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Progress in the Chronotherapy of Nocturnal Asthma

  • Chapter
Physiology and Pharmacology of Biological Rhythms

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 125))

Abstract

Bronchial asthma is a chronic airways disease. Symptoms include dyspnea, wheezy chest, cough, and fatigue. It is seldom a problem for those who suffer from the mild form of the disease. However, it is a significant and even life-threatening one for those prone to severe asthma. Asthma is characterized by persistent airways inflammation, airways hyperreactivity, and compromised pulmonary function (Martin 1993). All are reversible, at least to some extent, with medication and environmental control. Asthma severity varies between patients and even in the same patient over time. Most patients experience worsening of symptoms during the night; many experience symptoms only at night (Dethlefsen and Repges 1985; Turner-Warwick 1988). Successful asthma management must address the major features of the disease — airways inflammation and hyperreactivity, compromised pulmonary function, and temporal patterning.

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Authors
  1. M. H. Smolensky
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  2. G. E. D’Alonzo
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Editors and Affiliations

  1. School of Pharmacy and Pharmacology, University of Bath, Claverton Down, BA1 7AY, Bath, UK

    Peter H. Redfern BPharm, PhD

  2. Instituts für Pharmakologie und Toxikologie Fakultät für klinische Medizin Mannheim, Universität Heidelberg, Maybachstr. 14-16, 68169, Mannheim, Germany

    B. Lemmer (Direktor) (Direktor)

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Smolensky, M.H., D’Alonzo, G.E. (1997). Progress in the Chronotherapy of Nocturnal Asthma. In: Redfern, P.H., Lemmer, B. (eds) Physiology and Pharmacology of Biological Rhythms. Handbook of Experimental Pharmacology, vol 125. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-09355-9_9

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