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Biological Rhythms in Pain and Analgesia

  • Chapter
Book cover Physiology and Pharmacology of Biological Rhythms

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 125))

Abstract

Pain is one of the most common causes for which patients seek advice and help from health professionals. This is a very complex phenomenon always characterized as an unpleasant sensation which often disturbs the normal patterns of a patient’s activity, sleep and thoughts. Pain is a subjective phenomenon and factors such as anxiety, fatigue, suggestion or emotion as well as prior experiences can influence its perception. Thus, the patient is the only person who can describe the intensity of his or her pain and clinicians must rely on this subjective information to prescribe analgesic drugs. This is also why it is very difficult to have a good experimental model of pain.

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References

  • Auvil-Novak SE, Novak RD, Smolensky MH, Kavanagh JJ, Kwan JW, Wharthon JT (1988) Twenty-four hour variation in self-administration of morphine sulfate and hydromorphone by post-surgical gynecologic cancer patient. Annu Rev Chronopharmacol 5: 343 - 346

    Google Scholar 

  • Auvil-Novak SE, Novak RD, Smolensky MH, Morris MM, Kwan JW (1990) Temporal variation in the self-administration of morphine sulfate via patient-controlled analgesia in post-operative gynecologic cancer patients. Annu Rev Chronopharmacol 7: 253 - 256

    Google Scholar 

  • Bausbaum AI, Fields HF (1978) Endogenous pain control mechanisms: review and hypothesis. Ann Neurol 4: 451 - 462

    Article  Google Scholar 

  • Beckman AL, Llados-Eckman C, Stanton TL, Adler MW (1982) Seasonal variation of morphine physical dependence. Life Sci 30: 147 - 153

    Article  PubMed  CAS  Google Scholar 

  • Bellamy N, Sothern RB, Campbell J (1990) Rhythmic variations in pain perception in osteoarthritis of the knee. J Rheumatol 17: 364 - 372

    PubMed  CAS  Google Scholar 

  • Bichlmayer A (1937) Lokale Anästhesie und Allgemeinbetäubung in der Zahn-, Mund und Kieferheilkunde. Lehmanns, p 10

    Google Scholar 

  • Blitz B, Dinnerstein AJ (1968) Effects of different types of instructions on pain parameters. J Abnorm Psychol 73: 276 - 280

    Article  PubMed  CAS  Google Scholar 

  • Bodnar RJ, Kelly DD, Spiaggia A, Glusman M (1978) Biophasic alterations of noci-ceptive thresholds induced by food deprivation. Physiol Psychol 6: 391 - 395

    Google Scholar 

  • Boissier C, Decousus H, Perpoint B, 011agnier M, Mismetti P, Hocquart J, Queneau P (1990) Timing optimizes sustained-release ketoprofen treatment of osteoarthritis. Annu Rev Chronopharmacol 7: 289 - 292

    Google Scholar 

  • Bouchancourt P, Le Louarn C (1982) Etude chronothérapeutique de l’indomethacinmétacine à effet prolongé dans l’arthrose des membres inférieurs. Tribune Med [Suppl]: 32 - 35

    Google Scholar 

  • Bourdallé-Badie C, Bruguerolle B, Labrecque G, Robert S, Erny P (1990a) Biological rhythms in pain and anesthesia. Annu Rev Chronopharmacol 6: 155 - 182

    Google Scholar 

  • Bourdallé-Badie C, Andre M, Pourquier P, Robert S, Cambar J, Erny P (1990b) Cir-cadian rhythm of pain in man: study by measure of nociceptive flexion reflex. Annu Rev Chronopharmacol 7: 249 - 252

    Google Scholar 

  • Bruera E, Macmilland K, Kuehn N, Miller MJ (1992) Circadian distribution of extra doses of narcotic analgesics in patients with cancer pain: a preliminary report. Pain 49: 311 - 314

    Article  PubMed  CAS  Google Scholar 

  • Buckett WR (1981) Circadian and seasonal rhythm in stimulation produced analgesia. Experientia 37: 878 - 879

    Article  PubMed  CAS  Google Scholar 

  • Chapman CR, Casey KL, Dubner R, Foley KM, Gracely RH, Reading AE (1985) Pain measurement: an overview. Pain 22: 1 - 31

