Skip to main content

Chirurgische Therapie von Karzinomen der extrahepatischen Gallenwege und der Gallenblase

  • Chapter
Praxis der Viszeralchirurgie

Zusammenfassung

Die Behandlung von Malignomen der Gallenblase und der extrahepatischen Gallenwege stellt eine besondere Herausforderung dar. Bis heute ist wegen der bei diesen Tumoren nur selten realisierten Frühdiagnose und ihrer engen anatomischen Lagebeziehung zu komplexen Nachbarstrukturen bzw. anderen Organen allenfalls eine Minderheit der betroffenen Patienten chirurgisch kurativ resezierbar. Endoskopische und/oder radiologisch-interventionelle Verfahren haben eine zunehmende Bedeutung innerhalb interdisziplinärer Palliationskonzepte. Primär palliativ orientierte chirurgische Operationsverfahren verlieren komplementär an Stellenwert. Ausgewählten Patienten kann jedoch durch eine adäquate chirurgische Therapie eine ernstzunehmende Heilungschance bei akzeptabler perioperativer Morbidität eröffnet werden. Hierzu adjuvante chemo- wie auch strahlentherapeutische Verfahren befinden sich meist noch in Entwicklungs- bzw. Erprobungsstadien. In den folgenden Abschnitten werden die Grundsätze heute etablierter chirurgischer Behandlungsstrategien aufgezeigt.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 54.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Literatur

  • Adler A, Velzke W, Abou-Rebyeh H et al. (1997) Follow up in patients with Klatskin tumor type III after combined stenting, embolsation and partial liver resection. Gastroenetrology 112: A530

    Article  Google Scholar 

  • Adkins RB Jr, Chapman WC, Reddy VS (2000) Embryology, anatomy, and surgical applications of the extrahepatic biliary system. Surg Clin North Am 80: 363–379

    Article  PubMed  Google Scholar 

  • Albores-Saavedra J, Henson DE, Sobin H (1991) Histological typing of tumors of the gallbladder and extrahepatic bile ducts, 2nd edn. In: WHO International histological classification of tumors. Springer, Berlin Heidelberg New York Tokyo

    Book  Google Scholar 

  • Allessiani M, Tzakis A, Todo S et al. (1995) Assessment of 5-year experience with abdominal organ cluster transplantation. J Am Coll Surg 180: 1–9

    Google Scholar 

  • Altae MY, Johnson PJ, Farrant JM et al. (1991) Etiological and clinical characterstics of peripheral and hilar cholangiocarcinoma. Cancer 68: 2051–2055

    Article  Google Scholar 

  • Altemeier WA, Gall EA, Zinninger MM et al. (1957) Sclerosing carcinoma of the major intrahepatic bile ducts. Ann Surg 75: 450–461

    CAS  Google Scholar 

  • Anderson JB, Cooper MJ, Williamson RCN (1985) Adenocarcinoma of the extrahepatic biliary tree. Ann R Coll Surg Engl 67: 139–143

    PubMed  CAS  Google Scholar 

  • Azuma T, Yoshikawa T, Araida T, Takasaki K (1999) Intraoperative evaluation of the depth of invasion of gallbladder cancer. Am J Surg 178: 381–384

    Article  PubMed  CAS  Google Scholar 

  • Ballinger AB, Mc Hugh M, Catnach SM, Alstead EM, Clark ML (1995) Symptom relief and quality of life after stenting for malignant bile duct obtstruction. Gut 35: 467–470

    Article  Google Scholar 

  • Baer HU, Rhymer M, Stain SC et al. (1994) The effect of communication between the right and left liver on the outcome of surgical drainage for jaundice due to malignant obstruction at the hilus of the liver. HPB Surg 8: 27–31

    Article  PubMed  CAS  Google Scholar 

  • Baillie J (1999) Tumors of the gallbladder and bile ducts. J Clin Gastroenterol 29: 14–21

    Article  PubMed  CAS  Google Scholar 

  • Banarjee B, Teplick S (1995) Nonsurgical management of primary cholangiocarcinoma. Rterospective analysis of 40 cases. Dig Dis Sci 40: 701–705

    Article  Google Scholar 

  • Barlett DL, Fong Y, Fortner JG, Brennan MF, Blumgart LH (1996) Long-term results after resection for gallbladder cancer. Implications for staging and management. Ann Surg 224: 639–643

    Google Scholar 

  • Beahrs OH, Henson DE, Hutter RVP, Myers (eds) (1988) Manual for staging cancer. JB Lippincott, Philadelphia

    Google Scholar 

  • Beazley RM, Hadjis N, Benjamin IS, Blumgart LH (1984) Clinicopathological aspects of high bile duct cancer. Ann Surg 199: 623–626

    Article  PubMed  CAS  Google Scholar 

  • Becker CD, Glatti A, Maibach R, Baer HU (1993) Percutaneous palliation of malignant obstructive jaundice with Wallstent endoprosthesis: Follow-up and reintervention in patients with hilar and non-hilar obstruction. J. Vasc Intery Radiol 4: 597–604

    Google Scholar 

  • Beckurts KTE, Hölscher AH, Bauer TH, Siewert JR (1997) Maligne Tumoren der Hepaticusgabel - Ergebnisse der chirurgischen Therapie and Prognosefaktoren. Chirurg 68: 378384

    Google Scholar 

  • Bengmark S, Tranberg KG (1988) Surgical management in high bile duct tumors. In: Bengmark S (ed) Progress in surgery of the liver, pancreas and biliary system. Martinus Nijhof, The Hague, pp 214–227

    Google Scholar 

  • Bengmark S, Ekberg H, Evander A et al. (1988) Major liver resection for hilar cholangiocarcinoma. Ann Surg 207: 120125

    Google Scholar 

  • Benoist S, Panis Y, Fagnies PL (1998) Long-term results after curative resection for carcinoma of the gallbladder. French University Association for Surgical Research. Am J Surg 175: 118–122

    Google Scholar 

  • Bergquist A, Glaumann H, Persson B et al. (1998) Risk factors and clinical presentation of hepatobiliary carcinoma in patients with primary sclerosing cholangitis: A case-control study. Hepatology 27: 311–316

    Google Scholar 

  • Berk RN, Armbruster TG, Saltzstein SL (1993) Carcinoma in the porcelain gallbladder. Radiology 106: 29–31

    Google Scholar 

  • Berr F, Tannapfel A, Pahernik S et al. (1997) Selektive lokale Destruktion von Gallengangskarznomen mit photodynamischer Therapie. Endoskopie heute 10: 145

