Abstract
Diabetes mellitus therapy, in which the treatment must maintain a moment-to-moment glycaemic balance, is a major domain in which the principles of chronopharmacology must be included in the therapeutic regime. The therapeutic action, via insulin treatment in the case of insulin-dependent diabetes, or oral sulfamides or biguanides in the case of non-insulin-dependent diabetes, must take into account the physiological variations in induced blood glucose levels in order to avoid hyper or hypoglycaemia.
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Mejean, L., Stricker-Krongrad, A., Lluch, A. (1997). The Endocrine System and Diabetes. In: Redfern, P.H., Lemmer, B. (eds) Physiology and Pharmacology of Biological Rhythms. Handbook of Experimental Pharmacology, vol 125. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-09355-9_12
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