    Article  PubMed  CAS  Google Scholar 

  • Chapman WP, Jones CM (1944) Variations in cutaneous and visceral pain sensitivity in normal subjects. J Clin Invest 23: 81 - 91

    Article  PubMed  CAS  Google Scholar 

  • Citron ML, Kaira JM, Seltzer VL, Hoffman M, Walczak ML (1992) Patient-controlled analgesia for cancer pain: a long-term study of inpatient and outpatient use. Cancer Invest 10: 335 - 341

    Article  PubMed  CAS  Google Scholar 

  • Crockett RS, Bornschein RL, Smith RP (1977) Diurnal variation in response to thermal stimulation: mouse hot-plate test. Physiol Behav 18: 193 - 196

    Article  PubMed  CAS  Google Scholar 

  • Davis GC, Buchsbaum MS, Bunnew WE (1978) Naloxone decreases diurnal variation in pain sensitivity and somatosensory evoked potentials. Life Sci 23: 1449 - 1460

    Article  PubMed  CAS  Google Scholar 

  • Deschamps M, Band PR, Coldman AJ (1988) Assessment of adult cancer pain: shortcomings of current methods. Pain 32: 133 - 139

    Article  PubMed  CAS  Google Scholar 

  • Dunn M, Blouin D, Labrecque G (1993) Time-dependent variations in morphine-requirements in patients with post-operative pain. Proceedings of the 21st conference of the International Society for Chronobiology, Quebec (Canada), abstract no III - 10

    Google Scholar 

  • Fishman SM, Carr DB (1992) Basic mechanisms of pain. Hospital Practice, 15 Oct, pp 63 - 76

    Google Scholar 

  • Foley KM (1989) Controversies in cancer pain. Cancer 63: 2257 - 2265

    Article  PubMed  CAS  Google Scholar 

  • Folkard S (1976) Diurnal variation and individual differences in the perception of intractable pain. J Psychosom Res 20: 289 - 301

    Article  PubMed  CAS  Google Scholar 

  • Frederickson RCA, Burgis V, Edwards JD (1977) Hyperanalgesia induced by naloxone follows diurnal rhythm in responsivity to painful stimuli. Science 198: 756 - 758

    Article  PubMed  CAS  Google Scholar 

  • Glynn CJ, Lloyd JW, Folkard S (1975) The diurnal variation in perception of pain. Proc R Soc Med 69: 369 - 372

    Google Scholar 

  • Göbel H, Cordes P (1990) Circadian variation of pain sensitivity in pericranial musculature. Headache 30: 418 - 422

    Article  PubMed  Google Scholar 

  • Grabfield GP, Martin EG (1912) Variations in the sensory threshold for faradic stimulation in normal human subjects I. The diurnal rhythm. Am J Physiol 31: 300-308

    Google Scholar 

  • Graham C, Bond SS, Gercovich MM, Cook MR (1980) Use of the McGill Pain Questionnaire in the assessment of cancer pain:replicability and consistency. Pain 8: 377 - 387

    Article  PubMed  CAS  Google Scholar 

  • Graves DA, Batenhorst RL, Bennett JG, Wettsetein WO, Griffen BD, Wright BD, Foster TS (1983) Morphine requirements using patient-controlled analgesia: influence of diurnal variation and morbid obesity. Clin Pharm 2: 49 - 53

    PubMed  CAS  Google Scholar 

  • Hamra JG, Kamerling SG, Wolfsheimer KJ, Bagwell CA (1993) Diurnal variation in plasma ir-beta-endorphin levels and experimental pain thresholds in the horse. Life Sci 53: 121 - 129

    Article  PubMed  CAS  Google Scholar 

  • Hanin E, Massarelli R, Costa E (1970) Acetylcholine concentrations in rat brain: diurnal oscillation. Science 170: 341 - 342

    Article  PubMed  CAS  Google Scholar 

  • Hardy DJ, Wolff HG, Goodell H (1940) Studies on pain. A new method for measuring pain: observations on spatial summation of pain. J Clin Invest 19: 649 - 657

    Article  PubMed  CAS  Google Scholar 

  • Heintz RC (1989) Pharmacocinétique du ténoxicam. In: Gaucher A, Pourel J, Netter P, Kessler M (eds) Actualités en physiopathologie et pharmacologie articulaire. Masson, Paris