    Google Scholar 

  • Bismuth H (1982) Surgical anatomy and anatomical surgery of the liver. World J Surg 6: 3–9

    Article  PubMed  CAS  Google Scholar 

  • Bismuth H (2000) Revisting liver transplantation for patients with hilar cholangiocarcinoma: The Mayo Clinic proposal (editorial; comment). Liver Transplant 6: 317–319

    Article  CAS  Google Scholar 

  • Bismuth H, Corlette MB (1957) Intrahepatic cholangioenteric anastomosis in carcinoma of the hilus of the liver. Surg Gynecol Obstet 140: 170

    Google Scholar 

  • Bismuth H, Krissat J (1999) Choledochal cystic malignancies. Ann Oncol 10 Suppl 4: 94–98

    Article  Google Scholar 

  • Bismuth H, Houssin D, Castaing D (1982) Major and minor segmentectomies „reglees“ in liver surgery. World J Surg 6: 10–24

    Article  PubMed  CAS  Google Scholar 

  • Bismuth H, Castaing D, Traynor 0 (1988) Resection or palliation. Priority of surgery in the treatment of hilar cancer. Worl J Surg 12: 39–47

    Google Scholar 

  • Bismuth H, Nakache R, Diamond T (1992) Management strategies for resection of hilar cholangiocarcinoma. Ann Surg 215: 31–37

    Article  PubMed  CAS  Google Scholar 

  • Bloom CM, Langer B, Wilson SR (1999) Role of US in the detection, characterization and staging of cholangiocarcinoma. Radiographics 19: 119–128

    Google Scholar 

  • Blumgart LH, Benjamin IS (1989) Liver resection for bile duct cancer. Surg Clin North Am 69: 323–337

    PubMed  CAS  Google Scholar 

  • Bornmann PC, Krige JEJ (1997) Surgical palliation of pancreatic and periampullary tumors. In: Trede M, Carter DC (eds) Surgery of the pancreas. Churchill Livingstone, New York, pp 533–540

    Google Scholar 

  • Braasch JW, Rossi RL, Watkins E et al. (1996) Pyloric and gastric preserving pancreatic resection. Ann Surg 20: 411–418

    Google Scholar 

  • Burhans R, Myers RT (1971) Benign neoplasms of the extrahepatc biliary ducts. Am Surg 37: 161–166

    PubMed  CAS  Google Scholar 

  • Burke EC, Jarnagin WR, Hochwald SN, Pisters PW, Fong Y, Blumgart LH (1998) Hilar cholangiocarcinoma: Patterns of spread, the importance of hepatic resection for curative operation, and a presurgical clinical staging system. Ann Surg 228: 385–394

    Google Scholar 

  • Calleri MP, Strasberg SM, Doherty GM et al. (1997) Staging laparoscopy with laparoscopic ultrasonography: Optimizing resectability in hepatobiliary and pancreatic malignancy. J Am Coll Surg 185: 33–39

    Google Scholar 

  • Cameron JL (1993) Klatskin tunor resection. In: Skinner DB (ed) Atlas of biliar tract surgery. Churchill Livingstone, New York, pp 100–115

    Google Scholar 

  • Cameron JL, Broe P, Zuidema G (1998) Proximal bile duct tumors. Surgical management with silastic transhepatic biliary stents. World J Surg 6: 76–80

    Google Scholar 

  • Carr-Locke D, Ball TJ, Connors PJ et al. (1993) Multicenter randomized trial of wallstent biliary endoprosthesis versus plastic. Gastrointest Endosc 39: 310

    Google Scholar 

  • Castaing D, Azoulay D, Fecteau AH, Bismuth H (1998) Implantable hepatic arterial infusion device: Placement without laparotomy via an intercostal artery. J Am Coll Surg 187: 565568

    Google Scholar 

  • Castaing D, Azoulay D, Bismuth H (1999) Ponction percutanee de l’anse intestinale d’une hepatico-jejunostomie: Une nouvelle possibilite dans le traitment de lesions biliares complexes. Gastroenterol Clin Biol 23: 882–886

    Google Scholar 

  • Chalasani N, Balayut A, Ismail A, Zaman A et al. (2000) Cholangiocarcinoma in patients with primary sclerosing cholangitis: A multicenter case-control study. Hepatology 31: 7–11

    Google Scholar 

  • Chamberlain RS, Blumgart LH (2000) Hilar cholangiocarcinoma: A review and comment. Ann Surg Oncol 7: 55–66 Chang WH, Kortan PH, Haber GB (1998) Outcome in patients with bifurcation tumors who undergo unilateral versus biateral hepatic duct drainage. Gastrointest Endosc 47: 354–362 Chapman RW (1999) Risc factors for biliary tract carcinogenesis. Ann Oncol 10: 308–311

    Google Scholar 

  • Cherqui D, Benoist S, Malassagne B, Humeres R, Rodriguez V, Fagnies PL (2000) Major liver resection for carcinoma in jaundiced patients without preoperative biliary drainage. Arch Surg 135: 302–308

    Article  PubMed  CAS  Google Scholar 

  • Cheung KL, Lai ECS (1995) Endoscopic stenting for maligant biliary obstruction. Arch Surg 130: 204–207

    Article  PubMed  CAS  Google Scholar 

  • Chijiiwa K, Tanaka M (1994) Carcinoma of the gallbladder: An appraisal of surgical resection. Surgery 115: 751–756 Chung C, Bautista N, O’Connel TX (1998) Prognosis and treatment of bile duct carcinoma. Am Surg 64: 921–925 Confalonieri F, Ballerini A (1998) Palliative cholangiojejunostomy on the duct of hepatic segment III. Minerva Chir 53: 709–714

    Google Scholar 

  • Colombardi R, Tsui WMS (1995) Biliary tumors of the liver. Se-min Liv Dis 15: 402–413

    Article  Google Scholar 

  • Costamagna G, Multignani M, Perri V et al. (1995) Results of endoscopic biliary drainage in primary tumors of the common bile duct. Chir Ital 47: 18–23

    PubMed  CAS  Google Scholar 

  • Couinaud C (1957) Le foie - studies anatomique et chirurgicales. Masson, Paris

    Google Scholar 

  • Craig JR, Peters RL, Edmunson HA (1989) Tumors of the liver and intrahepatic bile ducts. Atlas of tumor pathology. Armed Forces Institute of Pathology, Washington/DC

