationaler Studien durchgeführt und ausgewertet. Cirka 90% der Patienten werden hierdurch erfasst. Hauptziel dieser Studien ist die Dokumentation aller klinischen Daten, um Grundlagen für eine zukünftige hocheffiziente und möglichst untoxische Therapie zu erhalten. Weitere Ziele sind

  • die Verbesserung gegenwärtiger Therapien zur Verminderung der Behandlungskosten bezüglich er Akut- und Spättoxizität,

  • die Verbesserung der psychosozialen Aspekte der Chemotherapie und Bestrahlung sowie

  • die Verbesserung des Rezidivrisikos.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 54.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Literatur

  • Ambros PF, Ambros IM, Strehl S et al. (1995) Regression and progression in neuroblastoma. Does genetics predict tumour behaviour? Eur J Cancer 31: 510–515

    Article  Google Scholar 

  • American Society of Clinical Oncology (1994) Recommendations for the use of hematopoietic colony-stimulating factors: Evidence-based, clinical practice guidelines. J Clin Oncol 12: 2471–2508

    Google Scholar 

  • Beckwith JB, Kiviat NB, Bonadio JF (1990) Nephogenic rests, nephroblastomatosis, and the pathogenesis of Wilms’tumor. Pediatr Pathol 10: 1–36

    Article  PubMed  CAS  Google Scholar 

  • Berthold F, Hero B (2000) Neuroblastoma. Current drug therapy recommendations as part of the total treatment approach. Drugs 59: 1261–1277

    Google Scholar 

  • Berthold F, Kassenbömer R, Zieschang J(1994) Multivariate evaluation of prognostic factors in localized neuroblastoma. Am J Pediatr Hematol Oncol 16: 107–115

    Google Scholar 

  • Bordow SB, Norris MD, Haber PS, Marshall GM, Haber M (1998) Prognostic significance of MYCN oncogene expression in childhood Neuroblastoma. J Clin Oncol 16: 3286–3294

    PubMed  CAS  Google Scholar 

  • Breslow NE, Norkool PA, Olshan A, Evans A, D’Angio G (1988) Second malignant neoplasm in survivors of Wilms’ tumor: A report from the national Wilms’ tumor study. J Natl Cancer Inst 80: 592–595

    Google Scholar 

  • Brodeur GM (1995) Molecular basis for heterogenity in human neuroblastomas. Eur J Cancer 31: 505–510

    Article  Google Scholar 

  • Brodeur GM, Seeger RC, Schwab, M, Varmus HE, Bishop JM (1984) Amplifikation of N-myc in untreated human neuroblastomas correlates with advanced disease stage. Science 224: 1121–1124

    Article  PubMed  CAS  Google Scholar 

  • Carlsen NL, Ornvold K, Christensen IJ, Laursen H, Larsen JK (1992) Prognostic importance of DNA flow cytometrical, histopathological and immunhistochemical parameters in neuroblastoma. Virchows Arch A Pathol Anat Histopathol 420: 411–418

    Article  PubMed  CAS  Google Scholar 

  • Caron H (1995) Allelic loss of chromosome 1 and additional chromosome 17 materialare both of unfavourable prognostic markers in neuroblastoma. Med Pediatr Oncol 24: 215221

    Google Scholar 

  • Caron H, van Sluis P, de Kraker J et al. (1996) Allelic loss of chromosome 1p as a predictor of unfavorable outcome in patients with neuroblastoma. N Engl J Med 334: 225–230

    Article  PubMed  CAS  Google Scholar 

  • Christiansen H, Lampert F (1988) Tumour karyotype discriminates between good and bad prognostic outcome in neuroblastoma. Br J Cancer 57: 121–126

    Article  PubMed  CAS  Google Scholar 

  • Christiansen H, Sahin K, Berthold F, Hero B, Terpe HJ, Lampert F (1995) Comparison of DNA aneuploidy, chromosome 1 abnormalities, MYCN amplification and CD44 expression as prognostic factors in neuroblastoma. Eur J Cancer 31: 541–544

    Article  Google Scholar 

  • Donaldson S, Jundt S, Ricour C, Sarrazin D, Lemerle J, Schweisgut O (1975) Radiation enteritis in children. Cancer 35: 1167–1178