    Google Scholar 

  • Hindmarsh KW, Tan L, Sankaran K, Laxdal VA (1989) Diurnal rhythms of cortisol, ACTH and 13-endorphin levels in neonates and adults. West J Med 151: 153 - 156

    PubMed  CAS  Google Scholar 

  • Hummel T, Hepper M, Kaiser R, Bös R, Liehold J, Kobal G (1992) Investigation of circadian effects on the plasma levels of dihydrocodeine and tramadol after peroral administration. Proceedings of the 5th International Conference on Biological Rhythms and Medications, Amelia Island (F1), abstract no X111 - 4

    Google Scholar 

  • Hummel T, Kraetsch HG, Lötsch J, Hepper M, Liefhold J, Kobal G (1994) Analgesic effects of dihydrocodeine and tramadol when administered either in the morning or evening. Chronobiol Int 12: 62 - 72

    Article  Google Scholar 

  • Huskisson EC (1983) Visual analogue scales. In: Melzack R (ed) Pain measurement and assessment. Raven, New York, pp 33 - 37

    Google Scholar 

  • Jensen MP, Karoly P, Braver S (1986) The measurement of clinical pain intensity: a comparison of six methods. Pain 27: 117 - 126

    Article  PubMed  CAS  Google Scholar 

  • Jessel TM (1983) Substance P in the nervous system. In: Iversen LL, Iversen SD, Snyder SH (eds) Neuropetides. Plenum, New York (Handbook of psychopharmacology, vol 16 )

    Google Scholar 

  • Job-Deslandre C, Reinberg A, Delbarre F (1983) Chronoeffectiveness of indomethacin in four patients suffering from an evolutive osteoarthritis of the hip or knee. Chronobiologia 10: 245 - 254

    PubMed  CAS  Google Scholar 

  • Jores A, Frees J (1937) Die Tagenschwankungen der Schmerzempfindung. Deutsche Med Wochenschr 63: 963 - 963

    Article  Google Scholar 

  • Kavaliers M, Hirst M (1983) Daily rhythms of analgesia in mice: effects of age and photoperiod. Brain Res 279: 387 - 393

    Article  PubMed  CAS  Google Scholar 

  • Kavaliers M, Ossenkopp KP (1988) Day-night rhythms of opioid and non-opioid stress-induced analgesia: differential inhibitory effects of exposure to magnetic fields. Pain 32: 223 - 229

    Article  PubMed  CAS  Google Scholar 

  • Kavaliers M, Hirst M, Teskey GC (1983) Ageing, opioid analgesia and the pineal gland. Life Sci 32: 2279 - 2287

    Article  PubMed  CAS  Google Scholar 

  • Kerdelhue B, Palkovits M, Karteszi M, Reinberg A (1981) Circadian variation in substance P, luliberin (LH-RH) and thyroliberin ( TRH) contents in hypothalamic and extra hypothalamic brain nuclei of adult male rats. Brain Res 206: 405-413

    Google Scholar 

  • Kerdelhue B, Karteszi M, Pasqualini C, Reinberg A, Mezzy E, Palkovits M (1983) Circadian variations in beta-endorphin concentrations in pituitary and in some brain nuclei in the adult male rat. Brain Res 261: 243 - 248

    Article  PubMed  CAS  Google Scholar 

  • Kobal G, Hummel T, Kraetsch HG, Lötsch J (1992) Circadian analgesic effects of dihydrocodeine and tramadol. Proceedings of the 5th international conference on biological rhythms and medications, Amelia Island (FI), abstract no X111 - 5

    Google Scholar 

  • Kosterlitz HW, Hughes J (1975) Some thought on the significance of enkephalin, the endogenous ligand. Life Sci 17: 91 - 96

    Article  PubMed  CAS  Google Scholar 

  • Kowanko IC, Pownall R, Knapp MS, Swannel AJ, Mahoney PGC. (1981) Circadian variations in the signs and symptoms of rheumatoid arthritis and in the therapeutic effectiveness of flurbiprofen at different times of the day. Br J Clin Pharmacol 11: 477 - 484

    Article  PubMed  CAS  Google Scholar 

  • Kowanko ICR, Knapp MS, Pownall R, Swannel AJ (1982) Domiciliary self-measurement in rheumatoid arthritis and the demonstration of circadian rhythmicity. Ann Rheum Dis 41: 453 - 455

    Article  PubMed  CAS  Google Scholar 

  • Labrecque G (1973) Acetylcholine antirelease effect of selected narcotic agonists and antagonists. PhD thesis, University of Michigan

    Google Scholar 

  • Labrecque G, Domino EF (1975) Chronopharmacologie I. Variation de l’effet de la morphine sur l’acétylcholine cérébral en fonction du rythme nycthéméral. Vie Med Can Franc 4: 130-135

    Google Scholar 

  • Labrecque G, Domino EF, Halberg F (1982) Circadian rhythm of total brain acetylcholine content: effect of light and blindness. In: Takahashi R, Halberg F, Walker CA (eds) Toward chronopharmacology. Pergamon, New York, p 19 (Advances in the biosciences, vol 41 )

    Google Scholar 

  • Labrecque G, Lepage-Savary D, Poulin E (1988) Time-dependent variations in morphine-induced analgesia. Annu Rev Chronopharmacol 5: 135 - 138

    Google Scholar 

  • Labrecque G, Bureau JP, Reinberg A (1994) Biological rhythms in the inflammatory response and in the effects of non-steroidal anti-inflammatory agents. Pharmacol Ther 66: 285 - 300

    Article  Google Scholar 

  • Lemmer B, Wiemers R (1989) Circadian changes in stimulus threshold in the effect of local anesthetic drug in human teeth: studies with an electronic pulptester. Chronobiol Int 6: 157 - 162

    Article  PubMed  CAS  Google Scholar 

  • Levi F, Le Louarn C, Peltier A (1982) Etude chronopharmacologique en double-aveugle de 75 mg d’indometacine à effet prolongé dans l’arthrose. Tribune Med [Suppl]: 48 - 53

    Google Scholar 

  • Lévi F, Le Louarn C, Reinberg A (1984) Chronotherapy of osteoarthritic patients: optimization of indomethacin sustained release ( ISR ). Annu Rev Chronopharmacol 1: 345-348

    Google Scholar 

  • Lévi F, Le Louarn C, Reinberg A (1985) Timing optimized sustained indomethacin treatment of osteoarthritis. Clin Pharmacol Ther 37: 77 - 84

    Article  PubMed  Google Scholar 

  • Macht DJ, Herman NB, Levy CS (1916) A quantitative study of the analgesia produced by opium alkaloids, individually and in combination with each other in normal man. J Pharmacol Exp Ther 8: 1 - 37

    Google Scholar 

  • Marks RM, Sachar EJ (1973) Undertreatment of medical inpatients with narcotic analgesics. Ann Intern Med 78: 173 - 181

    PubMed  CAS  Google Scholar 

  • Martin EG, Bigelow GH, Grabfield GB (1914) Variations in the sensory threshold for faradic stimulation in normal human subjects II. The nocturnal rhythm. Am J Physiol 33: 415-422

    Google Scholar 

  • Martínez-Gómez M, Cruz Y, Salas M, Hudson R, Pachero P (1994) Assessing pain threshold in the rat:Changes with estrus and time of day. Physiol Behav 55: 651 - 657

    Article  PubMed  Google Scholar 

  • Master AM (1960) The role of effort and occupation (including physicians) in coronary occlusion. JAMA 174: 942 - 948

    Article  PubMed  CAS  Google Scholar 

  • Mayer DJ, Liebeskind JC (1974) Pain reduction by focal electrical stimulation of the brain: an anatomical and behavioral analysis. Brain Res 68: 73 - 93

    Article  PubMed  CAS  Google Scholar 

  • McGrath PA (1987) An assessment of children’s pain: a review of behavioral, physiological and direct scaling techniques. Pain 31: 147 - 176

    Article  PubMed  CAS  Google Scholar 

  • McGrath PA (1990) Pain in children: nature, assessment, and treatment. Guilford, New York

    Google Scholar 

  • Melzack R (1975) The McGill pain questionnaire: major properties and scoring methods. Pain 1: 277 - 299

    Article  PubMed  CAS  Google Scholar 

  • Melzack R (1983) The McGill pain questionnaire. In: Melzack R (ed) Pain measurement and assessment. Raven, New York, pp 111 - 117

    Google Scholar 

  • Melzack R, Torgerson WS (1971) On the language of pain. Anesthesiology 34:50-59 Moore JG, Goo R (1987) Day and night aspirin-induced gastric mucosal damage and protection by ranitidine in man. Chronobiol Int 4: 11 - 116

    Google Scholar 

  • Morawetz RF, Parth P, Pöppel E (1984) Influence of the pain measurement technique on the diurnal variation of pain perception. In: Bromm B (ed) Pain measurement in man. Elsevier, Amsterdam, pp 409 - 415

    Google Scholar 

  • Morris RW, Lutsch EF (1967) Susceptibility of morphine-induced analgesia in mice. Nature 216: 494 - 495

    Article  PubMed  CAS  Google Scholar 

  • Mudge AW, Leeman SE, Fischbach GD (1979) Enkephalin inhibits release of substance P from sensory neurons in culture and decreases action potential duration. Proc Natl Acad Sci USA 76: 526 - 530

    Article  PubMed  CAS  Google Scholar 

  • Muller JE, Stone PH, Turin ZG, Rutherford JD, Czeisler CA, Parker C, Poole WK, Passamani E, Robert R, Robertson T, Sobel BE, Willerson JT, Braunwald E (1985) The Milis Study Group: circadian variation in the frequency of onset of acute myocardial infarction. N Engl J Med 313: 1315 - 1322

    Article  PubMed  CAS  Google Scholar 

  • Naber D, Cohen RM, Pickar D, Kahn NH, Davis G, Pert CB, Bunney WE Jr (198la) Episodic secretion of opioid activity in human plasma and monkey CSF. Life Sci 28: 931 - 935

    Google Scholar 

  • Naber D, Wirz-Justice A, Kafka MS (1981b) Circadian rhythm in rat brain opiate receptor. Neurosci Lett 21: 45 - 50

    Article  PubMed  CAS  Google Scholar 

  • Nold G, Drossard K, Lehman K, Lemmer B (1995) Gastric mucosal lesions after morning versus evening application of 75 mg or 1000 mg acetylsalicylic acid ( ASA ). Naunyn Schmiedebergs Arch Pharmacol 351: R17

    Google Scholar 

  • Oliverio A, Castellano C, Puglisi-Allegra S (1982) Opiate analgesia: evidence for a circadian rhythm in mice. Brain Res 249: 265 - 270

    Article  PubMed  CAS  Google Scholar 

  • Ostfeld AM (1963) The natural history and epidemiology of migraine and muscle contraction headache. Neurology 13: 11 - 15

    Article  Google Scholar 

  • Pednault L, Parent M (1993) Circadian rhythm of chronic low back pain caused by discal degeneration, fusion pseudoarthrosis or discoidectomy. Proceedings of the 21st conference of the International Society of Chronobiology, Quebec (Canada), abstract no III - 9

    Google Scholar 

  • Pernow B (1983) Substance P. Pharmacol Rev 35: 85 - 141

    CAS  Google Scholar 

  • Petraglia F, Facchinetti F, Parrini D, Micieli G, De Luca S, Genazzi AR (1983) Simultaneous circadian variation of plasma ACTH, 13-lipoprotein, 3-endorphin and cortisol. Horm Res 17: 147 - 152

    Article  PubMed  CAS  Google Scholar 

  • Pickard GE (1987) Circadian rhythm of nociception in the golden hanster Brain Res 425: 395 - 400

    CAS  Google Scholar 

  • Pöllmann L (1984) Duality of pain demonstrated by the circadian variation in tooth sensitivity. In: Haus E, Kabat H (eds) Chronobiology 1982-1983. Karger, Basel, p 225

    Google Scholar 

  • Pöllmann L (1987) Circadian variation of potency of placebo as analgesic. Funct Neurol 22: 99 - 103

    Google Scholar 

  • Pownall R, Pickvance NJ (1985) Does treatment matter? A double blind crossover study of ibuprofen 2400 mg per day in different dosage schedules in treatment of chronic low back pain. Br J Clin Pract 39: 267 - 275

    PubMed  CAS  Google Scholar 

  • Proccaci P, Moretti R, Zoppi M, Cappelletti C, Voegelin MR (1973) Rythmes circadiens et circatrigindiens du seuil de la douleur cutanée chez l’homme. Bull Groupe Et Rythmes Biol 5: 65 - 75

    Google Scholar 

  • Proccaci P, Dellacorte M, Zoppi M, Maresca M (1974) Rhythmic changes of the cu-taneous pain threshold in man. A general review. Chronobiologia 1: 77-87

    Google Scholar 

  • Puglisi-Allegra S, Castellano C, Oliverio A (1982) Circadian variations in stress-induced analgesia. Brain Res 252: 373 - 376

    Article  PubMed  CAS  Google Scholar 

  • Räisänen I (1988) Plasma levels and diurnal variation of 3-endorphin, ß-lipotropin and corticotropin during pregnancy and early puerperium. Eur J Obstet Gynecol Re-prod Biol 27: 13 - 20

    Article  Google Scholar 

  • Reading AE (1989) Testing pain mechanisms in persons in pain. In:Wall PD, Melzack R (eds) Textbook of pain, 2nd edn. Churchill Livingstone, Edinburgh, p 269

    Google Scholar 

  • Reinberg A, Reinberg MA (1977) Circadian changes of the duration of local anesthetic agents. Naunyn Schmiedebergs Arch Pharmacol 297: 149 - 152

    Article  PubMed  CAS  Google Scholar 

  • Reinberg A, Manfredi R, Khan MF, Chaouat D, Chaouat Y, Delcambre B, Legoff P, Maugars Y, Valat JP (1991) Chronothérapie de ténoxicam. Therapie 46: 101 - 108

    PubMed  CAS  Google Scholar 

  • Rejholec V, Vitulova V, Vachtenheim J (1984) Preliminary observations from a double-blind crossover study to evaluate the efficacy of flurbiprofen given at different times of day in the treatment of rheumatoid arthritis. Annu Rev Chronopharmacol 1: 357 - 360

    Google Scholar 

  • Rigas B, Torosis J, McDougall CJ, Vener KJ, Spiro HM (1990) The circadian rhythm of biliary colic. J Clin Gastroenterol 12: 409 - 414

    Article  PubMed  CAS  Google Scholar 

  • Rivot JP, Weil-Fugazza J, Godefroy F, Bineau-Thurotte M, Ory-Lavollée L, Besson JM (1984) Involvement of serotonin in both morphine and stimulation-produced analgesia: electochemical and biochemical approaches. In: Kruger L, Liebeskind JV (eds) Advances in pain research and therapy, vol 6. Raven, New York, p 135

    Google Scholar 

  • Rolandi E, Gandolfo C, Franceschini R, Cataldi A, Garibaldi A, Barreca T (1992) Twenty-four-hour beta-endorphin secretory pattern in Alzeimer’s disease. Neuropsychobiology 25: 188 - 192

    Article  PubMed  CAS  Google Scholar 

  • Sankaran K, Hindmarsh KW, Tan L (1989) Diurnal rhythm of 3-endorphin in neonates. Dev Pharmacol Ther 12: 1 - 6

    PubMed  CAS  Google Scholar 

  • Schumacher GA, Goodell H, Hardy JF, Wolff HG (1940) Uniformity of pain threshold in man. Science 92: 110 - 112

    Article  PubMed  CAS  Google Scholar 

  • Scott J, Huskisson EC (1976) Graphic representation of pain. Pain 2: 175 - 184

    Article  PubMed  CAS  Google Scholar 

  • Simon L, Hérisson P, Le Louarn C, Lévi F (1982) Etude hospitaliére de chronothe-rapeutique avec 75 mg d’indométacinemétacine à effet prolongé en pathologie rhumatismale dégénérative. Tribune Med [Suppl]: 43 - 47

    Google Scholar 

  • Sittl R, Kamp HD, Knoll R (1990) Zirkadiane Rhythmik des Schmerzempfindens bei Tumorpatienten. Nervenheilkunde 9: 22 - 24

    Google Scholar 

  • Solomon GD (1992) Circadian rhythms and migraine. Cleve Clin J Med 59: 326 - 329

    PubMed  CAS  Google Scholar 

  • Stacher G, Bauer P, Schneider C, Winklehner S, Schmierer G (1982) Effects of com- bination of oral naproxen sodium and codeine in experimentally induced pain. Eur J Clin Pharmacol 21: 485 - 490

    Article  PubMed  CAS  Google Scholar 

  • Strian F, Lautenbacher S, Galfe G, Hölzl R (1989) Diurnal variations in pain perception and thermal sensitivity. Pain 36: 125 - 131