    Google Scholar 

  • Cubertafond P, Mathonnet M, Gainant A, Launois B (1999) Radical surgery for gallbladder cancer. Results of the French surgical association survey. Hepatogastroenterology 46: 1567–1571

    Google Scholar 

  • Curley SA, Levin B, Rich TA (1995) Management of specific maligancies: Liver and bile ducts. In: Abelhof MD, Armitage JO, Lichter AS, Niederhuber JE (eds) Clinical oncology. Churchill Livingstone, New York, pp 1305–1372

    Google Scholar 

  • Dayton MT, Longmire WP, Thompkins RK (1983) Caroli’s syndrom: A premalignant condition? Surgery 145: 41–48

    Google Scholar 

  • De Aretxabala XA, Roa IS, Burgos LA (1999) Gallbldder cancer, management of early tumors. Hepatogastroenterology 46: 1547–1551

    PubMed  Google Scholar 

  • De Baere T, Roche A, Vavasseur D (1993) Portal vein embolisation: Utility for inducing left hepatic lobe hypertrophy before surgery. Radiology 188: 73–77

    Google Scholar 

  • De Groen PC, Gores GJ, LaRusso NF, Gunderson LL, Nagorney DM (1999) Biliary tract cancers. New Engl J Med 341: 1368 1378

    Google Scholar 

  • Delbeke D, Martin WH, Sandler MP et al. (1998) Evaluation of benign versus maligant hepatic lesions with positron emission tomography. Arch Surg 133: 510–516

    Article  PubMed  CAS  Google Scholar 

  • Deviere J, Baize M, de Toeuf J et al. (1988) Long term follow up of patients with hilar malignant stricture treated by endoscopic internal biliary drainage. Gastrointest Endosc 34: 95101

    Article  Google Scholar 

  • De Vreede I, Steers JL, Burch PA et al. (2000) Prolonged disease-free survival after orthotopic liver transplantation plus adjuvant chemoirradiation for cholangiocarcinoma. Liver Transpl 6: 309–316

    Article  PubMed  Google Scholar 

  • Diehl AK (1980) Epidemiology of gallbladder cancer: A synthesis of recent data. J Natl Cancer Inst 65: 1209–1214

    PubMed  CAS  Google Scholar 

  • Ducreux M, Liguory CL, Lefebvre JF et al. (1992) Management of malignant hilar biliary obstruction by endoscopy. Results an prognostic factors. Dig Dis Sci 37: 778–783

    Google Scholar 

  • Düber C, Klose KJ, Braunstein S, Rumpelt HJ (1991) Verschlußikterus. Histologische Diagnostik durch perkutane endoluminale Gallengangsbiopsie. Fortschr Röntgenstr 155: 246250

    Google Scholar 

  • Dumas R, Demuth N, Buckley M et al. (2000) Endoscopic bilateral metal stent placement for malignant hilar stenoses: Identification of optimal technique. Gastrointest Endosc 51: 334–348

    Google Scholar 

  • Falkson G, McIntyre JM, Moertel CG (1984) Eastern Cooperative Oncology Group experiance with chemotherapy for inoperable gallbladder and bile duct cancer. Cancer 54: 965

    Article  PubMed  CAS  Google Scholar 

  • Ferrari JA, Lichtenstein DR, Slivka A et al. (1994) Brush cytology during ERCP for the diagnosis of biliary and pancreatic malignancies. Gastrointest Endosc 40: 140–145

    Article  Google Scholar 

  • Figueras J, Llado-Garriga L, Lama C et al. (1998) Resection as elective treatment of hilar cholangiocarcinoma. J Gastroenterol Hepatol 21: 218–223

    CAS  Google Scholar 

  • Fleischmann D, Ringl H, Schöfl R et al. (1996) Three dimensional spiral CT cholangiography in patients with suspected obstructive biliary disease: Comparison with endoscopic retrograde cholangiography. Radiology 198: 862–868

    Google Scholar 

  • Flickinger JL, Iwatsuki S, Starzl TE (1991) Radiation therapy for primary carcinoma of the biliary system. Cancer 68: 289294

    Google Scholar 

  • Fujita N, Noda Y, Kobayashi G, Kimura K, Yago A (1999) Diagnosis of the depth of invasion of gallbladder carcinoma by EUS. Gastrointest Endosc 50: 659–663

    Article  PubMed  CAS  Google Scholar 

  • Gallinger S, Gluckman D, Langer B (1990) Proximal bile duct cancer. Adv Surg 23: 89–113

    PubMed  CAS  Google Scholar 

  • Gazzaniga GM, Filauro M, Bagarolo C et al. (1993) Neoplasms of the hepatic hilum: The role of resection. Hepatogastroenterology 40: 244

    Google Scholar 

  • Gazzaniga GM, Filauro M, Ciferri E, Neumaier CE (1995) Klatskin tumor; radical and palliative treatment. Chir Ital 47: 2–6

    PubMed  CAS  Google Scholar 

  • Georgopoulos SK, Schwartz LH; JarnaginW et al. (1999) Comparison of magnetic resonance and endoscopic retrograde cholangiopancreatography in malignant pancreaticobiliary obstruction. Arch Surg 134: 1002–1007

    Article  PubMed  CAS  Google Scholar 

  • Gerhards MF, van Gulik TM, Bosna A et al. (1999) Long term survival after resection of proximal bile duct carcinoma. World J Surg 23: 91–96

    Article  PubMed  CAS  Google Scholar 

  • Gerhards MF, van Gulik TM, de Wit LT et al. (2000) Evaluation of morbidity and mortality after resection for hilar cholangiocarcinoma–a single center experience. Surgery 127: 395–404

    Article  PubMed  CAS  Google Scholar 

  • Glatti A, Stain SC, Baer HU et al. (1993) Unresectable malignant biliary obstruction. Treatment by self expandable biliary endoprostheses. HPB Surg 6: 175–184

    Google Scholar 

  • Gonzales D, Gerard JP, Maners AW et al. (1990) Results of radiation therapy in carcinoma of the proximal bile duct ( Klatskin tumor ). Semin Liver Dis 10: 131–141

    Google Scholar 

  • Gouma DJ, Mutum SS, Benjamin IS, Blumgart LH (1984) Intra-hepatic biliary papillomatosis. Br J Surg 71: 72–74

    Article  PubMed  CAS  Google Scholar 

  • Guthrie CM, Haddock G, De Beaux AC et al. (1993) Changing trends in the mangement of extrahepatic cholangiocarcinoma. Br J Surg 80: 1434–1439

