Craniopharyngioma

  • R. Du
  • R. H. Lustig
  • B. Fisch
  • M. W. McDermott
Part of the Pediatric Oncology book series (PEDIATRICO)

Abstract

Craniopharyngiomas are histologically benign neuroepithelial tumors that arise from squamous cell rests found along the path of the primitive craniopharyngeal duct and adenohypophysis. They frequently involve vital structures in the sellar region including the optic apparatus and the pituitary, and often lead to visual, endocrine, and mental disturbances. Thus, despite their benign histology, the involvement of various neural structures in the suprasellar region makes the treatment and management of craniopharyngiomas difficult. There is an ongoing controversy regarding optimal treatment of craniopharyngiomas. The debate revolves around the risks and benefits of attempted gross total resection as compared to subtotal resection or biopsy followed by adjunctive therapy such as external beam radiotherapy, radiosurgery, intracavitary radiation, and/or chemotherapy.

Keywords

Fatigue Adenoma Dementia Cortisol Testosterone 

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References

  1. Anderson CA, Wilkening GN et al (1997) Neurobehavioral outcome in pediatric craniopharyngioma. Pediatr Neurosurg 26: 255 - 260PubMedCrossRefGoogle Scholar
  2. Barbosa M, Rios O et al (2001) Acetylcholinesterase and butyrylcholinesterase histochemical activities and tumor cell growth in several brain tumors. Surg Neurol 55: 106 - 112PubMedCrossRefGoogle Scholar
  3. Barloon TJ,Yuh WT et al (1988) Frontal lobe implantation of craniopharyngioma by repeated needle aspirations. AJNR Am J Neuroradiol 9: 406 - 407Google Scholar
  4. Blackburn TP, Doughty D et al (1999) Stereotactic intracavitary therapy of recurrent cystic craniopharyngioma by instillation of 9oyttrium. Br J Neurosurg 13: 359 - 365PubMedCrossRefGoogle Scholar
  5. Bulow B, Attewell R et al (1998) Postoperative prognosis in craniopharyngioma with respect to cardiovascular mortality, survival, and tumor recurrence. J Clin Endocrinol Me-tab 83:3897-3904Google Scholar
  6. Bunin GR, Surawicz TS et al (1998) The descriptive epidemiology of craniopharyngioma. J Neurosurg 89:547-551Google Scholar
  7. Cavalheiro S, Sparapani FV et al (1996) Use of bleomycin in intratumoral chemotherapy for cystic craniopharyngioma. Case report. J Neurosurg 84: 124-126Google Scholar
  8. Chiou SM, Lunsford LD et al (2001) Stereotactic radiosurgery of residual or recurrent craniopharyngioma, after surgery, with or without radiation therapy. Neurooncology 3: 159 - 166Google Scholar
  9. Chung WY, Pan DH et al (2000) Gamma knife radiosurgery for craniopharyngiomas. J Neurosurg 93 [Suppl 31:47-56Google Scholar
  10. De Divitiis E, Cappabianca P et al (2000) The role of the endoscopic transsphenoidal approach in pediatric neurosurgery. Childs Nery Syst 16: 692 - 696CrossRefGoogle Scholar
  11. De Vile CJ, Grant DB et al (1996a) Growth and endocrine se- quelae of craniopharyngioma. Arch Dis Child 75x08-114Google Scholar
  12. De Vile CJ, Grant DB et al (1996b) Management of childhood craniopharyngioma: can the morbidity of radical surgery be predicted? J Neurosurg 85: 73 - 81PubMedCrossRefGoogle Scholar
  13. Donnet A, Schmitt A et al (1999) Neuropsychological follow-up of twenty two adult patients after surgery for craniopharyngioma. Acta Neurochir (Wien) 141:1049-1054Google Scholar
  14. Donovan JL, Nesbit GM (1996) Distinction of masses involving the sella and suprasellar space: specificity of imaging features. AJR Am J Roentgenol 167: 597 - 603PubMedGoogle Scholar
  15. Duff JM, Meyer FB et al (2000) Long-term outcomes for surgically resected craniopharyngiomas. Neurosurgery 46: 291305Google Scholar
  16. Einhaus SL, Sanford RA (1999) Craniopharyngiomas. In: Albright L, Pollack I, Adelson D (eds) Principles and practice of pediatric neurosurgery. Thieme, New YorkGoogle Scholar
  17. Fahlbusch R, Honneger J et al (1999) Surgical treatment of craniopharyngiomas. J Neurosurg 90: 237 - 250Google Scholar
  18. Fischbein NJ, Dillon WP et al (zoo()) Teaching atlas of brain imaging. Thieme, New YorkGoogle Scholar
  19. Fisher PG, Jenab J et al (1998) Outcomes and failure patterns in childhood craniopharyngiomas. Childs Nery Syst 14558563Google Scholar
  20. Gupta K, Kuhn MJ et al (1999) Metastatic craniopharyngioma. AJNR Am J Neuroradiol 20: 1059 - 1060Google Scholar
  21. Habrand JL, Ganry O et al (1999) The role of radiation therapy in the management of craniopharyngioma: a 25-year experience and review of the literature. Int J Radiat Oncol Biol Phys 44: 255 - 263Google Scholar
  22. Hader WJ, Steinbok P et al (2000) Intratumoral therapy with bleomycin for cystic craniopharyngiomas in children. Pediatr Neurosurg 33: 211 - 218PubMedCrossRefGoogle Scholar
  23. Harwood-Nash DC (1994) Neuroimaging of childhood craniopharyngioma. Pediatr Neurosurg 21 [Suppl 11:2-10Google Scholar
  24. Hayward R (1999) The present and future management of childhood craniopharyngioma. Childs Nery Syst 15:764769Google Scholar
  25. Hetelekidis S, Barnes PD et al (1993) 20-year experience in childhood craniopharyngioma. Int J Radiat Oncol Biol Phys 27: 189 - 195Google Scholar
  26. Hoffman HJ, de Silva M et al (1992) Aggressive surgical management of craniopharyngiomas in children. J Neurosurg 76: 47 - 52PubMedCrossRefGoogle Scholar
  27. Hoffman HJ, Drake JM et al (1999) Craniopharyngiomas and pituitary tumors. In: Choux M, di Rocco C, Hockley AD, Walker ML (eds) Pediatric neurosurgery. Churchill Livingstone, New YorkGoogle Scholar
  28. Honegger J, Barocka A et al (1998) Neuropsychological results of craniopharyngioma surgery in adults: a prospective study. Surg Neurol 50: 19 - 28PubMedCrossRefGoogle Scholar
  29. Israel ZH, Pomeranz S (1995) Intracranial craniopharyngioma seeding following radical resection. Pediatr Neurosurg 22: 210 - 213Google Scholar
  30. Ito M, Jamshidi J et al (2001) Does craniopharyngioma metastasize? Case report and review of the literature. Neurosurgery 48:933-935; discussion 935-936Google Scholar
  31. Jakacki RI, Cohen B. H et al (2000) Phase II evaluation of interferon-alpha-2a for progressive or recurrent craniopharyngiomas. J Neurosurg 92: 255 - 260PubMedCrossRefGoogle Scholar
  32. Kalapurakal JA, Goldman S et al (2000) Clinical outcome in children with recurrent craniopharyngioma after primary surgery. Cancer J 6:388-393Google Scholar
  33. Kernohan JW (1971) Tumors of congenital origin. In: Minckler J (ed) Pathology of central nervous system. McGraw-Hill, New York, pp 1927-1937Google Scholar
  34. Khoo LT, Flagel J et al (2001) Craniopharyngiomas: surgical management. In: Petrovich P, Brady LW, Apuzzo ML, Bamberg M (eds) Combined modality therapy of central nervous system tumors. Springer, Berlin Heidelberg New York, pp 187 - 214CrossRefGoogle Scholar
  35. Kobayashi T, Tanaka T et al (1994) Stereotactic gamma radio-surgery of craniopharyngiomas. Pediatr Neurosurg z1 [Suppl 1]:69-74Google Scholar
  36. Kristopaitis T, Thomas C et al (2000) Malignant craniopharyngioma. Arch Pathol Lab Med 124x356-1360Google Scholar
  37. Laws ER Jr (1994) Transsphenoidal removal of craniopharyngioma. Pediatr Neurosurg 21 [Suppl 1]:57-63Google Scholar
  38. Lee JH, Kim CY et al (1999) Postoperative ectopic seeding of craniopharyngioma. Case illustration. J Neurosurg 90: 796Google Scholar
  39. Leksell L, Liden K (1952) A therapeutic trial with radioactive isotope in cystic brain tumor: radioisotope techniques I. Med Physiol Appl 1: 1 - 4Google Scholar
  40. Lunsford LD, Pollock BE et al (1994) Stereotactic options in the management of craniopharyngioma. Pediatr Neurosurg 21 [Suppl 1]: 90-97Google Scholar
  41. Lustig RH (2002) Hypothalamic obesity: the sixth cranial endocrinopathy. Endocrinologist 12: 210 - 217CrossRefGoogle Scholar
  42. Lustig RH, Post SR et al (2003) Risk factors for obesity in children surviving brain tumors. J Clin Endocrinol Metab 88: 6u - 616Google Scholar
  43. Lustig RH, Rose SR et al (1999) Hypothalamic obesity caused by cranial insult in children: altered glucose and insulin dynamics and reversal by a somatostatin agonist. J Pediatr 135: 162 - 168Google Scholar
  44. Malik JM, Cosgrove GR et al (1992) Remote recurrence of craniopharyngioma in the epidural space. Case report. J Neurosurg 77: 804-807Google Scholar
  45. Matsuo M, Yonemitsu N et al (2001) Expression of prostaglandin H synthetase-2 in human brain tumors. Acta Neuropathol (Wien) 102: 181 - 187Google Scholar
  46. Merchant TE, Kiehna EN et al (2002) Craniopharyngioma: the St Jude Children’s Research Hospital experience 1984-zoo1. Int J Radiat Oncol Biol Phys 53:533-542Google Scholar
  47. Miller DC (1994) Pathology of craniopharyngiomas: clinical import of pathological findings. Pediatr Neurosurg 21 [Suppi1]x1-17Google Scholar
  48. Mokry M (1999) Craniopharyngiomas: a six year experience with Gamma Knife radiosurgery. Stereotact Funct Neurosurg 72 [Suppl 11: 140 - 149CrossRefGoogle Scholar
  49. Moore K, Couldwell WT (2000) Craniopharyngioma. In: Bernstein M, Berger MS (eds) Neuro-oncology: the essentials. Thieme, New YorkGoogle Scholar
  50. Moore K, Persaud TVN (1993) The developing human: clinically oriented embryology. Saunders, PhiladelphiaGoogle Scholar
  51. Nakamizo A, Inamura T et al (2001) Neuroendoscopic treatment of cystic craniopharyngioma in the third ventricle. Minim Invasive Neurosurg 44: 85 - 87PubMedCrossRefGoogle Scholar
  52. Norris JS, Pavaresh M et al (1998) Primary transsphenoidal microsurgery in the treatment of craniopharyngiomas. Br J Neurosurg 12:305-312Google Scholar
  53. Nozaki M, Tada M et al (1998) Rare occurrence of inactivating p53 gene mutations in primary non-astrocytic tumors of the central nervous system: reappraisal by yeast functional assay. Acta Neuropathol (Berl) 95: 291 - 296CrossRefGoogle Scholar
  54. Pierre-Kahn A, Sainte-Rose C et al (1994) Surgical approach to children with craniopharyngiomas and severely impaired vision: special considerations. Pediatr Neurosurg 21 [Suppl 11: 50 - 56Google Scholar
  55. Pollock BE, Lunsford LD et al (1995) Phosphorus-32 intracavitary irradiation of cystic craniopharyngiomas: current technique and long-term results. Int J Radiat Oncol Biol Phys 33: 437 - 446Google Scholar
  56. Raghavan R, Dickey WT Jr et al (2000) Proliferative activity in craniopharyngiomas: clinicopathological correlations in adults and children. Surg Neurol 54:241-247Google Scholar
  57. Ragoowansi AT, Piepgras DG (1991) Postoperative ectopic craniopharyngioma. Case report. J Neurosurg 74:653-655Google Scholar
  58. Regine WF, Mohiuddin M et al (1993) Long-term results of pediatric and adult craniopharyngiomas treated with combined surgery and radiation. Radiother Oncol 27: 13 - 21PubMedCrossRefGoogle Scholar
  59. Rilliet B, de Paul Djientcheu V et al (1999) Craniopharyngiomas, results in children and adolescents operated through a transsphenoidal approach compared with an intracranial approach. Front Radiat Ther Oncol 33:114-122Google Scholar
  60. Riva D, Pantaleoni C et al (1998) Late neuropsychological and behavioural outcome of children surgically treated for craniopharyngioma. Childs Nery Syst 14: 179 - 184CrossRefGoogle Scholar
  61. Samii M, Tatagiba M (1997) Surgical management of craniopharyngiomas: a review. Neurol Med Chir (Tokyo) 37:141149Google Scholar
  62. Sanford RA (1994) Craniopharyngioma: results of survey of the American Society of Pediatric Neurosurgery. Pediatr Neurosurg 21 [Suppl 11:39-43Google Scholar
  63. Sanford RA, Muhlbauer MS (1991) Craniopharyngioma in children. Neurol Clin 9: 453 - 465PubMedGoogle Scholar
  64. Sarubi JC, Bei H, et al (2001) Clonal composition of human adamantinomatous craniopharyngiomas and somatic mutation analyses of the patched (PTCH), Gsalpha and Gi2alpha genes. Neurosci Lett 310: 5 - 8PubMedCrossRefGoogle Scholar
  65. Sheline GE, Wara WM et al (1980) Therapeutic irradiation and brain injury. Int J Radiat Oncol Biol Phys 6: 1215 - 1228PubMedCrossRefGoogle Scholar
  66. Sidawy MK, Jannotta FS (1997) lntraoperative cytologic diagnosis of lesions of the central nervous system. Am J Clin Pathol 108 [4 Suppl 1]:S56-S66Google Scholar
  67. Takahashi H, Nakazawa S et al (1985) Evaluation of postoperative intratumoral injection of bleomycin for craniopharyngioma in children. J Neurosurg 62: 120 - 127PubMedCrossRefGoogle Scholar
  68. Tarbell NJ, Barnes P et al (1994) Advances in radiation therapy for craniopharyngiomas. Pediatr Neurosurg 21 [Suppl 1]: 101 - 107PubMedCrossRefGoogle Scholar
  69. Thapar K, Stefaneanu L et al (1994) Estrogen receptor gene expression in craniopharyngiomas: an in situ hybridization study. Neurosurgery 35a012-1017Google Scholar
  70. Tomita T, McLone DG (1993) Radical resections of childhood craniopharyngiomas. Pediatr Neurosurg 19: 6 - 14Google Scholar
  71. Van Effenterre R, Boch A (2002) Craniopharyngioma in adults and children: a study of 122 surgical cases. J Neurosurg 973-11Google Scholar
  72. Vidal S, Kovacs K et al (2002) Angiogenesis in patients with craniopharyngiomas: correlation with treatment and outcome. Cancer 94: 738 - 745PubMedCrossRefGoogle Scholar
  73. Villani RM, Tomei G et al (1997) Long-term results of treatment for craniopharyngioma in children. Childs Nery Syst 13: 397 - 405CrossRefGoogle Scholar
  74. Voges J, Sturm V et al (1997) Cystic craniopharyngioma: longterm results after intracavitary irradiation with stereotactically applied colloidal beta-emitting radioactive sources. Neurosurgery 40: 263 - 269PubMedCrossRefGoogle Scholar
  75. Weiner HL, Wisoff JH et al (1994) Craniopharyngiomas: a clinicopathological analysis of factors predictive of recurrence and functional outcome. Neurosurgery 35: m01 - 1010CrossRefGoogle Scholar
  76. Weiss M, Sutton L et al (1989) The role of radiation therapy in the management of childhood craniopharyngioma. Int J Radiat Oncol Biol Phys 17: 1313 - 1321PubMedCrossRefGoogle Scholar
  77. Wilson JD, Foster DW et al (1998) Williams textbook of endocrinology. Saunders, PhiladelphiaGoogle Scholar
  78. Yasargil MG, Curcic M et al (1990) Total removal of craniopharyngiomas. Approaches and long-term results in 144 patients. J Neurosurg 73: 3 - 11PubMedCrossRefGoogle Scholar
  79. Yu X, Liu Z et al (2000) Combined treatment with stereotactic intracavitary irradiation and gamma knife surgery for craniopharyngiomas. Stereotact Funct Neurosurg 75: 117 - 122PubMedCrossRefGoogle Scholar
  80. Zuccaro G, Jaimovich R et al (1996) Complications in paediatric craniopharyngioma treatment. Childs Nery Syst 12: 385390Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2004

Authors and Affiliations

  • R. Du
  • R. H. Lustig
  • B. Fisch
  • M. W. McDermott

There are no affiliations available

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