    Article  PubMed  CAS  Google Scholar 

  • Swannel AJ (1983) Biological rhythms and their effect in the assessment of disease activity in rheumatoid arthritis. Br J Clin Pract 38 [Suppl 33]: 16 - 19

    Google Scholar 

  • Uting JE, Smith JM (1979) Postoperative analgesia. Anaesthesia 34: 320 - 332

    Article  Google Scholar 

  • Vanier MC, Labrecque G, Lepage-Savary D (1992) Temporal changes in the hydro-morphone analgesia in cancer patients. Proceedings of the 5th international con-ference on biological rhythms and medications, Amelia Island (F1), abstract no X111 - 8

    Google Scholar 

  • Von Knorring L, Almay BGL, Johansson F, Terenius L, Wahlström A (1982) Circannual variation in concentrations of endorphins in cerebrospinal fluid. Pain 12: 265 - 272

    Article  Google Scholar 

  • Waters WE, O’Connors Pl (1971) Epidemiology of headache and migraine in women. J Neurol Neurosurg Psychiatry 34: 148 - 153

    Article  PubMed  CAS  Google Scholar 

  • Wesche L, Frederickson RCA (1978) Diurnal differences in opioid peptide levels correlated with nociceptive sensitivity. Life Sci 24: 1861 - 1868

    Article  Google Scholar 

  • Wesche L, Frederickson RCA (1981) The role of the pituitary in the diurnal variation in tolerance to painful stimuli and brain enkephalin levels. Life Sci 29: 2199 - 2205

    Article  PubMed  CAS  Google Scholar 

  • Wilder-Smith CH, Wilder-Smith OH (1992) Diurnal patterns of pain in cancer patients during treatment with long-acting opioid analgesics. Proceedings of the 5th inter-national conference on biological rhythms and medications, Amelia Island (F1), abstract no X111 - 7

    Google Scholar 

  • Wilder-Smith CH, Schimke J, Bettiga A (1992) Circadian pain responses with tramadol (T), a short-acting opioid and alpha-adrenergic agonist, and morphine (M) in cancer pain. Proceedings of the 5th international conference on biological rhythms and medications. Amelia Island (F1), abstract no X111 - 6

    Google Scholar 

  • Willer JC (1977) Comparative study of perceived pain and nociceptive flexion reflex in man. Pain 3: 69 - 80

    Article  PubMed  CAS  Google Scholar 

  • Willer JC (1985) Studies on pain. Effects of morphine on a spinal nociceptive flexion reflex and relation pain sensation in man. Brain Res 331: 105 - 114

    Article  PubMed  CAS  Google Scholar 

  • Willis WD (1982) Control of nociceptive transmission in the spinal cord. In: Autrum H, Ottoson D, Perl ER, Schmidt RF (eds) Progress in sensory physiology, vol 3. Springer, Berlin Heidelberg New York, pp 1 - 159

    Google Scholar 

  • Wolff BB (1983) Laboratory methods of pain measurement. In: Melzack R (ed) Pain measurement and assessment. Raven, New York, pp 7 - 13

    Google Scholar 

  • Yaksh TL (1978) Analgesic action of intratechal opiates in cat and primate. Brain Res 153: 205 - 210

    Article  PubMed  CAS  Google Scholar 

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Authors
  1. G. Labrecque
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  2. M. Karzazi
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  3. M.-C. Vanier
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Editors and Affiliations

  1. School of Pharmacy and Pharmacology, University of Bath, Claverton Down, BA1 7AY, Bath, UK

    Peter H. Redfern BPharm, PhD

  2. Instituts für Pharmakologie und Toxikologie Fakultät für klinische Medizin Mannheim, Universität Heidelberg, Maybachstr. 14-16, 68169, Mannheim, Germany

    B. Lemmer (Direktor) (Direktor)

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Labrecque, G., Karzazi, M., Vanier, MC. (1997). Biological Rhythms in Pain and Analgesia. In: Redfern, P.H., Lemmer, B. (eds) Physiology and Pharmacology of Biological Rhythms. Handbook of Experimental Pharmacology, vol 125. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-09355-9_23

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  • DOI: https://doi.org/10.1007/978-3-662-09355-9_23

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