    Article  PubMed  CAS  Google Scholar 

  • Hadjis NS, Blenkharn JL, Alexander N et al. (1990) Outcome of radical surgery in hilar cholangiocarcinoma. Surgery 107: 597–604

    PubMed  CAS  Google Scholar 

  • Hatfiled ARW, Terblanche J, Fataar S et al. (1982) Preoperative drainage in obstructed jaundice. Lancet 23: 896–899

    Article  Google Scholar 

  • Harbinson J, Reynolds JV, Sheahan K et al. (1997) Evidence for the poly-cancer sequence in gallbladder cancer. Ir Med J 90: 98

    Google Scholar 

  • Harvey JH, Smith, Schein PS (1984) 5-Fluoruracil, Mitomycin and Doxorubicin ( FAM) in carcinoma of the biliary tract. J Clin Oncol 2: 1245–1248

    Google Scholar 

  • Healey JE, Schroy PC (1953) Anatomy of the biliary ducts within the human liver. Analysis of the prevailing patterns of branching and the major variations of the biliary ducts. Arch Surg 66: 599–616

    Google Scholar 

  • Hejna M, Pruckmayer M, Raderer M (1998) The role of chemotherapy and radiation in the management of biliary cancer. A review of the literature. Eur J Cancer 34: 977–986

    Google Scholar 

  • Hintze RE, Adler A, Veltzke W et al. (1996) Interdisciplinary treatment of primary non resective Klatskin tumors. Gastroenterology 110: A529

    Article  Google Scholar 

  • Hintze RE, Adler A, Veltzke T, Felix R (1997) Clinical significance of magnetic resonance cholangio-pancreaticography MRCP compared to endoscopic retrograde cholangiopancreaticography. Endoscopy 29: 1–5

    Article  Google Scholar 

  • Hoepffner N, Foerster EC, Domschke W (1998) Metallstents im biliopankreatischen Gangsystem–Standortbestimmung. Z Gastroenterol 36: 1059–1073

    PubMed  CAS  Google Scholar 

  • Holzinger F, Z’graggen K, Büchler MW (1999) Mechanisms of biliary carcinogenesis: A pathogenetic multi-stage cascade towards cholangiocarcinoma. Ann Oncol 10: 122–126

    Google Scholar 

  • Hutson DG, Russel E, Levy JU et al. (1995) Balloon dilatation through the subcutaneously placed afferent limb of a hepaticojejunostomy in patients with resected Klatskin tumors. Am Surg 61: 518–520

    PubMed  CAS  Google Scholar 

  • Interdisziplinäre Leitlinien der Deutschen Krebsgesellschaft e. V. and der Deutschen Gesellschaft für Chirurgie (1999) Onkologie 2: 155–157

    Google Scholar 

  • Ishak KG, Anthony PP, Sobin LH (1994) Histological typing of tumors of the liver, 2nd edn. WHO Series. Springer, Berlin Heidelberg New York Tokyo

    Book  Google Scholar 

  • Itoh A, Goto H, Naitoh Y et al. (1997) Intraductal ultrasound in diagnosing tumor extension of cancer of the papilla of Vater. Gastrointest Endosc 45: 251–260

    Article  PubMed  CAS  Google Scholar 

  • Iwasaki Y, Okomura T, Ozaki A (1986) Surgical treatment for carcinoma at the confluence of the major hepatic ducts. Surg Gynecol Obst 162: 457–464

    CAS  Google Scholar 

  • Iwatsuki S, Todo S, Marsh JW et al. (1998) Treatment of hilar cholangio carcinoma with resection or transplantation. J Am Coll Surg 187: 358–364

    Article  PubMed  CAS  Google Scholar 

  • Jarnagin WR, Burke E, Powers C, Fong Y, Blumgart LH (1998) Intrahepatic biliary enteric bypass provides effective palliation in selected patients, with malignant obstruction at the hepatic duct confluence. Am J Surg 175: 453–460

    Article  PubMed  CAS  Google Scholar 

  • Jonas S, Bechstein WO, Kling N, Neuhaus P (1997) Das Resektionsausmaß in der chirurgischen Therapie zentraler Gallengangskarzinome. Langenbecks Arch Chir Suppl 2: 1075–1077

    Google Scholar 

  • Jonas S, Bechstein WO, Keck H, Veltzke W, Hintze R, Vogl T, Neuhaus P (1998) Partial or total resection of the biliary tract–surgical strategies for hilar cholangiocarcinoma. Acta Chir Austriaca 30: 211–214

    Article  Google Scholar 

  • Kama NA, Coskun T, Yuksek YN, Yazgan A (1999) Factors affecting post-operative mortality in malignant biliary tract obstruction. Hepatogastroenterology 46: 103–107

    PubMed  CAS  Google Scholar 

  • Karr-Locke D, Ball TJ, Conners PJ et al. (1993) Multicenter randomized trial of wallstents biliary endoprosthesis versus plastic stents. Gastrointest Endosc 39: 310

    Google Scholar 

  • Kaskarelis IS, Minardos IA, Abatzis PP et al. (1996) Percutaneous metallic self-expandable endoprosthesis in biliary obstruction caused by metastatic cancer. Hepatogastroenterology 43: 785–791

    PubMed  CAS  Google Scholar 

  • Kawarada Y, Higashiguchi T, Yokoi H et al. (1995) Preoperative biliary drainage in obstructive jaundice. Hepatogastroenterology 42: 300–307

    PubMed  CAS  Google Scholar 

  • Kawasaki S, Makuuchi M, Miyagawa S, Kakazu T (1994) Radical operation after portal embolization for tumor of hilar bile. J Am Coll Surg 178: 480–486

    PubMed  CAS  Google Scholar 

  • Keiding S, Hansen SB, Rasmussen HH et al. (1998) Detection of cholangiocarcinoma in primary sclerosing cholangitis by positron emission tomography. Hepatology 28: 700–706

    Article  PubMed  CAS  Google Scholar 

  • Klatskin G (1957) Adenocarcinoma of the hepatic duct at its bi- furcation within the porta hepatis. Am J Med 38: 241–256

    Article  Google Scholar 

  • Klempnauer J, Ridder GJ, Werner et al. (1997) What constitutes long term survival after surgery for hilar cholangiocarcinoma? Cancer 79: 27–34

    Article  Google Scholar 

  • Komi N, Takehara H, Kunitomo K (1989) Choledochal cyst: Anomalous arrangement of the pancreaticobiliary ductal system and biliary maligancies. J Gastroenterol Hepatol 4: 6–74

    Google Scholar 

  • Kosuge T, Yamanoto J, Shimada K, Yamasaki S, Makutchi M (1999) Improved surgical results for hilar cholangiocarcinoma with procedures including major hepatic resection. Ann Surg 230: 663–671

    Article  PubMed  CAS  Google Scholar 

  • Krain LS (1972) Gallbadder and extrahepatic bile duct carcinoma. Geriatrics 27: 111–117

    PubMed  CAS  Google Scholar 

  • Kurokawa T, Nonami T, Nakao A et al. (1999) The role of extended radical procedures in advanced gallbladder cancer. Hepatogastroenterology 46: 1561–1566

    PubMed  CAS  Google Scholar 

  • Kurathong S, Lerdverasirikul P, Wongpaitoon V et al. (1985) Ophisthorchis viverrini infection and cholangiocarcinoma. A prospective, case controlled study. Gatroenterology 89: 151–156

    Google Scholar 

  • Lehr L, Siewert JR (1986) Gallenwegschirurgie im Licht moderner endoskopischer and radiologischer Techniken. Z Gastroenterol 24: 110–118

    PubMed  CAS  Google Scholar 

  • Lillemoe KD, Pitt HA (1996) Palliation: surgical and otherwise. Cancer 78: 605–614

    PubMed  CAS  Google Scholar 

  • Liu CL, Lo CM, Lai EC, Fan ST (1998) Endoscopic retrograde cholangiopancreaticography and endoscopic endoprosthesis insertion in patients with Klatskin tumor. Arch Surg 133: 293–296

    Article  PubMed  CAS  Google Scholar 

  • Luman W, Cull A, Palmer KR (1997) Quality of life in patients stented for malignant biliary obstruction. Eur J Gastroenterol Hepatol 9: 481–484

    Article  PubMed  CAS  Google Scholar 

  • Magistrelli P, Masetti R, Coppola R et al. (1993) Changing atttudes in the palliation of proximal malignant biliary obstruction. J Surg Oncol Suppl 3: 151–153

    Article  PubMed  CAS  Google Scholar 

  • Mainprize KS, Gould SW, Gilbert JM (2000) Surgical management of polypoid lesions of the gallbladder. Br J Surg 87: 414–417

    Article  PubMed  CAS  Google Scholar 

  • Makels JT, Kairaluoma MI (1993) Superselective intra-arterial chemotherapy with mitomycin for gallbladder cancer. Br J Surg 80: 912–915

    Article  Google Scholar 

  • Mansfield JC, Griffin SM, Wahedra V, Matthewson KA (1997) A prospective evaluation of cytology from biliary strictures. Gut 40: 671–677

    PubMed  CAS  Google Scholar 

  • Martin RF, Rossi RL (2000) Multidisciplinary considerations for patients with cancer of the pancreas or biliary tract. Surg Clin North Am 80: 709–728

    Article  PubMed  CAS  Google Scholar 

  • Martins EBG, Fleming KA, Garrido MC et al. (1994) Superficial thrombophlebitis, dysplasia and cholangiocarcinoma in primary sclerosing cholangitis. Arch Pathol Lab Med 113: 434–436

    Google Scholar 

  • Maurer CA, Dyong T, Baer HU (1995) Der segmentale Gallengangs-Bypass bei Obstruktion im Leberhilus: Nur eine Alternative? Chirurg 66: 794–797

    PubMed  CAS  Google Scholar 

  • McMasters KM, Tuttle TM, Leach SD et al. (1997) Neoadjuvant chemoradiation for extrahepatic cholangiocarcinoma. Am J Surg 98: 752–759

    Google Scholar 

  • McPherson GAD, Benjamin IS, Hodgson HIF et al. (1994) Preoperative percutaneous transhepatic biliary drainage. The results of a controlled trial. Br J Surg 71: 371–375

    Google Scholar 

  • Meyer CG, Penn I, Jamer L (2000) Liver transplantation for cholangiocarcinoma: Results in 207 cases. Transplantation 69: 1633–1637

    Article  PubMed  CAS  Google Scholar 

  • Mezger J, Sauerbruch R, Yo Y et al. (1998) Phase II Study with Gemcitabine in gallbladder and biliary tract carcinomas. Onkologie 21: 232–234

    Article  Google Scholar 

  • Michelassi F, Erroi F, Dawson P et al. (1989) Experiance with 647 consecutive tumors of the duodenum, ampulla, head of pancreas and distal common bile duct. Ann Surg 210: 544554

    Google Scholar 

  • Mittal B, Deutsch M, Iwatsuki S (1995) Primary cancers of the extrahepatic biliary passages. Int J Radiat Oncol Biol Phys 11: 849–855

    Article  Google Scholar 

  • Mitzumoto R, Suzuki H (1988) Surgical anatomy of the hepatic hilum with special reference to the caudate lobe. Worl J Surg 12: 2–10

    Article  Google Scholar 

  • Miyazaki M, Ito H, Nakagawa K et al. (1998) Aggressive surgical approaches to hilar cholangiocarcinoma: Hepatic or local resection? Surgery 123: 131–136

    Article  PubMed  CAS  Google Scholar 

  • Miyazaki M, Ito H, Nakagawa K, Ambiru S et al. (1999) Parenchyma-preserving hepatectomy in the surgical treatment of hilar cholangiocarcinoma. J Am Coll Surg 189: 575–583

    Article  PubMed  CAS  Google Scholar 

  • Morrow CE, Sutherland DER, Florack G, Eisenberg MM, Grage TG (1983) Primary gallblader carcinoma: Significance of subserosal lesions and results of aggressive surgical treatment and adjuvant chemotherapy. Surgery 94: 709–714

    Google Scholar 

  • Muratore A, Polastri R, Bouzari H, Vergara V, Capusotti L (2000) Radical surgery for gallbladder cancer: A worthwhile operation? Eur J Surg Oncol 26: 160–162

    Article  PubMed  CAS  Google Scholar 

  • Nagino M, Nimura Y, Kamiya J, Kondo S, Kanai M (1996) Selective percutaneous transhepatic embolisation of the portal vein in preparation for extensive liver resection: An ipsilateral approach. Radiology 200: 559–563

    Google Scholar 

  • Nagino M, Nimura Y, Kamiya Jet al. (1998) Segmental liver resection for hilar cholangiocarcinoma. Hepatogastroenterology 45: 7–13

    Google Scholar 

  • Nagino M, Kamiya J, Kanai M et al. (2000) Right trisegment portal vein embolisation for biliary tract carcinoma: Technique and clinical utility. Surgery 127: 155–160

    Google Scholar 

  • Nakashima T, Okuda K, Kojiro M et al. (1975) Primary liver cancer coincident with Schistosomisasis japonica. Cancer 36: 1483–1489

    Article  PubMed  CAS  Google Scholar 

  • Nakamura S, Nishiyama R, Yokoi Yet al. (1994) Hepatopancreatoduodenectomy for advanced gallbladder carcinoma. Arch Surg 129: 625–629

    Google Scholar 

  • Nakeeb A, Pitt HA, Sohn TA et al. (1996) Cholangiocarcinoma: A spectrum of intrahepatic, perihilar and distal tumors. Ann Surg 224: 463

    Google Scholar 

  • Neuhaus P, Blumhard G (1994) Extended bile duct resection–a new oncological approach to the treatment of central bile duct carcinomas? Description of method and early results. Langenbecks Arch Chir 379: 123–128

    Article  PubMed  CAS  Google Scholar 

  • Neuhaus P, Jonas S, Bechstein WO, Lohann R et al. (1999) Extended resections for hilar cholangiocarcinoma. Ann Surg 230: 808–818

    Article  PubMed  CAS  Google Scholar 

  • Nimura Y (1993) Staging of biliary carcinoma; cholangiography and cholangioscopy. Endoscopy 25: 76–89

    Article  PubMed  CAS  Google Scholar 

  • Nordback IH, Pitt H, Coleman J et al. (1994) Unresectable hilar cholangiocarcinoma: Percutaneous versus palliative palliation. Surgery 115: 597–603

    Google Scholar 

  • Oberfield RA, Rossi RL (1988) The role of chemotherapy in the treatment of bile duct cancer. Worl J Surg 12: 105–108

    Article  CAS  Google Scholar 

  • Ogura Y, Mizumoto R, Isaji S et al. (1991) Radical operations for carcinoma of the gallbladder. Present status in Japan. World J Surg 15: 337–343

    Google Scholar 

  • Ohnishi H, Asada M, Shichijo Y et al. (1995) External radiotherapy for biliary decompression of hilar cholangiocarcinoma. Hepatogastroenterology 42: 265–268

    PubMed  CAS  Google Scholar 

  • Okuda K, Kubo Y, Okazaki N, Arishima T, Hashimoto M (1977) Clinical aspects of intrahepatic bile duct carcinoma including hilar carcinoma: A study of 57 autopsy-proven cases. Cancer 39: 232–246

    Article  PubMed  CAS  Google Scholar 

  • Onoyama H, Yamamoto M, Tseng A, Ajiki T, Saitoh Y (1995) Extended cholecystectomy for carcinoma of the gallbladder. World J Surg 19: 758–763

    Article  PubMed  CAS  Google Scholar 

  • Ortner MA, Liebentruth J, Schreiber S et al. (1998) Photodynamic therapy of nonresectable cholangiocarcinoma. Gastroenterology 114: 536–542

    Article  PubMed  CAS  Google Scholar 

  • Ouchi K, Matsuno S, Sato T (1989) Long term survival in carcinoma of the biliary tree. Arch Surg 124: 248–252

    Article  PubMed  CAS  Google Scholar 

  • Ouchi K, Sugawara T, Ono H et al. (1999) Diagnostic capability and rational resectional surgery for early gallbladder cancer. Hepatogastroenterology 46: 1557–1560

    PubMed  CAS  Google Scholar 

  • Paquet KJ (1998) Appraisal of surgical resection of gallbladder carcinoma with special reference to hepatic resection. J Hepatobiliary Pancreat Surg 5: 200–206

    Article  PubMed  CAS  Google Scholar 

  • Pederson LC, Buchsbau DJ, Vickers SM et al. (1997) Molecular chemotherapy combined with radiation therapy enhances killing of cholangiocarcinoma cells in vitro and in vivo. Cancer Res 57: 4325–4332

    PubMed  CAS  Google Scholar 

  • Pichlmayr G, Ringe B, Lauchart W, Bechstein WO, Gubernatis G, Wagner E (1988) Radical resection and liver grafting as the two main components of surgical strategy in the treatment of proximal bile duct cancer. World J Surg 12: 68–77

    Article  PubMed  CAS  Google Scholar 

  • Pichlmayr R, Weimann A, Klempnauer J et al. (1996) Surgical treatment in proximal bile duct cancer. Ann Surg 224: 628–638

    Article  PubMed  CAS  Google Scholar 

  • Pichler JM, Crichlow RW (1978) Primary carcinoma of the gallbladder. Surg Gynecol Obstet 147: 929–942

    Google Scholar 

  • Pitt HA, Dooley WC, Yeo CL, Cameron JL et al. (1995 a) Malignancies of the biliary tree. Curr Probl Surg 32: 11

    Google Scholar 

  • Pitt HA, Nakeeb A, Abrams RA et al. ( 1995 b) Perihilar cholangiocarcinoma. Postoperative radiotherapy does not improve survival. Ann Surg 221: 788–789

    Google Scholar 

  • Polydorou AA, Cairns SR, Dowsett JF et al. (1991) Palliation of proximal malignant biliary obstruction by endoscopic stent insertion. Gut 32: 685–689

    Article  PubMed  CAS  Google Scholar 

  • Ramage JK, Donaghy A, Farrant JM et al. (1995) Serum tumor markers for the diagnosis of cholangiocarcinoma in primary sclerosing cholangitis. Gastroenterology 108: 865–869

    Article  PubMed  CAS  Google Scholar 

  • Rieber A, Brambs HJ (1997) Metallic stents in malignant biliary obstruction. Cardiovasc Intervent Radiol 20: 43–49

    Article  PubMed  CAS  Google Scholar 

  • Reinhold C, Bret P (1996) Current status of MR cholangiopancreaticography. AJR Am J Roentgenol 166: 1285–1295

    Article  PubMed  CAS  Google Scholar 

  • Reuther G, Kiefer B, Tuchmann A (1996) Cholangiography before surgery. Single shot MR cholangiography versus intravenous cholangiography. Radiology 198: 561–566

    Google Scholar 

  • Ringe B, Wittekind C, Bechstein WO et al. (1989) The role of liver transplantation in hepatobiliary malignany. Ann Surg 209: 88–89

    Article  PubMed  CAS  Google Scholar 

  • Robertson JM, Lawrence TS, Dworzanin LM et al. (1993) Treatment of primary hepatobiliary cancers with conformal radiation therapy and regional chemotherapy. J Clin Oncol 11: 1286–1291

    PubMed  CAS  Google Scholar 

  • Robledo R, Mundo A, Prieto ML (1996) Extrahepatic bile duct carcinoma: Ultrasound characteristics and accuracy in demonstration of tumors. Radiology 198: 869–873

    Google Scholar 

  • Rosen CB, Nagorney DM (1991) Cholangiocarcinoma complicating primary sclerosing cholangitis. Semin Liver Dis 11: 26–30

    Article  PubMed  CAS  Google Scholar 

  • Rumalla A, Baron TH (1999) Evaluation and endoscopic palliation of cholangiocarcinoma. Management of cholangiocarcinoma. Dig Dis 17: 194–200

    Google Scholar 

  • Saeger HD, Dobrowolski F, Naumann B, Wehrmann U (1999) Palliative Maßnahmen im hepatopankreatischen System. Chirurg 70: 1402–1407

    Article  PubMed  CAS  Google Scholar 

  • Sako K, Seitzinger GL, Garsise E (1957) Carcinoma of the extrahepatic bile ducts. Review of the literature and report of six cases. Surgery 42: 416–437

    Google Scholar 

  • Sampson LK, Vickers SM, Ying W et al. (1997) Tamoxifen-mediated growth inhibition of human cholangiocarcinoma. Cancer Res 57: 1743–1749

    PubMed  CAS  Google Scholar 

  • Sarfeh IJ, Rypins EB, Jakowatz JG, Juler GL (1988) A prospective randomized investigation of cholecystoenterostomy and choledocho-enterostomy. Am J Surg 155: 411–115

    Article  PubMed  CAS  Google Scholar 

  • Sarr MG, Cameron JL (1984) Surgical palliation of unresectable carcinoma of the pancreas. World J Surg 8: 906–911

    Article  PubMed  CAS  Google Scholar 

  • Schechter MS, Doemeny JM, Johnson JO (1993) Biliary ductal shave biopsy with use of the Simpson artherectomy catheter. J Vasc Intery Radiol 4: 819–824

    Article  CAS  Google Scholar 

  • Schoenthaler R, Phillips TL, Castro J, Efird JT, Better A, Way LW (1994) Carcinoma of the extrahepatic bile ducts. The University of California at San Francisco experience. Ann Surg 219: 267–274

    Google Scholar 

  • Shirai Y, Yoshida K, Tsukada K, Muto T, Watanabe H (1992) Radical surgery for gallbladder carcinoma: Long term results. Ann Surg 16: 565–568

    Google Scholar 

  • Smadja C, Blumgart LH (1988) The biliary tract and the anatomy of biliary tract exposure. In: Blumgart LH (ed) Surgery of the liver and biliary tract. Churchill Livingstone. Edinburgh

    Google Scholar 

  • Sotter CT, Lee TG, Katon RM (1976) Complications of endoscopic retrograde cholangiopancreaticography ERCP–A study of 10000 cases. Gastroenterology 70: 314–320

    Google Scholar 

  • Spiessl B, Beahrs OH, Hermanek Pet al. (1990) TNM atlas, 3rd edn. Springer, Berlin Heideberg New York Tokyo

    Google Scholar 

  • Stahl M, Wilke H (1997) Tumoren von Gallenblase and Gallenwegen. In: Schmoll H-J, Höffken K, Possinger K (Hrsg) Kompendium internistische Onkologie. Springer, Berlin Heidelberg New York Tokyo, S 797–809

    Google Scholar 

  • Starzl TE, Todo A, Tzakis Set al. (1989) Abdominal organ cluster transplantation for the treatment of upper abdominal malignancies. Ann Surg 210: 374–368

    Article  PubMed  CAS  Google Scholar 

  • Strohm BL, Hibberd PL, Soper KA, Stolley PD et al. (1985) International variations in epidemiology of cancers of the extrahepatic biliary tract. Cancer Res 45: 5165–5168

    Google Scholar 

  • Su CH, Tsay, Wu CC et al. (1996) Factors influencing postoperative morbidity, mortality and survival after resection for hilar cholangiocarcinoma. Ann Surg 223: 384–394

    Google Scholar 

  • Tada M, Omata M, Ohto M (1992) High incidence of ras gene mutations in intrahepatic cholangiocarcinoma. Cancer 69: 1115–1124

    Article  PubMed  CAS  Google Scholar 

  • Takasan H, Kim CL, Arii S et al. (1980) Clinicopathologic study of seventy patients with carcinoma of the biliary tract. Surg Gynecol Obstet 150: 1575–1580

    Google Scholar 

  • Tanaka N, Nobori M, Suzuki Y (1997) Does bile spillage during an operation present a risk for peritoneal metastasis in bile duct carcinoma? Surg Today 27: 1010–1014

    Article  PubMed  CAS  Google Scholar 

  • Taourel P, Bret PM, Reinhold C, Barkun AN, Atri M (1996) Anatomic variants of the biliary tree: Diagnosis with MRCholangiopancreaticography. Radiology 199: 521–527

    Google Scholar 

  • Tarnasky PR, Cotton PB (1995) Symptom relief and quality of life after stenting for malignant bile duct obstruction - review. Gastrointest Endosc 42: 191

    Article  Google Scholar 

  • Taschieri AM, Elli, Danielle PG, Cristaldi M, Montecamozzo G, Porretta T (1995) Third segment cholangio-jejunostomy in the treatment of unresectable klatskin tumors. Hepatogastroenterology 42: 597–600

    Google Scholar 

  • Taylor MC, McLeod RS, Langer B (2000) Biliary stenting versus bypass surgery for the palliation of malignant distal bile duct obstruction: A meta analysis. Liver Transpl 6: 302–308

    Google Scholar 

  • Ten Hoopen-Neumann H, Gerhards MF, van Gulik TM et al. (1999) Occurrence of implantation metatases after resection of Klatskin tumors. Dig Surg 16: 209–213

    Article  Google Scholar 

  • TerblancheJ, Kahn D, Bornman PC (1988) The treatment of U tube palliation in high bile duct carcinoma. Surgery 103: 624–632

    Google Scholar 

  • Terrada T, Shimiziu K, Izumi R et al. (1994) p53 expression in formalin-fixed, parafin-embedded archival specimen of intrahepatic cholangiocarcinoma: Retrival of p53 antigenecity by microwave oven heating of tissue sections. Mod Pathol 7: 249–252

    Google Scholar 

  • Terrada T, Ohta T, Minato H et al. (1995) Expression of pancreatic trypsinogen/trypsin and cathepsin B in human cholangiocarcinomas and hepatocellular carcinomas. Hum Pathol 26: 746–752

    Article  Google Scholar 

  • Tio TL, Sie LH, Kallimanis G et al. (1996) Staging of periampulary carcinoma: Comparison between endosonography and surgery. Gastrointest Endosc 44: 706–713

    Google Scholar 

  • Todoroki T, Iwasaki Y, Orii K et al. (1991) Resection combined with intraoperative radiation therapy (IORT) for stage IV ( TNM) gallbladder carcinoma. Worl J Surg 15: 357–366

    Google Scholar 

  • Tompkins RK (1988) Treatment and prognosis in bile duct cancer. Worl J Surg 12: 109–110

    Article  CAS  Google Scholar 

  • Tsukada K, Yoshida K, Aaono T et al. (1995) Major hepatectomy and pancreato-duodenectomy for irresectable hilar bile duct carcinoma. Br J Surg 82: 397–498

    Article  Google Scholar 

  • Tuluvath PJ, Rai R, Venbrux AC et al. (1997) Cholangiocarcinoma–A review. Gastroenterologist 5: 306–315

    Google Scholar 

  • Van Delden OM, de Wit LT, Nieveen van Dijkum EJ et al. (1997) Value of laparoscopic ultrasonography in staging of proximal bile duct tumors. J Ultrasound Med 16: 7–12

    PubMed  Google Scholar 

  • Van den Bosch R, van der Schelling GP, Klinkenbijl JHG et al. (1994) Guidelines for the application of surgery and endoprostheses in the palliation of obstructive jaundice in advanced cancer of the pancreas. Ann Surg 219: 18–24

    Article  PubMed  Google Scholar 

  • Van Leuven DJ, Huibregtse K, Tytgat GN (1990) Carcinoma of the hepatic confluence 25 years after Klatskin’s description: Diagnosis and endoscopic management. Semin Liv Dis 10: 102–113

    Google Scholar 

  • Verbeek PCM, van der Heyde MN, Ramsoenkh T, Bosma A (1990) Clinical significance of implantation metastases after surgical treatment of cholangiocarcinoma. Semin Liv Dis 10: 142–144

    Article  CAS  Google Scholar 

  • Vogl TJ Balzer JQ, Dette K et al. (1998) Initially unresectable hilar cholangiocarcinoma: Hepatic regeneration after trans-arterial embolization. Radiology 208: 217–222

    Google Scholar 

  • Wagner HJ, Knyrim K, Klose KJ (1993) Plastic endoprosthesis versus metal stents in the palliative treatment of malignant hilar biliary obstruction. A propective and randomized trial. Endoscopy 25: 213–218

    Google Scholar 

  • Wagner HJ, Hoppe M, Klose KJ (1995) Perkutane intraluminale Ultaschalluntersuchung der Gallenwege in der Diagnostik maligner biliärer Obstruktion. Dtsch Med Wochenschr 120: 472–477

    Article  PubMed  CAS  Google Scholar 

  • Warren KW, Mountain JC, Lloyd-Jones W (1972) Malignant tumors of the bile ducts. Br J Surg 59: 501

    Article  PubMed  CAS  Google Scholar 

  • Washburne WK, Lewis WD, Jenkins RL (1995) Aggressive surgical resection for cholangiocarcinoma. Arch Surg 130: 270279

    Google Scholar 

  • Watanapa R, Williamson RCN (1992) Surgical palliation for pancreatic cancer: Developments during the past two decades. Br J Surg 79: 8–14

    Google Scholar 

  • Weinbren K, Mutum SS (1983) Pathologic aspects of cholangiocarcinoma. Hum Patholl6: 719–727

    Google Scholar 

  • Welton JC, Marr JS, Friedman SM (1979) The association between hepatobiliary cancer and typhoid carrier status. Lancet 1: 791–794

    Article  PubMed  CAS  Google Scholar 

  • Wittekind C, Wagner G (1997) UICC-TNM-Klassifikation maligner Tumoren, 5. Aufl. Springer, Berlin Heidelberg New York Tokyo

    Google Scholar 

  • Yamaguchi K, Enjoji M, Nakayama F (1988) Cancer of the extrahepatic bile duct: A clinicopathologic study of immunohistochemistry for CEA, CA19–9, and p21. World J Surg 12: 11–17

    Article  PubMed  CAS  Google Scholar 

  • Yamamoto M, Onoyama H, Aijiki T et al. (1999) Surgical results of operations for carcinoma of the gallbladder. Hepatogastroenterology 46: 1552–1556

    PubMed  CAS  Google Scholar 

  • Yeh TS, Jan YY, Teseng JH et al. (2000) Malignant perihilar biliary obstruction: Magnetic resonance cholangiopancreatographic findings. Am J Gastroenterol 95: 432–440

    Google Scholar 

  • Yen S, Hsieh CC, MacMohen B (1987) Extrahepatic bile duct cancer and smoking, beverage consumption, past medical history and oral contraceptive use. Cancer 59: 2112–2116

    Article  PubMed  CAS  Google Scholar 

  • Yokoyama I, Carr B, Saitsu H et al. (1991) Accelerated growth rates of recurrent hepatocellular carcinoma after liver transplantation. Cancer 68: 2095–2100

    Article  PubMed  CAS  Google Scholar 

  • Yoo BM, Kim JH, Shin YJ et al. (1997) Selection of approach route for diagnosis and non-surgical management of malignant hilar biliary obstruction: ERC or PTC? Gastrointest Endosc 47: 132

    Google Scholar 

  • Zidi SH, Prat F, Le Guen O, Rondeau Y, Pelletier G (2000) Performance characteristics of magnetic resonance cholangiography in the staging of malignant hilar strictures. Gut 46: 103–106

    Article  PubMed  CAS  Google Scholar 

Download references

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2001 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Kraus, T., Herfarth, C. (2001). Chirurgische Therapie von Karzinomen der extrahepatischen Gallenwege und der Gallenblase. In: Siewert, J.R., Harder, F., Rothmund, M. (eds) Praxis der Viszeralchirurgie. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-09420-4_34

Download citation

  • DOI: https://doi.org/10.1007/978-3-662-09420-4_34

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-662-09421-1

  • Online ISBN: 978-3-662-09420-4

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics