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Radiopharmazie, Toxizität und Strahlendosis

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PET in der Onkologie
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Zusammenfassung

2-[l8F]-2-desoxy-D-glukose (2-[l8F]-FDG) ist die am häufigsten eingesetzte Substanz unter den PET-Ra-diopharmaka in Europa mit mehr als 200 Applikationen pro Woche (Meyer et al. 1995). Die in der Literatur beschriebenen Untersuchungen wurden mit unterschiedlichen 2-[l8F]-FDG-Präparaten durchgeführt, die sich nur unwesentlich voneinander unterscheiden. Für die Bewertung der klinischen Daten sind diese Unterschiede unerheblich.

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Literatur

  • Baudot P, Jaque M, Robin M (1977) Effect of a diazo-polyoxa-macroobicyclic complexing agent on the urinary elimination of lead in lead-poisened rats. Toxicol Appl Pharmacol 41: 113–115

    Article  PubMed  CAS  Google Scholar 

  • Baumann M, Schäfer E, Grein H (1984) Short term studies with the cryptating agent hexaoxa-diaza-bicyclo-hexacosane in rats. Arch Toxicol 55 [Suppl 7]: 427–429

    Article  Google Scholar 

  • Dowd MT, Chin-Tu C, Wendel MJ, Faulhaber PJ, Cooper MD (1991) Radiation dose to the bladder wall from 2-(l8F) fluoro-2-de-soxy-D-glucose in adult humans. J Nucl Med 32: 707–712

    PubMed  CAS  Google Scholar 

  • European Pharmacopoeia (1996) Radiopharmaceutical preparations, pp 1424–1433

    Google Scholar 

  • Gallagher BM, Ansari A, Atkins H et al. (1977) Radiopharmaceuticals XXVII. 18F-labeled 2-desoxy-2-fluoro-D-glucose as a radiopharmaceutical for measuring regional myocardial glucose metabolism in vivo: tissue distribution and imaging studies in animals. J Nucl Med 18: 990–996

    PubMed  CAS  Google Scholar 

  • Gallagher BM, Fowler JS, Gutterson NI, MacGregor RR, Wan CN, Wolf AP (1978). Metabolic trapping as a principle of radiopharmaceutical design: some factors responsible for the biodistribution of 2-Deoxy-2-[l8F]fluoro-D-glucose. J Nucl Med 19: 1154–1161

    PubMed  CAS  Google Scholar 

  • Hamacher K, Coenen HH, Stöcklin G (1986) Efficient stereospecific synthesis of no-carrier-added 2-[l8F] fluoro-2-deoxy-D-glucose using aminopolyether supported nucleophilic substitution. J Nucl Med 27: 235–238

    PubMed  CAS  Google Scholar 

  • Mejia AA, Nakamura T, Mastoshi I, Hatazawa J, Masaki M, Shoichi W (1991) Estimation of absorbed doses in humans due to intravenous administration of fluorine-l8F-fluorodeoxyglucose in PET studies. J Nucl Med 32: 699–706

    PubMed  CAS  Google Scholar 

  • Meyer G-J, Coenen HH, Waters SL et al. (1993) Quality assurance and quality control of short-lived radiopharmaceutikals for PET. In: Stöcklin and Pike (eds) Radiopharmaceuticals for PET. Kluwer, Amsterdam, pp 91–150

    Google Scholar 

  • Meyer GJ, Waters SL, Coenen H H., Luxen A, Maziere B, Langström B (1995) PET radiopharmaceuticals in Europe: current use and data relevant for the formulation of summaries of product characteristics (SPCs). Eur J Nucl Med 22/12: 1420–1432

    Article  PubMed  CAS  Google Scholar 

  • Oehr P, Ruhlmann J, Rink H (1989) 18F-FDG Transport: Abhängigkeit von Glucosekonzentration und Strahlendosis. Nuklearmedizin 37: A68

    Google Scholar 

  • Reivich M, Kühl D, Wolf A et al. (1979). The [l8F] fluorodeoxyglu-cose method for the measurement of local cerebral glucose utilization in man. Circ Res 44: 127–137

    Article  PubMed  CAS  Google Scholar 

  • Som P, Atkins HL, Bandoypadhyay D, Fowler JS et al. (1980) A fluorinated glucose analog, 2-fluoro-2-deoxy-D-glucose (F-18): nontoxic tracer for rapid tumor detection. J Nucl Med 21: 670–675

    PubMed  CAS  Google Scholar 

  • United States Pharmacopeia, USP (1995) Fludeoxyglucose F18 Injections. USP 23: 674

    Google Scholar 

  • Woosley RL, Kim YS, Huang KC (1970) Renal tubular transport of 2-deoxy-D-glucose in dogs and rats. J Pharmacol Exp Ther 173: 13–20

    PubMed  CAS  Google Scholar 

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Ruhlmann, J., Oehr, P. (1998). Radiopharmazie, Toxizität und Strahlendosis. In: Rühlmann, J., Oehr, P., Biersack, HJ. (eds) PET in der Onkologie. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-09242-2_2

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  • DOI: https://doi.org/10.1007/978-3-662-09242-2_2

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-662-09243-9

  • Online ISBN: 978-3-662-09242-2

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