Regulation of Cell Division Cycles by Circadian Oscillators: Signal Transduction Between Clocks

  • L. N. EdmundsJr.
Part of the Handbook of Experimental Pharmacology book series (HEP, volume 125)


An important consideration for maximizing the results of radio- and chemotherapy of mammalian cancers is that of host tolerance. It is unfortunate that in most of the earlier cancer work there is little mention of the role of rhythmic variations (particularly circadian periodicities) in the susceptibility of the whole organism to the toxicity of the drug(s) being utilized for treatment (chronotolerance). There now is abundant experimental evidence, however, that properly designed protocols (such as sinusoidally varying drug courses during the 24-h day) can dramatically enhance survival and cure rates by concomitantly maximizing the tolerance of the host to the drug through a temporal shielding of normal, healthy tissues (for recent reviews, see Lemmer 1989; Tourrou and Haus 1992; Chap. 11, this volume). Thus, “when” to treat must assume importance together with the “what” and “where” (Halberg 1975) — a concept embraced by the field of chronotherapeutics.


Circadian Clock cAMP Level Fission Yeast Cell Division Cycle Circadian Oscillator 
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© Springer-Verlag Berlin Heidelberg 1997

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