    Article  PubMed  CAS  Google Scholar 

  • Eberl W, Kwee T, Mau G (1991) Chylöser Aszites nach Tumornephrektomie mit retroperitonealer Lymphadenektomie. Monatsschr Kinderheilkd 139: 47–50

    PubMed  CAS  Google Scholar 

  • Evans AE, D’Angio GK, Randolph J (1971) A proposed staging for children with neuroblastoma. Cancer 27: 374–378

    Article  PubMed  CAS  Google Scholar 

  • Evans AE, D’Angio GJ, Probert K et al. (1987) Prognostic fac-tors in neuroblastoma. Cancer 59: 1853–1859

    Google Scholar 

  • Francke U, Holmes LB, Atkins L, Riccardi VM (1979) AniridiaWilms’tumor association: Evidence for specific deletion of 11p13. Cytogenet Cell Genet 24: 185–192

    Article  PubMed  CAS  Google Scholar 

  • Gehring M, Berthold F, Edler L, Schwab M, Amler LC (1995) The 1p deletion is not a reliable marker for the prognosis of patients with neuroblastoma. Cancer Res 55: 5366–5369

    PubMed  CAS  Google Scholar 

  • German Childhood Cancer Registry (GCCR) des Institutes für Medizinische Statistik und Dokumentation (IMSD) der Johannes Gutenberg-Universität Mainz, Annual Report 1998. Kaatsch P, Kaletsch U, Spix C, Michaelis J (Hrsg )

    Google Scholar 

  • Gundy P, Koufos A, Morgan K, Li FP, Meadows AT, Cavenee WK (1988) Familial predisposition to Wilms tumour does not map to the short arm of chromosome 11. Nature 336: 374–376

    Article  Google Scholar 

  • Gutjahr P ( 1993 b) Wilms-Tumor (Nephroblastom) In: Gutjahr P (Hrsg) Krebs bei Kindern und Jugendlichen. Deutscher Ärzte Verlag, Köln, S 329–348

    Google Scholar 

  • Gutjahr P ( 1993 a) Neuroblastome. In: Gutjahr P (Hrsg) Krebs bei Kindern und Jugendlichen. Deutscher Ärzte Verlag, Köln, S 349–367

    Google Scholar 

  • Gutjahr P, Kaatsch P, Spaar HJ et al. (1990) Klinik, Therapie und Prognose bei 373 Kindern mit Wilms-Tumoren–Ergebnisse der bundesweiten Studie 1980–1988. Akt Urol 21: 132–141

    Article  Google Scholar 

  • Haber DA, Buckler AJ, Glaser T et al. (1990) An internal deletion within an l 1p 13 zinc finger gene contributes to the development of Wilms tumor. Cell 61: 1257–1269

    Article  PubMed  CAS  Google Scholar 

  • Harms D, Schmidt D, Leuschner I (1989) Neue Aspekte der Nephroblastome ( Wilms-Tumoren) und anderer metanephrogener Neoplasmen. Verh Dtsch Ges Pathol 73: 350–371

    Google Scholar 

  • Heidemann RL, Haase GM, Foley Chl, Wilson HL, Bailey WC (1985) Nephroblastomatosis and Wilms’ tumor. Clinical experience and management of seven patients. Cancer 55: 1446–1451

    Google Scholar 

  • Hennigar RA, Othersen HB, Garvin AJ (1989) Clinicopatholo-gic features of nephroblastomatosis. Urology 33: 259–270

    Article  PubMed  CAS  Google Scholar 

  • Henry I, Grandjouan I, Coullin P et al. (1989) Tumor-spezificloss of l 1p 15.5 alleles in del l 1p 13 Wilms tumor and in fa-milial adrenocortical carconoma. Proc Natl Acad Sci USA 86: 3247–3251

    Article  PubMed  CAS  Google Scholar 

  • Hiyama E, Hiyama K, Yokoyama T, Matsuura Y, Piatyszek MA, Shay JW (1995) Correlating telomerase activity levels with human neuroblastoma outcomes. Nat Med 1: 249–255

    Article  PubMed  CAS  Google Scholar 

  • Huber A, Gutjahr P (1989) Mediastinales Neuroblastom bei Wiedemann-Beckwith-Syndrom. Monatsschr Kinderheik 137: 243–244

    CAS  Google Scholar 

  • Hudges M, Marsden HB, Palmer MK (1974) Histologic patterns of neuroblastoma related to prognosis and clinical staging. Cancer 34: 1706–1711

    Article  Google Scholar 

  • Huff V, Miwa H, Haber DA, Call KM, Housman D, Strong LC, Saunders GF (1991) Evidence for WT1 as a Wilms tumor ( WT) gene: Intragenic germinal deletion in bilateral WT. Am J Hum Genet 48: 997–1003

    Google Scholar 

  • Isaacs H Jr (1991) Neuroblastoma. In: Isaacs H Jr (ed) Tumors of the newborn and infant. Mosby Year Book, St. Louis, pp 22–42

    Google Scholar 

  • Knudson AG, Strong LC (1972) Mutation and cancer: A model for Wilms’ tumor of the kidney. J Natl Cancer Inst 48: 313324

    Google Scholar 

  • Koufos A, Grundy P, Morgan K et al. (1989) Familial Wiedemann-Beckwith syndrome and a second Wilms’ tumor locus map to l 1p 15.5. Ann Hum Genet 44: 711–719

    CAS  Google Scholar 

  • Look AT, Hayes FA, Shuster JJ et al. (1991) Clinical relevance of tumor cell ploidy and N-myc gene amplification in childhood neuroblastoma: A Pediatric Oncology Group study. J Clin Oncol 9: 581–591

    PubMed  CAS  Google Scholar 

  • Lopez R, Karakousis C, Rao U (1980) Treatment of adult neuro-blastoma. Cancer 45: 840–844

    Article  PubMed  CAS  Google Scholar 

  • Maitra A, Yashima K, Rathi A, Timmons CF, Rogers BB, Shay JW, Gazdar AF (1999) The RNA component of telomerase as a marker of biologic potential and clinical outcome in childhood neuroblastic tumors. Cancer 85: 741–749

    Article  PubMed  CAS  Google Scholar 

  • Marx JL (1984) The N-myc oncogene in neural tumors. Science 224: 1088

    Article  PubMed  CAS  Google Scholar 

  • Nephroblastomstudie SIOP 93–01/GPOH (1993) Neuroblstomstudie NB 97

    Google Scholar 

  • Norris MD, Bordow SB, Marshall GM, Huber PS, Cohn SL, Haber M (1996) Expression of the gene for multidrug-resistance-associated protein and outcome in patients with neuro-blastoma. N Engl J Med 334: 231–238

    Article  PubMed  CAS  Google Scholar 

  • Oberlin 0, Tournade MF, Daltroff G et al. (1989) Hepatic toxicity compatible with veinoocclusive disease ( VOD) after actinomycin D in non-irradiated Wilms’ tumors. Med Ped On-col 17: 317

    Google Scholar 

  • Pelletier J, Bruening W, Kashtan CE et al. (1991) Germline mutations in the Wilms tumor suppressor gene are associated with abnormal urogenital development in Denys-Drash syndrome. Cell 67: 437–447

    Article  PubMed  CAS  Google Scholar 

  • Pendergrass TW (1976) Congenital anomalies in children with Wilms’ tumor, a new survey. Cancer 37: 403–408

    Article  PubMed  CAS  Google Scholar 

  • Ping AJ, Reeve AE, Law DJ, Young MR, Boehnke M, Feinberg AP (1989) Genetic linkage of Beckwith-Wiedemann syndrome to l 1p 15. Am J Hum Genet 44: 720–723

    PubMed  CAS  Google Scholar 

  • Riccardi VM, Sujansky E, Smith AC, Francke U (1978) Chro-mosomal imbalance in the aniridia-Wilms’ tumor association 1 l interstitial deletion. Pediatrics 61: 604–610

    PubMed  CAS  Google Scholar 

  • Ritchey M, Kelalis PP, Breslow N, Etzioni R, Evans I, Haase GM, D’Angio GJ (1992) Surgical complications after nephrectomy for Wilms’ tumor. Surg Gynecol Obstet 175: 507–514

    PubMed  CAS  Google Scholar 

  • Roth H, Weirich A, Ludwig R, Daum R, Zimmermann H (1996) Die Resektion der Nephroblastoms: Probleme und Komplikationen–Auswertungen zur Nephroblastomstudie SIOP 9/ GPOH. Langenbecks Arch Chir Suppl II (Kongreßbericht 1996): 1078–1083

    Google Scholar 

  • Savelayeva L, Corvi R, Schwab M (1994) Translocation involving 1p and 17q is a recurrent genetic alteration of human Neuroblastoma cells. Am J Hum Genet 55: 334–340

    Google Scholar 

  • Schmidt D, Harms D (1983) Histologie und Prognose des Nephroblastoms unter Berücksichtigung der Sondervarianten. Klin Pädiatr 195: 214–221

    Article  PubMed  CAS  Google Scholar 

  • Schwab M (1991) Is there a neuroblastoma anti-oncogene? Prog Clin Biol 366: 1–9

    CAS  Google Scholar 

  • Schwab M, Ellison J, Busch M, Rosenau W, Varmus HE, Bishop JM (1984) Enhanced expression of the human gene N-myc consequent to amplification of DNA may contribute to malignant progressions of neuroblastoma. Proc Natl Acad Sci U S A 81: 4940–4944

    Article  PubMed  CAS  Google Scholar 

  • Schwartz CE, Haber DE, Stanton VP, Strong LC, Skolnick MH, Housman DE (1991) Familial predisposition to Wilms tumor does not segregate with the WT1 gene. Genomics 10: 927–930

    Article  PubMed  CAS  Google Scholar 

  • Seeger RC, Brodeur GM, Sather H, Dalton A, Siegel SE, Wong KY, Hammond D (1985) Association of multiple copies of the N-myc oncogene with rapid progression of neuroblastomas. N Engl. J Med 313: 1111–1116

    Google Scholar 

  • Staehler G, Liedl B, Kreuzer E, Sturm W, Schmiedt E (1987) Kidney cancer with invasion of the vena cava: Classification, surgical strategy and results of treatment. Urologe A 26: 46–50

    Google Scholar 

  • Thomas PRM, Tefft M, Compaan PJ, Norkool PP, Breslow NE, D’Angio GJ (1991) Results of two radiation therapy randomizations in the third National Wilms Tumor Study. Cancer 68: 1703–1707

    Article  PubMed  CAS  Google Scholar 

  • Träger J, Weirich A, Rieden K, Raschke K, Ludwig R, Schmidt D, Gamroth AH (1991) Zuverlässigkeit der Bildgebung vor präoperativer Chemotherapie: Erste Ergebnisse der Nephroblastomstudie SIOP 9/GPO. Zentralbl Radiol 144: A30, 641

    Google Scholar 

  • UICC/Union Internationale Contre le Cancer (1989) TNM Atlas. Illustrated guide to the TNM/pTNM-classification of malignant tumors (ed: Spiessl B). Springer, Berlin Heidelberg New York Tokyo, pp 322–328

    Google Scholar 

  • Weirich A, Rieden K, Träger J, Schmidt D, Ludwig R (1991) Diagnostische Sicherheit der bildgebenden Verfahren beim Nephroblastom vor präoperativer Chemotherapie: Erste Ergebnisse. Klin Pädiatr 203: 251–256

    Google Scholar 

  • Zeller W, Gutensohn K, Stockschläder M et al. (1996) Increase of mobilized CD34-positive peripheral blood progenitor cells in patients with Hodgkin’s disease, non-Hodgkin’s lymphoma, and cancer of the testis. Bone Marrow Transplantation 17: 709–713

    PubMed  CAS  Google Scholar 

Download references

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2001 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Roth, H.G., Daum, R. (2001). Maligne viszerale Tumoren des Kindes. In: Siewert, J.R., Harder, F., Rothmund, M. (eds) Praxis der Viszeralchirurgie. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-09420-4_44

Download citation

  • DOI: https://doi.org/10.1007/978-3-662-09420-4_44

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-662-09421-1

  • Online ISBN: 978-3-662-09420-4

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics