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Prinzipien der regionalen Hyperthermie in Kombination mit Strahlentherapie und Chemotherapie

  • P. Wust
  • B. Rau
  • P. Schlag

Zusammenfassung

Überwärumungstherapie (Hyperthermie) von Tumoren auf 40–44°C kann die Wirksamkeit von Radiotherapie und/oder Chemotherapie verstärken. Dazu tragen zytotoxische, sensibilisierende, physiologische und immunstimulierende Effekte bei, deren molekularbiologischer Hintergrund noch weiter abzuklären ist. Es wurden schon kommerzielle Therapiesysteme für die lokale, regionale und systemische (Ganzkörper-)Hyperthermie entwickelt und klinisch eingesetzt. In Phase-III-Studien konnte eine Erhöhung der lokalen Kontrolle bei malignen Melanomen (Rezidiven), Mammakarzinomrezidiven und Kopf-Hals-Karzinomen (Lymphknotenmetastasen) gezeigt werden, sogar ein verbessertes Überleben bei Glioblastomen und Zervixkarzinomen. In präoperativen Konzepten ist die Hyperthermie interessant, da sie weder die akute noch die perioperative Toxizität erhöht. Für eine routinemäßige Anwendung muss die Gerätetechnik weiterentwickelt werden, um Dosierbarkeit, Effektivität, Praktikabilität und Kosten-Nutzen-Relation zu verbessern.

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Copyright information

© Springer-Verlag Berlin Heidelberg 2001

Authors and Affiliations

  • P. Wust
  • B. Rau
  • P. Schlag

There are no affiliations available

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